Coronary artery disease最新文献_第10页

Sophoricoside enhances reparative macrophage polarization to promote cardiac repair postmyocardial infarction through PPAR-γ. 苦参皂苷通过PPAR-γ增强修复性巨噬细胞极化促进心肌梗死后心脏修复。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-21 DOI: 10.1097/MCA.0000000000001554

Zhuo Jing Xu, Si Yang Hao

{"title":"Sophoricoside enhances reparative macrophage polarization to promote cardiac repair postmyocardial infarction through PPAR-γ.","authors":"Zhuo Jing Xu, Si Yang Hao","doi":"10.1097/MCA.0000000000001554","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001554","url":null,"abstract":"Background: Myocardial infarction (MI) represents a significant cardiovascular condition that endangers human health. This research aimed to explore the therapeutic effectiveness of sophoricoside (Sop) using a mouse model of MI.Methods: To conduct this investigation, a mice model of MI was utilized, and Sop was delivered through oral administration via gavage. The area of MI in mice was assessed by Masson trichrome staining. Cardiac systolic function and left ventricular dilatation were measured by cardiac ultrasound. Picrosirius red staining and Masson's trichrome staining were performed to detect the collagen deposition and fibrosis. The expressions of reparative macrophage-associated markers were measured by quantitative real-time PCR. Western blotting was utilized to sense expression of lysyl oxidase (LOX), peroxisome proliferator-activated receptor γ (PPAR-γ), and collagen 1. Flow cytometry was performed to detect the number of macrophages. The Cell Counting Kit-8 assay was performed to detect Sop's cytotoxicity. The M2 polarization and efferocytosis in mice model of MI was verified by immunofluorescence assay.Results: Sop significantly reduced myocardial infarct size. Cardiac ultrasound evaluation further showed that Sop was effective in improving cardiac systolic dysfunction and left ventricular dilatation. In addition, Sop significantly promoted efferocytosis and reparative M2 macrophage polarization and inhibited glycolytic metabolic pathways, thereby promoting cardiac tissue repair. It was further found that Sop could obviously promote expression of PPAR-γ in the nucleus. GW9662 partially reversed the improvement of Sop on cardiac repair and reparative macrophage polarization in MI mice.Conclusion: In summary, this study elucidates that Sop enhances reparative macrophage polarization to promote cardiac repair post-MI through PPAR-γ.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of intravascular imaging on percutaneous coronary intervention outcomes in acute myocardial infarction: a systematic review and meta-analysis. 血管内成像对急性心肌梗死经皮冠状动脉介入治疗结果的影响：一项系统回顾和荟萃分析。

IF 2 4区医学

Coronary artery disease Pub Date : 2025-07-18 DOI: 10.1097/MCA.0000000000001553

Akshay Machanahalli Balakrishna, Dua Noor Butt, Alexander G Hall, Danielle B Dilsaver, Elissa S Altin, Srihari S Naidu, Jennifer A Rymer, Andrew M Goldsweig

{"title":"The impact of intravascular imaging on percutaneous coronary intervention outcomes in acute myocardial infarction: a systematic review and meta-analysis.","authors":"Akshay Machanahalli Balakrishna, Dua Noor Butt, Alexander G Hall, Danielle B Dilsaver, Elissa S Altin, Srihari S Naidu, Jennifer A Rymer, Andrew M Goldsweig","doi":"10.1097/MCA.0000000000001553","DOIUrl":"10.1097/MCA.0000000000001553","url":null,"abstract":"Background: Intravascular imaging (IVI) facilitates optimal outcomes in percutaneous coronary intervention (PCI). Focused data on the impact of IVI on outcomes of PCI in acute myocardial infarction (AMI), in particular, are scarce.Methods: A systematic search of the PubMed, EMBASE, Medline, and Cochrane databases was conducted from their inception to 1 December 2024 for studies comparing IVI to coronary angiography alone to guide PCI in AMI. Outcomes of interest included all-cause mortality (primary), cardiac mortality, major adverse cardiovascular events (MACE), recurrent myocardial infarction, target vessel revascularization (TVR), stent thrombosis, and target lesion revascularization (TLR). Random effects models were used to calculate relative risks (RRs) with 95% confidence intervals (CIs).Results: Fourteen studies (43 547 patients) met inclusion criteria; nine studies reported all-cause mortality. Among patients with AMI, compared with coronary angiography alone, patients with IVI-guided PCI had lower all-cause mortality (RR: 0.76, 95% CI: 0.64-0.89; P < 0.01). IVI had less cardiac death (RR: 0.71, 95% CI: 0.59-0.86; P < 0.01), MACE (RR: 0.85, 95% CI: 0.77-0.94; P < 0.01), recurrent MI (RR: 0.84, 95% CI: 0.71-99; P = 0.04), TVR (RR: 0.79, 95% CI: 0.70-0.89; P < 0.01), and stent thrombosis (RR: 0.69, 95% CI: 0.53-0.90; P = 0.01). TLR was not significantly different between IVI and coronary angiography alone.Conclusion: Among patients with AMI, IVI-guided PCI is associated with improved clinical outcomes compared with coronary angiography alone. Further high-quality randomized trials are needed to clarify the magnitude of benefit.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ticagrelor and sleep apnea: an international retrospective cohort study. 替格瑞洛与睡眠呼吸暂停：一项国际回顾性队列研究

IF 2 4区医学

Coronary artery disease Pub Date : 2025-07-18 DOI: 10.1097/MCA.0000000000001556

Ramzi Ibrahim, Mahmoud Abdelnabi, Mohamed Allam, Eiad Habib, Hoang Nhat Pham, Rahmeh Alasmar, Hashim Alhammouri, Chadi Ayoub, Eric Yang, John Sweeney, Kwan Lee, Dan Sorajja, David Fortuin, Reza Arsanjani

引用次数: 0

Left main coronary artery 'pseudo bridging' on angiogram: a rare angiographic entity. 冠状动脉左主干血管造影显示“假桥”：一种罕见的血管造影现象。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-16 DOI: 10.1097/MCA.0000000000001549

Pradnya Brijmohan Bhattad, Thomas C Piemonte

引用次数: 0

Trends and disparities in ischemic heart disease mortality in the United States: an analysis of CDC WONDER database, 1999-2020. 美国缺血性心脏病死亡率的趋势和差异：1999-2020年CDC WONDER数据库分析

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-07 DOI: 10.1097/MCA.0000000000001550

Muhammad Abdullah Naveed, Faizan Ahmed, Sherif Eltawansy, Ahila Ali, Zaima Afzaal, Bazil Azeem, Muhammad Kashan, Kainat Aman, Mushood Ahmed, Hritvik Jain, Omar Kamil, Faseeh Haider, Rabia Iqbal, Aman Ullah, Nisar Asmi, Muhammad Faizan Ali

{"title":"Trends and disparities in ischemic heart disease mortality in the United States: an analysis of CDC WONDER database, 1999-2020.","authors":"Muhammad Abdullah Naveed, Faizan Ahmed, Sherif Eltawansy, Ahila Ali, Zaima Afzaal, Bazil Azeem, Muhammad Kashan, Kainat Aman, Mushood Ahmed, Hritvik Jain, Omar Kamil, Faseeh Haider, Rabia Iqbal, Aman Ullah, Nisar Asmi, Muhammad Faizan Ali","doi":"10.1097/MCA.0000000000001550","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001550","url":null,"abstract":"Background: Ischemic heart disease (IHD) remains a leading cause of mortality globally and has a high prevalence in the USA, necessitating an understanding of long-term trends to inform interventions. Considering demographic and geographic disparities, this study examines IHD-related mortality trends among US adults from 1999 to 2020.Aim: This study aimed to evaluate patterns and geographical variations in mortality associated with IHD among adults in the USA.Methods: Death certificates from the CDC WONDER database spanning from 1999 to 2020 were analyzed to investigate mortality related to IHD among adults aged 35 years and above. Age-adjusted mortality rates (AAMRs) per 100 000 persons and annual percent change were calculated and stratified by year, sex, race/ethnicity, and geographic region.Results: IHD caused 12 756 359 deaths among U.S. adults aged 35 and above from 1999 to 2020. Annual trends in AAMRs declined from 48.7 in 1999 to 28.9 in 2020, with notable fluctuations. Men consistently had higher AAMRs than women. Non-Hispanic Black or African American individuals exhibited the highest AAMRs. Geographically, significant disparities existed among states and regions, with the Northeast having the highest mortality. Nonmetropolitan areas consistently had higher AAMRs than metropolitan areas, showing varying trends over the study period.Conclusion: Fluctuations in mortality trends among IHD patients were observed over the study duration, revealing significant disparities across demographic and geographic parameters. Targeted interventions are imperative to alleviate the burden of IHD and mitigate mortality rates in the USA.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pulse wave velocity and coronary atherosclerosis. 脉搏波速度与冠状动脉粥样硬化的关系。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-24 DOI: 10.1097/MCA.0000000000001548

Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro

{"title":"Association between pulse wave velocity and coronary atherosclerosis.","authors":"Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro","doi":"10.1097/MCA.0000000000001548","DOIUrl":"10.1097/MCA.0000000000001548","url":null,"abstract":"Background: Pulse wave velocity (PWV) is considered a more direct and accurate measure of arterial stiffness. This study explored the relationship between PWV and the presence and severity of coronary artery calcification (CAC) and coronary artery plaque (CAP).Methods: The current study was a cross-sectional analysis of data from the Miami Heart Study (MiHeart). The primary outcome variable of this study was the CAC score. The secondary outcome was the presence of CAC and CAP. Multivariable logistic regression and Bayesian linear regression were used to find the association between PWV CAC and CAP.Results: A total of 2359 participants were included in the study. The mean age (SD) of the sample was 53.4 (6.8) years and 50.4% were men. Multivariable logistic regression analysis showed that the odds of having CAC greater than 0 was significantly higher with increasing PWV [odds ratio (OR): 1.09, 95% confidence interval (CI): 1.01-1.18]. Similarly, multivariable logistic regression analysis also showed that the odds for CAP were significantly higher with increasing PWV (OR: 1.14, 95% CI: 1.06-1.23). The results of Bayesian linear regression analysis showed that there was a significant association between PWV and log CAC score.Conclusion: In a large sample of participants from the community and without a history of known cardiovascular disorder, we found that an increase in PWV was associated with the presence of CAC and CAP. In addition, we also found that PWV was associated with severity of CAC as well. Our findings show that PWV could be an important marker of subclinical coronary atherosclerosis in the general population.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the first-in-man study of a novel everolimus-coated balloon for coronary in-stent restenosis. 新型依维莫司涂层球囊治疗冠状动脉支架内再狭窄的首次人体研究的经验教训。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001541

Rupak Desai, Nihar K Jena

引用次数: 0

Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016. 内脏脂肪代谢评分与动脉粥样硬化性心血管疾病的相关性：来自NHANES 2005 - 2016的证据

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001545

Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li

{"title":"Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016.","authors":"Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li","doi":"10.1097/MCA.0000000000001545","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001545","url":null,"abstract":"Background: Obesity and metabolic disorders are key contributors to the development of atherosclerotic cardiovascular disease (ASCVD). This study sought to investigate the relationship between the newly introduced Metabolic Score for Visceral Fat (METS-VF) and ASCVD, utilizing data from the National Health and Nutrition Examination Survey (NHANES).Methods: Data from NHANES 2005-2016 were analyzed. Adults with complete METS-VF and ASCVD data were included. Weighted multivariate logistic regression models assessed associations between METS-VF and ASCVD. Smoothed curve fitting and subgroup analyses further explored the relationship. Receiver operating characteristic curves were used to compare the predictive performance of METS-VF with other indicators of visceral fat.Results: A total of 9979 participants were included, among whom 807 had ASCVD. In the fully adjusted model, each 1-unit increase in METS-VF was associated with a 43% higher ASCVD risk (OR = 1.43, 95% CI: 1.11-1.85). Compared with Q1, the ORs for Q2, Q3, and Q4 were 1.71, 1.72, and 2.10, respectively (P for trend <0.05). The curve fitting showed a linear positive association. Subgroup analyses indicated significant associations in men, non-Hispanic Whites and Blacks, and participants without hypertension, who smoked, drank alcohol, or physically inactive. METS-VF showed better predictive ability (AUC = 0.734) than LAP, VAI, WC, and WHtR.Conclusions: METS-VF is a reliable, noninvasive, and cost-effective predictor of visceral obesity that demonstrates a linear positive correlation with ASCVD, supporting its use as an accurate measure of ASCVD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated left main coronary artery disease in two young HIV-positive men without traditional risk factors. 孤立的左主干冠状动脉疾病的两个年轻的hiv阳性男子没有传统的危险因素。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001547

Didar Mirzamidinov, Kurtulus Karauzum, Hacer Dogan, Kaan Hanci, Irem Yilmaz, Goksel Kahraman, Tayfun Sahin

引用次数: 0

Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise. 胆红素可能介导有氧运动习惯的抗炎作用：有氧运动的抗动脉粥样硬化作用的含义。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001546

Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi

{"title":"Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise.","authors":"Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1097/MCA.0000000000001546","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001546","url":null,"abstract":"Background: Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.Methods: This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.Results: In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.Conclusion: Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0