Coronary artery disease最新文献

{"title":"Double kissing culotte or mini-crush stenting for true coronary bifurcation lesions: the multicenter COLLECT-BIF registry.","authors":"Ahmet Yaşar Çizgici, Aybüke Şimşek, Hande Uysal, Ahmet Güner, Mehmet Baran Karataş, Elnur Alizade, Ali Nazmi Çalik, İrfan Şahin, İbrahim Faruk Aktürk, Serkan Kahraman, Ömer Taşbulak, Ezgi Gültekin Güner, Ebru Serin, Veysel Ozan Tanik, Abdullah Doğan, Kaan Gökçe, Enes Arslan, Hamdi Püşüroğlu, Muhammed Furkan Deniz, Cemalettin Akman, Murat Gökalp, İlyas Çetin, Berkay Serter, Koray Çiloğlu, Mehmet Kocaağa, Kudret Keskin, Saner Bahadir Gök, Fatih Furkan Bedir, Eyüp Karaer, Ahmet Arif Yalçin, Fatih Uzun","doi":"10.1097/MCA.0000000000001560","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001560","url":null,"abstract":"<p><strong>Background: </strong>This multicenter observational study aimed to retrospectively evaluate the mid-term clinical outcomes of the mini-crush technique (MCT) and double kissing culotte technique (DKCT) in patients with coronary bifurcation lesions (CBLs).</p><p><strong>Methods: </strong>This large-scale, multicenter study (n = 8) included patients with CBLs who underwent percutaneous coronary intervention with either MCT or DKCT. The primary endpoint was defined as major adverse cardiac events (MACE), which include cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization.</p><p><strong>Results: </strong>A total of 728 patients [male: 584 (80.2%), mean age: 60.93 ± 10.46 years] were included. The initial revascularization strategy was MCT in 476 (65.4%) cases and DKCT in 252 (34.6%) cases. The number of balloons used (6.30 ± 1.84 vs. 5.43 ± 1.99, P < 0.001) and procedure time (65.10 ± 20.34 vs. 61.30 ± 18.48 min, P = 0.020) were significantly higher in the DKCT group. In multivariate Cox regression analysis, risk-adjusted mid-term MACE [hazard ratio (HR): 0.645, (95% confidence interval: 0.395-1.053), P = 0.079] did not differ in the MCT group compared to the DKCT group. Additionally, chronic kidney disease (HR = 2.434, P < 0.001), high SYNTAX score (HR = 1.085, P < 0.001), final kissing balloon inflation (HR = 0.110, P < 0.001), presence of nonfatal intraprocedural complications (HR = 5.818, P < 0.001), and high total cholesterol level (HR = 1.007, P = 0.005) were found to be independent predictors of MACE.</p><p><strong>Conclusion: </strong>This multicenter registry demonstrates that in patients with CBLs, the risk-adjusted MACE rate was similar between both techniques, with a nonsignificant trend favoring MCT at mid-term follow-up.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-enhanced recognition of occlusions in acute coronary syndrome (AERO-ACS): a retrospective study.","authors":"James W H Choi, Vincent Torelli, Alex Silverman, Sara Saravia Diaz, Darren Kong, Esha Vaish, Luka Katic, Alex Nagourney, Zara Khan, Lexi Robbins, Sean Pinney, Nitin Barman, Serdar Farhan","doi":"10.1097/MCA.0000000000001555","DOIUrl":"10.1097/MCA.0000000000001555","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) augmentation of ECG assessment has significant potential to improve patient outcomes in acute coronary syndrome.</p><p><strong>Objective: </strong>We sought to evaluate the performance of a novel AI device (PMCardio) in assessing angiographic occlusion myocardial infarction (OMI) and predicting clinical outcomes.</p><p><strong>Methods: </strong>We used a 1-year retrospective cohort of angiographic data from patients presenting with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). The device analyzed precatheterization ECGs to identify OMI, defined as a culprit vessel with thrombolysis In myocardial infarction (TIMI) 0-2 flow or TIMI 3 flow and peak cardiac troponin I > 10.0 ng/ml.</p><p><strong>Results: </strong>A total of 217 patients were included: 72 STEMI (32%) and 145 NSTEMI (65%). Angiographic OMI was confirmed in 60 (83%) STEMI and 51 (35%) NSTEMI cases. The AI model achieved a sensitivity of 86.5%, specificity of 82.2%, and an area under the curve of 0.84. Traditional STEMI criteria had a sensitivity of 54.1% and a specificity of 88.7%. The AI model was 100% sensitive in detecting STEMI-OMI. The odds ratio for mortality in AI-detected OMI patients was 12.44 (1.56-98.98), unplanned readmissions 1.15 (0.53-2.51), and reduced ejection fraction at 1 year 0.24 (0.26-2.16).</p><p><strong>Conclusions: </strong>The AI model demonstrated higher sensitivity and similar specificity compared with traditional STEMI criteria, improving OMI detection while reducing false positives. These findings suggest potential benefits in triage accuracy and resource utilization, but further prospective validation is needed to determine its clinical impact.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of Naples prognostic score in long-term outcomes after percutaneous coronary intervention in chronic total occlusions.","authors":"Cihan Aydin, Aykut Demirkiran, Hüseyin Orta","doi":"10.1097/MCA.0000000000001520","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001520","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"36 5","pages":"456-457"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncardiac chest computerized tomography scan as a predictor for plaque presence in coronary artery.","authors":"Zipi Regev-Avraham, Ina Rozenfeld, Osamah Hussein, Adi Sharabi-Nov, Majdi Halabi","doi":"10.1097/MCA.0000000000001477","DOIUrl":"10.1097/MCA.0000000000001477","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcium, a marker of coronary atherosclerosis, is often identified on noncoronary chest computed tomography (CT). We wanted to evaluate the correlation between the presence of coronary plaques in coronary artery catheterization and coronary calcifications as shown in noncardiac chest CT.</p><p><strong>Methods: </strong>A retrospective case-control study consisting of cases ( N  = 63) and controls ( N  = 29), aged 18-70 years old, residing in northern Israel and treated in the Intensive Cardiac Care Unit of Ziv Medical Center, between January 2020 and November 2022. All participants underwent coronary catheterization and noncoronary CT scans in the 5 years before the catheterization procedure. Data were taken from the participants' electronic files while considering the potential of cardiovascular risk factors.</p><p><strong>Results: </strong>The 92 participants had a mean age of 60.1 ± 10.3 years old. Multivariate logistic regression adjusted to age, sex, and hyperlipidemia showed that calcified coronary artery as shown on a previous noncardiac CT scan was positively and significantly associated with increasing risk of coronary plaque as presented in coronary catheterization: odds ratio = 5.93 (95% confidence interval: 1.85-19.07, P  < 0.01) and was also associated with male sex who were more likely to have plaque on coronary catheterization than females: odds ratio = 3.77 (95% confidence interval: 1.29-11.32, P  < 0.05).</p><p><strong>Conclusion: </strong>Coronary calcifications on a previous noncoronary CT scan and sex are positively and significantly associated with coronary plaque risk as present in coronary catheterization. Coronary evaluation on CT scans is important for early detection of coronary disease. Early treatment can avoid coronary disease complications and increase patient survival.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"373-377"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: 'The effectiveness of HALP score in predicting mortality in non-ST-elevation myocardial infarction patients'.","authors":"Cihan Aydin, Aykut Demirkiran, Mesut Engin, Ahmet Gültekin","doi":"10.1097/MCA.0000000000001514","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001514","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"36 5","pages":"455"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inadequate awareness and attention to non-HDL cholesterol: undertreatment of high-risk patients in cardiology practice in Turkey.","authors":"Gurbet Özge Mert, Kadir Uğur Mert, Özcan Başaran, Volkan Doğan, İbrahim Rencüzoğullari, Bülent Özlek, Göksel Çinier, Eda Özlek, Murat Biteker, Meral Kayikçioğlu","doi":"10.1097/MCA.0000000000001493","DOIUrl":"10.1097/MCA.0000000000001493","url":null,"abstract":"<p><strong>Background: </strong>The relationship between low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD) is well-established. Recently, non-high-density lipoprotein cholesterol (non-HDL-C) has been validated as a superior predictor of ASCVD, especially in individuals with mild to moderate hypertriglyceridemia. The EPHESUS study evaluated real-life hypercholesterolemia management and awareness of non-HDL-C in cardiology outpatient practices.</p><p><strong>Methods: </strong>Data from 1868 patients with ASCVD or high-risk primary prevention were analyzed to assess cholesterol goal attainment, statin adherence, and physician perceptions. This analysis focused on awareness of non-HDL-C as an ASCVD predictor, adherence to lipid-lowering therapy, and clinicians' perceptions. Associations between patient demographics, clinical characteristics, and statin adherence were examined.</p><p><strong>Results: </strong>Among patients, 20.2% achieved non-HDL-C and 16.5% achieved LDL-C goals. In primary prevention, 18.1% reached non-HDL-C and 10.6% reached LDL-C goals, while in secondary prevention, 20.8% and 18.0% met these goals. High-intensity statin therapy was observed in 21.2% of patients, with 30.3% and 24.3% achieving non-HDL-C and LDL-C targets, respectively. Statin use was lower in women than men (54.0% vs 66.9%, P  < 0.001). Women less frequently achieved non-HDL-C and LDL-C goals in both prevention groups.</p><p><strong>Conclusions: </strong>Non-HDL-C goal attainment remains suboptimal in both primary and secondary prevention of hypercholesterolemia, particularly in women who had lower statin use and goal achievement. These findings highlight the need for improved awareness, education, and treatment strategies to reduce residual cardiovascular risk and improve outcomes.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"396-405"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of dual antiplatelet treatment after percutaneous coronary intervention in patients with chronic kidney disease: a systematic review and meta-analysis.","authors":"Anastasios Apostolos, Maria Bozika, Kassiani-Maria Nastouli, Dimitrios-David Chlorogiannis, Kyriakos Dimitriadis, Konstantinos Toutouzas, Konstantinos Tsioufis, Periklis Davlouros, Grigorios Tsigkas","doi":"10.1097/MCA.0000000000001447","DOIUrl":"10.1097/MCA.0000000000001447","url":null,"abstract":"<p><p>Patients suffering from chronic kidney disease (CKD) have higher ischemic and bleeding risk compared with patients with normal renal function. The aim of our systematic review and meta-analysis is to compare shortened (≤3 months) dual antiplatelet therapy (DAPT) with longer DAPT in patients with CKD undergoing percutaneous coronary interventions. We systematically screened three major databases (Medline, Cochrane Central Register of Controlled Trials, and Scopus) searching for randomized-controlled trials or subanalyses of them, which compared shortened (S-DAPT) to longer (L-DAPT) regimens of DAPT in patients with CKD. The primary endpoint is the net adverse clinical events (NACE) and the secondary is major adverse cardiac events (MACE), and bleedings. Subgroup analyses included studies using only P2Y12 monotherapy, ticagrelor-based regimens, 1- and 3-month duration of DAPT. A total of 10 studies and 6688 patients were included in our analysis. No significant differences regarding NACE (RR: 0.97, 95% CI: 0.84-1.12, I2  = 0%), MACE (RR: 1.00, 95% CI: 0.85-1.117, I2  = 0%), and bleedings (RR: 0.78, 95% CI: 0.59-1.03, I2  = 25%) were observed between S-DAPT and L-DAPT in our meta-analysis. The findings from the subgroup analyses were in accordance with total findings; bleedings were significantly reduced in S-DAPT when only studies with 3-month duration of DAPT were analyzed (RR: 0.58, 95% CI: 0.40-0.85, I2  = 0%). Our systematic review and meta-analysis showed that no significant differences were observed between patients treated with S-DAPT or L-DAPT in the terms of MACE, NACE, and bleedings in patients with CKD. When it is required, S-DAPT could be considered in patients with CKD.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"437-445"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial progenitor cells have high predictive value for ventricular remodeling after percutaneous coronary intervention in acute myocardial infarction.","authors":"Yongxiang Ma, Lijian Niu, Jing Zhang, Fei Yu, Wenjun Huang","doi":"10.1097/MCA.0000000000001461","DOIUrl":"10.1097/MCA.0000000000001461","url":null,"abstract":"<p><strong>Objective: </strong>Acute myocardial infarction (AMI) and the following heart failure are main causes of disability and death across the globe. Endothelial progenitor cell (EPC) levels are linked to AMI. Herein, we assessed the predictive value of EPCs for post-percutaneous coronary intervention (PCI) ventricular remodeling in AMI patients.</p><p><strong>Methods: </strong>This study retrospectively analyzed 215 AMI patients receiving PCI, who were then categorized into the VR ( n  = 66) and N-VR ( n  = 149) groups as per whether they developed post-PCI ventricular remodeling. Left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and EPCs were measured. The correlations of LVEF and NT-pro-BNP with EPCs, the predictive value of EPCs for post-PCI ventricular remodeling, and the risk of post-PCI ventricular remodeling in AMI patients with different EPC levels were analyzed by Spearman's analysis, receiver-operating characteristic curve, and Kaplan-Meier curve.</p><p><strong>Results: </strong>LVEF and EPC levels were lower and NT-pro-BNP level was higher in the VR group than the N-VR group. EPC levels in the class III-IV group were lower than those in the class I-II group. EPC levels in AMI patients correlated positively with LVEF ( r  = 0.683) and negatively with NT-pro-BNP ( r  = -0.761). EPCs exhibited high predictive value for post-PCI ventricular remodeling in AMI [area under the curve (AUC) of 0.822] and anterior MI (AUC = 0.941) patients. AMI and anterior MI patients with low EPC levels had a higher risk of post-PCI ventricular remodeling.</p><p><strong>Conclusion: </strong>Low EPC levels have high predictive value for post-PCI ventricular remodeling, and increase the risk of post-PCI ventricular remodeling in AMI patients.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"365-372"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Q waves at presentation of anterior ST segment elevation myocardial infarction predict heart failure: a Southeast Asian perspective.","authors":"Marie Houdmont, Eng How Lim, Andie Djohan Hartanto, Vianne Lau, Siew Pang Chan, Saw Kalyar Win, Benjamin Tung, Zhe Yan Ng, Mark Chan, Ronald Lee, Adrian F Low, Huay Cheem Tan, Tiong-Cheng Yeo, Poay Huan Loh, Koo Hui Chan","doi":"10.1097/MCA.0000000000001475","DOIUrl":"10.1097/MCA.0000000000001475","url":null,"abstract":"<p><strong>Background: </strong>Pathological Q waves at presentation in ST segment elevation myocardial infarction (STEMI) have been associated with poorer clinical outcomes including heart failure. This observational study highlights the prognostic value of pathological Q waves at presentation in the Southeast Asian population.</p><p><strong>Methods: </strong>Multiethnic Asian patients presenting with STEMI and treated with primary coronary intervention were recruited from 2015 to 2019. The presenting ECG was reviewed for pathological Q waves and patients were divided into groups with and without Q waves. The confirmatory multivariate analyses concerning the presence of Q wave, occurrence of heart failure, time to heart failure at 1 year, and the mortality status were performed with generalized structural equation model.</p><p><strong>Results: </strong>A total of 1385 patients were included. Patients with pathological Q waves were more likely to suffer from anterior myocardial infarction (55.6 vs. 43.6%) and classified as Killip class >2 (13.5 vs. 8.0%). Among them, fewer reported ST segment resolution >50% (66.5 vs. 79.7%). They reported significantly lower LVEF (45.5 vs. 51.1%), longer symptom onset to ECG (168 vs. 111 min), and longer symptom-onset-to-balloon time (228 vs. 176 min). In addition, patients with Q waves were likely to stay longer in hospital (6.4 vs. 6.1 days) and faced a higher risk of heart failure (5.2 vs. 2.5%) in a year.</p><p><strong>Conclusion: </strong>We highlight the important morbidity associated with Q waves at presentation and found not only that heart failure occurrence was higher in the Q wave group, but there was also an acceleration of and shorter onset to heart failure.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"378-383"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All coronary arteries originating from the right sinus of Valsalva: a multimodality imaging approach.","authors":"Alexander Suchodolski, Aleksandra Korus, Dariusz Kucias, Jan Głowacki, Mariola Szulik","doi":"10.1097/MCA.0000000000001505","DOIUrl":"10.1097/MCA.0000000000001505","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"453-454"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}