Coronary artery disease最新文献_第3页

Triglyceride-glucose index as a predictor of contrast-induced nephropathy in nondiabetic patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a retrospective study.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-28 DOI: 10.1097/MCA.0000000000001524

Ayșe İrem Demirtola, Anar Mammadli, Gökhan Çiçek

{"title":"Triglyceride-glucose index as a predictor of contrast-induced nephropathy in nondiabetic patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a retrospective study.","authors":"Ayșe İrem Demirtola, Anar Mammadli, Gökhan Çiçek","doi":"10.1097/MCA.0000000000001524","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001524","url":null,"abstract":"Background: Contrast-induced nephropathy (CIN) is a significant complication following percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. This study aimed to evaluate the association between the triglyceride-glucose (TyG) index and CIN development in nondiabetic patients with STEMI undergoing PCI.Methods: This retrospective study included 1625 nondiabetic patients with STEMI treated with PCI within 12 h of symptom onset. CIN was defined as an increase in serum creatinine of greater than 25% or greater than or equal to 0.5 mg/dl from baseline within 48-72 h postprocedure. Patients were stratified into quartiles based on TyG index levels. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors of CIN and determine the optimal TyG index cutoff.Results: Among the 1625 patients, 14% developed CIN. Patients in the highest TyG quartile (Q4) exhibited the highest incidence of CIN (27%, P < 0.01). The TyG index was independently associated with CIN [odds ratio (OR): 2.054, 95% confidence interval (CI): 1.564-2.697, P < 0.001) alongside baseline creatinine (OR: 1.666, 95% CI: 1.053-2.635, P = 0.001) and contrast volume (OR: 1.003, 95% CI: 1.002-1.005, P = 0.005). ROC analysis yielded a TyG index cutoff value of 9.11 (AUC: 0.722)) with 70% sensitivity and 62% specificity.Conclusion: The TyG index is a reliable marker for predicting CIN in nondiabetic patients with STEMI undergoing PCI. Its independent association with CIN, combined with its cost-effectiveness, highlights its potential for improving risk stratification in this high-risk group.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective C-reactive protein apheresis in acute myocardial infarction: rationale and design of a prospective international randomized controlled trial.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-27 DOI: 10.1097/MCA.0000000000001521

Jan Torzewski, Stephan Mattecka, Benjamin Mayer, Gregg W Stone, Ahmed Sheriff

引用次数: 0

Left main coronary artery atresia: an extremely rare albeit lethal congenital coronary anomaly.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-24 DOI: 10.1097/MCA.0000000000001518

Charalampos Varlamos, Iosif Xenogiannis, Maria A Mademli, Vasilios D Kollias, Loukianos S Rallidis

引用次数: 0

Anomalous left coronary artery arising from the right sinus of Valsalva with an intramural course.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-21 DOI: 10.1097/MCA.0000000000001519

Leizhi Ku, Zheng Liu, Xiaojing Ma

引用次数: 0

Circulation of natural autoantibodies against an immunodominant region of the apolipoprotein B after an acute coronary syndrome: a prospective observational study.

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-05 DOI: 10.1097/MCA.0000000000001517

Tereza Luiza B Fakhouri, Daphnne Camaroske Vera, Viviane Aparecida R Sant'Anna, Esteferson F Rodrigues, Nelson C Farias, Maria Cristina O Izar, Francisco Antonio Fonseca, Magnus Gidlund, Henrique A R Fonseca

引用次数: 0

Split right coronary artery: a rare coronary artery anomaly. 右冠状动脉分裂：一种罕见的冠状动脉异常。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1097/MCA.0000000000001418

Konstantinos C Theodoropoulos, Matthaios Didagelos, Konstantinos Topaloglou, Ekaterina Atrashkevich, George Kassimis, Antonios Ziakas

引用次数: 0

First-in-man study of a novel everolimus-coated balloon for the treatment of coronary in-stent restenosis. 用于治疗冠状动脉支架内再狭窄的新型依维莫司涂层球囊的首次人体试验研究。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1097/MCA.0000000000001459

Fernando Alfonso, Tamaz Shaburishvili, Bruno Farah, Ikrali Gogorishvili, Jacques Monsegu, Arvydas Baranauskas, Erwan Bressollette, George Shaburishvili, Javier Cuesta, Fernando Rivero, Raul Moreno, Manel Sabate

{"title":"First-in-man study of a novel everolimus-coated balloon for the treatment of coronary in-stent restenosis.","authors":"Fernando Alfonso, Tamaz Shaburishvili, Bruno Farah, Ikrali Gogorishvili, Jacques Monsegu, Arvydas Baranauskas, Erwan Bressollette, George Shaburishvili, Javier Cuesta, Fernando Rivero, Raul Moreno, Manel Sabate","doi":"10.1097/MCA.0000000000001459","DOIUrl":"10.1097/MCA.0000000000001459","url":null,"abstract":"Background: Treatment of patients with in-stent restenosis (ISR) remains challenging. In this setting the use of drug-coated balloons (DCB) represents an attractive approach to avoid adding another metal layer to the coronary wall.Aims: The Chansu Vascular Technologies (CVT)-ISR trial aimed to evaluate the safety and efficacy of a novel everolimus-DCB (CVT-DCB) using a new coating formulation and crystalline everolimus.Methods: The CVT-ISR trial was a prospective, multicenter, open, single-arm, first-in-man (FIM) study. A total of 51 patients (mean age 69.2 years, 74.5% male) with single ISR coronary lesions (≤24 mm in length) were enrolled at nine sites in Europe.Results: The primary safety endpoint, freedom from target lesion failure (TLF) at 180 days, was 92.2%, with the lower bound of the 95% confidence interval (81.1%), above the protocol-defined objective performance criterion (OPC) (65% for conventional balloon angioplasty, P < 0.05). At 1 year freedom from TLF was 90.2%. The primary efficacy endpoint, in-stent late lumen loss at 180 days (evaluated in a predefined subgroup of 25 patients scheduled for late angiography), was 0.40 mm (median 0.30 mm), lower than the protocol-defined OPC of the plain balloon angioplasty historical control (0.80 mm, P < 0.001).Conclusion: This FIM study demonstrated the superior efficacy of the new everolimus CVT-DCB compared with conventional balloon angioplasty in the treatment of patients with ISR.Clinical trials registration: NCT05731700.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"91-98"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography versus angiography to guide percutaneous coronary intervention in patients with in-stent restenosis: an observational study. 光学相干断层扫描与血管造影指导经皮冠状动脉介入治疗支架内再狭窄患者：一项观察性研究。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1097/MCA.0000000000001458

Yi-Fei Wang, Tian Xu, Pei-Na Meng, Wei You, Yi Xu, Xiao-Han Kong, Xiang-Qi Wu, Zhi-Ming Wu, Meng-Yao Zhao, Hai-Bo Jia, Feng Wang, Fei Ye

{"title":"Optical coherence tomography versus angiography to guide percutaneous coronary intervention in patients with in-stent restenosis: an observational study.","authors":"Yi-Fei Wang, Tian Xu, Pei-Na Meng, Wei You, Yi Xu, Xiao-Han Kong, Xiang-Qi Wu, Zhi-Ming Wu, Meng-Yao Zhao, Hai-Bo Jia, Feng Wang, Fei Ye","doi":"10.1097/MCA.0000000000001458","DOIUrl":"10.1097/MCA.0000000000001458","url":null,"abstract":"Background: Although optical coherence tomography (OCT) guidance with the 'MLDMAX' criteria is very useful for de-novo lesions during percutaneous coronary intervention (PCI), there are limited studies on its benefits in patients with in-stent restenosis (ISR). This study aimed to compare the clinical outcomes of patients with ISR who underwent repeat PCI (re-PCI) with OCT or angiographic guidance.Methods: This retrospective study enrolled 2142 patients with ISR who underwent re-PCI at Nanjing First Hospital from January 2016 to January 2023. The primary endpoint was the incidence of target vessel failure (TVF) post-re-PCI within 3 years. The secondary endpoints included each component of TVF.Results: After propensity score matching, 161 matched pairs were enrolled. OCT guidance of re-PCI was associated with a significantly lower risk of TVF compared with angiographic guidance alone [hazard ratio (HR), 0.51; 95% confidence interval (CI), 0.31-0.83; P = 0.007] in patients with ISR. However, only 68.9% of patients with ISR met the final criteria of 'MLDMAX' post-re-PCI, which was associated with a lower risk of TVF compared with patients without meeting the OCT criteria (HR, 0.24; 95% CI, 0.11-0.54; P < 0.001), and satisfied the angiographic criteria (HR, 0.40; 95% CI, 0.19-0.85; P = 0.017).Conclusion: Compared with angiographic guidance, OCT guidance significantly reduced TVF risk following re-PCI for ISR lesions, especially for patients who met the final criteria of 'MLDMAX'.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"108-116"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic immune inflammatory response index (SIIRI) in acute myocardial infarction. 急性心肌梗死的全身免疫炎症反应指数（SIIRI）。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1097/MCA.0000000000001454

Ghazi Muheeb, Jamal Yusuf, Vimal Mehta, Md Faizuddin, Sumod Kurian, Girish M P, Mohit Dayal Gupta, Safal Safal, Ankur Gautam, Narendra Kumar Chauhan

{"title":"Systemic immune inflammatory response index (SIIRI) in acute myocardial infarction.","authors":"Ghazi Muheeb, Jamal Yusuf, Vimal Mehta, Md Faizuddin, Sumod Kurian, Girish M P, Mohit Dayal Gupta, Safal Safal, Ankur Gautam, Narendra Kumar Chauhan","doi":"10.1097/MCA.0000000000001454","DOIUrl":"10.1097/MCA.0000000000001454","url":null,"abstract":"Background: Different treatment approaches exist for non-ST elevation acute coronary syndrome (ACS) patients. This study assessed the systemic immune inflammatory response index (SIIRI) for its prognostic value and incremental clinical utility in determining optimal timing for percutaneous coronary intervention (PCI) in non-ST elevation myocardial infarction (NSTEMI) patients, particularly when troponin levels are initially negative.Methods: This study included 1270 ACS patients: 437 STEMI, 422 NSTEMI, and 411 unstable angina. Patients were stratified by SIIRI levels measured at admission, and coronary artery disease severity was evaluated using the SYNTAX score. The primary endpoint was major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, stroke, and revascularization. Secondary endpoints encompassed individual MACE components and heart failure hospitalisations.Results: The mean age was 54.93 years (83% male). SIIRI levels were significantly higher in STEMI patients (6.83 ± 6.43 × 10 5 ) compared to NSTEMI (4.5 ± 5.39 × 10 5 ) and unstable angina (3.48 ± 2.83 × 10 5 ) ( P < 0.001). Area under the curve for SIIRI distinguished NSTEMI and unstable angina from STEMI (0.81 and 0.80), with optimal cut-off points of 4.80 × 10 5 and 4.25 × 10 5 . In NSTEMI, 24.6% presented within 2 h of symptom onset, were troponin-negative, yet had elevated SIIRI. Post-PCI, SIIRI > 4.93 × 10 5 correlated with increased MACE at 1 year (17.2% vs 5%).Conclusion: NSTEMI and unstable angina patients with SIIRI values >4.80 × 10 5 and 4.25 × 10 5 respectively, may require urgent intervention (<2 h). SIIRI can be of significant utility in patients of NSTEMI who present earlier with negative troponins. SIIRI can also aid in identifying high-risk individuals post-PCI, providing a valuable tool for early and accurate assessment.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"139-150"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The triglyceride-glucose index as a new predictor of coronary artery complexity in elderly patients with non-ST-segment elevation acute coronary syndrome. 甘油三酯-葡萄糖指数作为老年非st段抬高急性冠脉综合征患者冠状动脉复杂性的新预测指标

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1097/MCA.0000000000001466

Ilke Erbay, Naile Eris Gudul, Ugur Kokturk, Ahmet Avci

{"title":"The triglyceride-glucose index as a new predictor of coronary artery complexity in elderly patients with non-ST-segment elevation acute coronary syndrome.","authors":"Ilke Erbay, Naile Eris Gudul, Ugur Kokturk, Ahmet Avci","doi":"10.1097/MCA.0000000000001466","DOIUrl":"10.1097/MCA.0000000000001466","url":null,"abstract":"Background: Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) has a significant impact on cardiovascular mortality in elderly patients. Identification of high-risk patients is essential to optimize clinical management. This study investigates the relationship between the TyG index and CAD complexity, as measured by the SYNTAX score, in elderly patients with NSTE-ACS.Methods: We performed a retrospective analysis of 216 patients aged >65 years undergoing coronary angiography stratified according to tertiles of the TyG index and the SYNTAX score (SYNTAX score ≤ 22 versus SYNTAX score > 22).Results: After adjustment for confounders, the TyG index was identified as an independent predictor of moderate/high scores (SYNTAX score > 22). As a continuous variable, it was significantly associated with moderate/high SYNTAX scores in both diabetic ( P = 0.003) and nondiabetic groups ( P = 0.004). When presented as a categorical variable, the TyG index remained a significant predictor after adjustment for sex, hypertension, BMI, and glomerular filtration rate. Compared with the T1 group, the risk of a moderate/high SYNTAX score was 5.410-fold (95% CI: 1.034-28.315; P = 0.046) and 7.774-fold (95% CI: 1.836-32.916; P = 0.005) higher in the T2 and T3 groups, respectively. The TyG index showed superior predictive ability for CAD complexity with an AUC of 0.747 compared with the AUC of 0.624 for HbA1c ( P = 0.005).Conclusion: This study showed that the TyG index is an independent predictor of moderate/high SYNTAX scores in elderly patients with NSTE-ACS, demonstrating superior predictive performance compared to HgA1c and highlighting its potential as a valuable tool for assessing CAD severity in this population.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"151-157"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0