Coronary artery disease最新文献

{"title":"Giant unruptured left sinus of Valsalva aneurysm with left coronary artery compression.","authors":"Leizhi Ku, Kai Liu, Xiaojing Ma","doi":"10.1097/MCA.0000000000001614","DOIUrl":"10.1097/MCA.0000000000001614","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"563-564"},"PeriodicalIF":2.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wire-free entrapment of an unexpanded left anterior descending stent: stepwise retrieval via extra-stent access.","authors":"Byeng-Ju Son, Hong-Ju Kim, Jun-Chang Jeong, Sun-Oh Kim","doi":"10.1097/MCA.0000000000001674","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001674","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary neutrophil gelatinase-associated lipocalin and clinical outcomes in patients with acute coronary syndrome: a focus on patients with impaired ejection fraction.","authors":"Yodo Gatate, Mitsunobu Nagai, Keisuke Matsuo, Hiroki Hoya, Saki Hasegawa-Tamba, Michiru Nomoto, Takahide Arai, Shintaro Nakano","doi":"10.1097/MCA.0000000000001682","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001682","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the prognostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) normalized to creatinine in patients with acute coronary syndrome (ACS), focusing on left ventricular ejection fraction (LVEF).</p><p><strong>Methods: </strong>This retrospective cohort study included 144 patients emergently admitted for ACS, with urinary NGAL measured 4-48 h postadmission. Primary and secondary outcomes were all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCEs), respectively. Optimal NGAL/creatinine cutoffs were determined using receiver operating characteristic analysis. Associations between urinary NGAL/creatinine and clinical outcomes were evaluated using Cox proportional hazards models.</p><p><strong>Results: </strong>During a median 734.5-day follow-up, 8 deaths and 44 MACCE occurred. The optimal NGAL/creatinine cutoff for predicting MACCE was 20.85 ng/mg creatinine. All deaths occurred in the high NGAL/creatinine group (≥20.85), but mortality analyses were limited by statistical separation. High NGAL/creatinine was significantly associated with MACCE (hazard ratio = 3.47, 95% confidence interval = 1.61-7.47) and remained associated with a higher event hazard after adjustment for age, brain natriuretic peptide, LVEF, and estimated glomerular filtration rate (adjusted hazard ratio = 2.75; P = 0.017). In subgroup analyses, the area under the curve for MACCE was numerically higher in patients with LVEF <50% than in those with LVEF ≥50% (0.753 vs. 0.581). Formal interaction testing in the Cox model, however, did not demonstrate significant effect modification by LVEF category (P for interaction = 0.100).</p><p><strong>Conclusion: </strong>Urinary NGAL/creatinine was significantly associated with long-term MACCE in patients with ACS. Although subgroup analyses showed numerically different associations according to LVEF, formal interaction testing did not demonstrate significant effect modification by LVEF.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial infarction caused by plaque rupture in a previously nonsevere lipidic coronary lesion: optical coherence tomography insights.","authors":"Ludovica Guerrieri, Carlos Collado, Carlos Frau, David Del Val, Javier Cuesta, Teresa Bastante, Fernando Rivero, Fernando Alfonso","doi":"10.1097/MCA.0000000000001684","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001684","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early vomiting after oral P2Y12 receptor inhibitor loading during percutaneous coronary intervention for acute coronary syndrome: should loading be repeated?","authors":"Yalcin Velibey, Erkan Kahraman, Rengin Cetin Guvenc, Mehmet Baran Karatas, Tolga Sinan Guvenc, Mehmet Eren","doi":"10.1097/MCA.0000000000001683","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001683","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac amyloidosis and coronary artery disease: an overlooked clinical intersection.","authors":"Jakub Kancerek, Alexander Suchodolski, Romuald Wojnicz, Mariola Szulik, Karol Miszalski-Jamka, Marek Waligóra, Zuzanna Jackowska, Jan Głowacki","doi":"10.1097/MCA.0000000000001679","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001679","url":null,"abstract":"<p><p>Cardiac amyloidosis has emerged as an important and underrecognized cause of heart failure with preserved ejection fraction, particularly in elderly patients who commonly carry concomitant coronary artery disease. The coexistence of these two conditions creates a layered diagnostic and therapeutic problem. Epicardial atherosclerosis is present in roughly 30-40% of patients with cardiac amyloidosis, yet the dominant ischemic mechanism in the amyloidotic heart is rarely flow-limiting epicardial obstruction. Instead, ischemia is driven by coronary microvascular dysfunction arising from amyloid infiltration of the arteriolar wall, capillary rarefaction, extravascular compression by the hypertrophied myocardium, and in light-chain disease direct endothelial toxicity. This distinction has immediate clinical consequences. Chronic troponin elevation from subendocardial ischemia and wall stress frequently mimics acute coronary syndromes, prompting invasive procedures that carry disproportionate risk in this population, while pressure-derived indices such as fractional flow reserve are unreliable because the infiltrated microvasculature cannot mount a normal hyperemic response. This review synthesizes the pathophysiological interplay between amyloid infiltration and coronary disease, defines the diagnostic pitfalls of the dual pathology, and proposes a multimodality imaging strategy, integrating advanced echocardiography, cardiac magnetic resonance, nuclear perfusion imaging, and cardiac computed tomography that distinguishes microvascular from epicardial ischemia and supports more rational clinical decisions. Critical evidence gaps, foremost the absence of randomized data comparing revascularization with medical therapy in this population, are discussed alongside emerging tools for refining ischemic assessment in the amyloidotic heart.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left circumflex artery origin from the right pulmonary artery with associated anomalous pulmonary venous drainage.","authors":"Mansi Verma, Arun Sharma, Parag Barwad, Manphool Singhal","doi":"10.1097/MCA.0000000000001676","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001676","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital and mid-term outcomes of catheter-induced iatrogenic coronary artery dissection: a retrospective case-control study.","authors":"Özdemir Kuzucu, Kutluhan Eren Hazir, Tuğçe İndağ","doi":"10.1097/MCA.0000000000001677","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001677","url":null,"abstract":"<p><strong>Background and objectives: </strong>Catheter-induced iatrogenic coronary artery dissection (CICAD) is a rare but catastrophic complication of coronary angiography and percutaneous coronary intervention (PCI). Data on its, management strategies, and mid-term outcomes remain scarce. This study aimed to evaluate the in-hospital and follow-up outcomes of CICAD and compare them with a contemporaneous control population.</p><p><strong>Methods: </strong>This single-center retrospective case-control study included 55 consecutive patients who developed CICAD during coronary angiography or PCI between November 2023 and December 2025. A control group of 169 patients without dissection during the same period was randomly selected to achieve a 1 : 3 case-to-control ratio. The primary outcome was 1-month major adverse cardiac events (MACE), defined as the composite of all-cause death, myocardial infarction, and stroke. Six-month MACE was a prespecified exploratory secondary endpoint.</p><p><strong>Results: </strong>In-hospital mortality was significantly higher in the CICAD group (16.4 vs. 1.2%; P < 0.001). All MACE in the CICAD group occurred within 30 days (1-month MACE: 29.1 vs. 6.5%; P < 0.001). Six-month MACE remained higher in the CICAD group (29.1 vs. 14.8%; P = 0.026). Kaplan-Meier analysis demonstrated a sharp decline in MACE-free survival in the CICAD group, with subsequent stabilization and a parallel trajectory with the control group (log-rank P = 0.023). Repeat revascularization at 6 months was higher in the CICAD group (29.1 vs. 2.4%; P < 0.001).</p><p><strong>Conclusion: </strong>CICAD carries a high burden of early mortality and morbidity, concentrated entirely within 30 days. Survivors achieve mid-term outcomes comparable to controls, suggesting aggressive early management may mitigate long-term risk.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of high-sensitivity C-reactive protein-triglyceride glucose index and coronary artery calcification with adverse outcomes in patients with coronary artery disease: a large-scale cohort study.","authors":"Song Wen, Zhanyuan Chen, Rui Fu, Lingbing Meng, Bowen Li, Kefei Dou","doi":"10.1097/MCA.0000000000001681","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001681","url":null,"abstract":"<p><strong>Background: </strong>The high-sensitivity C-reactive protein triglyceride glucose index (CTI) integrates metabolic dysregulation and systemic inflammation, whereas moderate-to-severe coronary artery calcification (MSCAC) reflects anatomic atherosclerotic burden. Whether CTI prognostic value varies by MSCAC status and whether these measures interact clinically remains unclear.</p><p><strong>Methods: </strong>This prospective cohort study included 22 218 patients with angiography‑confirmed coronary artery disease (CAD) enrolled from January 2017 to December 2018, categorized by CTI median (≤9.08 vs. >9.08) and MSCAC presence. CTI was calculated as Ln(fasting glucose [mg/dl] × triglycerides [mg/dl])/2 + Ln(hs‑CRP [mg/L]) × 0.412. The primary endpoint was cardiovascular events; the secondary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE). Restricted cubic spline, Kaplan-Meier, and Cox regression analyses were applied.</p><p><strong>Results: </strong>Each 1-unit CTI increase was associated with 15% higher cardiovascular event risk [hazard ratio: 1.15, 95% confidence interval (CI): 1.02-1.29] and 9% higher MACCE risk (hazard ratio: 1.09, 95% CI: 1.03-1.15). MSCAC independently conferred a 32% higher risk of cardiovascular events (hazard ratio: 1.32, 95% CI: 1.05-1.67) and 23% higher MACCE risk (hazard ratio: 1.23, 95% CI: 1.10-1.38). Patients with both elevated CTI and MSCAC had 66% increased cardiovascular event risk (hazard ratio: 1.66, 95% CI: 1.20-2.30) and 38% increased MACCE risk (hazard ratio: 1.38, 95% CI: 1.18-1.62) versus neither. No statistically significant additive or multiplicative interaction was detected.</p><p><strong>Conclusion: </strong>In patients with CAD, elevated CTI and MSCAC independently portend adverse outcomes, and their coexistence identifies a particularly high‑risk phenotype. These findings support the complementary value of metabolic‑inflammatory and anatomic measures in risk stratification.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The C-reactive protein-albumin-lymphocyte index is associated with coronary collateral circulation in patients with chronic total occlusion.","authors":"Güney Erdoğan, Mustafa Yenercağ, Serkan Sivri, Yaşar Turan, Berkant Öztürk, Enes Kaya, Mustafa Yilmaz, Umut Can Alim, Faruk Boyaci, Onur Osman Şeker, Sevim Türkday Derebey, Muhammed Furkan Deniz, Ahmet Karagöz","doi":"10.1097/MCA.0000000000001680","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001680","url":null,"abstract":"<p><strong>Objective: </strong>Well-developed coronary collateral circulation (CCC) protects the myocardium from ischemia, but its development varies among individuals. The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite marker of nutritional and inflammatory status. This study evaluated its association with well-developed CCC in patients with chronic total occlusion (CTO).</p><p><strong>Methods: </strong>We included 369 patients with stable angina pectoris and CTO in at least one major epicardial coronary artery. The CALLY index was calculated from serum albumin, lymphocyte, and C-reactive protein levels. Patients were classified as having poor CCC (Rentrop 0-1, n = 140) or good CCC (Rentrop 2-3, n = 229).</p><p><strong>Results: </strong>Patients with good CCC had higher CALLY index values than those with poor CCC [3.13 (interquartile range: 1.92-5.01) vs. 1.89 (1.17-2.66)]. The CALLY index showed moderate discrimination for good CCC [area under the receiver operating characteristic curve (AUC): 0.704, cutoff: 2.23, sensitivity: 64.2%, specificity: 65.7%]. In multivariable analysis, CALLY was independently associated with good CCC [odds ratio: 1.617, 95% confidence interval (CI): 1.374-1.902]. Adding CALLY to the baseline clinical model increased the AUC from 0.666 (95% CI: 0.609-0.723) to 0.761 (95% CI: 0.712-0.810; ΔAUC = 0.095; DeLong P < 0.001). CALLY also improved discrimination (integrated discrimination improvement: 0.120, 95% CI: 0.070-0.179, P < 0.001; continuous net reclassification improvement: 0.107, 95% CI: 0.004-0.229; P = 0.030).</p><p><strong>Conclusion: </strong>CALLY was independently associated with well-developed CCC and showed the highest discriminative performance among the evaluated inflammatory and nutritional indices. Its addition to the clinical model significantly improved discrimination, suggesting potential value in assessing CCC in patients with CTO.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}