GARLIC EXTRACT IN RHEUMATOLOGICAL DISEASES: A REVIEW.

IF 0.8 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary Medicine Research Pub Date : 2025-07-02 DOI:10.1159/000547181

Jozélio Freire de Carvalho, Aaron Lerner, Carina Benzvi

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引用次数: 0

Abstract

Background: Garlic and garlic extract (GE) are highly consumed traditional and popular food spices. They are reported to have antioxidant, anti-inflammatory, and infection-protecting properties. The aim of this study was to review the use of GE in various rheumatic diseases.

Summary: PubMed/MEDLINE, EMBASE, and Scielo were searched for articles on GE and rheumatic diseases between 1966 and May 2024. Four articles were found, including 176 patients. The investigated diseases were RA (n=3) and OA (n=1). Age varied from 51.06 ± 13.8 to 58.9 ± 7.5 years old, and female gender was the only one included in all studies. The disease duration was 6.58 ± 7.75 years. The GE dosage ranged from 600 mg to 1,000 mg/day. The follow-up ranged from 4 to 12 weeks. All articles demonstrated improvements in the diverse rheumatic disease parameters (e.g., pain, function, disease activity, tender and swollen joints, stiffness, and WOMAC) and reduced inflammatory biomarkers (C-reactive protein, tumor necrosis factor, malondialdehyde(. Key-messages: GE is a safe and well-tolerated therapy for RA and OA. However, studies with more participants are needed to confirm, replicate, and further explore the topic.

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大蒜提取物在风湿病中的研究进展。

背景：大蒜和大蒜提取物（GE）是消费量很大的传统和流行的食品香料。据报道，它们具有抗氧化、抗炎和抗感染的特性。本研究的目的是回顾GE在各种风湿性疾病中的应用。摘要：PubMed/MEDLINE， EMBASE和Scielo检索了1966年至2024年5月期间关于GE和风湿病的文章。共发现4篇文章，176例患者。调查疾病为RA （n=3）和OA （n=1）。年龄范围为51.06±13.8 ~ 58.9±7.5岁，所有研究均纳入女性。病程为6.58±7.75年。GE的剂量从600毫克到1000毫克/天不等。随访时间为4至12周。所有的文章都证明了各种风湿性疾病参数（如疼痛、功能、疾病活动性、关节压痛和肿胀、僵硬和WOMAC）的改善，以及炎症生物标志物（c反应蛋白、肿瘤坏死因子、丙二醛（C-reactive protein））的降低。关键信息：GE是一种安全且耐受性良好的RA和OA治疗方法。然而，需要更多参与者的研究来证实、重复和进一步探索这一主题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

2.90

自引率

5.60%

发文量

期刊介绍： Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR