Complementary Medicine Research最新文献

{"title":"Systematic Review and Meta-Analysis of Herbal and Traditional Medicine-Derived Interventions for Sarcopenia and Exploration of Core Herbs.","authors":"Wen-Shin Chiang, Wan-Yi Lin, Zi-Yu Chang, Yuan-Chieh Yeh, Jian-An Liao","doi":"10.1159/000552418","DOIUrl":"https://doi.org/10.1159/000552418","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia is a medical condition predominantly associated with aging process. Currently, the most effective approach for sarcopenia involves a combination of physical activity and nutritional supplementation. However, older individuals may face challenges in engaging in physical activity due to inconvenience or limited access to consistent nutritional resources. Previous studies suggest that Traditional Chinese Medicine (TCM) can enhance muscle strength in sarcopenia patients; however, its effectiveness remains unclear. This study aims to evaluate the efficacy of TCM in treating sarcopenia through a systematic review and meta-analysis and to identify key herbal medicines through pharmacological analysis.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a comprehensive database search was conducted, yielding 11 randomized controlled trials (RCTs) with 781 participants. Studies were selected based on stringent criteria and assessed for methodological quality using the Risk of Bias 2.0 tool. A TCM network and data mining analysis to identify the core TCM from the enrolled trials and to investigate the potential pharmacological pathways through which they may exert their effects.</p><p><strong>Results: </strong>The analysis suggested that traditional Chinese medicine (TCM), particularly Bu-Zhong-Yi-Qi (BZYQ) decoction, may improve handgrip strength and appendicular skeletal muscle mass (ASM) index in patients with sarcopenia, with few reported adverse effects. Network pharmacology analysis indicated that key components, such as Astragalus membranaceus, may act through multiple signaling pathways. Core genes identified, including AKT1, TNF, IL6, and FOS, showed high centrality in the interaction network, suggesting their potential relevance as therapeutic targets.</p><p><strong>Conclusions: </strong>TCM may have potential benefits in improving muscle strength and muscle mass in patients with sarcopenia. However, the certainty of the evidence is very low, and the findings should be interpreted with considerable caution.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-24"},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000550925","DOIUrl":"https://doi.org/10.1159/000550925","url":null,"abstract":"<p><p>In the article \"Effect of Amla Extract on Body Mass Index, Waist Circumference, Total Body Fat, Visceral Fat, Skeletal Muscle Mass, Body Age, and Related Parameters: A Randomized, Open-Label Clinical Study in Obese Participants\" [Complement Med Res. 2025;32:326-340; https://doi.org/10.1159/000545247] by Rathore et al., the name of one of the co-authors is incorrectly given.The correct name of the second author is Ankita Yadav.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1"},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Patients with Anxiety Symptoms Benefit Most from Treatment with Bryophyllum pinnatum? A Secondary Analysis of a Prospective, Single-Arm Study.","authors":"Tiffany Huber, Daniel Krüerke, Matthias Kröz, Markus Schlemmer, Ana Paula Simões-Wüst","doi":"10.1159/000552252","DOIUrl":"https://doi.org/10.1159/000552252","url":null,"abstract":"<p><p>Introduction Bryophyllum spp. preparations are frequently used in integrative settings. A recent study observed a reduction in anxiety symptoms among a heterogeneous group of psychiatric/psychosomatic patients after two weeks of treatment with Bryophyllum 50% chewable tablets. This secondary analysis aims to identify variables associated with stronger reduction in anxiety symptoms. Methods Fifty-four patients with anxiety symptoms were recruited from the waiting list for inpatient care at the \"Klinik Arlesheim\", Department of Psychiatry and Psychosomatics and treated with Bryophyllum 50% chewable tablets (3x2 per day; Weleda AG, Arlesheim, Switzerland). The primary outcome was a change in anxiety symptoms, measured by the Beck Anxiety Inventory (BAI) after two weeks of treatment relatively to baseline (ΔBAI). Comparisons were made across subgroups using one-way ANOVA. Multivariate analyses were conducted to assess the relative importance of various independent variables, including the Depression Scale (PHQ-9). Results BAI score decreased by an average of 5 points (from 27.4 ± 12.0 to 22.4 ± 12.1; p < 0.001, n = 54). ΔBAI decreased progressively across age quartiles, and increased with baseline BAI scores (BAIbl). Patients on benzodiazepines showed less improvement compared to those who were not. MVA indicated that ΔBAI was significantly associated with age (inversely) and with BAIbl (proportionally), after adjusting for other relevant variables. When BAIbl was excluded from the MVA model, a non-significant association was observed between ΔBAI and PHQ-9. Conclusion Due to the uncontrolled single-arm design, our findings are exploratory and do not permit causal inferences. Nevertheless, this explorative analysis suggests that younger age and more severe anxiety symptoms were associated with greater reductions in anxiety symptoms burden during treatment with Bryophyllum 50% chewable tablets.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-17"},"PeriodicalIF":0.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which terms for traditional, complementary and integrative medicine would be the most useful in Germany? Results from a large online cross-sectional study.","authors":"Tido von Schoen-Angerer, Manfred Wischnewsky, Michael Jeitler, Benno Brinkhaus, Miriam Ortiz, Christian S Kessler","doi":"10.1159/000551812","DOIUrl":"https://doi.org/10.1159/000551812","url":null,"abstract":"<p><strong>Introduction: </strong>The World Health Organization recently issued new definitions of traditional medicine, complementary medicine and integrative medicine (TCIM), raising questions about their implementation in different languages. This paper explores the knowledge and perceptions of TCIM terms in the German public with the aim of identifying term(s) that could be the most useful in public and political dialogue on TCIM in Germany.</p><p><strong>Method: </strong>This study is based on a cross-sectional survey of an online-representative sample of the German-speaking residential population aged 18-75 years (n=4,065), using a comprehensive questionnaire on TCIM use, attitudes and terms. Descriptive analyses were performed and decision trees calculated, using Exhaustive Chi-squared Automatic Interaction Detection (CHAID) to identify predictors of self-perceived TCIM benefit.</p><p><strong>Results: </strong>The German term \"Naturheilkunde\" (literal translation from German: \"knowledge of natural healing\") was the most familiar term (55.3%), followed by alternative medicine (43.8%), complementary medicine (19.2%) and integrative medicine (15.6%). Conventional medicine generated the most positive attitude (63.1%), followed by NHK (52.0%), integrative medicine (41.1%), complementary medicine (35.0%) and alternative medicine (25.1%). The CHAID algorithm identified a positive attitude to \"Naturheilkunde\" as the most significant predictor (p<0.001) for experiencing benefit from TCIM. Attitudes towards complementary medicine or alternative medicine were no relevant predictors in this analysis.</p><p><strong>Conclusions: </strong>The historically rooted German term \"Naturheilkunde\" was the best known and positively connoted TCIM term in our study. Furthermore, a positive attitude towards Naturheilkunde was strongly associated with experiencing benefit from TCIM. While \"integrative medicine\" is yet unfamiliar within the German public, the positive connotations it evokes and its perceived benefits suggest it also has potential for public discourse. We recommend a national Delphi process with TCIM-experts and -stakeholders in Germany to clearly define, prioritize and align commonly used TCIM terms in Germany. The selection of terminology for public discourse should consider the insights from this study as well as appropriate communication expertise.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-15"},"PeriodicalIF":0.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Traditional Korean Medicine Use on Medical Costs in Patients with Cancer in Korea.","authors":"Ji-Eun Yu, Hui-Yong Kwak, Eunji Ahn, Dongsu Kim","doi":"10.1159/000551613","DOIUrl":"https://doi.org/10.1159/000551613","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer remains a leading cause of death worldwide, and many patients use traditional medicine (TM) or complementary and alternative medicine (CAM) to manage symptoms; however, their economic impact remains unclear. In Korea, traditional Korean medicine (TKM) is practiced alongside Western medicine (WM); however, some CAM practices lie outside licensed TKM. This study investigated TKM use and its costs among cancer patients, examining its relationship with WM and CAM costs.</p><p><strong>Methods: </strong>This study classified cancer patients from the 2016 Korean Health Panel Survey (KHPS) into treatment and comparison groups based on TKM use in 2017. Propensity score matching (PSM) was applied to ensure comparability, while WM and CAM costs in 2018 were analyzed using generalized linear models and marginal effects.</p><p><strong>Results: </strong>After 1:2 PSM, 374 cancer patients were included (125 TKM users; 249 nonusers). TKM use was not significantly associated with WM costs; however, it was linked to reduced CAM costs. TKM costs showed no significant association with WM or CAM costs. Subgroup analysis revealed that TKM use was associated with a greater decrease in CAM costs among survivors diagnosed more than five years prior.</p><p><strong>Conclusion: </strong>TKM use among cancer patients was associated with reduced CAM costs but not with WM costs. The CAM cost-saving effect was more substantial in long-term survivors, suggesting a shift toward institutionalized TKM use; however, increased TKM spending did not further reduce CAM costs. These findings imply a need for policies that promote evidence-based, appropriate TKM use to improve healthcare cost efficiency.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-24"},"PeriodicalIF":0.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warm acupuncture for Refractory Thrombocytopenia Induced by Cancer Treatment:Two Case Reports.","authors":"Zi Ke, Jixian Ke, Wei Liu, Yong Zhao, Xuanxuan Wang","doi":"10.1159/000551389","DOIUrl":"https://doi.org/10.1159/000551389","url":null,"abstract":"<p><p>Introduction：Cancer treatment-induced thrombocytopenia (CTIT) is a common adverse complication during antineoplastic treatment. Although standardized Western medical treatment is available, CTIT cannot be totally improved in some patients due to the severe degree of myelosuppression or low sensitivity to thrombopoietic agents. Case Presentation：We report two cases of cancer treatment-induced thrombocytopenia (CTIT) that demonstrated insufficient response to conventional platelet-raising treatment, but achieved better curative effect after the addition of warm acupuncture therapy. Case 1: A 50-year-old man was diagnosed with right-sided renal carcinoma accompanied by multiple metastases of both lungs and multiple bone metastases. After radiotherapy and immunotherapy, the patient developed thrombocytopenia. On February 28, the blood routine examination indicated that the platelet count was 24×109/L, which dropped to 20×109/L three days later. Conventional platelet-raising therapy has shown suboptimal efficacy, and the patient was unable to have a platelet transfusion due to irregular antibodies on his blood-crossing test, so warm acupuncture therapy was initiated as a complementary treatment on March 21. After two weeks of acupuncture treatment, the patient's platelet count steadily increased (68×109/L, April 3) and eventually returned to normal (122×109/L, April 18). Case 2: A 61-year-old woman was diagnosed with primary ovarian adenocarcinoma and developed thrombocytopenia after receiving chemotherapy and radiotherapy, which was suspended due to a persistent decrease in platelet count. After more than 14 days of platelet-raising medication, the patient's platelet count continued to drop (39×109/L, April 17). After combined one course of warm acupuncture treatment, her platelet count rebounded (48×109/L, April 21), so radiotherapy was continued, and the patient's platelet count returned to normal after two courses of combined warm acupuncture treatment (187×109/L, April 26). Conclusion：Warm acupuncture may be a potentially complementary treatment for refractory CTIT.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-17"},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homoeopathic Management of a Lower Leg Ulcer with Cellulitis: An Evidence-Based Case Report.","authors":"Archana Archana, Himani Garg, Roja Varanasi","doi":"10.1159/000551408","DOIUrl":"https://doi.org/10.1159/000551408","url":null,"abstract":"<p><strong>Background: </strong>Cellulitis is an acute bacterial infection involving the dermis and subcutaneous tissue, characterized by erythema, warmth, swelling, and pain. It commonly follows disruption of skin integrity and may progress to ulceration. Leg ulcers are chronic or acute breaches in skin continuity of the lower limb, frequently associated with infection, inflammation, delayed healing, and significant morbidity. When cellulitis complicates a leg ulcer, the risk of tissue damage and prolonged recovery increases. Although antibiotics constitute standard management, integrative approaches are increasingly explored to support wound healing and reduce complications.</p><p><strong>Case presentation: </strong>A female patient presented with a painful ulcer on the left lower leg that had evolved from a pimple-like lesion. Clinical examination revealed diffuse erythema, oedema, warmth, tenderness, and ulceration consistent with cellulitis. No systemic complications were noted at presentation. An individualized homoeopathic treatment strategy was adopted based on clinical assessment. Pyrogenium, Calendula officinalis, and Myristica sebifera were prescribed sequentially according to symptom evolution. Supportive management included antiseptic wound cleansing, maintenance of dryness, and topical application of Calendula officinalis ointment. Serial photographic documentation was performed to monitor progression.</p><p><strong>Results: </strong>Progressive reduction in pain, inflammation, and ulcer dimensions was observed during follow-up, with satisfactory wound healing and no reported adverse events. Causality assessment using the Modified Naranjo Criteria for Homoeopathy (MONARCH) yielded a positive attribution score, suggesting a possible relationship between the intervention and clinical improvement.</p><p><strong>Conclusion: </strong>This case highlights favourable clinical evolution of lower leg ulcer with cellulitis managed with individualized homoeopathy alongside wound care, warranting further controlled investigation.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-15"},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Exercise Therapy on Non-Obese Women with Polycystic Ovary Syndrome: a protocol for randomized controlled trial.","authors":"Xiaodie Yang, Hong Yang, Jianting Lao, Qiang Zhang, Zhehao Li, Liping Bai, Chan Zhu","doi":"10.1159/000551231","DOIUrl":"https://doi.org/10.1159/000551231","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting up to 13% of women of reproductive age, with associated reproductive, metabolic, and psychological complications. While lifestyle interventions, particularly exercise therapy, are crucial in managing PCOS in obese individuals, their impact on non-obese patients remains inadequately explored. This study aims to assess the effects of exercise therapy on menstrual regularity, hormonal profiles, and metabolic parameters in non-obese women with PCOS.</p><p><strong>Methods: </strong>This protocol outlines a single-blind, randomized controlled trial (RCT). Forty-eight non-obese women with PCOS (BMI ≤ 25) meeting the inclusion criteria were enrolled and randomized into three groups: aerobic exercise with usual care (AE+UC), resistance exercise with usual care (RE+UC), and usual care alone (UC). The interventions spanned 12 weeks, with assessments at baseline, 4, 8, and 12 weeks. Primary outcomes include menstrual regularity and anthropometric indices, while secondary outcomes encompass hormonal levels, insulin resistance, and ovarian morphology. Data analysis was performed using SPSS version 27.0, with statistical significance set at p < 0.05.</p><p><strong>Discussion: </strong>The study aims to provide robust evidence supporting the efficacy of exercise therapy in non-obese women with PCOS and to determine the most effective exercise modality for this population. The findings emphasize the importance of individualized exercise interventions and provide a foundation for larger-scale RCTs to further substantiate these results.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry (https://www.chictr.org.cn/), identifier ChiCTR2500097708. Registration date: 2025-02-24.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-15"},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Preliminary Psychometric Evaluation of Agni Assessment Scale: A Measure of Functional Digestive Capacity Based on Ayurveda.","authors":"Ashwathykutty V, Kamlesh Singh, Shabdapriti G, Bhogavalli Chandrasekhara Rao, Narayanam Srikanth, Rabinarayan Acharya","doi":"10.1159/000551010","DOIUrl":"10.1159/000551010","url":null,"abstract":"<p><strong>Background: </strong>As traditional systems of medicine gain global popularity and acceptance, it has become essential to validate their unique concepts using evidence-based research methodologies. This study aims to develop a self-assessment tool called the Agni Assessment Scale (AAS) to identify the state of Agni, a key concept in Ayurveda that represents digestive and metabolic functions. It also seeks to evaluate the psychometric properties of the scale.</p><p><strong>Methods: </strong>The development of the scale was divided into two phases involving 467 participants from India. In the first phase, an initial pool of items was created through a literature review, consultations with clinicians, and a field study (n = 100). The second phase screened the items for their content validity, conducted an exploratory factor analysis (n = 367), and tested for reliability.</p><p><strong>Results: </strong>Preliminary evidence supported the factorial structure of the 26-item Agni Assessment Scale. Exploratory factor analysis (EFA) provided support for four subscales: Samagni subscale, Vishamagni subscale, Mandagni subscale, and Tikshnagni subscale. The final version demonstrated acceptable internal consistency (subscale α ranging from 0.57 to 0.83), with all subscales except Samagni meeting conventional reliability thresholds.</p><p><strong>Conclusion: </strong>The EFA demonstrated promising psychometric properties and conceptual coherence with Ayurvedic theory, though further validation in clinical and cross-cultural contexts is essential.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-12"},"PeriodicalIF":0.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Acupuncture-Related Interventions for Fatigue Quality of Life and Cancer-Related Indicators in Cancer Patients: A Systematic Review and Network Meta-Analysis.","authors":"Zhaojing Yao, Yuxuan Ren, Lishi Liu, Sinuo Li, Jun Yan","doi":"10.1159/000549482","DOIUrl":"10.1159/000549482","url":null,"abstract":"<p><strong>Objective: </strong>Although studies have explored the analysis of acupuncture therapy in the treatment of cancer-related fatigue, there are still deficiencies in terms of the degree of fatigue, quality of life, and cancer-related indicators. The best option remains elusive regarding the degree of improvement in these aspects. This systematic review and network meta-analysis (NMA) compared the efficacy of various acupuncture therapies on the degree of fatigue, quality of life, and cancer-related indicators (natural killer [NK] cells, CD3+ cells, CD4+ cells) among cancer survivors.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across eight databases from their establishment to September. The methodological quality of the included randomized controlled trials was assessed using the Cochrane Collaboration's Risk of Bias Tool. Pairwise meta-analysis was performed in Review Manager (version 5.3), while traditional meta-analysis for continuous outcomes was conducted using Stata 18.0 software with a random-effects model, reporting effect sizes as both standardized mean differences and weighted mean differences. NMA was employed to synthesize the data, with network diagrams illustrating comparisons between interventions for different outcome measures. We evaluated the consistency of results, performed sensitivity analyses, and examined publication bias to assess its influence on individual studies. Additionally, subgroup and network meta-regression analyses were conducted to explore potential sources of heterogeneity.</p><p><strong>Results: </strong>This study included 30 studies involving 2,287 patients and 6 acupuncture-related interventions. Our results suggest that acupuncture methods have great advantages in improving fatigue, quality of life, and cancer-related indicators in cancer survivors. In particular, moxibustion may be the best acupuncture modality for improving CRF, quality of life, CD3+ cells, and CD4+ cells. In contrast, warm acupuncture contributes more to increasing NK cells. Sensitivity analysis validated the robustness of the research findings. Although there was publication bias, it did not affect the overall results of the NMA.</p><p><strong>Conclusion: </strong>Our findings suggest that moxibustion has great potential in treating CRF. It may improve quality of life, CD3+ cells, and CD4+ cells. For NK cells, warm acupuncture may be the optimal regimen to personalize the treatment when clinical problems are encountered.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"149-173"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}