Jia-Xin Wang, Yan-Li Xu, Cheng-Jie Ma, Guo-Dong Li, Yu-Xuan Yang, Jie Lian, Bo Li, Yi-Ying Wang, Jian-Ping Liu, Le Ngoc Hung, Ngo Thi Phuong, Le Minh Ha, Dinh Thi Lan Huong, Hui-Juan Cao
{"title":"Shengmai Liquid (Chinese Patent Medicine) for the Treatment of Post-COVID-19 Fatigue: A Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Jia-Xin Wang, Yan-Li Xu, Cheng-Jie Ma, Guo-Dong Li, Yu-Xuan Yang, Jie Lian, Bo Li, Yi-Ying Wang, Jian-Ping Liu, Le Ngoc Hung, Ngo Thi Phuong, Le Minh Ha, Dinh Thi Lan Huong, Hui-Juan Cao","doi":"10.1159/000553019","DOIUrl":"10.1159/000553019","url":null,"abstract":"<p><strong>Introduction: </strong>Fatigue is one of the most common symptoms of post-COVID syndrome. The Chinese herbal medicine Shengmai liquid has been recorded in ancient books, and modern studies have shown its ability to relieve fatigue. This study aims to assess the clinical efficacy and safety of Shengmai liquid in improving fatigue symptoms in post-COVID syndrome patients.</p><p><strong>Methods: </strong>We plan to enroll 100 eligible patients with post-COVID-19 fatigue from Beijing Ditan Hospital, randomly allocating them into either the Shengmai liquid or placebo group. Blinding will be maintained for the personnel responsible for evaluating outcomes and performing statistical analysis. The participants will be treated for 8 weeks and followed for another 30 days. We utilized the modified Fatigue Impact Scale as our main endpoint to evaluate changes in patient fatigue. The secondary outcomes will include the Traditional Chinese Medicine Syndrome Score Scale, Hamilton Depression Inventory-17 items, Hamilton Anxiety Scale, Pittsburgh Sleep Quality Scale, World Health Organization Quality-of-Life Scale, and 6-min walk distance. All the statistical analyses will use SPSS software with a 0.05 significance level and follow the intention-to-treat principle.</p><p><strong>Conclusion: </strong>This randomized, single-center, double-blind trial will provide robust clinical evidence regarding the short-term efficacy and safety of Shengmai liquid for the treatment of post-COVID-19 fatigue.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Traditional Chinese Medicine Nursing Intervention in Chronic Obstructive Pulmonary Disease with Gastrointestinal Dysfunction: Bibliometric and Knowledge Graph Analysis, 2015-2025.","authors":"Shengxi Chen, Xinxin Chen, Panpan Zhang, Yanping Chen","doi":"10.1159/000552520","DOIUrl":"10.1159/000552520","url":null,"abstract":"<p><strong>Introduction: </strong>At present, bibliometric studies focusing explicitly on traditional Chinese medicine (TCM) nursing for patients with chronic obstructive pulmonary disease (COPD) and gastrointestinal (GI) dysfunction are limited, leaving critical gaps in understanding research dynamics and knowledge evolution. This study aimed to systematically analyse literature on TCM nursing interventions for COPD complicated by GI dysfunction, using bibliometric methods to identify research trends, thematic structures, and future research directions.</p><p><strong>Methods: </strong>This study conducted a bibliometric analysis of relevant literature. Publications from 2015 to 2025 on TCM nursing for COPD with GI dysfunction were retrieved from the Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure. After removing duplicates, 1,563 relevant publications were analysed. Bibliographic data were extracted and analysed using CiteSpace, VOSviewer, and bibliometrix (R package).</p><p><strong>Results: </strong>Annual publication volume exhibited steady growth, peaking in 2024. China emerged as the primary research contributor, collaborating extensively with the USA, Australia, and European nations. Institutional analysis revealed key research centres predominantly located in China, with increasing international cooperation. Core authors, such as Chen Wang and Ke Huang, significantly influenced research collaboration networks. Major thematic clusters included pulmonary rehabilitation, quality of life improvement, gut-lung interactions, and molecular mechanisms. Landmark references reflected the growing integration of TCM nursing into conventional COPD care and the increasing attention on patient-centred outcomes.</p><p><strong>Conclusion: </strong>Research in this niche is increasingly oriented towards rehabilitation-focused integrative care and mechanism-informed perspectives (gut-lung axis). Future studies should prioritise a GI-inclusive core outcome set, standardised reporting of nursing-deliverable TCM modalities, and pragmatic/hybrid effectiveness-implementation designs aligned with gut-lung-related hypotheses.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Li, Zilong Ma, Walter Falchi, Liyuan Huang, Zehuan Chen, Hai Wang
{"title":"Prediction of Treatment Response and Adverse Events in Pediatric Attention-Deficit/Hyperactivity Disorder Treated with Acupuncture Combined with Conventional Treatment.","authors":"Yang Li, Zilong Ma, Walter Falchi, Liyuan Huang, Zehuan Chen, Hai Wang","doi":"10.1159/000552870","DOIUrl":"10.1159/000552870","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to develop and externally validate machine learning (ML) models for predicting treatment response and adverse events in children with attention-deficit/hyperactivity disorder (ADHD) receiving acupuncture combined with conventional first-line care.</p><p><strong>Methods: </strong>In this multicentre retrospective study, demographic, clinical, behavioral, and laboratory data from 809 children with ADHD aged 6-12 years were used to develop and evaluate ten ML models. Treatment response was defined as a ≥30% reduction in the Swanson, Nolan, and Pelham-IV total score 8-16 weeks after treatment initiation, and adverse events were recorded from parent reports. Model development used repeated 10-fold cross-validation, with evaluation in an internal testing cohort and two external cohorts. Discrimination, calibration, and clinical utility were assessed, and model interpretability was examined using SHapley Additive exPlanations.</p><p><strong>Results: </strong>The extreme gradient boosting model demonstrated the best discriminative performance for predicting treatment response and was retained for further analyses. For treatment response prediction, it achieved an area under the receiver operating characteristic curve (AUROC) of 0.83 in the internal testing cohort and showed stable external performance, with AUROCs ranging from 0.78 to 0.87 across both external cohorts. For adverse event prediction, discriminative performance was moderate, with external AUROCs ranging from 0.73 to 0.85. Model interpretability analyses suggested that multiple clinical feature domains contributed to model predictions.</p><p><strong>Conclusion: </strong>Using routinely collected clinical data, ML-based models showed reproducible discrimination for predicting treatment response and adverse events in children with ADHD receiving acupuncture as adjunctive therapy. They may support individualized benefit-risk stratification in integrative treatment settings, although prospective assessment of clinical impact is warranted.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanie Schwermer, Alfred Längler, Thomas Ostermann, Katharina Fetz, David D Martin, Tycho Zuzak
{"title":"A Prospective Longitudinal Survey about Parents' Experiences with an Integrative-Therapy Concept for Acute Gastroenteritis in a German Anthroposophic Hospital.","authors":"Melanie Schwermer, Alfred Längler, Thomas Ostermann, Katharina Fetz, David D Martin, Tycho Zuzak","doi":"10.1159/000552455","DOIUrl":"10.1159/000552455","url":null,"abstract":"<p><strong>Introduction: </strong>In specialized children's hospitals, patients with acute gastroenteritis received supportive anthroposophic drug and non-drug therapies to improve the course of disease. In addition to actual effectiveness of the therapy, parents' experience of the hospital stay is an important factor in children's recovery. Both effectiveness and satisfaction were assessed by a parent survey.</p><p><strong>Methods: </strong>The results presented here are part of a non-controlled, prospective case series study conducted between April 2018 and April 2020 in a department of integrative medicine for children and adolescents in a German anthroposophic hospital. Parents of hospitalized children were invited to participate in a prospective longitudinal survey (t1: during hospital stay; t2: 4-6 weeks after discharge). The survey covered socio-demographic data, course of symptoms, parental satisfaction and factors influencing recovery.</p><p><strong>Results: </strong>Data from 60/62 (t1) and 36/62 (t2) questionnaires were analysed. There was a reduction in symptoms during hospitalization. Parents rated the effectiveness of the therapy as good (1.8 ± 0.6; 1 = very good; 6 = very bad) and were very satisfied (1.5 ± 0.5). Parents of children older than one year were more satisfied than parents of younger children. Out of all treatments, parents felt that rehydration therapy, the anthroposophic concept of the hospital and anthroposophic medicines had the most positive impact on their children's recovery.</p><p><strong>Conclusion: </strong>Parents were highly satisfied and felt that the anthroposophic therapy concept had beneficial effects on the course of disease.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of a Customized Yoga Therapy Module for Individuals with Early Parkinsonism: A Non-Randomized Controlled Clinical Trial Protocol.","authors":"A Lourdu Mary, Prabha Adhikari, Udayakumara K","doi":"10.1159/000551994","DOIUrl":"10.1159/000551994","url":null,"abstract":"<p><strong>Introduction: </strong>Neurological disorders are increasingly prevalent among older adults in India, often resulting in significant motor and non-motor impairments. There is a rising rates of elder care homes and the aging population, burdens the Parkinson's disease (PD) rising, particularly in countries with low- and middle-income. In response to this burden of neurodegenerative conditions including PD evidence-based, culturally adapted interventions such as yoga promise to offer holistic benefits.</p><p><strong>Methods: </strong>A controlled clinical trial will evaluate the efficacy of a customized yoga therapy module for early parkinsonism by targeting motor and non-motor symptoms. We aimed to recruit 130 participants in a 1:1 ratio, of 45-80 years from elder care homes around Mangalore, India, using cluster sampling. Both groups will receive geriatric physiotherapy as standard of care, and the intervention group will receive 1-h yoga sessions, 5 days/week, for 24 weeks. Outcomes of quality of life, cognition, postural stability, gastrointestinal dysfunction symptoms, and sleep will be assessed at baseline, 12 weeks, and 24 weeks and analyzed using SPSS v25. This study was approved by the Institutional Ethics Committee (YEC2 Protocol No.: YEC2/2024/130) and registered in the Clinical Trials Registry of India - CTRI/2025/07/090595.</p><p><strong>Conclusion: </strong>The Department of Geriatric Medicine will initiate PD screening at the designated study sites. A symptom-targeted, participant-specific, customized yoga module was developed, validated, and evaluated by experts.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"236-245"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhaojing Yao, Yuxuan Ren, Lishi Liu, Sinuo Li, Jun Yan
{"title":"Efficacy and Safety of Acupuncture-Related Interventions for Fatigue Quality of Life and Cancer-Related Indicators in Cancer Patients: A Systematic Review and Network Meta-Analysis.","authors":"Zhaojing Yao, Yuxuan Ren, Lishi Liu, Sinuo Li, Jun Yan","doi":"10.1159/000549482","DOIUrl":"10.1159/000549482","url":null,"abstract":"<p><strong>Objective: </strong>Although studies have explored the analysis of acupuncture therapy in the treatment of cancer-related fatigue, there are still deficiencies in terms of the degree of fatigue, quality of life, and cancer-related indicators. The best option remains elusive regarding the degree of improvement in these aspects. This systematic review and network meta-analysis (NMA) compared the efficacy of various acupuncture therapies on the degree of fatigue, quality of life, and cancer-related indicators (natural killer [NK] cells, CD3+ cells, CD4+ cells) among cancer survivors.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across eight databases from their establishment to September. The methodological quality of the included randomized controlled trials was assessed using the Cochrane Collaboration's Risk of Bias Tool. Pairwise meta-analysis was performed in Review Manager (version 5.3), while traditional meta-analysis for continuous outcomes was conducted using Stata 18.0 software with a random-effects model, reporting effect sizes as both standardized mean differences and weighted mean differences. NMA was employed to synthesize the data, with network diagrams illustrating comparisons between interventions for different outcome measures. We evaluated the consistency of results, performed sensitivity analyses, and examined publication bias to assess its influence on individual studies. Additionally, subgroup and network meta-regression analyses were conducted to explore potential sources of heterogeneity.</p><p><strong>Results: </strong>This study included 30 studies involving 2,287 patients and 6 acupuncture-related interventions. Our results suggest that acupuncture methods have great advantages in improving fatigue, quality of life, and cancer-related indicators in cancer survivors. In particular, moxibustion may be the best acupuncture modality for improving CRF, quality of life, CD3+ cells, and CD4+ cells. In contrast, warm acupuncture contributes more to increasing NK cells. Sensitivity analysis validated the robustness of the research findings. Although there was publication bias, it did not affect the overall results of the NMA.</p><p><strong>Conclusion: </strong>Our findings suggest that moxibustion has great potential in treating CRF. It may improve quality of life, CD3+ cells, and CD4+ cells. For NK cells, warm acupuncture may be the optimal regimen to personalize the treatment when clinical problems are encountered.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"149-173"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zi Ke, Jixian Ke, Wei Liu, Yong Zhao, Xuanxuan Wang
{"title":"Warm Acupuncture for Refractory Thrombocytopenia Induced by Cancer Treatment: Two Case Reports.","authors":"Zi Ke, Jixian Ke, Wei Liu, Yong Zhao, Xuanxuan Wang","doi":"10.1159/000551389","DOIUrl":"10.1159/000551389","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer treatment-induced thrombocytopenia (CTIT) is a common adverse complication during antineoplastic treatment. Although standardized western medical treatment is available, CTIT cannot be totally improved in some patients due to the severe degree of myelosuppression or low sensitivity to thrombopoietic agents.</p><p><strong>Case presentation: </strong>We report two cases of CTIT that demonstrated insufficient response to conventional platelet-raising treatment, but achieved better curative effect after the addition of warm acupuncture therapy. Case 1: A 50-year-old man was diagnosed with right-sided renal carcinoma accompanied by multiple metastases of both the lungs and multiple bone metastases. After radiotherapy and immunotherapy, the patient developed thrombocytopenia. On February 28, the blood routine examination indicated that the platelet count was 24 × 109/L, which dropped to 20 × 109/L 3 days later. Conventional platelet-raising therapy has shown suboptimal efficacy, and the patient was unable to have a platelet transfusion due to irregular antibodies on his blood-crossing test, so warm acupuncture therapy was initiated as a complementary treatment on March 21. After 2 weeks of warm acupuncture treatment, the patient's platelet count steadily increased (68 × 109/L, April 3) and eventually returned to normal (122 × 109/L, April 18). Case 2: A 61-year-old woman was diagnosed with primary ovarian adenocarcinoma and developed thrombocytopenia after receiving chemotherapy and radiotherapy, which was suspended due to a persistent decrease in platelet count. After more than 14 days of platelet-raising medication, the patient's platelet count continued to drop (39 × 109/L, April 17). After combined one course of warm acupuncture treatment, her platelet count rebounded (48 × 109/L, April 21), so radiotherapy was continued, and the patient's platelet count returned to normal after two courses of combined warm acupuncture treatment (187 × 109/L, April 26).</p><p><strong>Conclusion: </strong>Warm acupuncture may be a potentially complementary treatment for refractory CTIT.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"246-255"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tido von Schoen-Angerer, Manfred Wischnewsky, Michael Jeitler, Benno Brinkhaus, Miriam Ortiz, Christian S Kessler
{"title":"Which Terms for Traditional, Complementary, and Integrative Medicine Would Be the Most Useful in Germany? Results from a Large Online Cross-Sectional Study.","authors":"Tido von Schoen-Angerer, Manfred Wischnewsky, Michael Jeitler, Benno Brinkhaus, Miriam Ortiz, Christian S Kessler","doi":"10.1159/000551812","DOIUrl":"10.1159/000551812","url":null,"abstract":"<p><strong>Introduction: </strong>The World Health Organization recently issued new definitions of traditional medicine, complementary medicine, and integrative medicine (TCIM), raising questions about their implementation in different languages. This paper explores the knowledge and perceptions of TCIM terms in the German public with the aim of identifying term(s) that could be the most useful in public and political dialogue on TCIM in Germany.</p><p><strong>Method: </strong>This study is based on a cross-sectional survey of an online-representative sample of the German-speaking residential population aged 18-75 years (n = 4,065), using a comprehensive questionnaire on TCIM use, attitudes, and terms. Descriptive analyses were performed, and decision trees were calculated, using exhaustive chi-squared automatic interaction detection (CHAID) to identify predictors of self-perceived TCIM benefit.</p><p><strong>Results: </strong>The German term \"Naturheilkunde\" (literal translation from German: \"knowledge of natural healing\") was the most familiar term (55.3%), followed by alternative medicine (43.8%), complementary medicine (19.2%), and integrative medicine (15.6%). Conventional medicine generated the most positive attitude (63.1%), followed by \"Naturheilkunde\" (52.0%), integrative medicine (41.1%), complementary medicine (35.0%), and alternative medicine (25.1%). The CHAID algorithm identified a positive attitude to \"Naturheilkunde\" as the most significant predictor (p < 0.001) for experiencing benefit from TCIM. Attitudes toward complementary medicine or alternative medicine were no relevant predictors in this analysis.</p><p><strong>Conclusions: </strong>The historically rooted German term \"Naturheilkunde\" was the best-known and positively connoted TCIM term in our study. Furthermore, a positive attitude toward \"Naturheilkunde\" was strongly associated with experiencing benefit from TCIM. While \"integrative medicine\" is yet unfamiliar within the German public, the positive connotations it evokes and its perceived benefits suggest it also has potential for public discourse. We recommend a national Delphi process with TCIM experts and stakeholders in Germany to clearly define, prioritize, and align commonly used TCIM terms in Germany. The selection of terminology for public discourse should consider the insights from this study as well as appropriate communication expertise.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"293-302"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and Safety of Retention Enema with Traditional Chinese Medicine for Chronic Radiation-Induced Rectal Injury: Study Protocol for a Multicenter Randomized Controlled Trial.","authors":"Shulan Hao, Xiaoli Li, Hanying Zhang, Likun Liu, Qiming Zhong, Yanni Lou, Zhiqiang Cheng, Liqun Jia, Xixing Wang","doi":"10.1159/000550367","DOIUrl":"10.1159/000550367","url":null,"abstract":"<p><p><p>Background: Chronic radiation-induced rectal injury (RRI) is a complication of pelvic radiotherapy, with existing treatments often providing suboptimal symptom relief. Traditional Chinese medicine (TCM) retention enema therapy, leveraging localized anti-inflammatory and mucosal regenerative properties, offers a promising alternative. This trial aims to evaluate the efficacy and safety of changrui enema powder (CEP), aiming to establish an evidence-based protocol for managing chronic RRI. Patients and Methods: This multicenter, randomized, triple-blinded controlled trial will enroll 180 participants (2:1 allocation) with grade 2 chronic RRI following pelvic radiotherapy. The experimental group will receive daily CEP enemas for 4 weeks plus a concurrent 1-week course of dexamethasone sodium phosphate (DEX) injection enemas, while the control group will receive an identical-appearing placebo enema for 4 weeks plus a concurrent 1-week course of DEX injection enema. Both interventions will be administered in a total enema volume of 100 mL. The primary outcome is the overall effective rate at 4 weeks, assessed using the LENT-SOMA scoring system. Secondary outcomes encompass TCM syndrome efficacy, the Vienna Rectoscopy Score, pain assessment, and quality of life. Conclusion: This trial is the first study to evaluate the efficacy and safety of a standardized TCM retention enema formulation (CEP) as an add-on to a short-course standard corticosteroid regimen for chronic RRI. The findings are expected to provide an objective clinical basis for integrating TCM into the management of chronic RRI and may inform the development of relevant clinical guidelines. </p>.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"139-148"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13021226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three New Philosophical Categories for Holistically Assessing Complementary Medicine, Derived from the History and Theory of Medicine.","authors":"Josef M Schmidt","doi":"10.1159/000551108","DOIUrl":"10.1159/000551108","url":null,"abstract":"<p><p><p>Background: Based on recent medical-historical research, the attempt is made to introduce three new philosophical categories for holistically assessing complementary medicine and delineate their characteristics, genealogy, and socio-economic background. Apart from modern, predominantly rational science and culture, the history and theory of medicine are able to reveal dimensions and traditions of thinking that in the modern age have obviously been neglected or forgotten. Summary: As an example, homoeopathy appears to be constituted by what may be called lógos-thinking, hómoion-thinking and iásthai-thinking, thus connecting with three powerful traditions of thinking that can be traced back to Ancient Greece and pre-Socratic times. By contrast, modern technological medicine seems to be mainly fixed on lógos-thinking. Other realms of modern civilisation, such as science, art, education, politics, philosophy, and religion, to a large extent also suffer from a lack of, or are oblivious to, hómoion-thinking and iásthai-thinking. Key Messages: The introduction of these new categories may serve as a key to a raised awareness towards the shortcomings and one-dimensionality of the present lógos-driven world-view and for the opening up of a qualitatively richer multi-dimensional world and life. </p>.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"107-114"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}