Complementary Medicine Research最新文献

{"title":"Efficacy of combined herbal and Western medicine based on Traditional Chinese Medicine for mild cognitive impairment and dementia in Parkinson's disease: A systematic review and meta-analysis.","authors":"Eunbyul Cho, Hui Yan Zhao, Purumea Jun, Jung-Hee Jang","doi":"10.1159/000545937","DOIUrl":"https://doi.org/10.1159/000545937","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review aimed to assess the clinical evidence supporting the combination of syndrome differentiation (SD)-based herbal medicine (HM) and Western medicine (WM) in treating Parkinson's disease (PD)-mild cognitive impairment (PD-MCI) and -dementia (PDD).</p><p><strong>Methods: </strong>Ten electronic bibliographic databases were searched from inception to March 4, 2024, for randomized controlled trials (RCTs) comparing SD-based HM plus conventional therapies with conventional therapies alone for PD-MCI and PDD. Two authors independently screened and selected studies and extracted data related to trial quality, characteristics, and results. The mean difference (MD) was used to analyze continuous variables, and meta-analysis was performed using Reviewer Manager 5.4 software. The risk of bias was assessed using the Cochrane Risk of Bias Tool.</p><p><strong>Results: </strong>For the 15 articles selected for review, 12 trials were included in the meta-analysis: 9 comprising 688 patients with PD-MCI and 3 comprising 264 patients with PDD and with a type of SD, such as \"blood stasis and stirring wind\" or \"deficiency of the liver-kidney.\" The meta-analysis showed significant differences favoring HM plus WM with respect to the Montreal Cognitive Assessment score for PD-MCI (MD=2.30, 95% confidence interval [CI; 1.40, 3.19]; p<0.00001, I2=76%) and PDD (MD=3.14, 95% CI [0.48, 5.81]; p=0.02, I2=82%) compared with WM alone. Improvement of cognitive impairment treated using \"deficiency of the liver-kidney\" SD-based HM plus WM in PD-MCI was more beneficial than that treated using WM alone.</p><p><strong>Conclusions: </strong>SD-based HM may serve as an adjunctive treatment for PD-MCI and PDD, improving cognitive function and alleviating PD symptoms. No severe adverse event was observed in the HM plus WM group, suggesting that HM may be safe for patients with cognitive impairment in PD. However, evidence regarding the efficacy of HM based on SD for PD-MCI and PDD is of poor quality, and all studies were conducted in China. Thus, and rigorous, multicenter, and international RCTs are required.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-24"},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000545691","DOIUrl":"https://doi.org/10.1159/000545691","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1"},"PeriodicalIF":1.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring yoga immersion and gratitude as pathways to enhanced well-being.","authors":"Carolin Nögel, Mario Wenzel, Thomas Kubiak","doi":"10.1159/000545916","DOIUrl":"https://doi.org/10.1159/000545916","url":null,"abstract":"<p><strong>Introduction: </strong>The popularity of yoga practice is steadily increasing. Previous studies have highlighted numerous beneficial effects of yoga. The present study aimed to investigate gratitude as a mediator of the relationship between yoga and well-being. Additionally, we examined the role of the involvement in yoga philosophy.</p><p><strong>Methods: </strong>344 yoga practitioners aged between 19 and 87 completed an online survey. Yoga practice was operationalized via the frequency of practice in days per week. The Yoga Immersion Scale was used to measure the respondents' involvement in yoga philosophy.</p><p><strong>Results: </strong>We found positive associations between yoga frequency and well-being and between gratitude and well-being. There was no evidence for the hypothesized mediating effect of gratitude. Furthermore, yoga immersion did neither moderate the direct relationship between yoga and well-being nor the indirect relationship via gratitude; however, significant correlations between yoga immersion and gratitude and between yoga immersion and well-being were found.</p><p><strong>Conclusion: </strong>The results underscore the relevance of yoga immersion for yoga practice but at the same time new questions arise, particularly concerning the role of gratitude. Future research is needed to further gain a better understanding of these relationships.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Amla extract on Body Mass Index, waist circumference, total body fat, visceral fat, skeletal muscle mass, body age and related parameters: A randomized, open label clinical study in obese participants.","authors":"Raksha Rathore, Ankia Yadav, Avni Khatkar, Deepa Suhag, Giriraja Kanakapura Vrushabaiah, Sumanraj Govindaraj","doi":"10.1159/000545247","DOIUrl":"https://doi.org/10.1159/000545247","url":null,"abstract":"<p><strong>Background: </strong>The escalating prevalence and severity of obesity and its associated co-morbidities globally necessitate effective interventions. This randomized open label clinical study aims to assess the efficacy of amla (Emblica officinalis) extract AMX-160 in adult individuals with obesity.</p><p><strong>Trial design: </strong>This study is a randomized, open-label clinical study conducted at Rajalakshmi hospital, Mangalore. The study adhered to the declaration of Helsinki and ICH-GCP guidelines, with protocol approval from institutional ethics committee and registration with the Clinical Trials Registry-India (CTRI/2019/01/017201). All participants provided written, signed, and dated informed consent before any study-related procedures.</p><p><strong>Methods: </strong>Forty obese patients were enrolled and divided into two groups. AMX-160 capsules, at doses of 500 mg once daily (AMX-M1) and twice daily (AMX-M2), were administered. Patients were monitored as outpatients for 90 days. Efficacy assessments included anthropometric measurements, Bioelectric Impedance analysis, lipid profile analysis, and the Global Physical Activity Questionnaire (GPAQ) at scheduled visits.</p><p><strong>Results: </strong>Supplementation with 1 gram of AMX-160 (500 mg twice daily) significantly (p<0.05) reduced visceral fat, increased skeletal muscle mass, and decreased subcutaneous fat. Additionally, it effectively decreased body age and various anthropometric parameters (e.g., waist circumference, waist-to-hip ratio) significantly (p<0.05), along with reducing BMI, body weight, and improving lipid profile (p<0.05). The 500 mg once daily dose also significantly (p<0.05) impacted most parameters. Physical activity levels remained consistent in both groups throughout the study (p>0.05).</p><p><strong>Conclusion: </strong>The amla extract AMX-160 (Tri-Low®) demonstrated efficacy in reducing subcutaneous and visceral fat, waist circumference, and body age, while increasing skeletal muscle mass. These findings suggest its potential as a supplement for managing obesity and its associated disorders.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000544803","DOIUrl":"https://doi.org/10.1159/000544803","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1"},"PeriodicalIF":1.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vom Spezifischen zum Systemischen - am Beispiel Tormentill / Blutwurz, der Heilpflanze des Jahres 2024].","authors":"Reinhard Saller, Herbert Schwabl, Matthias Rostock, Maja Dal Cero","doi":"10.1159/000545128","DOIUrl":"https://doi.org/10.1159/000545128","url":null,"abstract":"<p><p>Am Beispiel des in verschiedenen lokalen Traditionen genutzten Blutwurz, Tormentill (Potentilla erecta) wird exemplarisch eine offensichtliche Kluft zwischen üblichen indikationsgetriebenen Zulassungsverfahren und der empirischen Realität sowie dem Potential vieler Heilpflanzen aufgezeigt. Für Tormentillae rhizoma ist ein breites Spektrum an Inhaltsstoffen und das mit dem Vielstoffgemisch einhergehende Wirkprofil einer u.a. vielfältig antiinflammatorisch wirkenden, systemischen Droge experimentell belegt. Die traditionelle Empirie der dämpfenden Effekte im Entzündungsgeschehen wird dadurch plausibilisiert. Die moderne Forschung liefert also Daten für einen sinnvollen Einsatz einer gut verträglichen Heilpflanze mit vielfältigen Anwendungsmöglichkeiten für Haut und Schleimhaut (innerlich und äusserlich). Auf dem Markt gibt es aber, abgesehen von vereinzelten topischen Spezialitäten und Arzneitees, kaum Zubereitungen als zugelassene Arzneispezialität. Denn die derzeitige Praxis der Arzneimittelzulassung bevorzugt die spezifischen und organbezogenen Wirkungen und übersieht dabei das systemische Potential, die Modulationsfähigkeit dieser natürlichen Stoffgemische, wie sie durch traditionelle und empirische Belege angezeigt wird. Systemische Wirkungen zeigen ihre Stärke gerade im Zusammenspiel mit anderen Therapien insbesondere beim additiven Einsatz mit Spezifika, indem sie bestimmte Wirkungen verstärken bzw. abschwächen oder die Verträglichkeit der Spezifika erhöhen bzw. deren Nebenwirkungen abmildern. Die Kombination von spezifisch wirkenden Arzneimitteln mit solchen Systemmitteln (wie z.B. Blutwurz, Tormentill) stellt damit eine weitere Therapieoption dar, die als sinnvolle Ergänzung, wenn nicht sogar als Grundlage bei Prävention, Therapie und Lebensgestaltung zu werten ist.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga Asana Increases Prefrontal Cortex Activity and Reduces Resting-State Functional Connectivity.","authors":"Michelle Goodrick, Eleazar Samuel Kolosovas-Machuca, Edgar Guevara","doi":"10.1159/000545381","DOIUrl":"10.1159/000545381","url":null,"abstract":"<p><strong>Introduction: </strong>Various aspects of yoga have been researched for their psychological benefits, yet the neurological mechanisms underlying physical yoga postures (asana) remain inadequately explored due to limitations in prior neuroimaging techniques. The prefrontal cortex (PFC) has been established as an important region of interest concerning psychological health. Therefore, this study aimed to characterize changes in the PFC before, during, and after asana by applying the functional near-infrared spectroscopy (fNIRS) mobile neuroimaging technique.</p><p><strong>Methods: </strong>Twenty-seven healthy adults completed two 6-min, task-independent resting states before and after a 23-min asana routine. With the fNIRS device positioned on the frontal region of the skull, PFC activity was measured during each asana and resting state. The block design involved alternating between three active postures and one control posture. Each active posture was performed for 30 s and repeated 8 times, while the control posture was held during inter-trial intervals lasting 25-30 s. Across the session, this block design resulted in a total of 24 active blocks (8 repetitions of each active posture) and 25 baseline blocks (control posture intervals).</p><p><strong>Results: </strong>All three active asanas significantly increased PFC activity versus baseline, particularly in the right PFC. Furthermore, analysis of short-term changes in resting-state functional connectivity (rsFC) revealed a significant decrease, primarily in the left medial PFC, a key region of the default mode network (DMN), an area known to exhibit heightened activity in individuals suffering from depression and anxiety.</p><p><strong>Conclusion: </strong>This study provides neurological insight into the effects of yoga asana and supports fNIRS for assessing movement-based practices in real-world settings.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Manual Acupuncture Improve Gastroesophageal Reflux Disease Symptoms? A Trial Sequential Meta-Analysis.","authors":"Jinjin Yin, Ming Yin, Tianwen Liu, Shumin Qin","doi":"10.1159/000544956","DOIUrl":"10.1159/000544956","url":null,"abstract":"<p><strong>Introduction: </strong>The role of acupuncture in treating gastroesophageal reflux disease (GERD) has been previously investigated; however, it is unclear whether manual acupuncture is effective for treating GERD. This study aimed to evaluate the effectiveness and safety of manual acupuncture in treating GERD.</p><p><strong>Methods: </strong>Potentially eligible studies were identified from PubMed, Embase, Cochrane Central Registry for Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (Sinomed). Sensitivity analysis was conducted through excluding low-quality studies. Subgroup analysis was performed according to different proton pump inhibitors (PPIs) and treatment duration. Certainty of evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework.</p><p><strong>Results: </strong>Based on 504 records, 12 relevant studies were included in our meta-analysis. Trial sequential analysis confirmed that manual acupuncture improved symptom scores (mean difference [MD] = -3.43, 95% CI = -5.14 to -1.73, I2 = 88%, p < 0.001, very low evidence) and reduced recurrence rates (risk ratio [RR] = 0.32, 95% confidence interval = 0.16 to 0.64, I2 = 0%, p = 0.001, very low evidence). Although meta-analysis showed no difference in adverse events between manual acupuncture and PPIs (RR = 0.38, 95% CI = 0.09 to 1.58, I2 = 0%, p = 0.18, very low evidence), TSA revealed extremely insufficient statistical power. Furthermore, the global symptom improvement rate was lower with acupuncture compared to PPIs (RR = 1.22, 95% CI = 1.14 to 1.30, I2 = 18%, p < 0.001, low evidence). Sensitivity analysis demonstrated the robustness of the results. Subgroup analysis suggested the therapeutic effects of manual acupuncture alone irrespective of categories of PPIs and treatment duration.</p><p><strong>Conclusion: </strong>Manual acupuncture has the potential to alleviate the severity of symptoms and decrease the recurrence rate in patients with GERD. However, considering the efficacy of PPI therapy in significantly improving overall symptoms, along with its established safety profile and extensive clinical utilization over the years, we do not recommend manual acupuncture alone as the primary treatment for patients with GERD.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in the Study of Peppermint in Aromatherapy on Cognition and Attention: A Critical Scoping Review.","authors":"Ryusei Nishi, Kenichiro Sagiyama, Takamasa Fukumoto, Haruka Amitani, Akihiro Asakawa","doi":"10.1159/000543974","DOIUrl":"10.1159/000543974","url":null,"abstract":"<p><strong>Introduction: </strong>Aromatherapy has not accrued enough evidence to be integrated into standardized clinical medicine. If high-quality evidence supports the effects of aromatherapy, it will be handled as a parallel option to standardized medical treatment. The aromatherapeutic impact of peppermint (Mentha × piperita L.) essential oil has been researched to a certain extent, such as on pain, anxiety, fatigue, or depression. Considering the rising expenditure on dementia care, the potential effects of peppermint scents on cognition have become increasingly significant. Therefore, we performed a scoping review of the studies on the impact of peppermint scents on cognition and attention.</p><p><strong>Methods: </strong>We focused on human research, and the effects of peppermint scents were required to be inhaled. According to the inclusion criteria, searching from PubMed, Scopus, and Gale Academic OneFile, we identified a total of 115 studies. Finally, eight references were selected for review. The risk of bias was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.</p><p><strong>Results: </strong>Each reviewed reference had its own strength in investigating the effects of peppermint scents. However, as most studies have noted, the impact of peppermint scent should be assessed from multiple perspectives, including psychological, physiological, neurological, and pharmacological factors. The risk of bias was not found to be severe (high risk of bias rate: 35.7 ± 3.4%); our critical review elucidated the heterogeneity of the reviewed studies.</p><p><strong>Conclusion: </strong>In summary, drawing a definitive conclusion at this stage is premature. Therefore, more carefully designed studies are needed to confirm this hypothesis.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Appraisal Tool for Homeopathic Intervention Studies: CATHIS.","authors":"Katharina Gaertner, Robert G Hahn, Radmila Razlog, Frauke Musial, Stephan Baumgartner, Martin Loef, Harald Walach","doi":"10.1159/000542920","DOIUrl":"10.1159/000542920","url":null,"abstract":"<p><strong>Background: </strong>The quality of homeopathic research studies is controversially discussed. In order to improve, the overall assessment of homeopathic studies and subsequently facilitate evidence-based clinical decision-making, we aimed to combine methodological tools for scientific rigor with tools for external and model validity into one global tool.</p><p><strong>Method: </strong>Against the background of previous literature and the results of a preparatory survey, a first draft of a potential overarching tool was presented to an expert panel. Then, Delphi feedback rounds were conducted to elicit responses on the feasibility. The resulting preliminary tool was pilot-tested by five research experts on five randomly selected studies. After further optimization, another five studies were assessed by the same experts and another three experts tested the second version. The ratings were tested for interrater-reliability using Gwet's AC2.</p><p><strong>Results: </strong>The appraisal tool comprises four domains. These are (1) the assessment of risk-of-bias using the Cochrane Tool, (2) the studies' credibility including the CONSORT statement and its extension on homeopathy, (3) the study interventions' coherence with homeopathic textbooks and previous research, and (4) the studies' clinical relevance. Each domain is assessed using a point system, which is then added up to an overall score. The instrument was evaluated as useful and \"easy to apply\" by the raters. The interrater reliability was 0.81 (95% CI 0.75-0.88) for five raters, and 0.64 (95% CI 0.49-0.79) for additional three raters in round 2, signifying good to moderate interrater reliability.</p><p><strong>Conclusion: </strong>We have developed an applicable and reliable assessment tool for homeopathic intervention studies. Using it in systematic reviews and meta-analyses will increase their scientific value.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}