Coronary artery disease最新文献

{"title":"Puerarin alleviates diabetic atherosclerosis through controlling the follistatin-like 1 related inflammation.","authors":"Jiajun Chen, Zhen Hu, Meimei Fang, Xiang Hu, Xiaoqiong Pan, Xiaofen Ni","doi":"10.1097/MCA.0000000000001597","DOIUrl":"10.1097/MCA.0000000000001597","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored the therapeutic potential of puerarin in diabetic atherosclerosis (DA) by targeting endothelial dysfunction and lipid metabolism in apolipoprotein E (APOE)-/- mice.</p><p><strong>Methods: </strong>In vitro, human aortic endothelial immortalized cells cultured under high glucose conditions were treated with puerarin. Cell viability was quantified using cell counting kit-8 (CCK-8) assay. Apoptosis rates were measured via Annexin V/PI flow cytometry. Lipid accumulation was assessed through Oil Red O staining. iNOS levels were detected by ELISA. In vivo, diabetic APOE-/- mice fed a high-fat diet received daily puerarin administration. Aortic collagen deposition was evaluated using Masson trichrome staining. Plaque burden was analyzed via hematoxylin-eosin staining. Serum lipid profiles, including low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were determined by enzymatic assays. Follistatin-like 1 (Fstl1) protein expression and downstream inflammatory mediators were examined through Western blot and immunofluorescence.</p><p><strong>Results: </strong>Puerarin significantly improved endothelial cell survival and reduced apoptosis under high glucose. Lipid droplet formation decreased alongside iNOS suppression. In diabetic mice, puerarin attenuated aortic plaque area and collagen content while improving dyslipidemia. Fstl1 expression and associated inflammatory markers were downregulated.</p><p><strong>Conclusion: </strong>Puerarin alleviates DA progression through dual modulation of endothelial protection and Fstl1-mediated inflammatory pathways.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"37 3","pages":"229-237"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of invasive versus noninvasive treatments in elderly patients with non-ST-segment myocardial infarction: a systematic review and meta-analysis.","authors":"Shanza Malik, Zahra Quettawala Mufaddal, Lida Koskina, Omer Mustafa Siddiqui, Mohamad Mansour, Khushboo Nusrat, Rafay Khan, Muhammad Umer Sohail, Syed Husain Farhan, Deepinder Singh, Eman Ali, Ishaque Hameed","doi":"10.1097/MCA.0000000000001586","DOIUrl":"10.1097/MCA.0000000000001586","url":null,"abstract":"<p><strong>Background: </strong>Historically, the elderly population was underrepresented in clinical trials evaluating the optimal treatment for non-ST-segment elevation myocardial infarction (NSTEMI). Therefore, we aimed to compare invasive versus noninvasive strategies for the management of NSTEMI in older adults.</p><p><strong>Methods: </strong>PubMed, SCOPUS, and Cochrane Central Register of Controlled Trials were screened for studies evaluating medical therapy or invasive revascularization in elderly patients with NSTEMI. Following outcomes were extracted: all-cause mortality, cardiovascular death, fatal or nonfatal MI, repeat coronary revascularization, major adverse cardiovascular events (MACE), bleeding, stroke, noncardiovascular death, and repeat hospitalization for heart failure. Data were pooled using random-effects model to evaluate weighted mean differences and risk ratios with 95% confidence intervals (CIs). This study is registered with PROSPERO, CRD42024622236.</p><p><strong>Results: </strong>Seven studies ( n  = 2997 patients) were included. Patients treated with medical versus invasive therapies showed no significant difference in all-cause mortality (risk ratio: 1.05, 95% CI: 0.94-1.18, P  = 0.37); however, invasive therapies significantly decreased the risk of fatal or nonfatal MI (risk ratio: 0.75, 95% CI: 0.59-0.96, P  = 0.02), repeat coronary revascularizations (risk ratio: 0.29, 95% CI: 0.21-0.40, P  < 0.00001), and risk of MACE (risk ratio: 0.74, 95% CI: 0.61-0.89, P  = 0.002). Lastly, invasive therapies were associated with increased risk of bleeding.</p><p><strong>Conclusion: </strong>Invasive therapy, in comparison to medical management, has reduced incidence of fatal or nonfatal MI, MACE, and the need for revascularization; however, no benefit was noted for all-cause and cardiovascular mortality. Age-specific guidelines must be established for the management of NSTEMI among older adults.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"206-214"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug choice for drug-coated balloons for the treatment of in-stent restenosis: a meta-analysis of randomized trials.","authors":"Andrea Milzi, Antonio Landi","doi":"10.1097/MCA.0000000000001603","DOIUrl":"10.1097/MCA.0000000000001603","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"238-240"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular imaging vs. angiography alone to guide percutaneous coronary intervention in older adults: a meta-analysis of randomized controlled trials.","authors":"Chidubem Ezenna, Sammudeen Ibrahim, Mahmoud Ismayl, Mrinal Murali Krishna, Kuan-Yu Chi, Meghna Joseph, Zafer Akman, Raiza Rossi, Armin Nouri, Mohammad Al Mouslmani, Abdulla Damluji, Andrew M Goldsweig, Michael G Nanna","doi":"10.1097/MCA.0000000000001584","DOIUrl":"10.1097/MCA.0000000000001584","url":null,"abstract":"<p><strong>Background: </strong>Older adults undergoing percutaneous coronary intervention (PCI) face unique challenges due to complex anatomy and comorbidities. Intravascular imaging [including intravascular ultrasound (IVUS) and optical coherence tomography (OCT)] has been shown to improve PCI outcomes, but its benefits in older adults are less well established. We conducted a meta-analysis of randomized controlled trials (RCTs) to compare intravascular imaging with angiography alone to guide PCI in older adults.</p><p><strong>Methods: </strong>Cochrane, PubMed, and Scopus were searched for RCTs comparing intravascular imaging (IVUS or OCT) vs. angiography alone in adults aged ≥65 years. The outcome of interest was major adverse cardiovascular events (MACE) at the longest follow-up, as defined by each trial. Subgroup analyses were performed based on intravascular imaging modality, age group, and lesion complexity. Data were pooled using random-effects models, and heterogeneity was assessed using Higgins' I ² statistic.</p><p><strong>Results: </strong>Nine RCTs ( n  = 7164, intravascular imaging = 3703, angiography alone = 3461) met the inclusion criteria. Intravascular imaging significantly reduced MACE compared with angiography alone [relative risk (RR) 0.66, 95% confidence interval (CI) 0.56-0.77; P  < 0.001; I ² = 0%]. IVUS demonstrated superiority over angiography alone (RR 0.55, 95% CI 0.43-0.72; P  < 0.001; I ² = 0%), while OCT demonstrated only a trend toward MACE reduction (RR 0.80, 95% CI 0.62-1.02). Subgroup analyses indicated consistent benefits with intravascular imaging for adults aged ≥65 and ≥70 years, respectively, and among those with complex coronary lesions (RR 0.65, 95% CI 0.53-0.79; P  < 0.001).</p><p><strong>Conclusion: </strong>Intravascular imaging guidance, especially IVUS, reduces MACE in older adults undergoing PCI compared with angiography alone.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"195-205"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention for bifurcation lesions: a systematic review and meta-analysis.","authors":"Ricardo F O Suruagy-Motta, Julia Tirelli-Rocha, Luiz Guilherme Silva Almeida, Ana Beatriz P Aguiar-Barros, Lucas Lima Mendes, Leonardo Dexheimer da Silva, Kalgi Modi, Pedro Cox-Alomar, Pedro Henrique Magalhães Craveiro de Melo, Evandro Martins Filho, Alexandre Abizaid, Brunna Pileggi","doi":"10.1097/MCA.0000000000001648","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001648","url":null,"abstract":"<p><strong>Background: </strong>The optimal duration of dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention for coronary bifurcation lesions remains uncertain. This meta-analysis focused on comparing ischemic and bleeding outcomes between short-term (≤6 months) and long-term (>6 months) DAPT in this high-risk subgroup.</p><p><strong>Methods: </strong>We included six studies comprising 12 066 patients with bifurcation lesions treated with drug-eluting stents and either short- or long-term DAPT. Pooled relative risk (RR) and 95% confidence intervals (CI) were calculated for major adverse cardiovascular events (MACE), all-cause and cardiac mortality, myocardial infarction, stent thrombosis, stroke, bleeding, and target lesion revascularization.</p><p><strong>Results: </strong>Short-term DAPT was associated with significantly higher risks of MACE (RR 1.79; 95% CI 1.05-3.07), all-cause mortality (RR: 2.78; 95% CI: 1.49-5.19), cardiac death (RR 2.29; 95% CI 1.34-3.91), and stent thrombosis (RR: 4.90; 95% CI: 2.78-8.66). Although the risks of myocardial infarction (RR: 1.75; 95% CI: 0.69-4.47), stroke (RR: 1.07; 95% CI: 0.61-1.67), bleeding (RR: 1.49; 95% CI: 0.24-9.48), and target lesion revascularization (RR: 1.35; 95% CI: 0.85-2.12) did not reach statistical significance, the effect estimates consistently favored long-term DAPT.</p><p><strong>Conclusion: </strong>In patients undergoing percutaneous coronary intervention for bifurcation lesions, short-term DAPT was associated with significantly worse ischemic outcomes, including increased rates of MACE, death, and stent thrombosis. These findings support the use of extended DAPT duration as the preferred strategy in this anatomical subgroup, with treatment tailored according to individual bleeding risk.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of treatment patterns of in-hospital heart failure on clinical outcomes after myocardial infarction.","authors":"Shogo Okita, Yuichi Saito, Hiroaki Yaginuma, Kazunari Asada, Hiroki Goto, Tatsuro Yamazaki, Osamu Hashimoto, Takanori Sato, Kan Saito, Naoto Mori, Hideki Kitahara, Yoshio Kobayashi","doi":"10.1097/MCA.0000000000001644","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001644","url":null,"abstract":"<p><strong>Background: </strong>Heart failure is a common complication after acute myocardial infarction (AMI). However, the prognostic impact of patterns of heart failure management during hospitalization remains unclear.</p><p><strong>Methods: </strong>This multicenter, retrospective study included 2426 patients with AMI undergoing percutaneous coronary intervention. Patients were categorized into three groups: no intravenous (i.v.) heart failure treatment (patients received neither i.v. diuretics nor inotropes/vasopressors), diuretics only (diuretics without inotropes/vasopressors), and inotropes (inotropes/vasopressors with or without diuretics) groups. The primary endpoints included all-cause death during hospitalization and a composite of all-cause death and heart failure rehospitalization after discharge.</p><p><strong>Results: </strong>Overall, 646 patients (26.6%) developed in-hospital heart failure. During hospitalization, the mortality rate was higher in the inotropes group (34.9%), followed by the diuretics only group (5.9%) and the no i.v. heart failure treatment group (2.2%) (P < 0.001). During a median follow-up of 535 days, 196 (9.7%) patients developed the primary endpoint after discharge. A composite of all-cause death and heart failure rehospitalization occurred in 6.5% of the no i.v. heart failure treatment group, while those in the diuretics group (21.2%) and inotropes group (24.3%) had a similar risk of the primary endpoint.</p><p><strong>Conclusion: </strong>Heart failure events requiring i.v. treatments during hospitalization were associated with an increased in-hospital mortality, particularly in those treated with inotropes in patients with AMI. Among patients who were discharged alive, however, long-term outcomes did not differ significantly between patients treated with diuretics only and inotropes.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardizing the definition of premature coronary artery disease: the case for less than or equal to 40 years.","authors":"Pablo Juan-Salvadores, Víctor A Jiménez Díaz","doi":"10.1097/MCA.0000000000001645","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001645","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary computed tomography angiography versus functional testing in a multi-ethnic urban county population.","authors":"Joshua R Colasurdo, Naofumi Yamamoto, April Kinninger, Matthew J Budoff, Sion K Roy","doi":"10.1097/MCA.0000000000001643","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001643","url":null,"abstract":"<p><strong>Background: </strong>The greater positive predictive value of coronary computed tomography angiography (CCTA) relative to myocardial perfusion imaging (MPI) and exercise treadmill stress test (ETT) presents the opportunity to optimize resource utilization in identifying coronary artery disease. This study aims to compare the performance of CCTA with functional testing in an understudied, multi-ethnic urban population.</p><p><strong>Methods: </strong>This retrospective observational study evaluated patients at Harbor-UCLA Medical Center (Torrance, California, USA) who were referred for invasive coronary angiography (ICA) following positive CCTA, MPI, or ETT from 2012 to 2022. ICA results were reviewed to ascertain the rate of indication for revascularization following CCTA, MPI, and ETT.</p><p><strong>Results: </strong>A total of 224 patients were included (mean age 58.8 ± 9.6 year, 63% male, and greater than 56% ethnic minority). Of the 67 patients with positive CCTA referred for ICA, 49 (73%) had an indication for revascularization. In comparison, of the 116 patients with positive MPI, only 49 (42%) had an indication for revascularization, and of the 41 patients with positive ETT, only 16 (39%) had an indication for revascularization. The adjusted odds of CCTA correctly predicting indication for revascularization versus MPI were 6.34 (95% confidence interval: 2.70, 14.92; P ≤ 0.001). Similar odds were found comparing CCTA and ETT, with adjusted odds ratio of 5.97 (95% confidence interval: 2.09, 16.99, P = 0.008).</p><p><strong>Conclusion: </strong>In a multi-ethnic urban population, CCTA provides a greater positive predictive value in the diagnosis of obstructive coronary artery disease than MPI and ETT. These results may help guide the allocation of diagnostic resources in a public, urban hospital.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical versus percutaneous revascularization in multivessel non-ST-elevation acute coronary syndrome: a meta-analysis of 77 989 patients.","authors":"Mohammed A Elbahloul, Ahmed Elbataa, Momen Hajali, Ahmed Wahdan Kasem, Samer O Alalalmeh, Mohamed El-Moslemani, Mohamed Ahmed Zanaty, Ahmed Shawky, Ahmed K Awad, Andrea Amabile, Massimo Baudo, Gianluca Torregrossa, Sameer Hirji","doi":"10.1097/MCA.0000000000001642","DOIUrl":"10.1097/MCA.0000000000001642","url":null,"abstract":"<p><p>Multivessel coronary artery disease (MVD) significantly complicates the management of patients with non-ST-elevation acute coronary syndrome, worsening their clinical and angiographic outcomes. However, the optimal revascularization strategy in this subset of patients is still controversial. Our systematic review and meta-analysis aimed to compare coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in patients with MVD and non-ST-elevation acute coronary syndrome . We performed a comprehensive search of four electronic databases (PubMed, Scopus, WOS, and Cochrane) from inception till 15 December 2024. The outcomes were reported as a relative risk (RR) and 95% confidence interval (CI) in the random-effect model. Our primary outcome was all-cause mortality, while the secondary outcomes were major adverse cardiovascular events (MACCE), myocardial infarction (MI), cardiac death, repeated revascularization, and stroke. Fourteen studies, comprising 77 989 patients, were included. CABG was associated with lower risk of all-cause mortality (RR: 0.80, 95% CI: 0.68-0.93), MACCE (RR: 0.70, 95% CI: 0.59-0.83), MI (RR: 0.53, 95% CI: 0.42-0.67), cardiac death (RR: 0.77, 95% CI: 0.68-0.89), and repeated revascularization (RR: 0.41, 95% CI: 0.33-0.51) in long-term follow-up. However, stroke incidence was higher with CABG in long-term follow-up (RR: 1.36, 95% CI: 1.07-1.73). CABG and PCI showed no significant difference in clinical outcomes at 30-day follow-up. This meta-analysis showed that CABG was associated with favorable long-term outcomes compared to PCI, including lower mortality, MACCE, MI, and repeated revascularization. Time-dependent hazard ratio showed that CABG was associated with better survival over a 16-year follow-up period. perioperative outcomes were comparable in both CABG and PCI.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term prognostic impact of atrial fibrillation subtypes in unselected patients undergoing coronary angiography.","authors":"Henning Johann Steffen, Tobias Schupp, Mohammad Abumayyaleh, Lasse Kuhn, Philipp Steinke, Jonas Dudda, Marielen Reinhardt, Kathrin Weidner, Jonas Rusnak, Mahboubeh Jannesari, Fabian Siegel, Michael Behnes, Ibrahim Akin","doi":"10.1097/MCA.0000000000001641","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001641","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the long-term prognostic impact of atrial fibrillation and its subtypes in an unselected cohort undergoing coronary angiography.</p><p><strong>Background: </strong>Atrial fibrillation is common in patients undergoing coronary angiography and linked to adverse outcomes, but the long-term prognostic impact of atrial fibrillation subtypes, particularly regarding heart failure risk, remains unclear.</p><p><strong>Methods: </strong>Patients undergoing coronary angiography from 2016 to 2022 were stratified by atrial fibrillation status and subtype (paroxysmal, persistent, permanent, new-onset). The primary endpoint was heart failure-related rehospitalization at 36 months. Secondary endpoints included coronary revascularization, acute myocardial infarction (AMI), and in-hospital all-cause mortality.</p><p><strong>Results: </strong>Among 7529 patients, 26.8% had atrial fibrillation (i.e. paroxysmal: 37.7%; persistent: 14.8%, permanent: 16.6%, and new-onset atrial fibrillation: 31.0%). Compared with patients without atrial fibrillation, atrial fibrillation patients were older (median 76 vs. 67 years; P  = 0.001) and had higher rates of heart failure, chronic kidney disease, and acute heart failure. At 36 months, heart failure-related rehospitalization occurred more frequently in atrial fibrillation patients (30.2 vs. 18.4%; P  = 0.001), whereas AMI rates were similar, and coronary revascularization rates were lower. Atrial fibrillation was independently associated with heart failure-related rehospitalization (hazard ratio = 1.246, 95% confidence interval: 1.108-1.400, P  = 0.001), but not with coronary revascularization or AMI. H eart failure rehospitalization increased stepwise across atrial fibrillation subtypes, with the highest in permanent atrial fibrillation (42.5%; P  = 0.001) and progressively lower risk in persistent (34.8%; P  = 0.001), paroxysmal (26.9%; P  = 0.001), and new-onset atrial fibrillation (23.6%; P  = 0.002).</p><p><strong>Conclusion: </strong>Atrial fibrillation independently predicts long-term heart failure-related rehospitalization after coronary angiography, highest in permanent followed by persistent atrial fibrillation.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}