Complementary Medicine Research最新文献

{"title":"Efficacy and Safety of Retention Enema with Traditional Chinese Medicine for Chronic Radiation-Induced Rectal Injury: Study Protocol for a Multicenter Randomized Controlled Trial.","authors":"Shulan Hao, Xiaoli Li, Hanying Zhang, Likun Liu, Qiming Zhong, Yanni Lou, Zhiqiang Cheng, Liqun Jia, Xixing Wang","doi":"10.1159/000550367","DOIUrl":"10.1159/000550367","url":null,"abstract":"<p><p><p>Background: Chronic radiation-induced rectal injury (RRI) is a complication of pelvic radiotherapy, with existing treatments often providing suboptimal symptom relief. Traditional Chinese medicine (TCM) retention enema therapy, leveraging localized anti-inflammatory and mucosal regenerative properties, offers a promising alternative. This trial aims to evaluate the efficacy and safety of changrui enema powder (CEP), aiming to establish an evidence-based protocol for managing chronic RRI. Patients and Methods: This multicenter, randomized, triple-blinded controlled trial will enroll 180 participants (2:1 allocation) with grade 2 chronic RRI following pelvic radiotherapy. The experimental group will receive daily CEP enemas for 4 weeks plus a concurrent 1-week course of dexamethasone sodium phosphate (DEX) injection enemas, while the control group will receive an identical-appearing placebo enema for 4 weeks plus a concurrent 1-week course of DEX injection enema. Both interventions will be administered in a total enema volume of 100 mL. The primary outcome is the overall effective rate at 4 weeks, assessed using the LENT-SOMA scoring system. Secondary outcomes encompass TCM syndrome efficacy, the Vienna Rectoscopy Score, pain assessment, and quality of life. Conclusion: This trial is the first study to evaluate the efficacy and safety of a standardized TCM retention enema formulation (CEP) as an add-on to a short-course standard corticosteroid regimen for chronic RRI. The findings are expected to provide an objective clinical basis for integrating TCM into the management of chronic RRI and may inform the development of relevant clinical guidelines. </p>.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"139-148"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13021226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three New Philosophical Categories for Holistically Assessing Complementary Medicine, Derived from the History and Theory of Medicine.","authors":"Josef M Schmidt","doi":"10.1159/000551108","DOIUrl":"10.1159/000551108","url":null,"abstract":"<p><p><p>Background: Based on recent medical-historical research, the attempt is made to introduce three new philosophical categories for holistically assessing complementary medicine and delineate their characteristics, genealogy, and socio-economic background. Apart from modern, predominantly rational science and culture, the history and theory of medicine are able to reveal dimensions and traditions of thinking that in the modern age have obviously been neglected or forgotten. Summary: As an example, homoeopathy appears to be constituted by what may be called lógos-thinking, hómoion-thinking and iásthai-thinking, thus connecting with three powerful traditions of thinking that can be traced back to Ancient Greece and pre-Socratic times. By contrast, modern technological medicine seems to be mainly fixed on lógos-thinking. Other realms of modern civilisation, such as science, art, education, politics, philosophy, and religion, to a large extent also suffer from a lack of, or are oblivious to, hómoion-thinking and iásthai-thinking. Key Messages: The introduction of these new categories may serve as a key to a raised awareness towards the shortcomings and one-dimensionality of the present lógos-driven world-view and for the opening up of a qualitatively richer multi-dimensional world and life. </p>.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"107-114"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Metabolomics Study on Acupuncture plus Wet Cupping Therapy for Post-Stroke Depression: A Pilot Study.","authors":"Dong Li, Hang Gao, Jin Li, Larissa Tao, Weidong Shen, Wa Cai","doi":"10.1159/000550810","DOIUrl":"10.1159/000550810","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate urinary metabolomics alterations associated with acupuncture plus wet cupping (AC) therapy in patients with post-stroke depression (PSD).</p><p><strong>Methods: </strong>A total of 40 subjects were randomly allocated to either the acupuncture plus wet cupping group (AC group, n = 20) or the acupuncture group (Acu group, n = 20). Morning urine samples were collected at baseline and after 4 weeks of treatment, yielding a total of 80 samples. An additional 20 healthy volunteers served as a blank control group, from whom urine samples were also obtained. Urinary metabolites were analyzed using gas chromatography-mass spectrometry. Differential metabolites and related metabolic pathways were identified. Clinical efficacy was assessed using the Hamilton Depression Rating Scale-24 items (HAMD-24) at baseline and post-treatment. Correlation analysis was performed to assess the relationship between metabolic changes and clinical improvement.</p><p><strong>Results: </strong>After 4 weeks of treatment, the HAMD-24 scores in the AC group (median: 10.00, IQR: 9.00-13.00) were significantly lower than those in the Acu group (median: 18.00, IQR: 15.25-19.00), with a statistically significant between-group difference (p < 0.01). Metabolomic profiling revealed significant differences between healthy volunteers and untreated PSD patients, with 21 differential metabolites identified. Caffeine metabolism emerged as the most significantly altered pathway (FDR-P <0.05). No significant metabolic changes were detected in the Acu group after treatment. In contrast, the AC group demonstrated marked alterations, with 33 differential metabolites identified and starch and sucrose metabolism emerging as the most affected pathway (FDR-P <0.05). Furthermore, direct comparisons between the AC and Acu groups post-treatment identified 13 differential metabolites, with tyrosine metabolism as the most significantly impacted pathway (FDR-P <0.05). Correlation analysis showed that the differential metabolites in the AC group were significantly correlated with HAMD-24 score changes (p <0.05).</p><p><strong>Conclusions: </strong>Caffeine metabolism was associated with the metabolic distinction between healthy volunteers and PSD patients. AC therapy was associated with clinical improvement in PSD and alterations in starch and sucrose metabolism as well as tyrosine metabolism. Tyrosine metabolism may be the key metabolic pathway distinguishing AC therapy from acupuncture alone. These findings suggested that AC therapy may exert its effects through associations with alterations in energy metabolism and neurotransmitter synthesis, which was linked to the core pathophysiological mechanisms of PSD, though causal relationships require further investigation.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"115-138"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the Belief Scale for Complementary and Alternative Medicine.","authors":"Şule Çalışır Kundakçı, Tuğba Öz, Yusuf Karaşin, Yalçın Karagöz","doi":"10.1159/000550024","DOIUrl":"10.1159/000550024","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to develop a psychometric measurement tool to assess beliefs regarding complementary and alternative medicine and to ensure its validity.</p><p><strong>Methods: </strong>For the purpose of the study, sample of 735 people was reached between December 2023 and April 2024. During the scale development process, exploratory factor analysis was first conducted using packaged programs. The accuracy of structure determined by exploratory factor analysis was confirmed by confirmatory factor analysis.</p><p><strong>Results: </strong>The scale comprises 6 subdimensions, including psychological, self-efficacy, perceived barriers, acceptance, perceived benefits, and spirituality, with a total of 37 items. The Kaiser-Meyer-Olkin (KMO) value of the developed Belief Scale for Complementary and Alternative Medicine was calculated as 0.925. The Bartlett's test result was significant (p = 0.000), indicating high correlations among variables.</p><p><strong>Conclusion: </strong>The developed Belief Scale for Complementary and Alternative Medicine was found to be a reliable and valid scale with psychometric properties.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"79-88"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Exercise Tolerance and Physical Function in Elderly Patients with Heart Failure with Preserved Ejection Fraction by QiShen YiQi Dripping Pills.","authors":"YuXin Li, JunHao Gong, XiangPei Wang","doi":"10.1159/000550786","DOIUrl":"10.1159/000550786","url":null,"abstract":"<p><strong>Objective: </strong>Decreased exercise tolerance and impaired physical function in elderly patients with heart failure with preserved ejection fraction (HFpEF) are key issues affecting the quality of life, with limited enhancement from available treatments. QiShen YiQi (QSYQ) dripping pills have the effect of benefiting qi and activating blood. The aim of this study was to investigate its effects on the improvement of exercise tolerance, physical function, and cardiac function in elderly patients with HFpEF.</p><p><strong>Methods: </strong>This study is an open-label, evaluator-blinded randomized controlled trial, which included 84 elderly HFpEF patients ≥65 years old from January 2023 to March 2025, and is randomly divided into a control group (42 patients) and a treatment group (42 patients). The control group was treated with basic HFpEF therapy (following the 2022 ESC and 2023 Chinese Heart Failure Guidelines), and the treatment group was treated with QSYQ dropping pills (0.5 g/trip, 3 times daily for 12 weeks) in combination with basic therapy. The primary endpoint was 6-min walking distance (6MWD) at 12 weeks, and secondary endpoints included physical function indices (4-meter walking speed, grip strength, SPPB total score, etc.), quality of life score (KCCQ, etc.), laboratory index (NT-proBNP), and echocardiographic parameters (LVEF, LAVI, etc.).</p><p><strong>Results: </strong>The baseline characteristics of the two groups were comparable (p > 0.05). After 12 weeks of treatment, 6MWD increased significantly in the treatment group compared with the control group (difference between groups: 20.38 meters, 95% CI: 1.74-39.02, p = 0.035) and showed a trend of continuous improvement with the duration of treatment (baseline vs. 12 weeks, p = 0.010). Among the secondary endpoints, the treatment group showed significantly better improvement in SPPB total score (p < 0.001), KCCQ score (p < 0.001), and LAVI (p = 0.039) than the control group, and there was a trend of decreasing NT-proBNP, but the difference was not statistically significant between the groups (p = 0.096). After adjusting for confounders, the improvement of 6MWD in the treatment group was still significantly better than that in the control group (p = 0.035).</p><p><strong>Conclusion: </strong>The combination of QSYQ dripping pills with standard therapy may yield limited improvements in exercise tolerance, physical function, and quality of life for elderly patients with HFpEF, and may potentially mitigate left atrial remodeling. However, given the sample size and design limitations of this study, these findings are exploratory. Their precise clinical value and long-term safety require validation through further large-scale studies.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"95-106"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Medicine Research Activity in Switzerland: A Systematic Review and Bibliometric Analysis.","authors":"Bingjun Chen, Xiaoying Lv, Koryna Lottenbach, Chantal Zeier, Dominic Jaminet, Sarangoo Solongo, Timo Hummel, Talia Wicker, Ahmet Sevik, Xiaying Wang, Michael Hammes, Yiming Li, Saroj K Pradhan, Michael Furian","doi":"10.1159/000550868","DOIUrl":"10.1159/000550868","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional Chinese medicine (TCM) is becoming popular in Switzerland; however, Swiss TCM research activity and scientific output have not been investigated. The objective of this work was to describe the Swiss TCM research activities and main health conditions studied.</p><p><strong>Methods: </strong>A systematic literature search of PubMed (covering databases such as MEDLINE, life science journals and online books) and Embase was performed from database inception to December 31, 2023. Articles describing a TCM-related therapy modality in humans with at least one author affiliated with a Swiss institution were selected for the study. The primary outcome was the main health condition studied. Secondary outcomes were the total number of articles published over time, the TCM therapies used, and the Swiss institutions involved.</p><p><strong>Results: </strong>Of the 223 published articles included in the final analysis, 68.2% originated from the top 3 of 73 Swiss institutions: the University of Zurich (32.3%), University of Bern (30.0%), and University of Basel (7.6%). Overall, 116 (52.0%) articles described original studies containing primary data. The top health category studied was pain management (16.4%). The most used TCM therapies were acupuncture and moxibustion (61.2%).</p><p><strong>Conclusion: </strong>Until 2023, the total number of scientific TCM output by Swiss authors is steadily increasing but remains small. More effort to conducted TCM research and elucidate the TCM therapy effects in Switzerland is warranted.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"174-184"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000550266","DOIUrl":"10.1159/000550266","url":null,"abstract":"<p><p>In the article by Kalbermatten and Saller entitled \"St John's Wort (Hypericum perforatum) Fresh Plant Tincture for Patients with Mild to Moderate Depression: A Prospective Observational Study\" [Complement Med Res. 2025;32:363-375; https://doi.org/10.1159/000547920], there is an error in Table 1. In the row for \"C-SJW-ft (pp strict)\", several values were incorrectly reported due to an extraneous \"1\" being added before the correct numbers and abbreviations. The correct values should be: \"C-SJW-ft (pp strict)\" (not \"1C-SJW-ft\"), 42 (not 142), 76% (not 176%), 24% (not 124%), 51 (not 151), 11.8 drops (not 111.8 drops), 49% (not 149%), and 50% (not 150%).The original article has been updated.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"89"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000551265","DOIUrl":"10.1159/000551265","url":null,"abstract":"<p><p>The article \"Yoga Nidra and Pain: A between-, within-Group Meta-Analysis and Dose Response Meta-Regression\" [Complement Med Res. 2025;32:495-521; https://doi.org/10.1159/000549416] by Ghai and Ghai was published with the wrong open access license. The correct license of the article is CC-BY.The original article has been updated.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"185"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Adult Lead Poisoning following the Use of Nonprescription Ayurvedic Medication in Germany.","authors":"Rodina Acharya-Büch, Pune Ivaki, Michael Jeitler, Vijayendra Murthy, Christian S Kessler","doi":"10.1159/000549523","DOIUrl":"10.1159/000549523","url":null,"abstract":"<p><strong>Introduction: </strong>This case report describes a 65-year-old female patient from Germany who developed clinically significant lead poisoning following the use of Ayurvedic herbal preparations provided by an unlicensed practitioner in a major German city.</p><p><strong>Case presentation: </strong>Although the patient presented with nonspecific symptoms such as weight loss, fatigue, and gastrointestinal complaints - possible indicators of heavy metal toxicity - these warning signs were initially overlooked by the practitioner. It was only after a colleague at the same institute raised concerns that appropriate diagnostic investigations were initiated. Laboratory analyses revealed a markedly elevated blood lead level (BLL) of 574 µg/L, prompting hospitalization and initiation of chelation therapy with dimercaptosuccinic acid (DMSA). The patient responded well to DMSA therapy, with subsequent serum lead levels showing a marked decrease to 86 µg/L at a 10-months follow-up. She tolerated the treatment without significant adverse effects and is in good health, able to engage fully in both her personal and professional life. Despite this adverse experience with lead toxicity resulting from advice given by an unlicensed Ayurvedic practitioner, the patient remains interested in Ayurveda - now with a strong preference for treatment by qualified and licensed professionals.</p><p><strong>Conclusion: </strong>This case underscores a key lesson: adverse outcomes in traditional medicine often result not from the therapeutic system itself but from its use outside of regulatory and ethical frameworks. It highlights the importance of seeking care from trained and licensed practitioners and emphasizes the necessity of sourcing botanical products only from rigorously tested, quality-controlled, and legally registered suppliers within the European Union or other places outside Ayurveda´s countries of origin. Using preparations following rasa-śāstra -practice is contraindicated in the EU because of possibly toxic doses of heavy metals.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"59-68"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tai Chi and Qigong on Heart Rate Variability: A Systematic Review and Meta-Analysis Examining Baseline Autonomic Function and Intervention Complexity as Moderators in Adults.","authors":"Yasmine A Gunawan, Mein-Woei Suen, Hanifa M Denny, Ishita Chauhan, Milcha Fakhria, Siswi Jayanti, Earl F I Mallari","doi":"10.1159/000550084","DOIUrl":"10.1159/000550084","url":null,"abstract":"<p><strong>Introduction: </strong>Tai Chi and Qigong (TCQ) are mind-body practices widely recognized for their psychological benefits; however, the underlying physiological mechanisms remain less clearly defined. Time-domain heart rate variability (HRV) indices, specifically standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences (RMSSD), serve as valuable markers of autonomic function. This meta-analysis quantified the effects of TCQ on these HRV parameters and examined whether baseline autonomic function and intervention complexity influenced outcomes.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines and a registered protocol (PROSPERO CRD420251053398), randomized controlled and quasi-experimental studies comparing TCQ with control interventions in adults were systematically synthesized. Comprehensive searches were conducted in PubMed, Scopus, CINAHL Ultimate, and MEDLINE Ultimate databases from 2022 to 2025, with earlier studies identified through backward citation tracking. Eligible studies reported time-domain HRV outcomes with SDNN and RMSSD as the primary endpoints. The risk of bias was assessed using RoB 2 for randomized controlled trials and ROBINS-I for non-randomized studies. Random-effects meta-analyses were conducted to estimate Hedges' g with 95% confidence intervals. Pre-specified moderators included baseline autonomic function and intervention complexity.</p><p><strong>Results: </strong>Fifteen studies met the inclusion criteria, all involving participants who were naïve to TCQ. Ten studies (N = 543) provided SDNN data, and pooled analyses showed a moderate improvement with TCQ (g = 0.47, 95% CI: [0.22, 0.72]; p < 0.001; I2 = 49%; τ2 = 0.078). Four studies (N = 212) reported RMSSD data, revealing a significant increase (g = 0.60, 95% CI: [0.21, 0.99]; p = 0.002; I2 = 49%; τ2 = 0.078). The risk of bias was generally assessed as having some concerns. Notably, baseline autonomic function significantly moderated treatment effects, with larger gains observed in participants exhibiting preserved baseline autonomic function (Q = 7.59, p = 0.014); however, intervention complexity did not significantly influence outcomes (Q = 0.02, p = 0.89).</p><p><strong>Conclusion: </strong>TCQ was associated with moderate improvements in time-domain HRV (SDNN and RMSSD). The effects were larger at normal baseline HRV, and we found no evidence that intervention complexity modified the outcomes. The certainty of evidence is limited by the risk of bias, potential confounding, and heterogeneity. Low-complexity readiness-tailored routines may be appropriate for pilot prevention or adjunctive programs. Confirmation requires well-powered baseline-stratified trials, particularly in impaired cohorts.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"42-58"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}