Complementary Medicine Research最新文献

{"title":"Evaluating the efficacy of probiotics in the treatment of oral Candida infection: A meta-analysis.","authors":"Rong Tang, Fang Zhang, Xiaoyan Wang, Haiyue Long, Xiaoyi Hu","doi":"10.1159/000547106","DOIUrl":"https://doi.org/10.1159/000547106","url":null,"abstract":"<p><strong>Objective: </strong>This paper aims to assess the impact of probiotics on oral Candida infection using an evidence-based medicine approach.</p><p><strong>Methods: </strong>Randomized controlled trials evaluating the efficacy of probiotics in the treatment of oral Candida infection were retrieved from databases including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, VIP Database, Wanfang Database, and China Biomedical Literature Database, up until December 2022. Two researchers independently conducted data extraction and quality assessment. Meta-analysis of the extracted data was performed using the statistical software RevMan 5.4. The study included a total of 12 trials, comprising 4 in English and 8 in Chinese, with 1029 subjects (537 in the experimental group and 492 in the control group).</p><p><strong>Results: </strong>Results indicated that probiotics effectively treated oral Candida infection [OR = 7.80, 95% CI (4.78, 12.75), P < 0.001], reduced the detection rate of oral Candida [OR = 0.06, 95% CI (0.01, 0.57), P = 0.01], and lowered the recurrence rate after cure [OR = 0.21, 95% CI (0.12, 0.35), P < 0.001]. These effects were observed in studies using probiotics both with and without antifungal agents, though a more consistent benefit was reported in studies using combination therapy.</p><p><strong>Conclusions: </strong>Probiotics demonstrated a significant impact on the treatment of oral Candida infection by reducing oral Candida colonization and minimizing recurrence rates post-cure.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-18"},"PeriodicalIF":0.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an adjunctive therapy for acute cerebral infarction: A modified Delphi consensus study.","authors":"Fang Xie, Yi He, Lu-Qiang Sun, Hui Zheng, Jia-Xin Xie, Xiao-Shuang Feng, Yu-Fei Wang, Yuan-Hui Gan, Xin-Ru Pan, Yao-Dan Zhang, Peng-Fei Wang, Ying Li, Xiao-Yi Xiong","doi":"10.1159/000547286","DOIUrl":"https://doi.org/10.1159/000547286","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is an effective adjunctive therapy for stroke and has been suggested for the treatment for acute cerebral infarction (ACI). However, there is a lack of high-quality data from randomized clinical trials. Thus, this study aims to reach a consensus to guide the clinical research and practice.</p><p><strong>Methods: </strong>The initial project list was based on a systematic review of research evidence and a clinical problem survey conducted by a multidisciplinary team. After discussion with experts and a two-round Delphi consensus survey, the final list was optimized. Then, Likert scale of 9 points was used to measure the degree of expert consensus (1 = strongly disagree, 9 = strongly agree) and 80% of scores between 7 and 9 were defined as \"agreement\".</p><p><strong>Results: </strong>A total of 30 professionals (response rate: 100%) confirmed their participation in the voting group. After two rounds of Delphi voting, a consensus was achieved including 34 items that can be broadly categorized into six aspects. According to expert consensus, acupuncture should be initiated within 6 hours and the main acupoints are Shuigou (GV26), Neiguan (PC6), Hegu (LI4), and Taichong (LR3), while the auxiliary acupoints include Quchi (LI11), Waiguan (SJ5), Huantiao (GB30), Weizhong (BL40), etc. Furthermore, the adverse events of acupuncture are generally considered to be few, only subcutaneous hematoma is commonly reported.</p><p><strong>Conclusion: </strong>This expert consensus provides recommendations for clinical research and practice in treating ACI with acupuncture. However, due to the limited clinical evidence, further exploration is needed through rigorous clinical trials.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GARLIC EXTRACT IN RHEUMATOLOGICAL DISEASES: A REVIEW.","authors":"Jozélio Freire de Carvalho, Aaron Lerner, Carina Benzvi","doi":"10.1159/000547181","DOIUrl":"https://doi.org/10.1159/000547181","url":null,"abstract":"<p><strong>Background: </strong>Garlic and garlic extract (GE) are highly consumed traditional and popular food spices. They are reported to have antioxidant, anti-inflammatory, and infection-protecting properties. The aim of this study was to review the use of GE in various rheumatic diseases.</p><p><strong>Summary: </strong>PubMed/MEDLINE, EMBASE, and Scielo were searched for articles on GE and rheumatic diseases between 1966 and May 2024. Four articles were found, including 176 patients. The investigated diseases were RA (n=3) and OA (n=1). Age varied from 51.06 ± 13.8 to 58.9 ± 7.5 years old, and female gender was the only one included in all studies. The disease duration was 6.58 ± 7.75 years. The GE dosage ranged from 600 mg to 1,000 mg/day. The follow-up ranged from 4 to 12 weeks. All articles demonstrated improvements in the diverse rheumatic disease parameters (e.g., pain, function, disease activity, tender and swollen joints, stiffness, and WOMAC) and reduced inflammatory biomarkers (C-reactive protein, tumor necrosis factor, malondialdehyde(. Key-messages: GE is a safe and well-tolerated therapy for RA and OA. However, studies with more participants are needed to confirm, replicate, and further explore the topic.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructive Evaluation of \"Critical Appraisal Tool for Homeopathic Intervention Studies: CATHIS\".","authors":"Himanshu Shekhar, Parth Aphale, Shashank Dokania","doi":"10.1159/000547168","DOIUrl":"10.1159/000547168","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of Pestle Needle Therapy in Managing Insomnia, Cervical Spondylosis and Other Systemic Diseases.","authors":"Jiaqi Wang, Yingchao Wang, Shudan Yu, Shujun Li, Ning Liu, Genghui Zhang","doi":"10.1159/000546785","DOIUrl":"https://doi.org/10.1159/000546785","url":null,"abstract":"<p><strong>Objective: </strong>To examine the efficacy and safety of pestle needle therapy (PNT) across several prevalent conditions, including insomnia, cervical spondylosis, lumbar disc herniation and other systemic diseases.</p><p><strong>Methods: </strong>We searched eight databases (SinoMed, China National Knowledge Infrastructure, Wanfang Data, VIP Database, Google Scholar, PubMed, Embase and Web of Science) from inception to 31 December 2023, using both subject terms and free-text terms related to 'pestle needle' and 'randomised controlled trial'. Eligible randomised controlled trials (RCTs) that investigated PNT alone or in combination with other therapies were included. Primary outcomes included the overall response rate (ORR) and incidence of adverse events.</p><p><strong>Results: </strong>A total of 29 RCTs involving 2,614 patients were included. Meta-analysis results showed that, compared with controls, PNT significantly improved ORR in insomnia (odds ratio [OR] = 4.07, 95% confidence interval [CI]: 2.33, 7.09), cervical spondylosis (OR = 4.38, 95% CI: 2.41, 7.97), lumbago and leg pain (OR = 3.32, 95% CI: 1.86, 5.91) and lumbar disc herniation (OR = 1.92, 95% CI: 1.12, 3.29). Regarding cervical spondylosis, the intervention of the observation group was significantly better than that of the control group (Z = 4.84, P < 0.001). In terms of low back pain and leg pain, the intervention of the observation group was significantly better than that of the control group (Z = 4.07, P < 0.001). The intervention of the observation group was significantly better than in the control group in improving the total effective rate of the treatment of lumbar disc herniation (Z = 2.37, P = 0.02).</p><p><strong>Conclusion: </strong>Pestle needle therapy is a safe and effective treatment modality that can complement or substitute conventional interventions. This systematic review and meta-analysis contributes to the evidence base for acupuncture-related therapies, highlighting the potential of PNT to address both musculoskeletal and neurological conditions, thus offering new clinical options and underscoring the need for large-scale, high-quality RCTs to refine treatment protocols.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Amla Extract on Body Mass Index, Waist Circumference, Total Body Fat, Visceral Fat, Skeletal Muscle Mass, Body Age, and Related Parameters: A Randomized, Open-Label Clinical Study in Obese Participants.","authors":"Raksha Rathore, Ankia Yadav, Avni Khatkar, Deepa Suhag, Giriraja Kanakapura Vrushabaiah, Suman Govindaraj","doi":"10.1159/000545247","DOIUrl":"10.1159/000545247","url":null,"abstract":"<p><strong>Background: </strong>The escalating prevalence and severity of obesity and its associated comorbidities globally necessitate effective interventions. This randomized open-label clinical study aims to assess the efficacy of amla (Emblica officinalis) extract AMX-160 in adult individuals with obesity.</p><p><strong>Trial design: </strong>This study is a randomized, open-label clinical study conducted at Rajalakshmi Hospital, Mangalore. The study adhered to the declaration of Helsinki and ICH-GCP guidelines, with protocol approval from institutional ethics committee and registration with the Clinical Trials Registry - India (CTRI/2019/01/017201). All participants provided written, signed, and dated informed consent before any study-related procedures.</p><p><strong>Methods: </strong>Forty obese patients were enrolled and divided into two groups. AMX-160 capsules, at doses of 500 mg once daily (AMX-M1) and twice daily (AMX-M2), were administered. Patients were monitored as outpatients for 90 days. Efficacy assessments included anthropometric measurements, bioelectric impedance analysis, lipid profile analysis, and the Global Physical Activity Questionnaire (GPAQ) at scheduled visits.</p><p><strong>Results: </strong>Supplementation with 1 g of AMX-160 (500 mg twice daily) significantly (p < 0.05) reduced visceral fat, increased skeletal muscle mass, and decreased subcutaneous fat. Additionally, it effectively decreased body age and various anthropometric parameters (e.g., waist circumference, waist-to-hip ratio) significantly (p < 0.05), along with reducing BMI, body weight, and improving lipid profile (p < 0.05). The 500 mg once daily dose also significantly (p < 0.05) impacted most parameters. Physical activity levels remained consistent in both groups throughout the study (p > 0.05).</p><p><strong>Conclusion: </strong>The amla extract AMX-160 (Tri-Low®) demonstrated efficacy in reducing subcutaneous and visceral fat, waist circumference, and body age, while increasing skeletal muscle mass. These findings suggest its potential as a supplement for managing obesity and its associated disorders.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Acupressure on Chemotherapy-Induced Anxiety and Depression: A Systematic Review and Meta-Analysis.","authors":"Chunping Zhang, Jian Chen, Yiwen Zhang, Chuanzhu Yan","doi":"10.1159/000542022","DOIUrl":"10.1159/000542022","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer patients are prone to experiencing negative emotions such as anxiety and depression after receiving chemotherapy. Research has shown that acupressure may be beneficial in relieving the anxiety and depression caused by chemotherapy, but high-quality evidence is lacking. This study was designed to systematically evaluate the efficacy of acupressure for relieving chemotherapy-induced anxiety and depression.</p><p><strong>Methods: </strong>This review was conducted in accordance with the PRISMA framework. Four English databases (PubMed, Embase, Web of Science, and the Cochrane Library) and four Chinese databases (CNKI, Wanfang, VIP, and CBM) were searched from inception to December 31, 2022, to identify randomized clinical trials examining the use of acupressure for the treatment of chemotherapy-induced anxiety and depression. Cochrane Review Manager 5.4 and RStudio were used for the meta-analysis.</p><p><strong>Results: </strong>This meta-analysis included 1,119 patients from 12 randomized controlled trials. We mainly compared acupressure with sham acupressure and routine nursing. The results showed that acupressure alleviated chemotherapy-induced anxiety (standardized mean difference [SMD] = -0.72, 95% confidence interval [CI] [-1.15, -0.28], p = 0.001) and depression (SMD = -0.75, 95% CI [-1.36, -0.14], p = 0.02) more effectively than sham acupressure and routine nursing.</p><p><strong>Conclusion: </strong>This meta-analysis found that acupressure (body point) can relieve chemotherapy-induced anxiety and depression and improve the quality of life of patients. However, the current relevant literature has low quality and is highly heterogeneous, which reduces the credibility of the research results. Therefore, more rigorously designed randomized controlled trials are needed to verify these conclusions.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"55-66"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Difference Has Been Made...","authors":"Frauke Musial","doi":"10.1159/000542512","DOIUrl":"10.1159/000542512","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study.","authors":"Miriam Ortiz, Katharina Schnabel, Sylvia Binting, Susanne Lezius, Karl Wegscheider, Michael Teut, Ralf Suhr, Benno Brinkhaus","doi":"10.1159/000544712","DOIUrl":"10.1159/000544712","url":null,"abstract":"<p><strong>Introduction: </strong>A healthy lifestyle is considered to be an important factor for healthy aging. Kneipp therapy (KT) includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities, and healthy nutrition. In this study, we investigated the effectiveness of KT care on activities of daily living, health, and quality of life in residents of nursing homes.</p><p><strong>Methods: </strong>We conducted a prospective, two-armed comparative observational study to compare matched nursing homes with KT (Kneipp group) versus nursing homes with common preventive interventions (control group) over a 12-month period. Outcome measures included activities of daily living (Barthel Index), cognition (Mini-Mental State Examination [MMSE]), and quality of life (QUALIDEM; Short-Form 12 [SF-12]).</p><p><strong>Results: </strong>We included 7 nursing homes (n = 105 residents) for the Kneipp group and 6 nursing homes (n = 69) as control. Except for Barthel Index, there were no time point-dependent differences between the groups. The Barthel Index showed a smaller difference from baseline in the control group (mean difference 0.94, 95% CI [-1.94; 3.82]) compared to the Kneipp group (-4.08, 95% CI [-6.46; -1.69]; p = 0.009) after 6 months; mean difference between groups Kneipp versus control: 5.01, 95% CI [1.25; 8.77]; p = 0.009. Pooled over the time points, the SF-12 mental health sum scale exhibited a smaller difference from baseline in the Kneipp group (-1.3, 95% CI [-3.6; 0.9]) compared to the control group (-3.8, 95% CI [-6.3; -1.4]; p = 0.027). Furthermore, the MMSE sum score decreased less in the Kneipp group compared to control (-1.1, 95% CI [-2.2, -0.1]; p = 0.033) after 12 months. A post hoc comparison of residents from both groups who received at least 30 preventive interventions monthly exhibited better values for QUALIDEM items \"social relations,\" \"social isolation,\" and \"feeling at home.\"</p><p><strong>Conclusion: </strong>This comparative observational study showed only small differences in outcome measures between the groups. The frequency of treatments may positively influence social components of behavior and well-being in residents. High-quality pragmatic randomized trials are needed for further investigations.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"122-137"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological Complications of Cupping Therapy: A Comprehensive Review.","authors":"Babak Daneshfard, Sajjad Sadeghi, Dennis Cordato","doi":"10.1159/000543511","DOIUrl":"10.1159/000543511","url":null,"abstract":"<p><strong>Background: </strong>Cupping therapy, a traditional treatment method, has been shown to be effective in various studies. However, there have been reports of significant neurological complications following cupping therapy. This comprehensive review aimed to investigate the important and potentially severe neurological complications documented in the literature.</p><p><strong>Summary: </strong>The review analyzed case reports and case studies published in three major databases (PubMed, Google Scholar, and Cochrane) up to June 2024. The search strategy involved a three-step process, where two traditional medicine experts independently searched for case reports and published case series, and then a 3-person committee consisting of two traditional medicine experts and a neurologist reviewed the selected articles. Out of 280 case reports and case series, 12 studies were included in the review, reporting 14 patients with neurological complications. The majority of cases (7/14) involved interventions combining cupping with other traditional medicine manual therapies. Complications reported included vascular and infectious complications, with subdural hemorrhage being the most common (4/14). Most patients (11/14) were free of underlying diseases, and all but 3 patients recovered from their complications with surgical and medical treatments.</p><p><strong>Key messages: </strong>The study concludes that although rare, neurological complications of cupping therapy can be severe and potentially life-threatening. Therefore, it is essential for traditional medicine practitioners to be aware of these risks and take necessary precautions to prevent them. Adopting proper techniques and adhering to health guidelines can help mitigate the likelihood of complications. The creation of an international system to record and report the side effects of cupping therapy is also recommended.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"151-159"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}