Coronary artery disease最新文献

{"title":"A rare constellation: Behcet's disease, moyamoya syndrome, and recurrent ostial coronary occlusions.","authors":"Aziz Inan Celik, Burcu Kodal, Tahir Bezgin","doi":"10.1097/MCA.0000000000001619","DOIUrl":"10.1097/MCA.0000000000001619","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"244-245"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ST-elevation myocardial infarction in a patient with extremely rare single coronary artery anatomy.","authors":"Konstantinos C Theodoropoulos, Spyridon-Filippos Papadopoulos, Alexandra Liakopoulou, Charalambos Kakderis, Matthaios Didagelos, George Kassimis, Antonios Ziakas","doi":"10.1097/MCA.0000000000001620","DOIUrl":"10.1097/MCA.0000000000001620","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"246-247"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of orbital atherectomy is associated with prior rotational atherectomy and a greater preprocedural lumen area.","authors":"Ryosuke Amisaki, Tomomi Watanabe, Masaru Kato","doi":"10.1097/MCA.0000000000001585","DOIUrl":"10.1097/MCA.0000000000001585","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) in severely calcified lesions remains challenging. While orbital atherectomy is a treatment option for calcified lesions, the specific patient and lesion characteristics that predict successful debulking with orbital atherectomy remain unclear. This study aimed to identify the factors associated with a greater minimum lumen area (MLA) after orbital atherectomy.</p><p><strong>Methods: </strong>We retrospectively identified 77 lesions in 68 patients who underwent PCI with orbital atherectomy at Tottori University Hospital from May 2020 to June 2024. Among these, 62 lesions with a measurable intraluminal area by intravascular imaging were included in the analysis. The lesions were divided into two groups on the basis of a median post-orbital atherectomy MLA of 2.5 mm 2 : the large group (≥2.5 mm 2 ) and the small group (<2.5 mm 2 ). We compared the patients' background, characteristics of the lesions, procedural details, and imaging findings between the two groups.</p><p><strong>Results: </strong>The large group more frequently had prior rotational atherectomy use (35.5 vs. 3.2%; P  = 0.004) and had a greater pre-orbital atherectomy MLA [2.36 (2.01-3.10) vs. 1.37 mm 2 (0.99-1.76); P  < 0.001] than the small group. No significant differences in major complications or 1-year outcomes were observed between the two groups.</p><p><strong>Conclusion: </strong>Optimal lumen gain following orbital atherectomy was associated with a greater pre-orbital atherectomy MLA and prior rotational atherectomy. Pretreatment with rotational atherectomy may establish a sufficient lumen, subsequently enhancing the efficacy of orbital atherectomy. These results suggest the effectiveness of a strategy of using rotational atherectomy before orbital atherectomy.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"215-221"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puerarin alleviates diabetic atherosclerosis through controlling the follistatin-like 1 related inflammation.","authors":"Jiajun Chen, Zhen Hu, Meimei Fang, Xiang Hu, Xiaoqiong Pan, Xiaofen Ni","doi":"10.1097/MCA.0000000000001597","DOIUrl":"10.1097/MCA.0000000000001597","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored the therapeutic potential of puerarin in diabetic atherosclerosis (DA) by targeting endothelial dysfunction and lipid metabolism in apolipoprotein E (APOE)-/- mice.</p><p><strong>Methods: </strong>In vitro, human aortic endothelial immortalized cells cultured under high glucose conditions were treated with puerarin. Cell viability was quantified using cell counting kit-8 (CCK-8) assay. Apoptosis rates were measured via Annexin V/PI flow cytometry. Lipid accumulation was assessed through Oil Red O staining. iNOS levels were detected by ELISA. In vivo, diabetic APOE-/- mice fed a high-fat diet received daily puerarin administration. Aortic collagen deposition was evaluated using Masson trichrome staining. Plaque burden was analyzed via hematoxylin-eosin staining. Serum lipid profiles, including low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were determined by enzymatic assays. Follistatin-like 1 (Fstl1) protein expression and downstream inflammatory mediators were examined through Western blot and immunofluorescence.</p><p><strong>Results: </strong>Puerarin significantly improved endothelial cell survival and reduced apoptosis under high glucose. Lipid droplet formation decreased alongside iNOS suppression. In diabetic mice, puerarin attenuated aortic plaque area and collagen content while improving dyslipidemia. Fstl1 expression and associated inflammatory markers were downregulated.</p><p><strong>Conclusion: </strong>Puerarin alleviates DA progression through dual modulation of endothelial protection and Fstl1-mediated inflammatory pathways.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"37 3","pages":"229-237"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of invasive versus noninvasive treatments in elderly patients with non-ST-segment myocardial infarction: a systematic review and meta-analysis.","authors":"Shanza Malik, Zahra Quettawala Mufaddal, Lida Koskina, Omer Mustafa Siddiqui, Mohamad Mansour, Khushboo Nusrat, Rafay Khan, Muhammad Umer Sohail, Syed Husain Farhan, Deepinder Singh, Eman Ali, Ishaque Hameed","doi":"10.1097/MCA.0000000000001586","DOIUrl":"10.1097/MCA.0000000000001586","url":null,"abstract":"<p><strong>Background: </strong>Historically, the elderly population was underrepresented in clinical trials evaluating the optimal treatment for non-ST-segment elevation myocardial infarction (NSTEMI). Therefore, we aimed to compare invasive versus noninvasive strategies for the management of NSTEMI in older adults.</p><p><strong>Methods: </strong>PubMed, SCOPUS, and Cochrane Central Register of Controlled Trials were screened for studies evaluating medical therapy or invasive revascularization in elderly patients with NSTEMI. Following outcomes were extracted: all-cause mortality, cardiovascular death, fatal or nonfatal MI, repeat coronary revascularization, major adverse cardiovascular events (MACE), bleeding, stroke, noncardiovascular death, and repeat hospitalization for heart failure. Data were pooled using random-effects model to evaluate weighted mean differences and risk ratios with 95% confidence intervals (CIs). This study is registered with PROSPERO, CRD42024622236.</p><p><strong>Results: </strong>Seven studies ( n  = 2997 patients) were included. Patients treated with medical versus invasive therapies showed no significant difference in all-cause mortality (risk ratio: 1.05, 95% CI: 0.94-1.18, P  = 0.37); however, invasive therapies significantly decreased the risk of fatal or nonfatal MI (risk ratio: 0.75, 95% CI: 0.59-0.96, P  = 0.02), repeat coronary revascularizations (risk ratio: 0.29, 95% CI: 0.21-0.40, P  < 0.00001), and risk of MACE (risk ratio: 0.74, 95% CI: 0.61-0.89, P  = 0.002). Lastly, invasive therapies were associated with increased risk of bleeding.</p><p><strong>Conclusion: </strong>Invasive therapy, in comparison to medical management, has reduced incidence of fatal or nonfatal MI, MACE, and the need for revascularization; however, no benefit was noted for all-cause and cardiovascular mortality. Age-specific guidelines must be established for the management of NSTEMI among older adults.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"206-214"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug choice for drug-coated balloons for the treatment of in-stent restenosis: a meta-analysis of randomized trials.","authors":"Andrea Milzi, Antonio Landi","doi":"10.1097/MCA.0000000000001603","DOIUrl":"10.1097/MCA.0000000000001603","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"238-240"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular imaging vs. angiography alone to guide percutaneous coronary intervention in older adults: a meta-analysis of randomized controlled trials.","authors":"Chidubem Ezenna, Sammudeen Ibrahim, Mahmoud Ismayl, Mrinal Murali Krishna, Kuan-Yu Chi, Meghna Joseph, Zafer Akman, Raiza Rossi, Armin Nouri, Mohammad Al Mouslmani, Abdulla Damluji, Andrew M Goldsweig, Michael G Nanna","doi":"10.1097/MCA.0000000000001584","DOIUrl":"10.1097/MCA.0000000000001584","url":null,"abstract":"<p><strong>Background: </strong>Older adults undergoing percutaneous coronary intervention (PCI) face unique challenges due to complex anatomy and comorbidities. Intravascular imaging [including intravascular ultrasound (IVUS) and optical coherence tomography (OCT)] has been shown to improve PCI outcomes, but its benefits in older adults are less well established. We conducted a meta-analysis of randomized controlled trials (RCTs) to compare intravascular imaging with angiography alone to guide PCI in older adults.</p><p><strong>Methods: </strong>Cochrane, PubMed, and Scopus were searched for RCTs comparing intravascular imaging (IVUS or OCT) vs. angiography alone in adults aged ≥65 years. The outcome of interest was major adverse cardiovascular events (MACE) at the longest follow-up, as defined by each trial. Subgroup analyses were performed based on intravascular imaging modality, age group, and lesion complexity. Data were pooled using random-effects models, and heterogeneity was assessed using Higgins' I ² statistic.</p><p><strong>Results: </strong>Nine RCTs ( n  = 7164, intravascular imaging = 3703, angiography alone = 3461) met the inclusion criteria. Intravascular imaging significantly reduced MACE compared with angiography alone [relative risk (RR) 0.66, 95% confidence interval (CI) 0.56-0.77; P  < 0.001; I ² = 0%]. IVUS demonstrated superiority over angiography alone (RR 0.55, 95% CI 0.43-0.72; P  < 0.001; I ² = 0%), while OCT demonstrated only a trend toward MACE reduction (RR 0.80, 95% CI 0.62-1.02). Subgroup analyses indicated consistent benefits with intravascular imaging for adults aged ≥65 and ≥70 years, respectively, and among those with complex coronary lesions (RR 0.65, 95% CI 0.53-0.79; P  < 0.001).</p><p><strong>Conclusion: </strong>Intravascular imaging guidance, especially IVUS, reduces MACE in older adults undergoing PCI compared with angiography alone.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"195-205"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention for bifurcation lesions: a systematic review and meta-analysis.","authors":"Ricardo F O Suruagy-Motta, Julia Tirelli-Rocha, Luiz Guilherme Silva Almeida, Ana Beatriz P Aguiar-Barros, Lucas Lima Mendes, Leonardo Dexheimer da Silva, Kalgi Modi, Pedro Cox-Alomar, Pedro Henrique Magalhães Craveiro de Melo, Evandro Martins Filho, Alexandre Abizaid, Brunna Pileggi","doi":"10.1097/MCA.0000000000001648","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001648","url":null,"abstract":"<p><strong>Background: </strong>The optimal duration of dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention for coronary bifurcation lesions remains uncertain. This meta-analysis focused on comparing ischemic and bleeding outcomes between short-term (≤6 months) and long-term (>6 months) DAPT in this high-risk subgroup.</p><p><strong>Methods: </strong>We included six studies comprising 12 066 patients with bifurcation lesions treated with drug-eluting stents and either short- or long-term DAPT. Pooled relative risk (RR) and 95% confidence intervals (CI) were calculated for major adverse cardiovascular events (MACE), all-cause and cardiac mortality, myocardial infarction, stent thrombosis, stroke, bleeding, and target lesion revascularization.</p><p><strong>Results: </strong>Short-term DAPT was associated with significantly higher risks of MACE (RR 1.79; 95% CI 1.05-3.07), all-cause mortality (RR: 2.78; 95% CI: 1.49-5.19), cardiac death (RR 2.29; 95% CI 1.34-3.91), and stent thrombosis (RR: 4.90; 95% CI: 2.78-8.66). Although the risks of myocardial infarction (RR: 1.75; 95% CI: 0.69-4.47), stroke (RR: 1.07; 95% CI: 0.61-1.67), bleeding (RR: 1.49; 95% CI: 0.24-9.48), and target lesion revascularization (RR: 1.35; 95% CI: 0.85-2.12) did not reach statistical significance, the effect estimates consistently favored long-term DAPT.</p><p><strong>Conclusion: </strong>In patients undergoing percutaneous coronary intervention for bifurcation lesions, short-term DAPT was associated with significantly worse ischemic outcomes, including increased rates of MACE, death, and stent thrombosis. These findings support the use of extended DAPT duration as the preferred strategy in this anatomical subgroup, with treatment tailored according to individual bleeding risk.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardizing the definition of premature coronary artery disease: the case for less than or equal to 40 years.","authors":"Pablo Juan-Salvadores, Víctor A Jiménez Díaz","doi":"10.1097/MCA.0000000000001645","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001645","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side-branch rescue through balloon deflection technique.","authors":"Dimitrios Karelas, Konstantinos Manousopoulos, Konstantinos Filippou, Panagiotis Varelas, Ioannis Papadopoulos, Ioannis Tsiafoutis","doi":"10.1097/MCA.0000000000001638","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001638","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}