Urinary sodium-potassium ratio as a genetic predictor of myocardial infarction.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-05-06 DOI:10.1097/MCA.0000000000001532

Ziyang Wu, Dong Wang, Chengchun Tang

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引用次数: 0

Abstract

Background: The relationship between the urinary sodium-potassium ratio (USPR) and risk factors for heart disease has been observed over time. We evaluated the relationship between USPR and myocardial infarction (MI).

Methods: Causal relationships were estimated based on USPR and MI data from genome-wide association studies. The main analysis method for bidirectional two-sample Mendelian randomization was inverse-variance weighting (IVW), with four other supplementary methods used.

Results: The IVW method indicated a positive correlation between USPR levels and MI (IVW, odds ratio = 1.504, 95% confidence interval: 1.108-2.041, P = 0.009). In contrast, the inverse analysis provided evidence suggesting that MI affected USPR (P > 0.05). The Cochran Q test showed heterogeneity, while the intercept test revealed no horizontal pleiotropy, and the leave-one-out analysis demonstrated that the analyses were reliable.

Conclusions: This study provides evidence for the causal effect of the USPR on MI; however, this was not the case in the opposite situation. It is plausible that the USPR serves as a promoting factor for MI.

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尿钠钾比作为心肌梗死的遗传预测因子。

背景：随着时间的推移，人们已经观察到尿钠钾比（USPR）与心脏病危险因素之间的关系。我们评估了USPR与心肌梗死（MI）的关系。方法：基于全基因组关联研究的USPR和MI数据估计因果关系。双向双样本孟德尔随机化的主要分析方法是逆方差加权法（IVW），并辅以其他4种方法。结果：IVW法显示USPR水平与心肌梗死呈正相关（IVW，优势比为1.504,95%可信区间为1.108 ~ 2.041,P = 0.009）。相反，反向分析提供证据表明MI影响USPR （P < 0.05）。Cochran Q检验显示异质性，而截距检验显示没有水平多效性，留一分析表明分析是可靠的。结论：本研究为USPR对心肌梗死的因果效应提供了证据；然而，在相反的情况下，情况并非如此。USPR是MI的促进因素，这似乎是合理的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.