Mechanisms of traditional chinese medicine in advanced gastric cancer: insights from meta-analysis and network pharmacology.

IF 0.8 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary Medicine Research Pub Date : 2025-09-22 DOI:10.1159/000548562

Zhenzheng Zhu, Yuhan Fu, Qingyang Liu, Leitao Sun, Jieru Yu, Ying Zhu

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引用次数: 0

Abstract

Background: Traditional Chinese medicine (TCM) is widely used as an adjuvant therapy for advanced gastric cancer (AGC), yet its underlying mechanisms and targets remain inadequately characterized.

Methods: This study integrated meta-analysis and network pharmacology to evaluate the therapeutic effects of TCM, identify core effective prescriptions (CEPs), and predict potential molecular targets.

Results: Seventeen studies comparing TCM combined with chemotherapy versus chemotherapy alone for AGC were identified through a search of seven databases.Meta-analysis showed that TCM significantly improved overall survival (OS) (HR: 1.65, 95% CI: 1.23-2.22, p < 0.001, I² = 0%). Core effective prescriptions (CEPs) and their chemical constituents were identified. A Component-Target (C-T) network was constructed, revealing the top 10 core genes were TP53, AKT1, CASP3, MYC, IL6, ESR1, EGFR, TNF, PTEN, and HIF1A.

Conclusion: This meta-analysis demonstrates that TCM combined with chemotherapy improves OS in AGC patients more effectively than chemotherapy alone. Network pharmacology offered complementary mechanistic insights, laying a foundation for future experimental research.

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中医药治疗晚期胃癌的机制：来自meta分析和网络药理学的见解。

背景：中药作为晚期胃癌（AGC）的辅助治疗被广泛使用，但其潜在机制和靶点尚未充分研究。方法：采用荟萃分析和网络药理学相结合的方法，评价中药的治疗效果，鉴定核心有效方剂，预测潜在的分子靶点。结果：通过对7个数据库的检索，确定了17项比较中药联合化疗与单独化疗治疗AGC的研究。meta分析显示，中药显著提高了总生存率（OS）（HR: 1.65, 95% CI: 1.23-2.22, p < 0.001, I²= 0%）。鉴定了核心有效方及其化学成分。构建组件-目标（C-T）网络，发现前10个核心基因为TP53、AKT1、CASP3、MYC、IL6、ESR1、EGFR、TNF、PTEN和HIF1A。结论：本荟萃分析表明，中药联合化疗比单独化疗更有效地改善AGC患者的OS。网络药理学提供了互补的机制见解，为今后的实验研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

2.90

自引率

5.60%

发文量

期刊介绍： Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR