Risk factors that predict for presence of clinically significant, noncalcified plaque in younger adults.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-01-31 DOI:10.1097/MCA.0000000000001495

Aditya Mehta, Felix Thomas, Venkat Manubolu, April Kinninger, Matthew Budoff, Sion K Roy

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引用次数: 0

Abstract

Objective: Coronary artery calcium (CAC) scoring may be a useful tool for assessing cardiovascular disease in young adults, particularly in those with risk factors such as hypertension, dyslipidemia, or smoking. In this study, we aimed to address the risk factors for developing noncalcified plaque in young adults by assessing total plaque burden.

Methods: A single-center retrospective cohort study was conducted among 1026 consecutive patients aged 18-45 years who underwent CAC scoring and coronary computed tomography (CT) angiograms for clinical indications. CAC scores and total plaque scores (TPS) were calculated using standard scoring protocols. Multiple logistic regression analysis was conducted to identify independent risk factors of significant, noncalcified plaque in subjects where CAC = 0.

Results: This single-center retrospective cohort study included 1026 patients aged 18-45 years who underwent CAC scoring and coronary CT angiograms for clinical indications. The mean age of the population was 38.8 years old. Sixty-three patients had a CAC score of 0 and a TPS >0. Of the patients with noncalcified plaque burden, 15% had a stenosis >50%, and 10% had a stenosis >70%. The odds of a subject having noncalcified plaque presence and CAC absent were significantly associated with being Hispanic, having diabetes, and having hyperlipidemia.

Conclusion: In young adults aged 18-45 years old, we found diabetes, hyperlipidemia, and being of Hispanic origin to be significantly associated with noncalcified plaque burden.

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预测年轻成人存在临床意义的非钙化斑块的危险因素。

目的：冠状动脉钙（CAC）评分可能是评估年轻人心血管疾病的有用工具，特别是那些有高血压、血脂异常或吸烟等危险因素的人。在这项研究中，我们旨在通过评估总斑块负担来解决年轻人发生非钙化斑块的危险因素。方法：对1026例年龄在18-45岁的连续患者进行了单中心回顾性队列研究，这些患者接受了CAC评分和冠状动脉计算机断层扫描（CT）检查临床指征。采用标准评分方案计算CAC评分和总斑块评分（TPS）。进行多元logistic回归分析，以确定CAC = 0的受试者中显著的非钙化斑块的独立危险因素。结果：这项单中心回顾性队列研究纳入了1026例年龄在18-45岁的患者，他们接受了CAC评分和冠状动脉CT血管造影的临床适应症。人口平均年龄为38.8岁。63例患者的CAC评分为0，TPS评分为100。在有非钙化斑块负担的患者中，15%的患者有50%的狭窄，10%的患者有70%的狭窄。非钙化斑块存在和CAC缺失的几率与西班牙裔、糖尿病和高脂血症显著相关。结论：在18-45岁的年轻人中，我们发现糖尿病、高脂血症和西班牙裔与非钙化斑块负担显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.