Coronary artery disease最新文献

{"title":"Rising burden of coronary artery disease-related mortality among USA adults with atrial fibrillation from 1999 to 2020.","authors":"Muhammad Saad, Ifrah Ansari, Muhammad Umer Sohail, Syed Ibad Ahsan, Saad Ahmed Waqas, Muhammad Sameer Arshad","doi":"10.1097/MCA.0000000000001540","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001540","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) and atrial fibrillation (AF) are significant cardiovascular conditions with substantial health and economic burdens. Despite advancements in treatment, long-term mortality trends among individuals with both conditions remain underexplored. This study investigates age-adjusted mortality rates (AAMRs) from 1999 to 2020 and examines trends to address these gaps and highlight demographic and geographic disparities.</p><p><strong>Methods: </strong>Mortality data from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database were analyzed for cases where CAD (ICD-10 codes I20-I25) and AF (ICD-10 code I48) were either contributing or underlying causes of death. Individuals aged 25 years and older were included in the analysis. AAMRs were calculated using direct standardization to the 2000 USA population, and trends were assessed using Joinpoint regression analysis. Mortality trends were stratified by sex, race, geography, and urbanization to identify disparities.</p><p><strong>Results: </strong>Between 1999 and 2020, AAMRs for CAD- and AF-related mortality increased from 14.4 to 23.4 per 100 000, with an average annual percent change of +2.2% (95% confidence interval: 2.0-2.4). Men consistently exhibited higher overall AAMRs than women (22.9 vs. 13.1 ). Non-Hispanic (NH) White individuals had the highest AAMR (18.6), followed by NH American Indians (12.3), NH Blacks (10.0), Hispanics (9.4), and NH Asians (8.0). Rural areas experienced significantly higher AAMRs than urban areas (19.2 vs. 16.6). AAMRs were disproportionately higher in Western (17.7) and Midwestern USA regions (17.7). States in the top 90th percentile reported nearly double the AAMRs compared to those in the bottom 10th percentile.</p><p><strong>Conclusion: </strong>Mortality rates associated with coexisting CAD and AF have significantly increased, with the most pronounced rise occurring after 2018. The findings reveal substantial disparities across sex, race, and geography. Targeted interventions are essential to address these inequalities, improve health outcomes, and reduce the growing burden of CAD and AF-related mortality.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is coronary vasospasm the pathophysiologic mechanism of takotsubo syndrome?","authors":"John E Madias","doi":"10.1097/MCA.0000000000001523","DOIUrl":"10.1097/MCA.0000000000001523","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"348-349"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare finding after acute myocardial infarction.","authors":"Diamantis Kosmidis, Nikolaos Gouliaros, Evangelia Sotiroglou, Dimitris Vatitsis, Charalampos Stefanidis, Christos Chatzieleftheriou","doi":"10.1097/MCA.0000000000001473","DOIUrl":"10.1097/MCA.0000000000001473","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"358-359"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocannabinoids 2-arachidonoylglycerol and N-arachidonoylethanolamine measured in hair decrease before the occurrence of acute myocardial infarction, possibly reflecting an exhaustion of the stress-buffer system.","authors":"Nikolaos Kosmas, Panagiotis Simitsis, Evangelos Alevyzakis, Emmanouil Rizos, Dimitrios Zapantiotis, Loukianos S Rallidis","doi":"10.1097/MCA.0000000000001484","DOIUrl":"10.1097/MCA.0000000000001484","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"335-336"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A very rare variant of single coronary artery.","authors":"Iosif Bikakis, Konstantinos C Theodoropoulos, Matthaios Didagelos, Georgios Perdikos, Alexandra Liakopoulou, Antonios Kouparanis, Antonios Ziakas","doi":"10.1097/MCA.0000000000001424","DOIUrl":"10.1097/MCA.0000000000001424","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"351-352"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index as a predictor of contrast-induced nephropathy in nondiabetic patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a retrospective study.","authors":"Ayșe İrem Demirtola, Anar Mammadli, Gökhan Çiçek","doi":"10.1097/MCA.0000000000001524","DOIUrl":"10.1097/MCA.0000000000001524","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is a significant complication following percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. This study aimed to evaluate the association between the triglyceride-glucose (TyG) index and CIN development in nondiabetic patients with STEMI undergoing PCI.</p><p><strong>Methods: </strong>This retrospective study included 1625 nondiabetic patients with STEMI treated with PCI within 12 h of symptom onset. CIN was defined as an increase in serum creatinine of greater than 25% or greater than or equal to 0.5 mg/dl from baseline within 48-72 h postprocedure. Patients were stratified into quartiles based on TyG index levels. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors of CIN and determine the optimal TyG index cutoff.</p><p><strong>Results: </strong>Among the 1625 patients, 14% developed CIN. Patients in the highest TyG quartile (Q4) exhibited the highest incidence of CIN (27%, P  < 0.01). The TyG index was independently associated with CIN [odds ratio (OR): 2.054, 95% confidence interval (CI): 1.564-2.697, P  < 0.001] alongside baseline creatinine (OR: 1.666, 95% CI: 1.053-2.635, P  = 0.001) and contrast volume (OR: 1.003, 95% CI: 1.002-1.005, P  = 0.005). ROC analysis yielded a TyG index cutoff value of 9.11 (AUC: 0.722) with 70% sensitivity and 62% specificity.</p><p><strong>Conclusion: </strong>The TyG index is a reliable marker for predicting CIN in nondiabetic patients with STEMI undergoing PCI. Its independent association with CIN, combined with its cost-effectiveness, highlights its potential for improving risk stratification in this high-risk group.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"326-332"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term (12 months) vs. short-term (<12 months) dual antiplatelet therapy post-percutaneous coronary intervention with drug-eluting stents: a critical appraisal and systematic review.","authors":"Kolten Abbott, Nicholas Seton, Gurjeevan Kaur, Jilai Zhao, Mark Jones, Kuljit Singh","doi":"10.1097/MCA.0000000000001483","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001483","url":null,"abstract":"<p><strong>Background: </strong>A growing body of evidence supports short-term DAPT as safe and efficacious following PCI with DES. However, methodological criticism of RCTs has led to caution when translating results into clinical practice. This study aimed to critically appraise the methodological rigour of included studies and consolidate the evidence on the safety and efficacy of short-term DAPT.</p><p><strong>Methods: </strong>Medline, Cochrane Library and Embase were searched from inception until August 2022. The primary outcome was the methodological quality of published primary studies. Risk of bias was assessed using RoB 2.0 and the CASP tool. Evidence was rated for quality using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) score approach. Other endpoints were all-cause mortality and major bleeding.</p><p><strong>Results: </strong>Eighteen RCTs were included. Based on GRADE score, there was a moderate level of certainty that the reported results for both outcomes are probably close to the true effect. A total of 78% (14/18) of RCTs had a low risk of bias when assessing all-cause mortality and 61% (11/18) when assessing major bleeding. The CASP tool confirmed methodological rigour; however, only 33% (6/18) of studies were applicable beyond the studied populations. Compared with 12 months of DAPT, short-term DAPT was associated with a reduced risk of major bleeding [relative risk (RR): 0.69, 95% CI: 0.54-0.88, P = 0.003, I2 = 45%] and trended towards a reduced risk in all-cause mortality (RR: 0.90, 95% CI: 0.79-1.01, P = 0.08, I2 = 0%).</p><p><strong>Conclusion: </strong>With moderate certainty evidence, short-term DAPT appears safe and efficacious post-PCI with DES in the studied populations.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"36 4","pages":"312-325"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body surface area or sex for stent sizing in proximal coronary arteries.","authors":"James Nguyen, Evan Shlofmitz, Doosup Shin, Sarah Malik, Susan V Thomas, Craig Porter, Koshiro Sakai, Jeffrey W Moses, Akiko Maehara, David J Cohen, Ziad A Ali, Richard A Shlofmitz, Allen Jeremias","doi":"10.1097/MCA.0000000000001463","DOIUrl":"10.1097/MCA.0000000000001463","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"333-334"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triggering type and long-term survival following ST segment elevation-myocardial infarction treated with primary percutaneous coronary intervention.","authors":"Moaad Slieman, Inbal Greenberg, Zach Rozenbaum, Yoav Granot, Yacov Shacham, David Zahler, Maayan Konigstein, Amir Halkin, Shmuel Banai, Jeremy Ben-Shoshan","doi":"10.1097/MCA.0000000000001455","DOIUrl":"10.1097/MCA.0000000000001455","url":null,"abstract":"<p><strong>Background: </strong>Physical and emotional stress are recognized triggers of acute coronary syndromes, including ST segment elevation-myocardial infarction (STEMI). We have previously shown that identifiable triggers precede symptoms in over one-third of STEMI patients and inversely correlate with the extent of coronary artery disease (CAD). This study aims to investigate the association between trigger type (physical vs. emotional) and long-term mortality in STEMI patients treated with primary percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This retrospective, single-center observational study included all patients admitted with an STEMI diagnosis from January 2008 to December 2013. Physical and emotional triggers were identified retrospectively from patient records. Mortality data were obtained from the Israeli Ministry of Health.</p><p><strong>Results: </strong>Of 1345 consecutive STEMI patients treated with primary PCI, mortality data were available for 1267 patients (median age: 61 years). A trigger preceding symptoms onset was identified in 36.5% of patients, with 85% experiencing physical stress and 15% emotional stress. Triggered STEMI patients tended to be younger with fewer comorbidities and lower incidence of multiple vessel CAD compared with nontriggered patients. Notably, emotionally triggered STEMI patients exhibited improved long-term survival compared with those without emotional triggers or with physical triggers. Emotional triggering was identified as an independent predictor of enhanced long-term survival post-PCI compared with physical triggering.</p><p><strong>Conclusion: </strong>Patients with emotionally triggered STEMI showed less extensive CAD and improved long-term survival following PCI compared with those with physically triggered STEMI. These findings highlight the importance of considering both the presence and type of trigger in the management of STEMI patients and their long-term prognosis.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"281-286"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of perceived stress on the prognosis in patients undergoing percutaneous coronary intervention.","authors":"Qiuyin Shi, Xuefei Wang, Dongxia Zhao, Weihong Tang, Yongzhen Mo","doi":"10.1097/MCA.0000000000001478","DOIUrl":"10.1097/MCA.0000000000001478","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of perceived stress levels in patients undergoing percutaneous coronary intervention (PCI) on the occurrence of major adverse cardiovascular events (MACEs) within a 6-month follow-up period postprocedure.</p><p><strong>Methods: </strong>A cohort of 339 hospitalized patients with coronary heart disease undergoing initial PCI was prospectively enrolled in the Department of Cardiology at two branches of Zhongda Hospital Affiliated to Southeast University between January 2022 and July 2022. Baseline data including demographic and clinical characteristics, along with the Chinese Perceived Stress Scale (CPSS), were collected. The occurrence of MACE was evaluated at 3 and 6 months post-PCI. Kaplan-Meier survival analysis and Cox regression models were engaged to analyze the relationship between perceived stress and MACE within 6 months after PCI.</p><p><strong>Results: </strong>MACE occurred in 16.22% (55/339) of patients during the 6 following months. High CPSS at baseline was significantly associated with an increasing risk of short-term MACE occurrence (HR: 6.48, 95% confidence interval: 2.98-14.11, P < 0.05).</p><p><strong>Conclusion: </strong>High perceived stress during the baseline period after PCI was significantly correlated with increased incidence of MACE within 6 months postprocedure. The perceived stress level could help to identify patients undergoing PCI at heightened risk of short-term MACE.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"303-311"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}