Coronary vasomotor response incidence to intracoronary acetylcholine provocation test according to the severity of insignificant coronary artery stenosis in Korean population.
Tae Shik Park, Woo Jin Ahn, Seung-Woon Rha, Se Yeon Choi, Jinah Cha, Sujin Hyun, Markz Rmp Sinurat, Soohyung Park, Cheol Ung Choi, Chang Gyu Park, Dong Joo Oh, Byoung Geol Choi
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引用次数: 0
Abstract
Background: Coronary artery spasm (CAS) is a cause of variant angina. However, the understanding of CAS patterns in the presence of mild-to-moderate coronary artery stenosis is limited. This study aimed to evaluate the incidence and patterns of CAS in patients with insignificant coronary artery stenosis using intracoronary acetylcholine (ACH) provocation test.
Methods: In this study, 6513 patients without significant coronary artery stenosis who underwent intracoronary ACH provocation test were enrolled. Patients were divided into three groups, based on the severity of coronary artery stenosis: the non group (stenosis <30%, n = 2833), the mild group (30-49%, n = 3278) and the moderate group (50-69%, n = 402). Vasomotor responses were observed among three different groups.
Results: The baseline characteristics of the patients in the mild and moderate groups were worse than in the non group. They were older, had higher prevalence of hypertension, diabetes, dyslipidemia, and smoking habit. During the ACH test, CAS was observed in 58.1% of the overall population. The mild group (60.1%) and the moderate group (60.9%) showed a higher incidence than the non group (55.3%, P < 0.001). In addition, among cases of CAS, the mild group (3.2%) and the moderate group (8.5%) responded more at a lowest dose of ACH than the non group (3.1%, P < 0.001).
Conclusion: In patients with chest pain without significant coronary artery stenosis, CAS was observed in over half of the cases. Furthermore, CAS was found to be more frequent and more susceptible in patients with mild-to-moderate coronary artery stenosis compared with those without fixed stenosis.
期刊介绍：
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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