Coronary artery disease最新文献

{"title":"Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise.","authors":"Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1097/MCA.0000000000001546","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001546","url":null,"abstract":"<p><strong>Background: </strong>Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.</p><p><strong>Methods: </strong>This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.</p><p><strong>Results: </strong>In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.</p><p><strong>Conclusion: </strong>Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease.","authors":"Ingela Khan, Caroline A B Hondros, Silja Hanseth, Eva R Pedersen, Siren Hovland, Terje H Larsen, Mai Tone Lønnebakken","doi":"10.1097/MCA.0000000000001539","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001539","url":null,"abstract":"<p><strong>Background: </strong>Inflammation is a driver of atherosclerosis and plaque vulnerability. Epicardial adipose tissue (EAT) accumulation is associated with inflammation. The aim of this study was, therefore, to explore the association between EAT volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease (CAD).</p><p><strong>Methods: </strong>We identified 31 individuals [median age 58 (52, 68) years, 42% women] from the Norwegian Registry of Invasive Cardiology with nonobstructive CAD undergoing clinically indicated serial cardiac computed tomography (CT) and coronary CT angiography (CCTA). EAT volume was measured at baseline by a semiautomatic analysis software. Patients were grouped according to lower or higher than median baseline EAT (b-EAT) volume. Plaque progression was quantified by CCTA as annual change in total and compositional plaque volume. Hypodense plaques were adjudicated as vulnerable plaques.</p><p><strong>Results: </strong>Patients with high b-EAT volume had numerically lower calcium score, coronary artery segment involvement score, total coronary plaque burden, and increased prevalence of vulnerable plaques compared with patients with low EAT volume at baseline and follow-up, even if it did not reach statistical significance. Compared with patients with low b-EAT volume, patients with high b-EAT volume tended to have an annual regression in total plaque volume, while the proportion of vulnerable hypodense plaque volume increased.</p><p><strong>Conclusion: </strong>In nonobstructive CAD, patients with high b-EAT volume tended to have a regression of total plaque volume, but a transformation into a vulnerable plaque phenotype during follow-up. Whether lifestyle changes may improve prognosis in nonobstructive CAD needs to be confirmed in larger trials.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio is a novel biomarker for predicting all-cause mortality and cardiovascular mortality in patients with ST-segment elevation myocardial infarction.","authors":"Hong Wei, Yanji Zhou, Yu Wang, Dan Xu, Yunhong Yang, Tao Shi, Sirui Yang, Xinuo Ma, Lixing Chen","doi":"10.1097/MCA.0000000000001544","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001544","url":null,"abstract":"<p><strong>Background: </strong>Uric acid-to-albumin ratio (UAR) and monocyte-to-lymphocyte ratio (MLR) predict adverse outcomes in cardiovascular disease (CVD). We aim to explore the predictive value of UAR combined with MLR for all-cause and cardiovascular mortality in patients with ST-segment elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>This retrospective cohort study included 1045 patients with STEMI who had undergone emergency percutaneous coronary intervention (PCI) (2018-2023). Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio (UAML) was defined as the product of UAR and MLR. Mortality prediction was evaluated via Kaplan-Meier, Cox regression, and time-dependent receiver operating characteristic (ROC) analyses.</p><p><strong>Results: </strong>Stratifying 1045 patients with STEMI by median UAML (3.35) revealed significantly higher cumulative all-cause mortality (log-rank χ2 =41.114, P < 0.001) and cardiovascular mortality (χ2 = 32.153, P < 0.001) in the high-UAML (≥3.35) vs. low-UAML (<3.35) group. Multivariate Cox analysis confirmed UAML as an independent predictor of all-cause mortality [hazard ratio (HR) = 2.217, 95% confidence interval (CI): 1.399-3.514; P < 0.001] and cardiovascular mortality (HR = 2.160, 95% CI: 1.267-3.618; P = 0.005). Time-dependent ROC demonstrated superior predictive discrimination for UAML over individual components in both all-cause mortality [area under the ROC curve (AUC) = 0.704 vs. UAR = 0.686/MLR = 0.627] and cardiovascular mortality (AUC = 0.700 vs. 0.690/0.615).</p><p><strong>Conclusion: </strong>UAML may serve as a strong prognostic factor for all-cause and cardiovascular mortality in patients with STEMI who undergo emergency PCI, and UAML has a stronger predictive value than UAR or MLR.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual anomalous origins of the left anterior descending and left circumflex from the right coronary sinus with interarterial and retroaortic course.","authors":"Kurtulus Karauzum, Didar Mirzamidinov, Ozgur Cakir, Irem Yilmaz, Tayfun Sahin","doi":"10.1097/MCA.0000000000001538","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001538","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising burden of coronary artery disease-related mortality among USA adults with atrial fibrillation from 1999 to 2020.","authors":"Muhammad Saad, Ifrah Ansari, Muhammad Umer Sohail, Syed Ibad Ahsan, Saad Ahmed Waqas, Muhammad Sameer Arshad","doi":"10.1097/MCA.0000000000001540","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001540","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) and atrial fibrillation (AF) are significant cardiovascular conditions with substantial health and economic burdens. Despite advancements in treatment, long-term mortality trends among individuals with both conditions remain underexplored. This study investigates age-adjusted mortality rates (AAMRs) from 1999 to 2020 and examines trends to address these gaps and highlight demographic and geographic disparities.</p><p><strong>Methods: </strong>Mortality data from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database were analyzed for cases where CAD (ICD-10 codes I20-I25) and AF (ICD-10 code I48) were either contributing or underlying causes of death. Individuals aged 25 years and older were included in the analysis. AAMRs were calculated using direct standardization to the 2000 USA population, and trends were assessed using Joinpoint regression analysis. Mortality trends were stratified by sex, race, geography, and urbanization to identify disparities.</p><p><strong>Results: </strong>Between 1999 and 2020, AAMRs for CAD- and AF-related mortality increased from 14.4 to 23.4 per 100 000, with an average annual percent change of +2.2% (95% confidence interval: 2.0-2.4). Men consistently exhibited higher overall AAMRs than women (22.9 vs. 13.1 ). Non-Hispanic (NH) White individuals had the highest AAMR (18.6), followed by NH American Indians (12.3), NH Blacks (10.0), Hispanics (9.4), and NH Asians (8.0). Rural areas experienced significantly higher AAMRs than urban areas (19.2 vs. 16.6). AAMRs were disproportionately higher in Western (17.7) and Midwestern USA regions (17.7). States in the top 90th percentile reported nearly double the AAMRs compared to those in the bottom 10th percentile.</p><p><strong>Conclusion: </strong>Mortality rates associated with coexisting CAD and AF have significantly increased, with the most pronounced rise occurring after 2018. The findings reveal substantial disparities across sex, race, and geography. Targeted interventions are essential to address these inequalities, improve health outcomes, and reduce the growing burden of CAD and AF-related mortality.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is coronary vasospasm the pathophysiologic mechanism of takotsubo syndrome?","authors":"John E Madias","doi":"10.1097/MCA.0000000000001523","DOIUrl":"10.1097/MCA.0000000000001523","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"348-349"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare finding after acute myocardial infarction.","authors":"Diamantis Kosmidis, Nikolaos Gouliaros, Evangelia Sotiroglou, Dimitris Vatitsis, Charalampos Stefanidis, Christos Chatzieleftheriou","doi":"10.1097/MCA.0000000000001473","DOIUrl":"10.1097/MCA.0000000000001473","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"358-359"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocannabinoids 2-arachidonoylglycerol and N-arachidonoylethanolamine measured in hair decrease before the occurrence of acute myocardial infarction, possibly reflecting an exhaustion of the stress-buffer system.","authors":"Nikolaos Kosmas, Panagiotis Simitsis, Evangelos Alevyzakis, Emmanouil Rizos, Dimitrios Zapantiotis, Loukianos S Rallidis","doi":"10.1097/MCA.0000000000001484","DOIUrl":"10.1097/MCA.0000000000001484","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"335-336"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A very rare variant of single coronary artery.","authors":"Iosif Bikakis, Konstantinos C Theodoropoulos, Matthaios Didagelos, Georgios Perdikos, Alexandra Liakopoulou, Antonios Kouparanis, Antonios Ziakas","doi":"10.1097/MCA.0000000000001424","DOIUrl":"10.1097/MCA.0000000000001424","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"351-352"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index as a predictor of contrast-induced nephropathy in nondiabetic patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a retrospective study.","authors":"Ayșe İrem Demirtola, Anar Mammadli, Gökhan Çiçek","doi":"10.1097/MCA.0000000000001524","DOIUrl":"10.1097/MCA.0000000000001524","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is a significant complication following percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. This study aimed to evaluate the association between the triglyceride-glucose (TyG) index and CIN development in nondiabetic patients with STEMI undergoing PCI.</p><p><strong>Methods: </strong>This retrospective study included 1625 nondiabetic patients with STEMI treated with PCI within 12 h of symptom onset. CIN was defined as an increase in serum creatinine of greater than 25% or greater than or equal to 0.5 mg/dl from baseline within 48-72 h postprocedure. Patients were stratified into quartiles based on TyG index levels. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors of CIN and determine the optimal TyG index cutoff.</p><p><strong>Results: </strong>Among the 1625 patients, 14% developed CIN. Patients in the highest TyG quartile (Q4) exhibited the highest incidence of CIN (27%, P  < 0.01). The TyG index was independently associated with CIN [odds ratio (OR): 2.054, 95% confidence interval (CI): 1.564-2.697, P  < 0.001] alongside baseline creatinine (OR: 1.666, 95% CI: 1.053-2.635, P  = 0.001) and contrast volume (OR: 1.003, 95% CI: 1.002-1.005, P  = 0.005). ROC analysis yielded a TyG index cutoff value of 9.11 (AUC: 0.722) with 70% sensitivity and 62% specificity.</p><p><strong>Conclusion: </strong>The TyG index is a reliable marker for predicting CIN in nondiabetic patients with STEMI undergoing PCI. Its independent association with CIN, combined with its cost-effectiveness, highlights its potential for improving risk stratification in this high-risk group.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"326-332"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}