{"title":"Mechanisms of traditional chinese medicine in advanced gastric cancer: insights from meta-analysis and network pharmacology.","authors":"Zhenzheng Zhu, Yuhan Fu, Qingyang Liu, Leitao Sun, Jieru Yu, Ying Zhu","doi":"10.1159/000548562","DOIUrl":"https://doi.org/10.1159/000548562","url":null,"abstract":"<p><strong>Background: </strong>Traditional Chinese medicine (TCM) is widely used as an adjuvant therapy for advanced gastric cancer (AGC), yet its underlying mechanisms and targets remain inadequately characterized.</p><p><strong>Methods: </strong>This study integrated meta-analysis and network pharmacology to evaluate the therapeutic effects of TCM, identify core effective prescriptions (CEPs), and predict potential molecular targets.</p><p><strong>Results: </strong>Seventeen studies comparing TCM combined with chemotherapy versus chemotherapy alone for AGC were identified through a search of seven databases.Meta-analysis showed that TCM significantly improved overall survival (OS) (HR: 1.65, 95% CI: 1.23-2.22, p < 0.001, I² = 0%). Core effective prescriptions (CEPs) and their chemical constituents were identified. A Component-Target (C-T) network was constructed, revealing the top 10 core genes were TP53, AKT1, CASP3, MYC, IL6, ESR1, EGFR, TNF, PTEN, and HIF1A.</p><p><strong>Conclusion: </strong>This meta-analysis demonstrates that TCM combined with chemotherapy improves OS in AGC patients more effectively than chemotherapy alone. Network pharmacology offered complementary mechanistic insights, laying a foundation for future experimental research.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-26"},"PeriodicalIF":0.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acupuncture Relative to Sham Control in Managing Breast Cancer-Related Hot Flashes: A Meta-Analysis of Randomized Controlled Trials.","authors":"Dao-Fu Xu, Hai-Zhen Zheng, Si-Yu Jiang, Bao-Hao Chen, Han-Lin Zou, Ying-Jie Li, Wen-Zhe Wu, Zheng-Yun Zuo","doi":"10.1159/000547579","DOIUrl":"10.1159/000547579","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is the leading cause of morbidity and mortality among female cancers globally. Hot flashes are among the most bothersome complications in women with breast cancer. Acupuncture is a common complementary approach for cancer worldwide. Here we aimed to determine the differential effect between acupuncture and sham acupuncture on hot flashes among breast cancer patients.</p><p><strong>Methods: </strong>Eight English and Chinese databases through 10 October 2024, such as PubMed, Cochrane Library, ScienceDirect, Web of Science, etc., were searched to identify the randomized controlled trials (RCTs) about acupuncture relative to sham control treating breast cancer patients experiencing hot flashes. Outcomes included hot flash frequency per day, hot flash severity score, quality of life related to hot flashes, response rate. Continuous variables and categorical ones were expressed as standardized mean difference (SMD) or MD, and risk ratio (RR), with 95% confidence interval (CI), respectively, for meta-analysis. Sensitivity analysis and Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) of evidence were conducted additionally.</p><p><strong>Results: </strong>Eight RCTs involving 493 participants were included. Relative to sham control, acupuncture was significantly more efficacious in improving the quality of life of breast cancer patients experiencing hot flashes (165 participants, SMD [95% CI]: -1.01 [-1.99, -0.03], I2 = 88%, p = 0.04) at the end of treatment, as well as at follow-up of over 3 months (59 participants, MD [95% CI]: -3.38 [-4.83, -1.93]). With respect to response rate, acupuncture achieved a higher rate versus sham acupuncture (118 subjects, RR [95% CI]:2.66 [1.63, 4.36], I2 = 0, p < 0.0001). Sensitivity analysis solely supported the statistically significant difference between the two groups in terms of response rate (RR [95% CI]: 2.14 [1.03, 4.44]) or 3.20 [1.64, 6.23]). As for frequency and hot flash severity, no difference was noted between groups. GRADE of evidence showed low to very low quality.</p><p><strong>Conclusions: </strong>Acupuncture reached a significantly higher response rate compared to sham control in breast cancer patients with hot flashes, whereas its efficacy on the quality of life showed inconsistency. Given significant heterogeneity and low quality of evidence, future large-sample-size and high-quality RCTs are warranted.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-15"},"PeriodicalIF":0.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunxia Zhao, Min Wu, BingAn Zheng, XiaoMing Shao, Yi Zhao
{"title":"Combination Therapy for Simple Obesity: Acupoint Needling and Auricular Acupressure Effects.","authors":"Yunxia Zhao, Min Wu, BingAn Zheng, XiaoMing Shao, Yi Zhao","doi":"10.1159/000547693","DOIUrl":"https://doi.org/10.1159/000547693","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the efficacy and safety of acupoint-embedded needling combined with auricular acupressure in treating simple obesity associated with spleen deficiency and dampness accumulation.</p><p><strong>Methods: </strong>Ninety-six patients with simple obesity were randomized into two groups. The intervention group received acupoint-embedded needling and auricular acupressure, while the control group received conventional acupuncture. After 30 days, body weight, body mass index (BMI), waist circumference, blood lipid profiles, traditional Chinese medicine (TCM) syndrome scores, and metabolic markers were assessed. These included homeostasis model assessment of insulin resistance (HOMA-IR), serum leptin, high-sensitivity C-reactive protein (hs-CRP), body fat percentage, and basal metabolic rate (BMR). Adverse events were monitored.</p><p><strong>Results: </strong>Compared to the control group, the intervention group showed significantly greater reductions in body weight, BMI, waist circumference, total cholesterol, triglycerides, and low-density lipoprotein cholesterol, as well as increases in high-density lipoprotein cholesterol (all p < 0.05). TCM scores and metabolic indicators also showed significant improvement. The overall adverse event rate was lower in the intervention group (8.33% vs. 29.17%, p = 0.019), although individual event types showed no statistically significant difference.</p><p><strong>Conclusion: </strong>Acupoint-embedded needling combined with auricular acupressure is an effective and well-tolerated approach for managing simple obesity associated with spleen deficiency and dampness, with benefits in weight loss, improved metabolism, and symptom relief.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-31"},"PeriodicalIF":0.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"St John's wort (Hypericum perforatum) fresh plant tincture for patients with mild to moderate depression - a prospective observational study.","authors":"Natalie Kalbermatten, Reinhard Saller","doi":"10.1159/000547920","DOIUrl":"https://doi.org/10.1159/000547920","url":null,"abstract":"<p><strong>Background: </strong>High-dosed dry extract preparations of St John's wort (Hypericum perforatum) (hd-SJW) are equally effective as synthetic antidepressants for mild to moderate depression as shown by various randomised controlled trials (RCTs). Other available preparations of SJW such as fresh plant tinctures are dosed lower and no clinical study about their effect has been published so far.</p><p><strong>Objectives: </strong>To evaluate the effect of a SJW fresh plant tincture (C-SJW-ft) on depressive symptoms and its tolerability in patients comparable to patients reported in hd-SJW RCTs applying the same outcome, the Hamilton Depression Scale 17 (HAM-D17).</p><p><strong>Methods: </strong>Prospective observational study of outpatients with mild to moderate depressive episodes (ICD-10/DSM-IV) treated with C-SJW-ft. Outcomes were HAM-D17 decline between inclusion and 6 weeks (42 days ±7 days), percentage of responders, (>50% decline), and frequency and type of adverse events. Descriptive analysis was performed. From a systematic literature review of RCTs of hd-SJW applying HAM-D17 as efficacy outcome at 6 weeks, the characteristics of the included patient population and the outcomes were extracted for comparison (rRCTs [\"reference RCTs\"]).</p><p><strong>Results: </strong>52 evaluable patients were included, 1 patient dropped out (switch to synthetic antidepressants), of the 51 (per protocol [PP] \"expanded\") patients, 42 completed the second HAM-D 17 within 42 ± 7 days (PP \"strict\"). The included patient population was comparable to the 10 identified rRCTs with hd-SJW for age (51/50.6 years [mean, pp strict/pp expanded], 40.2-51.4 years [mean, rRCTs] and gender (76%/75% female [pp strict/pp expanded], 54-86% [rRCTs]). The baseline HAM-D17 was slightly lower (PP strict: 16.4 [mean, range 9-28]; PP expanded 16.9 [9-28) compared to rRCTs (19.7-22.8). The decline of HAM-D17 in patients treated with C-SJW-ft (baseline/end of observation period) was 49% (PP strict) and 52% (PP expanded) comparable to the decline of 45-59% in the rRCTs of hd-SJW; likewise, responders were 50% and 57% compared to 42-70%. Adverse events were lower (4%) compared to 20-39% in the rRCTs.</p><p><strong>Conclusion: </strong>In an observational prospective patient cohort with mild to moderate depressive episodes corresponding to patients included in RCTs of hd-SJW, applying the same efficacy outcome and timeframe, C-SJW-ft showed comparable effects and good tolerability. Further clinical trials seem justified.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-22"},"PeriodicalIF":0.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William W N Tsang, Yuen Ting Wong, Joshua S H Tsang
{"title":"Seated Tai Chi Improves Dynamic Finger-Pointing Task and Sitting Balance Control in Subjects with Parkinson's Disease: A Prospective Comparative Observational Study.","authors":"William W N Tsang, Yuen Ting Wong, Joshua S H Tsang","doi":"10.1159/000547567","DOIUrl":"10.1159/000547567","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the effects of 3 months of seated Tai Chi (TC) practice on the eye-hand coordination and sitting balance control of subjects with Parkinson's disease.</p><p><strong>Method: </strong>A prospective non-randomized study was conducted with 29 subjects practicing TC and 27 subjects as controls according to their preference. The seated TC group underwent 3 months of training with a total of 24 sessions (1 h/session, 2 sessions/week). The outcome measures included a dynamic finger-pointing task (reaction time, movement time, and accuracy), and a sequential weight-shifting balance control test (completion time) while seated.</p><p><strong>Results: </strong>The TC group showed faster movement time in the dynamic finger-pointing task (p = 0.003). They also achieved a faster completion time of the sequential weight-shifting balance test (p = 0.021). No significant difference was observed in the control group.</p><p><strong>Conclusions: </strong>The results demonstrate that 3 months of seated TC training could improve movement time in the finger-pointing task and sitting balance control in subjects with Parkinson's disease. A future randomized controlled trial is warranted.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-10"},"PeriodicalIF":0.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Creative arts therapies to improve health and well-being in obesity? A systematic literature review of current research.","authors":"Renate Oepen","doi":"10.1159/000547592","DOIUrl":"https://doi.org/10.1159/000547592","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this systematic literature review was to assess the effects of creative arts therapies on the health and well-being of overweight/obese patients.</p><p><strong>Methods: </strong>The database search was conducted in \"American Search Ultimate, PsycINFO, PsycARTICLES, ERIC, MEDLINE (via PubMed), OpenDissertations, PSYNDEX Literature with PSYNDEX Test, SocINDEX, SocINDEX wih Full text\", covering the period from 2000 to 2024. Studies with evidence level I-IV, subjects with a BMI > 25 were included.</p><p><strong>Results: </strong>12 studies, including five controlled studies, were analysed. Significant results were achieved in self-esteem, quality of life, body awareness, dissatisfaction with one's own body, social relationships, changes in health and eating behaviour; lower impact on body image, emotional eating, communication skills, dealing with your own body shape.</p><p><strong>Discussion/conclusion: </strong>Creative arts therapies can make a valuable contribution to health promotion for overweight individuals. Increased integration into weight reduction programmes would be a logical next step. Future research should place greater emphasis on increasing sample sizes, employing control group, specifying types of intervention and settings, and expanding the inclusion of children and adolescents as target groups to validate existing findings and to enhance the informative value of the results.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-17"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silin Ou, Ming Dong, Ying Wei, Hongmei Huan, Wenqian Wang
{"title":"Commonality Analysis of High-Quality Acupuncture Clinical Trial Articles.","authors":"Silin Ou, Ming Dong, Ying Wei, Hongmei Huan, Wenqian Wang","doi":"10.1159/000547403","DOIUrl":"10.1159/000547403","url":null,"abstract":"<p><strong>Background: </strong>With a wide range of clinical needs, evidence-based support for acupuncture therapy through clinical trials is essential for enhancing its scientific value, clinical application, and international influence.</p><p><strong>Objective: </strong>The aim of this study was to provide design ideas and specific methodology references for acupuncturists and researchers for the design, implementation, and publication of high-level acupuncture clinical research.</p><p><strong>Data sources: </strong>The data came from PubMed, Web of Science, and EBSCO databases since its inception until February 28, 2024. A total of 89 articles were retrieved, and the primary interventions were manual acupuncture, electroacupuncture, auricular acupuncture, and laser acupuncture. Eighty-five clinical trials on manual acupuncture and electroacupuncture as primary interventions were included.</p><p><strong>Results: </strong>All of the high-quality clinical trial publications on acupuncture included in the review adhered to the Consolidated Standards of Reporting Trials (CONSORT) statement and the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). They demonstrated rigor and accuracy in trial design selection, inclusion criteria development, sample size calculations, and statistical methodology, and provided clear, concise details of acupuncture interventions and control settings.</p><p><strong>Conclusion: </strong>These trials have elevated the overall quality of the research and provided invaluable insights and methodological frameworks for designing randomized controlled trials (RCTs) in acupuncture. Despite these advancements, several limitations remain that warrant attention in future endeavors. Addressing these shortcomings is crucial for enhancing the methodological rigor and reliability of acupuncture trials and advancing evidence-based practice in this field.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-12"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derya Egeli Yilmaz, İçim Gökkaya, Gülin Renda, Murat Kartal
{"title":"Physicians' and Pharmacists' Knowledge, Thoughts, and Attitudes of Homeopathy: A Comparative Survey in Türkiye.","authors":"Derya Egeli Yilmaz, İçim Gökkaya, Gülin Renda, Murat Kartal","doi":"10.1159/000548047","DOIUrl":"https://doi.org/10.1159/000548047","url":null,"abstract":"<p><p>Background Homeopathy, included in traditional and complementary medicine (TCM), is defined as a complementary treatment that aims to improve health through personalized therapy. Physicians and pharmacists play a crucial role in the practice of homeopathy and the delivery of homeopathic medicinal products to the public in Türkiye. This study aims to evaluate the knowledge, thoughts, and attitudes of physicians and pharmacists on homeopathy in accordance with Turkish regulations. Methods This descriptive study was carried out on physicians and pharmacists via a web-based questionnaire method. The survey form includes three sections and twenty-three questions. Participants received the survey form via Facebook, Instagram, X (Twitter), and LinkedIn. A total of 475 questionnaires that met the data quality criteria were included in the study. The analysis of the data was performed with the SPSS 23.0 statistical program, with a statistical significance level set at p < 0.05. Results The study population included 70.3% (n = 334) pharmacists and 29.7% (n = 141) physicians. The study's results demonstrate that 86.5% of participants had heard of the concept of homeopathy. It was found that a higher rate of hearing of homeopathy was associated with being a pharmacist (OR: 31.5, p = 0.000) and having ten years or more of professional experience (OR: 7.274, p = 0.000). The participants had correct knowledge about the definition and basic principles of homeopathy. The respondents lacked knowledge on certain aspects of the regulation of homeopathic practice in Türkiye. The primary source of information for pharmacists was undergraduate courses (n = 185, 58.2%), but for physicians, it was social media/television (n = 41, 50.0%). 70.1% (n = 288) thought that homeopathy needs to be incorporated into the undergraduate curriculum. 91.7% of participants thought that further scientific research on homeopathy is required. Conclusion Homeopathy courses should be integrated into undergraduate education to improve the awareness of healthcare professionals. Further, the organization of seminars and training courses would enhance their knowledge of the relevant subject.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-18"},"PeriodicalIF":0.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Raposo, Katharina Gaertner, Robert G Hahn, Radmila Razlog, Frauke Musial, Stephan Baumgartner, Martin Loef, Harald Walach
{"title":"Response to the Letter: \"Constructive Evaluation of CATHIS\".","authors":"Marta Raposo, Katharina Gaertner, Robert G Hahn, Radmila Razlog, Frauke Musial, Stephan Baumgartner, Martin Loef, Harald Walach","doi":"10.1159/000547571","DOIUrl":"10.1159/000547571","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-3"},"PeriodicalIF":0.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Long COVID, Post-COVID-Syndrom: Langzeitfolgen von SARS-CoV-2-Infektionen und Nutzen von standardisierten Ginkgo-biloba Extrakten].","authors":"Andreas Schapowal","doi":"10.1159/000548075","DOIUrl":"10.1159/000548075","url":null,"abstract":"<p><p>Hintergrund: Long COVID und das Post-COVID-Syndrom sind langfristige Folgen einer SARS-CoV-2-Infektion, die eine Vielzahl physischer, kognitiver und psychischer Symptome hervorrufen können. Dazu gehören Erschöpfung, Atemnot, Gedächtnisstörungen und Schlafprobleme. Die zugrunde liegenden Mechanismen sind noch nicht vollständig geklärt, umfassen jedoch persistierende Viruspartikel, mikrovaskuläre Dysfunktionen, Autoimmunreaktionen und eine Dysregulation des autonomen Nervensystems. Fragestellung: Welchen Nutzen könnten standardisierte Ginkgo-biloba-Extrakte aufgrund ihrer pharmakologischen Wirkungen und ihrer klinischen Wirksamkeit bei Long COVID und Post-COVID-Syndrom bringen? Zusammenfassung: Die Diagnose von Long COVID bleibt aufgrund fehlender standardisierter Tests eine Herausforderung. Therapeutisch wird ein multimodaler Ansatz empfohlen, der symptomatische Medikation, Physiotherapie, Psychotherapie sowie Ernährungs- und Bewegungstherapie umfasst. Ein vielversprechender ergänzender Therapieansatz ist die Verwendung von standardisierten Ginkgo-biloba-Extrakten. Dank ihrer antioxidativen, entzündungshemmenden und neuroprotektiven Eigenschaften könnten sie zur Verbesserung kognitiver Beeinträchtigungen, Fatigue und kardiovaskulärer Symptome beitragen. Erste Studien und Fallberichte deuten auf positive Effekte hin, jedoch sind weitere klinische Untersuchungen erforderlich, um die Wirksamkeit zu bestätigen. Kernaussagen: Long COVID und das Post-COVID-Syndrom betreffen zahlreiche Organsysteme und beeinträchtigen die Lebensqualität erheblich. Die Diagnose bleibt schwierig, da es keine spezifischen Tests gibt. Eine multimodale Therapie ist derzeit der vielversprechendste Behandlungsansatz. Standardisierte Ginkgo-biloba-Extrakte zeigen in ersten Studien positive Effekte auf neurokognitive und kardiovaskuläre Symptome.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-6"},"PeriodicalIF":0.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}