Garlic Extract in Rheumatological Diseases: A Systematic Review.

IF 0.8 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary Medicine Research Pub Date : 2025-07-02 DOI:10.1159/000547181

Jozélio Freire de Carvalho, Aaron Lerner, Carina Benzvi

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引用次数: 0

Abstract

Background: Garlic and garlic extract (GE) are highly consumed traditional and popular food spices. They are reported to have antioxidant, anti-inflammatory, and infection-protecting properties. The aim of this study was to review the use of GE in various rheumatic diseases.

Summary: PubMed/MEDLINE, Embase, and SciELO were searched for articles on GE and rheumatic diseases between 1966 and May 2024. Four articles were found, including 176 patients. The investigated diseases were rheumatoid arthritis (RA) (n = 3) and osteoarthritis (OA) (n = 1). Age varied from 51.06 ± 13.8 to 58.9 ± 7.5 years old, and female gender was the only one included in all studies. The disease duration was 6.58 ± 7.75 years. The GE dosage ranged from 600 mg to 1,000 mg/day. The follow-up ranged from 4 to 12 weeks. All articles demonstrated improvements in the diverse rheumatic disease parameters (e.g., pain, function, disease activity, tender and swollen joints, stiffness, and WOMAC) and reduced inflammatory biomarkers (C-reactive protein, tumor necrosis factor, malondialdehyde).

Key messages: GE is a safe and well-tolerated therapy for RA and OA. However, studies with more participants are needed to confirm, replicate, and further explore the topic.

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大蒜提取物在风湿病中的研究进展。

背景：大蒜和大蒜提取物（GE）是消费量很大的传统和流行的食品香料。据报道，它们具有抗氧化、抗炎和抗感染的特性。本研究的目的是回顾GE在各种风湿性疾病中的应用。摘要：PubMed/MEDLINE， EMBASE和Scielo检索了1966年至2024年5月期间关于GE和风湿病的文章。共发现4篇文章，176例患者。调查疾病为RA （n=3）和OA （n=1）。年龄范围为51.06±13.8 ~ 58.9±7.5岁，所有研究均纳入女性。病程为6.58±7.75年。GE的剂量从600毫克到1000毫克/天不等。随访时间为4至12周。所有的文章都证明了各种风湿性疾病参数（如疼痛、功能、疾病活动性、关节压痛和肿胀、僵硬和WOMAC）的改善，以及炎症生物标志物（c反应蛋白、肿瘤坏死因子、丙二醛（C-reactive protein））的降低。关键信息：GE是一种安全且耐受性良好的RA和OA治疗方法。然而，需要更多参与者的研究来证实、重复和进一步探索这一主题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

2.90

自引率

5.60%

发文量

期刊介绍： Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR