Complementary Medicine Research最新文献

{"title":"Dose-Response Relationship between Fasting Plasma Glucose and Abnormal Lung Function in a Health Screening Population.","authors":"Ying Tang, Tong Wu, Jinhan Nan, Yu Zhu, Ying Zhu, Jia Li, Yunhang Wang, Jinping Liu, Fanghong Yan, Yuxia Ma","doi":"10.1159/000552382","DOIUrl":"10.1159/000552382","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging evidence has suggested complex relationships between glucose metabolism and pulmonary health. However, the nature of the association between fasting plasma glucose (FPG) and lung function remains inadequately characterized. This study aimed to explore this association and provide further evidence.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 6,597 adults in a Chinese health check-up cohort. Lung function was classified into two groups: normal and abnormal. Binary logistic regression was performed to identify the association between FPG and the risk of lung function abnormalities. Restricted cubic splines (RCSs) were used to model the FPG-lung function relationship, stratified by sex, age, and BMI.</p><p><strong>Results: </strong>A significant nonlinear dose-response relationship (p < 0.05) was found between FPG and lung function abnormalities. RCS analysis showed that increasing FPG from 4.78 to 5.6 mmol/L elevated the risk of lung function abnormalities by 32.0% (OR = 1.32, 95% CI: 1.17-1.49). Gender disparities were evident, with women exhibiting a steeper risk gradient (OR = 1.43 vs. 1.29 in men). Overweight/obese individuals (BMI ≥24 kg/m2) demonstrated a stronger association (OR = 1.45) compared to those of normal weight (OR = 1.21).</p><p><strong>Conclusion: </strong>FPG was determined to be an independent predictor of lung function abnormalities, exhibiting a pronounced nonlinear dose-response relationship. Maintaining FPG below 5.6 mmol/L may help prevent lung function impairment, underscoring the importance of early glycemic monitoring in predicting lung function.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Saturated Fatty Acid and Protein Intakes Are Inversely Associated with Hyperandrogenism Risk among Lean Adult Women: An Analysis of NHANES 2013-2016.","authors":"Danqi Shao, Zhiwei Zheng, Ruibin Cai, Dezhi Zou, Panyu Chen, Xiangwen Diao","doi":"10.1159/000553497","DOIUrl":"10.1159/000553497","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperandrogenism (HA) is a common endocrine disorder marked by excessive androgen secretion and substantial adverse effects on women's health. HA patients included both lean and obese individuals with distinct symptoms. HA was treated through diverse methods, with dietary control being a key element. However, research on diets for lean HA patients was limited. We aimed to investigate the relationship between dietary intake and the risk of HA in lean adult women.</p><p><strong>Methods: </strong>This study conducted a secondary analysis of 2013-2016 National Health and Nutrition Examination Survey (NHANES) data to investigate diet-HA associations in reproductive-aged lean adult women (BMI <25 kg/m2) using multivariable logistic regression and restricted cubic spline modeling.</p><p><strong>Results: </strong>The study cohort included 1,141 participants, with 10.95% identified as having at-risk HA. Significant differences in testosterone levels and free androgen index were observed between at-risk HA and non-risk HA groups. Intake of saturated fatty acids (SFAs) and protein was significantly lower in the at-risk HA group compared to the non-risk HA group. Weighted regression analysis revealed a significant negative correlation between SFA/protein intakes and HA risk. Restricted cubic spline analysis further demonstrated a significant nonlinear relationship between SFA intake and both at-risk HA and testosterone levels.</p><p><strong>Conclusion: </strong>Among lean adult women in the USA, dietary intake of SFA and protein was negatively correlated with the risk of HA. This finding may point to a potential role of SFA and protein intake in HA risk modulation among lean adult women.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive strategy to explore the effects of processing on the medicinal properties of the Herba Siegesbeckiae and the component attribution.","authors":"Ajiao Hou, Chao Yu, Haixue Kuang, Liu Yang, Hai Jiang","doi":"10.1159/000553224","DOIUrl":"https://doi.org/10.1159/000553224","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to clarify the effects of processing on the medicinal properties of the Herba Siegesbeckiae(HS), and to determine its regulatory on the neural-endocrine-metabolic enzymes in the rat and the attribution of its components.</p><p><strong>Methods: </strong>D101 macroporous resin was adopted to isolate chemical component clusters (CCCs) from raw and processed HS. A neuro-endocrine-metabolic network was used to characterize medicinal properties. The indicators of antipyretic, analgesia, anti-inflammatory, and liver-tonifying and kidney-reinforcing were performed to determine medicinal flavor, while an electronic tongue was applied for gustatory taste quantification. Chemometric analyses were used to explore the influence of processing on HS and its CCCs.</p><p><strong>Results: </strong>Raw HS and its CCCs suppressed neuro-endocrine-metabolic enzyme activities, corresponding to a cold medicinal property, whereas processed HS and its CCCs exerted opposite effects and displayed warm properties. The medicinal flavor results showed that S30, S70 and Z70 contributed to the pungent, bitter, sweet flavor respectively. The taste results demonstrated that the bitter taste of raw HS primarily originated from S95 and S70, and Z70 functioned as the core CCCs responsible for elevated sweetness after processing.</p><p><strong>Conclusions: </strong>Z70 acts as the pivotal component coordinating processing-triggered synchronous changes in medicinal properties and medicinal flavors of HS.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Series: Real-Life Experience with Vitex Agnus-Castus Extract Ze 440 Medication in Adolescents.","authors":"Anna Kathrin Erkert","doi":"10.1159/000553039","DOIUrl":"10.1159/000553039","url":null,"abstract":"<p><strong>Introduction: </strong>Menstrual disorders are common in adolescents and can significantly impact quality of life. Nonhormonal treatment options are of particular interest in this population, especially for those not requiring contraception. Vitex agnus-castus (VAC) extract Ze 440 is a well-established phytotherapeutic agent shown to be effective in adult women, though clinical data in adolescents remain limited.</p><p><strong>Methods: </strong>This case series presents real-life clinical experience with Ze 440 in 6 adolescent patients aged 12-17 years with various menstrual disorders. Patients were followed in routine clinical practice for up to 6 months.</p><p><strong>Results: </strong>Treatment with Ze 440 demonstrated good efficacy in relieving dysmenorrhea and stabilizing the menstrual cycle. In several cases, the use of non-steroidal anti-inflammatory drugs (NSAIDs) could be reduced or discontinued. Two patients with pronounced hypermenorrhea required additional therapy with tranexamic acid; one of them was switched to norethisterone after 6 months due to poor tolerance of tranexamic acid. Ze 440 was well tolerated, and no adverse events were reported.</p><p><strong>Conclusion: </strong>Ze 440 appears to be a practical, well tolerated, nonhormonal option for managing menstrual disorders in adolescents. It supports the natural menstrual cycle without hormonal suppression. Regular clinical follow-up is recommended to optimize treatment outcomes and adjust therapy as needed.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apriori Correlation Analysis of Geriatric Malnutrition, Sarcopenia, Frailty, and Traditional Chinese Medicine Syndromes Based on Data Mining Techniques.","authors":"Jingran Cao, Ruiyu Mou, Zhiling Yang, Peiying Yang, Yong Wang, Yingjie Jia","doi":"10.1159/000553380","DOIUrl":"10.1159/000553380","url":null,"abstract":"<p><strong>Introduction: </strong>Malnutrition, sarcopenia, and frailty are highly prevalent (with rates ranging from 56% to 74%) among hospitalized elderly patients with comorbidities, and they are key geriatric syndromes that contribute to disability, reduced quality of life, and poor clinical outcomes. However, existing Western medicine guidelines mainly focus on isolated nutritional support and exercise interventions, lack holistic thinking and often treat the three conditions separately, which leads to suboptimal comprehensive clinical effectiveness. To address this, the present study adopts a cross-sectional design and employs data mining techniques to explore the intrinsic associations between these three geriatric conditions and traditional Chinese medicine (TCM) syndrome types in hospitalized elderly patients with comorbidities, aiming to provide empirical evidence for developing targeted integrated Chinese-Western dietary intervention strategies.</p><p><strong>Methods: </strong>This cross-sectional study enrolled hospitalized elderly patients to collect nutritional status indicators and TCM disease and syndrome diagnosis data. The Apriori algorithm was adopted to excavate association rules with screening criteria of support >0.01, confidence >0.5, lift >1, and p < 0.05. Association heatmaps were used to visualize correlation intensity.</p><p><strong>Results: </strong>A total of 1,049 patients were included. Among those with co-existing nutritional risk, malnutrition, sarcopenia, and frailty, the main TCM diseases were consumptive disease (\"Xū Láo\"), cough and fever, and the dominant TCM syndromes included turbid phlegm obstructing the lung, dual deficiency of qi and blood, qi deficiency combined with blood stasis. Statistically significant associations were found: dyspnea was related to nutritional risk; fever and cough were closely associated with frailty and nutritional risk; consumptive disease correlated with nutritional risk, malnutrition and frailty. Among TCM syndromes, dampness-heat pouring downward corresponded to nutritional risk; qi deficiency with blood stasis and turbid phlegm obstructing the lung were linked to frailty and nutritional risk, while qi-blood dual deficiency was associated with all three adverse nutritional conditions.</p><p><strong>Conclusion: </strong>Typical TCM diseases and common syndromes are closely associated with adverse nutritional status in elderly inpatients. Clinically, active targeted screening for malnutrition, sarcopenia, and frailty should be conducted in patients presenting the above TCM syndromes, with differentiated dietary interventions implemented simultaneously.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Traditional Chinese Acupoint Massage Combined with Tailored Tai Chi on Low Back Pain in Patients with Lumbar Disc Herniation: A Randomized Controlled Trial.","authors":"Shuaipan Zhang, Yongchao Wang, Chongjie Yao, Xin Zhou, Guangxin Guo, Jianhua Li, Min Fang, Qingguang Zhu","doi":"10.1159/000553337","DOIUrl":"10.1159/000553337","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the clinical efficacy of traditional Chinese acupoint massage (TCAM) combined with tailored tai chi on pain, disability, and selected quality-of-life domains in patients with lumbar disc herniation (LDH).</p><p><strong>Methods: </strong>Seventy-two patients with LDH and low back pain (LBP) were randomly assigned to an intervention group (IG, TCAM + tailored tai chi, n = 36) or a control group (CG, TCAM alone, n = 36). Interventions were conducted 3 times per week for 4 weeks. The primary outcome was Oswestry Disability Index (ODI). Secondary outcomes included the visual analog scale (VAS, 0-10 points) and selected domains of the 36-Item Short Form Health Survey (SF-36). Baseline participant and therapist expectation scores were recorded, and sensitivity analyses were performed adjusting for these scores. ANCOVA adjusted for baseline outcome values, age, sex, and disease duration was used for between-group comparisons. Bonferroni correction was applied for SF-36 subscales.</p><p><strong>Results: </strong>The primary outcome ODI decreased significantly more in the IG than in the CG (from 26.58 ± 7.79 to 9.67 ± 3.10 vs. 28.72 ± 9.25 to 15.69 ± 4.26; adjusted mean difference = 3.88, 95% CI: 0.50-7.27, p = 0.026). VAS scores improved on the 0-10 scale from 6.47 ± 1.47 to 2.21 ± 0.96 in the IG and from 6.71 ± 1.32 to 2.92 ± 0.99 in the CG, with an adjusted between-group difference of 0.47 (95% CI: 0.18-1.43, p = 0.012). Among SF-36 subscales, significant between-group differences after Bonferroni correction were observed in physical functioning, bodily pain, vitality, and mental health. Sensitivity analyses adjusting for expectation scores yielded consistent results. The total effective rate was 94.44% in the IG vs. 83.33% in the CG (p = 0.26).</p><p><strong>Conclusion: </strong>TCAM combined with tailored tai chi significantly improved functional disability, pain intensity, and selected quality-of-life domains compared with TCAM alone over 4 weeks. Sensitivity analyses suggest that these effects are robust and independent of baseline expectation scores. This multimodal physical therapy may be considered a complementary conservative treatment for patients with LBP due to LDH.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Gotu Kola (<i>Centella asiatica</i>), Phosphatidylcholine, and Taurine in Mood Disorders: A Systematic Scoping Review.","authors":"Bonifacio Ii C Pedregosa, Jose C Navarro, Gabriel Alejandro B Baroque, Michael Ian N Sta Maria, Meliza Angelica J De Leon, Mark Jenzen H Trivilegio, Laurence Kristoffer J Batino, John Abraham Nosce, Maria Lutgarda M Dorado, Alejandro Ii C Baroque","doi":"10.1159/000553172","DOIUrl":"10.1159/000553172","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Mood disorders are a leading cause of disability, with a substantial proportion of patients failing to respond adequately to first-line medications. Complementary interventions are thus being explored to augment standard treatment strategies. This review aimed to systematically map and describe the existing literature on the therapeutic potential of gotu kola (Centella asiatica), phosphatidylcholine, and taurine - the active nutraceutical constituents of Neurotain® Plus - in mood disorders and to assess whether the available evidence is sufficient to support subsequent meta-analyses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A scoping review was conducted in accordance with the JBI methodology and reported following the PRISMA-ScR guideline. PubMed, Web of Science, and Scopus were systematically searched for studies evaluating the mood-related behavioral effects of gotu kola, phosphatidylcholine, and taurine. The protocol for this review was prospectively registered in the Open Science Framework (&lt;ext-link ext-link-type=\"doi\" xlink:href=\"https://doi.org/10.17605/OSF.IO/ETRZP\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"&gt;https://doi.org/10.17605/OSF.IO/ETRZP&lt;/ext-link&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 2,238 identified citations, 29 were included: 12 on gotu kola (three human studies, n = 91; nine animal studies), three on phosphatidylcholine (two human studies, n = 7; one animal study), and 14 on taurine (one human study, n = 130; 13 animal studies); none evaluated any combination of these compounds. Across included studies, substantial methodological heterogeneity in design, population, intervention, and outcome measures indicates that the current evidence base remains insufficient to support quantitative synthesis. For gotu kola, two randomized trials in healthy participants (n = 58) reported improvements in alertness, while an open-label study in generalized anxiety disorder patients (n = 33) reported reductions in anxiety and depressive symptoms. Animal studies consistently demonstrated antidepressant-like effects in stress-induced models, whereas effects in non-stressed rodents were generally neutral; findings for anxiety-related outcomes were variable. For phosphatidylcholine, limited human evidence from patients with bipolar disorder suggested improvements in manic symptoms and mood stability, including sustained euthymia or remission, while an animal study demonstrated antidepressant-like effects and reversal of stress-induced cognitive impairment. For taurine, a case-control study found no association between dietary taurine intake and depression. Animal studies generally demonstrated antidepressant- and anxiolytic-like effects, particularly in stress-induced models, although findings were mixed and at times context-dependent. No serious adverse events were reported in any included human study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This review identified preliminary, hypothesis-generating evidence suggesting tha","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Neuroprotective Effects of Cortex of <i>Albizia julibrissin</i> Durazzini and Stems and Branches of <i>Uncariae rhynchophylla</i> (Miq.) Miq. in Models of 6-Hydroxydopamine-Induced Parkinson's Disease.","authors":"Eugene Huh, Hyeryeong Ju, Dongjin Noh, Jin Hee Kim, Myung Sook Oh","doi":"10.1159/000553261","DOIUrl":"10.1159/000553261","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons, leading to motor and non-motor symptoms. Current therapeutic options for PD have limited efficacy and cause significant side effects, necessitating the development of novel therapeutic strategies. In this study, we investigated the neuroprotective effects of the cortex of Albizia julibrissin Durazzini (AC) and stems and branches of Uncariae rhynchophylla (Miq.) Miq. (UR), individually and in combination, in cellular and animal models of PD.</p><p><strong>Methods: </strong>We evaluated the neuroprotective effects of the water extract of AC and UR individually in 6-hydroxydopamine (6-OHDA)-treated PC12 cells using the MTT assay. Combination index (CI) analysis was employed to determine the optimal AC:UR ratio for synergistic effects. The bioactivity of individual herbs and their optimized combination was assessed in 6-OHDA-lesioned mice through behavioral tests (pole, rotarod, and apomorphine-induced rotation) and immunohistochemical analysis of dopaminergic neurons in the striatum and substantia nigra pars compacta.</p><p><strong>Results: </strong>Both herbal remedies exhibited neuroprotective effects in 6-OHDA-treated PC12 cells. A 2:1 ratio of AC-to-UR yielded the most potent synergistic neuroprotective effect (CI = 0.38459), significantly improving motor function in 6-OHDA-lesioned mice. Immunohistochemical analysis revealed that the 2:1 AC-to-UR combination significantly protected dopaminergic neurons against 6-OHDA-induced neurodegeneration with efficacy comparable to or exceeding standard levodopa/benserazide treatment.</p><p><strong>Conclusion: </strong>Our findings establish a foundation for developing multi-target therapies based on natural products that may offer comprehensive neuroprotection with potentially fewer side effects than conventional pharmaceuticals.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of <i>Althaea officinalis</i> on Nicotine-Induced Lung Injury.","authors":"Ozlem Kara, Emin Kaymak","doi":"10.1159/000553245","DOIUrl":"10.1159/000553245","url":null,"abstract":"<p><strong>Introduction: </strong>Nicotine contributes to chronic pulmonary diseases by promoting oxidative stress, inflammation, and tissue remodeling, leading to alveolar destruction, septal thickening, and fibrosis. Althaea officinalis (AO), a medicinal plant with antioxidant and anti-inflammatory properties, may counteract these effects; however, its protective role against nicotine-induced lung injury is not well characterized. This study aimed to evaluate the impact of AO on nicotine-related oxidative and histological lung damage in rats.</p><p><strong>Methods: </strong>Thirty-two female Wistar albino rats were divided into four groups: control, AO (250 mg/kg), nicotine (0.5 mg/kg), and AO + nicotine. Treatments were administered for 14 days. Lung tissues were collected for biochemical and histopathological analyses. Oxidative stress was assessed by measuring superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels. Lung injury was evaluated using hematoxylin-eosin and Masson's trichrome staining, while apoptosis was assessed by Bax immunostaining.</p><p><strong>Results: </strong>Nicotine exposure increased MDA levels, Bax expression, and histological damage, while reducing SOD activity. AO co-treatment significantly reversed these effects by lowering MDA levels, reducing Bax immunoreactivity, restoring SOD activity, and improving lung architecture, including reduced alveolar destruction and septal thickening (p < 0.05).</p><p><strong>Conclusion: </strong>AO demonstrated notable antioxidant and cytoprotective effects against nicotine-induced lung injury. Its ability to reduce oxidative stress, apoptosis, and tissue damage suggests therapeutic potential for preventing pulmonary oxidative injury, supporting further research for possible clinical application.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1"},"PeriodicalIF":1.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and Alternative Medicine Use and Attitudes among Diabetes Patients in Primary Care: A Cross-Sectional Study.","authors":"Busra Bilik Sezer, Gizem Limnili, Nilgun Ozcakar","doi":"10.1159/000553036","DOIUrl":"10.1159/000553036","url":null,"abstract":"<p><strong>Introduction: </strong>Complementary and alternative medicine (CAM) is frequently used by individuals with chronic diseases, including diabetes mellitus. However, data regarding CAM use and attitudes among patients with diabetes in primary care settings remain limited, particularly in community-based populations.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 363 patients aged 18 years and older who were recruited through consecutive convenience sampling at family health centers and who presented for any reason between July and August 2023. Data were collected through face-to-face interviews. Instruments included a structured questionnaire (assessing sociodemographic and clinical characteristics and CAM-related variables) and the Complementary, Alternative, and Conventional Medicine Attitudes Scale (CACMAS).</p><p><strong>Results: </strong>Of the participants, 61.2% were female, the mean age was 59.8 ± 11.3 years, and the mean duration of diabetes was 9.2 ± 6.2 years. While 51.2% of participants were aware of CAM, 28.1% reported using at least one CAM modality - most frequently cupping and acupuncture - within the previous 12 months. The median CACMAS score was 97.0 (Q1-Q3: 90.0-108.0; range: 45.0-176.0). Higher CACMAS scores were observed among participants aged <65 years (p = 0.008), those with higher educational attainment (p = 0.001), higher income levels (p = 0.004), insulin users (p = 0.002), and CAM users (p < 0.001). In the multivariable regression analysis, higher monthly income remained the only variable associated with higher CACMAS scores (B = 5.82, 95% CI: 0.28-11.37, p = 0.040).</p><p><strong>Conclusion: </strong>In this cross-sectional primary care sample, CAM use and attitudes were associated with several sociodemographic and clinical characteristics; however, in the adjusted analysis, higher income was the only variable associated with more favorable CAM attitudes. As family physicians are often the first point of contact for individuals with diabetes, routinely inquiring about CAM use may support patient-centered care and facilitate communication between patients and healthcare providers. These findings reflect associations within the study sample rather than population-level prevalence estimates.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1"},"PeriodicalIF":1.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}