Association between pulse wave velocity and coronary atherosclerosis.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-06-24 DOI:10.1097/MCA.0000000000001548

Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro

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引用次数: 0

Abstract

Background: Pulse wave velocity (PWV) is considered a more direct and accurate measure of arterial stiffness. This study explored the relationship between PWV and the presence and severity of coronary artery calcification (CAC) and coronary artery plaque (CAP).

Methods: The current study was a cross-sectional analysis of data from the Miami Heart Study (MiHeart). The primary outcome variable of this study was the CAC score. The secondary outcome was the presence of CAC and CAP. Multivariable logistic regression and Bayesian linear regression were used to find the association between PWV CAC and CAP.

Results: A total of 2359 participants were included in the study. The mean age (SD) of the sample was 53.4 (6.8) years and 50.4% were men. Multivariable logistic regression analysis showed that the odds of having CAC greater than 0 was significantly higher with increasing PWV [odds ratio (OR): 1.09, 95% confidence interval (CI): 1.01-1.18]. Similarly, multivariable logistic regression analysis also showed that the odds for CAP were significantly higher with increasing PWV (OR: 1.14, 95% CI: 1.06-1.23). The results of Bayesian linear regression analysis showed that there was a significant association between PWV and log CAC score.

Conclusion: In a large sample of participants from the community and without a history of known cardiovascular disorder, we found that an increase in PWV was associated with the presence of CAC and CAP. In addition, we also found that PWV was associated with severity of CAC as well. Our findings show that PWV could be an important marker of subclinical coronary atherosclerosis in the general population.

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脉搏波速度与冠状动脉粥样硬化的关系。

背景：脉搏波速度（PWV）被认为是一种更直接和准确的测量动脉硬度的方法。本研究探讨PWV与冠状动脉钙化（CAC）和冠状动脉斑块（CAP）的存在和严重程度之间的关系。方法：目前的研究是对迈阿密心脏研究（MiHeart）数据的横断面分析。本研究的主要结局变量是CAC评分。次要结果是CAC和CAP的存在。采用多变量logistic回归和贝叶斯线性回归来寻找PWV CAC与CAP之间的关系。结果：共有2359名参与者纳入研究。样本的平均年龄（SD）为53.4（6.8）岁，50.4%为男性。多变量logistic回归分析显示，随着PWV的增加，CAC大于0的几率显著增加[比值比（OR）： 1.09, 95%可信区间（CI）： 1.01-1.18]。同样，多变量logistic回归分析也显示，随着PWV的增加，CAP的几率显著增加（OR: 1.14, 95% CI: 1.06-1.23）。贝叶斯线性回归分析结果表明，PWV与log CAC评分之间存在显著相关。结论：在一个没有已知心血管疾病史的社区参与者的大样本中，我们发现PWV的增加与CAC和CAP的存在有关。此外，我们还发现PWV也与CAC的严重程度有关。我们的研究结果表明，PWV可能是普通人群亚临床冠状动脉粥样硬化的重要标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.