Coronary artery disease最新文献_第3页

The fate of coronary artery bypass grafting in the elderly: treat and forget. 老年人冠状动脉搭桥术的命运：治疗后遗忘。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-08 DOI: 10.1097/MCA.0000000000001552

Elisa Gastino, Fabio Barili, Stefano Rosato, Francesco Pollari, Giovanni Baglio, Matteo Scarpanti, Gabriella Badoni, Giorgia Duranti, Francesco Donatelli, Alessandro Parolari, Paola D'Errigo

{"title":"The fate of coronary artery bypass grafting in the elderly: treat and forget.","authors":"Elisa Gastino, Fabio Barili, Stefano Rosato, Francesco Pollari, Giovanni Baglio, Matteo Scarpanti, Gabriella Badoni, Giorgia Duranti, Francesco Donatelli, Alessandro Parolari, Paola D'Errigo","doi":"10.1097/MCA.0000000000001552","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001552","url":null,"abstract":"Background: Coronary artery bypass grafting (CABG) is offered to a growing population of octogenarians, considering the constant rise of life expectancy. However, the mid-term benefit of surgical revascularization is still unclear. The aim of this study is to highlight the 10-year outcomes after isolated CABG in the elderly included in the Italian nationwide PRIORITY cohort.Methods: Patients younger and older than 80 years were identified within the PRIORITY project. Baseline differences between the study groups were balanced with propensity score matching and inverse probability of treatment. Time to events was analyzed using Cox regression and competing risk analysis.Results: The cohort consisted of 10 989 patients who underwent isolated CABG (7.9% OPCAB). The median follow-up time was 7.9 years. Octogenarians showed poorer 10-year survival [hazard ratio (HR) 3.09, 95% confidence interval (CI) 2.93-3.25, P < 0.001] and major adverse cardiac and cerebrovascular events (HR 2.13, 95% CI 2.04-2.22, P < 0.001). Interestingly, although presenting higher incidence of myocardial infarction (MI) at 10 years (HR 1.39, 95% CI 1.29-1.50, P < 0.001), octogenarians demonstrated a reduced incidence of 10-year myocardial revascularization (HR 0.53, 95% CI 0.48-0.59, P < 0.001), corroborating the hypothesis of undertreatment for elderly.Conclusions: With the increasing incidence of octogenarians undergoing CABG, undertreatment after surgery appears a critical issue. The higher incidence of 10-year MI, together with the opposite rate of myocardial revascularization, suggests a tendency for conservative approaches, opening a debate on the choice of treating the elderly with CABG without guaranteeing a clinical assistance comparable to younger patients.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and disparities in ischemic heart disease mortality in the United States: an analysis of CDC WONDER database, 1999-2020. 美国缺血性心脏病死亡率的趋势和差异：1999-2020年CDC WONDER数据库分析

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-07 DOI: 10.1097/MCA.0000000000001550

Muhammad Abdullah Naveed, Faizan Ahmed, Sherif Eltawansy, Ahila Ali, Zaima Afzaal, Bazil Azeem, Muhammad Kashan, Kainat Aman, Mushood Ahmed, Hritvik Jain, Omar Kamil, Faseeh Haider, Rabia Iqbal, Aman Ullah, Nisar Asmi, Muhammad Faizan Ali

{"title":"Trends and disparities in ischemic heart disease mortality in the United States: an analysis of CDC WONDER database, 1999-2020.","authors":"Muhammad Abdullah Naveed, Faizan Ahmed, Sherif Eltawansy, Ahila Ali, Zaima Afzaal, Bazil Azeem, Muhammad Kashan, Kainat Aman, Mushood Ahmed, Hritvik Jain, Omar Kamil, Faseeh Haider, Rabia Iqbal, Aman Ullah, Nisar Asmi, Muhammad Faizan Ali","doi":"10.1097/MCA.0000000000001550","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001550","url":null,"abstract":"Background: Ischemic heart disease (IHD) remains a leading cause of mortality globally and has a high prevalence in the USA, necessitating an understanding of long-term trends to inform interventions. Considering demographic and geographic disparities, this study examines IHD-related mortality trends among US adults from 1999 to 2020.Aim: This study aimed to evaluate patterns and geographical variations in mortality associated with IHD among adults in the USA.Methods: Death certificates from the CDC WONDER database spanning from 1999 to 2020 were analyzed to investigate mortality related to IHD among adults aged 35 years and above. Age-adjusted mortality rates (AAMRs) per 100 000 persons and annual percent change were calculated and stratified by year, sex, race/ethnicity, and geographic region.Results: IHD caused 12 756 359 deaths among U.S. adults aged 35 and above from 1999 to 2020. Annual trends in AAMRs declined from 48.7 in 1999 to 28.9 in 2020, with notable fluctuations. Men consistently had higher AAMRs than women. Non-Hispanic Black or African American individuals exhibited the highest AAMRs. Geographically, significant disparities existed among states and regions, with the Northeast having the highest mortality. Nonmetropolitan areas consistently had higher AAMRs than metropolitan areas, showing varying trends over the study period.Conclusion: Fluctuations in mortality trends among IHD patients were observed over the study duration, revealing significant disparities across demographic and geographic parameters. Targeted interventions are imperative to alleviate the burden of IHD and mitigate mortality rates in the USA.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why colchicine is not beneficial in patients with acute coronary syndrome? In search of a CLEAR answer. 为什么秋水仙碱对急性冠脉综合征患者无效？寻找一个明确的答案。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-07-07 DOI: 10.1097/MCA.0000000000001551

Stefano De Servi, Mauro Molteni, Claudio Cimminiello

引用次数: 0

Association between pulse wave velocity and coronary atherosclerosis. 脉搏波速度与冠状动脉粥样硬化的关系。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-24 DOI: 10.1097/MCA.0000000000001548

Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro

{"title":"Association between pulse wave velocity and coronary atherosclerosis.","authors":"Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro","doi":"10.1097/MCA.0000000000001548","DOIUrl":"10.1097/MCA.0000000000001548","url":null,"abstract":"Background: Pulse wave velocity (PWV) is considered a more direct and accurate measure of arterial stiffness. This study explored the relationship between PWV and the presence and severity of coronary artery calcification (CAC) and coronary artery plaque (CAP).Methods: The current study was a cross-sectional analysis of data from the Miami Heart Study (MiHeart). The primary outcome variable of this study was the CAC score. The secondary outcome was the presence of CAC and CAP. Multivariable logistic regression and Bayesian linear regression were used to find the association between PWV CAC and CAP.Results: A total of 2359 participants were included in the study. The mean age (SD) of the sample was 53.4 (6.8) years and 50.4% were men. Multivariable logistic regression analysis showed that the odds of having CAC greater than 0 was significantly higher with increasing PWV [odds ratio (OR): 1.09, 95% confidence interval (CI): 1.01-1.18]. Similarly, multivariable logistic regression analysis also showed that the odds for CAP were significantly higher with increasing PWV (OR: 1.14, 95% CI: 1.06-1.23). The results of Bayesian linear regression analysis showed that there was a significant association between PWV and log CAC score.Conclusion: In a large sample of participants from the community and without a history of known cardiovascular disorder, we found that an increase in PWV was associated with the presence of CAC and CAP. In addition, we also found that PWV was associated with severity of CAC as well. Our findings show that PWV could be an important marker of subclinical coronary atherosclerosis in the general population.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of drug-eluting stent combined with drug-coated balloon in the treatment of complex coronary artery lesions. 药物洗脱支架联合药物包被球囊治疗复杂冠状动脉病变的安全性和有效性。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-18 DOI: 10.1097/MCA.0000000000001543

Xiaotao Li, Yuhong Yang, Ran Zhang, Dawei Yang, Xiaojie Chen, Jia Wang, Chenhao Zhang

{"title":"Safety and efficacy of drug-eluting stent combined with drug-coated balloon in the treatment of complex coronary artery lesions.","authors":"Xiaotao Li, Yuhong Yang, Ran Zhang, Dawei Yang, Xiaojie Chen, Jia Wang, Chenhao Zhang","doi":"10.1097/MCA.0000000000001543","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001543","url":null,"abstract":"Objective: The aim of this study was to explore the safety and efficacy of drug-eluting stents (DES) combined with drug-coated balloons (DCB) in the treatment of complex coronary artery lesions.Methods: In total, 305 patients with complex coronary artery lesions who underwent percutaneous coronary intervention were retrospectively included in this study. The patients were divided into the DES combined with the DCB treatment group (hybrid group) and the DES-only treatment group (DES group), and the target lesion revascularization (TLR) and major adverse cardiovascular events (MACE) were compared between the two groups during 2-year follow-up.Results: There were no significant differences between the two groups in baseline clinical characteristics (P > 0.05). In the treated lesions of reference vessel diameters (RVD) ≥3 mm, there were no significant differences in coronary angiography and interventional characteristics between the two groups. In the treated lesion of RVD <3 mm, hybrid group had higher proportion of lesion preparation (P < 0.001) and a higher rate of residual stenosis after stent implantation (P < 0.001). During the 2-year follow-up, the clinical outcomes between the two groups showed no significant differences. After propensity score matching, there were still no significant differences between the two groups in the cumulative survival rates without TLR (95.8% vs. 94.2%; log-rank P = 0.560) or MACE (89.4% vs. 87.8%; log-rank P = 0.578) at 2-year follow-up.Conclusion: During the 2-year follow-up, DES combined with DCB treatment showed similar efficacy and safety compared with DES-only treatment in complex coronary artery lesions.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the first-in-man study of a novel everolimus-coated balloon for coronary in-stent restenosis. 新型依维莫司涂层球囊治疗冠状动脉支架内再狭窄的首次人体研究的经验教训。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001541

Rupak Desai, Nihar K Jena

引用次数: 0

Scoring-balloon fenestration for abrupt closure caused by spiral coronary artery dissection and hematoma immediately after intravascular lithotripsy. 记分球囊开窗治疗血管内碎石术后螺旋状冠状动脉剥离和血肿引起的突然关闭。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001542

Akira Shinoda, Kazuhiro Dan

引用次数: 0

Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016. 内脏脂肪代谢评分与动脉粥样硬化性心血管疾病的相关性：来自NHANES 2005 - 2016的证据

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001545

Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li

{"title":"Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016.","authors":"Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li","doi":"10.1097/MCA.0000000000001545","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001545","url":null,"abstract":"Background: Obesity and metabolic disorders are key contributors to the development of atherosclerotic cardiovascular disease (ASCVD). This study sought to investigate the relationship between the newly introduced Metabolic Score for Visceral Fat (METS-VF) and ASCVD, utilizing data from the National Health and Nutrition Examination Survey (NHANES).Methods: Data from NHANES 2005-2016 were analyzed. Adults with complete METS-VF and ASCVD data were included. Weighted multivariate logistic regression models assessed associations between METS-VF and ASCVD. Smoothed curve fitting and subgroup analyses further explored the relationship. Receiver operating characteristic curves were used to compare the predictive performance of METS-VF with other indicators of visceral fat.Results: A total of 9979 participants were included, among whom 807 had ASCVD. In the fully adjusted model, each 1-unit increase in METS-VF was associated with a 43% higher ASCVD risk (OR = 1.43, 95% CI: 1.11-1.85). Compared with Q1, the ORs for Q2, Q3, and Q4 were 1.71, 1.72, and 2.10, respectively (P for trend <0.05). The curve fitting showed a linear positive association. Subgroup analyses indicated significant associations in men, non-Hispanic Whites and Blacks, and participants without hypertension, who smoked, drank alcohol, or physically inactive. METS-VF showed better predictive ability (AUC = 0.734) than LAP, VAI, WC, and WHtR.Conclusions: METS-VF is a reliable, noninvasive, and cost-effective predictor of visceral obesity that demonstrates a linear positive correlation with ASCVD, supporting its use as an accurate measure of ASCVD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated left main coronary artery disease in two young HIV-positive men without traditional risk factors. 孤立的左主干冠状动脉疾病的两个年轻的hiv阳性男子没有传统的危险因素。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001547

Didar Mirzamidinov, Kurtulus Karauzum, Hacer Dogan, Kaan Hanci, Irem Yilmaz, Goksel Kahraman, Tayfun Sahin

引用次数: 0

Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise. 胆红素可能介导有氧运动习惯的抗炎作用：有氧运动的抗动脉粥样硬化作用的含义。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001546

Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi

{"title":"Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise.","authors":"Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1097/MCA.0000000000001546","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001546","url":null,"abstract":"Background: Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.Methods: This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.Results: In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.Conclusion: Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0