Coronary artery disease最新文献_第2页

Timing of coronary angiography in high-risk non-ST-elevation acute coronary syndrome: results from the Portuguese Registry for Acute Coronary Syndromes (ProACS). 高风险非 ST 段抬高型急性冠状动脉综合征的冠状动脉造影时机：葡萄牙急性冠状动脉综合征登记处 (ProACS) 的结果。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-11-07 DOI: 10.1097/MCA.0000000000001457

Catarina Ribeiro Carvalho, Marta Catarina Bernardo, Isabel Martins Moreira, Pedro Mateus, Ana Baptista, Ilídio Moreira

{"title":"Timing of coronary angiography in high-risk non-ST-elevation acute coronary syndrome: results from the Portuguese Registry for Acute Coronary Syndromes (ProACS).","authors":"Catarina Ribeiro Carvalho, Marta Catarina Bernardo, Isabel Martins Moreira, Pedro Mateus, Ana Baptista, Ilídio Moreira","doi":"10.1097/MCA.0000000000001457","DOIUrl":"10.1097/MCA.0000000000001457","url":null,"abstract":"Background: Current guidelines recommend an early invasive coronary angiography (ICA) within 24 h of admission for high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Nevertheless, meta-analyses failed to demonstrate a clear advantage of this strategy in reducing hard endpoints such as death or nonfatal myocardial infarction compared to a delayed approach. Thus, the optimal timing of ICA in high-risk NSTE-ACS remains undetermined.Objective: This study aimed to determine the optimal timing for ICA in high-risk NSTE-ACS, regarding 1-year all-cause mortality and cardiovascular rehospitalizations.Methods: We conducted a national multicenter retrospective study of high-risk NSTE-ACS patients included in the Portuguese Registry for Acute Coronary Syndromes. Patients were divided into three groups according to the time of ICA: within the first 24 h, between 24 and 48 h, and between 48 and 72 h. The incidence of in-hospital complications and mortality, 1-year mortality, and cardiovascular rehospitalizations were assessed.Results: Of the 9949 patients included, 46.7% underwent early ICA. This was associated with a lower incidence of acute heart failure (8.5% vs. 11.1% vs. 11.5%, P < 0.001) and shorter length of stay (3 vs. 4 vs. 6 days, P = 0.012). It, however, did not reduce in-hospital complications or mortality (1.2 vs. 0.7 vs. 0.8%, P = 0.066). We also found no significant association with the composite endpoint of 1-year mortality or cardiovascular rehospitalization (15.1 vs. 15.9 vs. 15.7%, P = 0.887).Conclusions: Early ICA was associated with a lower incidence of acute heart failure and shorter length of stay, without a significant impact on 1-year mortality risk or cardiovascular rehospitalizations.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"166-172"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the fibrosis-4 index in patients with ST-elevated myocardial infarction. 纤维化-4指数对ST段抬高型心肌梗死患者的影响。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-10-08 DOI: 10.1097/MCA.0000000000001431

Naoki Shibata, Takanori Ito, Yasuhiro Morita, Hidenori Toyoda, Yasunori Kanzaki, Naoki Watanabe, Naoki Yoshioka, Hiroyuki Miyazawa, Kazuki Shimojo, Takuma Ohi, Hiroki Goto, Hoshito Karasawa, Itsuro Morishima

{"title":"Impact of the fibrosis-4 index in patients with ST-elevated myocardial infarction.","authors":"Naoki Shibata, Takanori Ito, Yasuhiro Morita, Hidenori Toyoda, Yasunori Kanzaki, Naoki Watanabe, Naoki Yoshioka, Hiroyuki Miyazawa, Kazuki Shimojo, Takuma Ohi, Hiroki Goto, Hoshito Karasawa, Itsuro Morishima","doi":"10.1097/MCA.0000000000001431","DOIUrl":"10.1097/MCA.0000000000001431","url":null,"abstract":"Background: The fibrosis-4 (FIB4) index, a simple, noninvasive marker used for hepatic diseases, represents adverse outcomes. The aim of the present study was to evaluate whether the FIB4 index can predict adverse outcomes in patients with ST-elevation myocardial infarction (STEMI).Methods: We investigated patients with STEMI who underwent primary percutaneous coronary intervention (PCI) and were alive at discharge. The cut-off FIB4 index at discharge was investigated using the survival classification and regression tree (CART) model to predict adverse outcomes. The primary outcome was all-cause mortality.Results: Between January 2006 and December 2018, 1354 patients with STEMI (median age, 68 years; men, 76.1%) were investigated. The median value of the FIB4 index was 1.21 (0.84-1.78). The CART model divided the study population into low (FIB4 index <0.945; n = 435), intermediate (0.945 ≤ FIB4 index < 2.185; n = 692), and high (FIB4 index ≥2.185; n = 227) groups based on the significant predictive values for all-cause death. During a median follow-up period of 4.3 years, all-cause death occurred in 208 patients (15.4%). The Kaplan-Meier analysis showed a significant increase in mortality with higher FIB4 index values (log-rank, P < 0.001). The multivariate Cox regression model revealed that the FIB4 index was an independent risk predictor for all-cause death in patients with STEMI [low group as reference vs. intermediate group, hazard ratio: 1.975; 95% confidence interval (CI): 1.166-3.346; P = 0.011 and vs. high group, hazard ratio: 4.633; 95% CI: 2.549-8.418; P < 0.001].Conclusions: The FIB4 index was associated with the risk of all-cause mortality in patients with STEMI who underwent primary PCI.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"99-107"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-coated balloon coronary angioplasty: where are we going? 药物包覆球囊冠状动脉成形术：我们将走向何方？

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1097/MCA.0000000000001474

Fernando Alfonso, Islam Y Elgendy, Bernardo Cortese

引用次数: 0

Arteria lusoria: a rare challenge to coronary angiography.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-02-11 DOI: 10.1097/MCA.0000000000001511

Anderson Ariaga, Pradnya Brijmohan Bhattad, Eddison Ramsaran

引用次数: 0

The impact of the Naples prognostic score in long-term outcomes after percutaneous coronary intervention for chronic total occlusions.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-02-07 DOI: 10.1097/MCA.0000000000001512

Cihan Dündar, Ali Cevat Tanalp, Aysel Yağmur, Muhammet Buğra Karaaslan

{"title":"The impact of the Naples prognostic score in long-term outcomes after percutaneous coronary intervention for chronic total occlusions.","authors":"Cihan Dündar, Ali Cevat Tanalp, Aysel Yağmur, Muhammet Buğra Karaaslan","doi":"10.1097/MCA.0000000000001512","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001512","url":null,"abstract":"Background: Chronic total occlusions (CTOs) of coronary arteries present a significant challenge in cardiology, with long-term outcomes following percutaneous coronary intervention (PCI) for CTOs remaining variable and unpredictable. The Naples prognostic score (NPS), which incorporates markers of nutritional status and systemic inflammation, has shown potential in predicting outcomes in various cardiovascular settings. This study evaluates the NPS as a predictor of long-term outcomes after PCI for CTOs.Methods: A retrospective analysis was conducted on 287 patients who underwent coronary angiography. Patients were categorized into non-CTO-PCI and CTO-PCI groups. Patients were further stratified based on survival status. Cox regression and Kaplan-Meier survival analyses were used to evaluate the association between NPS and long-term outcomes.Results: The mean age of the study population was 63.5 ± 10.6 years, with 28.6% being female. The NPS was significantly higher in the CTO-PCI group compared to the non-CTO-PCI group ( P = 0.004) and was also elevated in the non-survival group ( P = 0.004). Multivariable Cox regression analysis identified NPS as an independent predictor of mortality ( P = 0.015). Kaplan-Meier analysis demonstrated significantly higher mortality in patients with an elevated NPS ( P = 0.009).Conclusion: The NPS is a valuable independent predictor of long-term mortality in patients undergoing CTO-PCI. Incorporating NPS into existing risk stratification models could improve predictive accuracy and guide individualized patient management. Further prospective studies are warranted to validate these findings and explore interventions targeting inflammation and nutrition in this high-risk population.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncardiac chest computerized tomography scan as a predictor for plaque presence in coronary artery.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-01-31 DOI: 10.1097/MCA.0000000000001477

Zipi Regev-Avraham, Ina Rozenfeld, Osamah Hussein, Adi Sharabi-Nov, Majdi Halabi

{"title":"Noncardiac chest computerized tomography scan as a predictor for plaque presence in coronary artery.","authors":"Zipi Regev-Avraham, Ina Rozenfeld, Osamah Hussein, Adi Sharabi-Nov, Majdi Halabi","doi":"10.1097/MCA.0000000000001477","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001477","url":null,"abstract":"Background: Coronary artery calcium, a marker of coronary atherosclerosis, is often identified on noncoronary chest computed tomography (CT). We wanted to evaluate the correlation between the presence of coronary plaques in coronary artery catheterization and coronary calcifications as shown in noncardiac chest CT.Methods: A retrospective case-control study consisting of cases (N = 63) and controls (N = 29), aged 18-70 years old, residing in northern Israel and treated in the Intensive Cardiac Care Unit of Ziv Medical Center, between January 2020 and November 2022. All participants underwent coronary catheterization and noncoronary CT scans in the 5 years before the catheterization procedure. Data were taken from the participants' electronic files while considering the potential of cardiovascular risk factors.Results: The 92 participants had a mean age of 60.1 ± 10.3 years old. Multivariate logistic regression adjusted to age, sex, and hyperlipidemia showed that calcified coronary artery as shown on a previous noncardiac CT scan was positively and significantly associated with increasing risk of coronary plaque as presented in coronary catheterization: odds ratio = 5.93 (95% confidence interval: 1.85-19.07, P < 0.01) and was also associated with male sex who were more likely to have plaque on coronary catheterization than females: odds ratio = 3.77 (95% confidence interval: 1.29-11.32, P < 0.05).Conclusion: Coronary calcifications on a previous noncoronary CT scan and sex are positively and significantly associated with coronary plaque risk as present in coronary catheterization. Coronary evaluation on CT scans is important for early detection of coronary disease. Early treatment can avoid coronary disease complications and increase patient survival.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors that predict for presence of clinically significant, noncalcified plaque in younger adults.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-01-31 DOI: 10.1097/MCA.0000000000001495

Aditya Mehta, Felix Thomas, Venkat Manubolu, April Kinninger, Matthew Budoff, Sion K Roy

{"title":"Risk factors that predict for presence of clinically significant, noncalcified plaque in younger adults.","authors":"Aditya Mehta, Felix Thomas, Venkat Manubolu, April Kinninger, Matthew Budoff, Sion K Roy","doi":"10.1097/MCA.0000000000001495","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001495","url":null,"abstract":"Objective: Coronary artery calcium (CAC) scoring may be a useful tool for assessing cardiovascular disease in young adults, particularly in those with risk factors such as hypertension, dyslipidemia, or smoking. In this study, we aimed to address the risk factors for developing noncalcified plaque in young adults by assessing total plaque burden.Methods: A single-center retrospective cohort study was conducted among 1026 consecutive patients aged 18-45 years who underwent CAC scoring and coronary computed tomography (CT) angiograms for clinical indications. CAC scores and total plaque scores (TPS) were calculated using standard scoring protocols. Multiple logistic regression analysis was conducted to identify independent risk factors of significant, noncalcified plaque in subjects where CAC = 0.Results: This single-center retrospective cohort study included 1026 patients aged 18-45 years who underwent CAC scoring and coronary CT angiograms for clinical indications. The mean age of the population was 38.8 years old. Sixty-three patients had a CAC score of 0 and a TPS >0. Of the patients with noncalcified plaque burden, 15% had a stenosis >50%, and 10% had a stenosis >70%. The odds of a subject having noncalcified plaque presence and CAC absent were significantly associated with being Hispanic, having diabetes, and having hyperlipidemia.Conclusion: In young adults aged 18-45 years old, we found diabetes, hyperlipidemia, and being of Hispanic origin to be significantly associated with noncalcified plaque burden.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery dominance influences the distribution of calcified plaques in the coronary tree.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-01-29 DOI: 10.1097/MCA.0000000000001500

Leili Pourafkari, Salman Ansari, April Kinninger, Matthew J Budoff

{"title":"Coronary artery dominance influences the distribution of calcified plaques in the coronary tree.","authors":"Leili Pourafkari, Salman Ansari, April Kinninger, Matthew J Budoff","doi":"10.1097/MCA.0000000000001500","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001500","url":null,"abstract":"Background: Coronary artery dominance is determined by the coronary artery emitting the posterior descending artery. In the left dominant system, a greater proportion of coronary flow enters the left coronary artery, potentially influencing calcified plaque development in the left anterior descending artery (LAD).Methods: This retrospective single-center cohort study analyzed patients who underwent computed tomography angiography from September 2006 to December 2022 at Harbor-UCLA in Los Angeles, California. Coronary artery calcium (CAC) was quantified for the three coronary vessels. The LAD calcium score was divided by the total calcium score to calculate the LAD calcium percentage, which was compared between left and right dominant coronary systems. Multivariable linear regression assessed the association between LAD calcium percentage and coronary dominance, adjusting for age, gender, BMI, hyperlipidemia, hypertension, family history of cardiovascular disease, and past smoking.Results: Among 9560 subjects, 6766 with CAC greater than zero were enrolled. The average age was 64.8 ± 10.7 years: 68% were male, and 9% had left dominant coronary systems. The median CAC was 51 [0-352] in the right dominant and 49 [0-358] in the left dominant system (P = 0.73). Adjusted analysis revealed that individuals with left dominant coronary systems had a 10.1% higher (CI 7.5-12.8%, P < 0.001) LAD calcium percentage than those with right dominant systems.Conclusion: Although coronary dominance does not influence overall plaque burden of atherosclerosis, it affects calcified plaque distribution. The left dominant system is associated with a higher proportion of calcified plaque in the LAD, potentially heightening the risk of adverse cardiovascular events.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical circulatory support devices in acute left main disease: a multicenter study.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-01-29 DOI: 10.1097/MCA.0000000000001510

Andreia Campinas, André Alexandre, Bruno Brochado, João Calvao, Marta Braga, João Carlos Silva, Mariana Brandão, Marisa Silva, Gustavo Pires-Morais, David Sá Couto, Mariana Santos, Catarina Gomes, Raquel Santos, André Luz, João Silveira, Severo Torres

引用次数: 0

Double trouble: thrombosis of giant coronary aneurysm with left ventricular aneurysm in child with Kawasaki disease.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-01-24 DOI: 10.1097/MCA.0000000000001509

Rakesh Kumar Pilania, Abarna Thangaraj, Harsimran Bhatia, Abhishek Mallick, Arun Sharma, Sanjeev Naganur, Surjit Singh, Manphool Singhal

引用次数: 0