CNS Spectrums最新文献_第6页

Anxious distress in people with major depressive episodes: a cross-sectional analysis of clinical correlates. 重度抑郁发作患者的焦虑痛苦：临床相关性横断面分析。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-07-25 DOI: 10.1017/S1092852923002377

Francesco Bartoli, Bianca Bachi, Tommaso Callovini, Dario Palpella, Susanna Piacenti, Marco Morreale, Maria Elisa Di Lella, Cristina Crocamo, Giuseppe Carrà

{"title":"Anxious distress in people with major depressive episodes: a cross-sectional analysis of clinical correlates.","authors":"Francesco Bartoli, Bianca Bachi, Tommaso Callovini, Dario Palpella, Susanna Piacenti, Marco Morreale, Maria Elisa Di Lella, Cristina Crocamo, Giuseppe Carrà","doi":"10.1017/S1092852923002377","DOIUrl":"10.1017/S1092852923002377","url":null,"abstract":"Objective: Most people with major depressive episodes meet the criteria for the anxious distress (AD) specifier defined by DSM-5 as the presence of symptoms such as feelings of tension, restlessness, difficulty concentrating, and fear that something awful may happen. This cross-sectional study was aimed at identifying clinical correlates of AD in people with unipolar or bipolar depression.Methods: Inpatients with a current major depressive episode were included. Data on socio-demographic and clinical variables were collected. The SCID-5 was used to diagnose depressive episodes and relevant specifiers. The Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to assess the severity of depressive and manic (mixed) symptoms, respectively. Multiple logistic regression analyses were carried out to identify clinical correlates of AD.Results: We included 206 people (mean age: 48.4 ± 18.6 yrs.; males: 38.8%) admitted for a major depressive episode (155 with major depressive disorder and 51 with bipolar disorder). Around two-thirds of the sample (N = 137; 66.5%) had AD. Multiple logistic regression models showed that AD was associated with mixed features, higher YMRS scores, psychotic features, and a diagnosis of major depressive disorder (p < 0.05).Conclusion: Despite some limitations, including the cross-sectional design and the inpatient setting, our study shows that AD is likely to be associated with mixed and psychotic features, as well as with unipolar depression. The identification of these clinical domains may help clinicians to better contextualize AD in the context of major depressive episodes.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring suicidality in the aftermath of the 2022 flood in Pakistan: insights from newspaper reports. 探索 2022 年巴基斯坦洪灾后的自杀现象：从报纸报道中获得的启示。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-08-15 DOI: 10.1017/S1092852923002419

Rameez A Mahesar, Hadia Khalil, Sadia Shaikh, Aqsa Kalhoro, Allah B Rajar, Momina A Memon, Mohammed A Mamun

引用次数: 0

Off-label psychopharmacological interventions for autism spectrum disorders: strategic pathways for clinicians. 标签外精神药物干预自闭症谱系障碍：临床医生的战略途径。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-08-04 DOI: 10.1017/S1092852923002389

Nihit Gupta, Mayank Gupta

{"title":"Off-label psychopharmacological interventions for autism spectrum disorders: strategic pathways for clinicians.","authors":"Nihit Gupta, Mayank Gupta","doi":"10.1017/S1092852923002389","DOIUrl":"10.1017/S1092852923002389","url":null,"abstract":"The prevalence of autism spectrum disorder (ASD) continues to see a trend upward with a noticeable increase to 1 in 36 children less than 8 years of age in the recent MMWR. There are many factors linked to the substantially increased burden of seeking mental health services, and clinically these individuals are likely to present for impairments associated with co-occurring conditions. The advances in cutting-edge research and the understanding of co-occurring conditions in addition to psychosocial interventions have provided a window of opportunity for psychopharmacological interventions given the limited availability of therapeutics for core symptomatology. The off-label psychopharmacological treatments for these co-occurring conditions are central to clinical practice. However, the scattered evidence remains an impediment for practitioners to systematically utilize these options. The review collates the crucial scientific literature to provide stepwise treatment alternatives for individuals with ASD; with an aim to lead practitioners in making informed and shared decisions. There are many questions about the safety and tolerability of off-label medications; however, it is considered the best practice to utilize the available empirical data in providing psychoeducation for patients, families, and caregivers. The review also covers experimental medications and theoretical underpinnings to enhance further experimental studies. In summary, amidst the growing clinical needs for individuals with ASD and the lack of approved clinical treatments, the review addresses these gaps with a practical guide to appraise the risk and benefits of off-label medications.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice. 精确精神病学和研究领域标准：对临床试验和未来实践的启示。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-07 DOI: 10.1017/S1092852923002420

Leanne M Williams, William T Carpenter, Carrie Carretta, Evangelos Papanastasiou, Uma Vaidyanathan

{"title":"Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice.","authors":"Leanne M Williams, William T Carpenter, Carrie Carretta, Evangelos Papanastasiou, Uma Vaidyanathan","doi":"10.1017/S1092852923002420","DOIUrl":"10.1017/S1092852923002420","url":null,"abstract":"Psychiatric disorders are associated with significant social and economic burdens, many of which are related to issues with current diagnosis and treatments. The coronavirus (COVID-19) pandemic is estimated to have increased the prevalence and burden of major depressive and anxiety disorders, indicating an urgent need to strengthen mental health systems globally. To date, current approaches adopted in drug discovery and development for psychiatric disorders have been relatively unsuccessful. Precision psychiatry aims to tailor healthcare more closely to the needs of individual patients and, when informed by neuroscience, can offer the opportunity to improve the accuracy of disease classification, treatment decisions, and prevention efforts. In this review, we highlight the growing global interest in precision psychiatry and the potential for the National Institute of Health-devised Research Domain Criteria (RDoC) to facilitate the implementation of transdiagnostic and improved treatment approaches. The need for current psychiatric nosology to evolve with recent scientific advancements and increase awareness in emerging investigators/clinicians of the value of this approach is essential. Finally, we examine current challenges and future opportunities of adopting the RDoC-associated translational and transdiagnostic approaches in clinical studies, acknowledging that the strength of RDoC is that they form a dynamic framework of guiding principles that is intended to evolve continuously with scientific developments into the future. A collaborative approach that recruits expertise from multiple disciplines, while also considering the patient perspective, is needed to pave the way for precision psychiatry that can improve the prognosis and quality of life of psychiatric patients.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship among posttraumatic stress disorder, posttraumatic growth, and suicidal ideation among Italian healthcare workers during the first wave of COVID-19 pandemic. 新冠肺炎第一波疫情期间意大利医护人员创伤后应激障碍、创伤后成长和自杀念头之间的关系。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-27 DOI: 10.1017/S1092852923002493

Camilla Gesi, Rita Cafaro, Francesco Achilli, Maria Boscacci, Matteo Cerioli, Giovanna Cirnigliaro, Fotios Loupakis, Massimo Di Maio, Bernardo Dell'Osso

{"title":"The relationship among posttraumatic stress disorder, posttraumatic growth, and suicidal ideation among Italian healthcare workers during the first wave of COVID-19 pandemic.","authors":"Camilla Gesi, Rita Cafaro, Francesco Achilli, Maria Boscacci, Matteo Cerioli, Giovanna Cirnigliaro, Fotios Loupakis, Massimo Di Maio, Bernardo Dell'Osso","doi":"10.1017/S1092852923002493","DOIUrl":"10.1017/S1092852923002493","url":null,"abstract":"Objective: The COVID-19 pandemic impacted mental health across different groups, including healthcare workers (HWs). To date, few studies focused on potential positive aspects that may follow the exposure to the pandemic. We investigated the prevalence of posttraumatic stress disorder (PTSD) in Italian HWs and whether posttraumatic growth (PTG) dimensions affected the risk of suicidal ideation (SI) during the first COVID-19 wave.Methods: An online self-report survey was conducted between April and May 2020. Sociodemographic data, information about COVID-19-related stressful events, Impact of the Event Scale-revised, and Post-Traumatic Growth Inventory-Short Form (PTGI-SF) scores were collected and compared between participants. Patient Health Questionnaire-9 scores were also collected to assess SI through item 9. Multivariate logistic regression was used to assess the relationship between PTGI and SI.Results: Among 948 HWs, 257 (27.0%) reported a provisional PTSD diagnosis. The median PTGI-SF score was 24. Participants reporting PTSD symptoms had higher scores in the Spiritual change, Appreciation of life, and New possibilities domains, and in the total PTG scale. A total of 100 HWs (10.8%) screened positive for SI. Improvements in Relating to others domain of PTGI-SF (odds ratioOR: .46; 95% confidence interval: .25-.85) were associated with lower odds of SI.Conclusions: COVID-19 pandemic has been indicated as a risk factor for SI, also among HWs. PTG may have a protective role on suicide risk. Improvements in Relating to others domain reduced odds of SI, consistently with the role of loneliness and lack of connectedness with others in enhancing suicidal risk.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from a multicenter, international, large sample size analysis of patients with obsessive-compulsive disorders: an overview of the ICOCS Snapshot studies. 一项针对强迫症患者的多中心、国际、大样本分析的经验教训：ICOCS快照研究综述。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-11 DOI: 10.1017/S1092852923002432

Matteo Vismara, Beatrice Benatti, Naomi A Fineberg, Eric Hollander, Michael Van Ameringen, Jose M Menchon, Joseph Zohar, Bernardo Dell'Osso

引用次数: 0

Duration of untreated illness in gambling disorder. 赌博障碍未经治疗的疾病持续时间。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-11 DOI: 10.1017/S1092852923002444

Jon E Grant, Samuel R Chamberlain

{"title":"Duration of untreated illness in gambling disorder.","authors":"Jon E Grant, Samuel R Chamberlain","doi":"10.1017/S1092852923002444","DOIUrl":"10.1017/S1092852923002444","url":null,"abstract":"Objective: Gambling disorder is common, affects 0.5-2% of the population, and is under-treated. Duration of untreated illness (DUI) has emerged as a clinically important concept in the context of other mental disorders, but DUI in gambling disorder, has received little research scrutiny.Methods: Data were aggregated from previous clinical trials in gambling disorder with people who had never previously received any treatment. DUI was quantified, and clinical characteristics were compared as a function of DUI status.Results: A total of 298 individuals were included, and the mean DUI (standard deviation) was 8.9 (8.4) years, and the median DUI was 6 years. Longer DUI was significantly associated with male gender, older age, earlier age when the person first started to gamble, and family history of alcohol use disorder. Longer DUI was not significantly associated with racial-ethnic status, gambling symptom severity, current depressive or anxiety severity, comorbidities, or disability/functioning. The two groups did not differ in their propensity to drop out of the clinical trials, nor in overall symptom improvement associated with participation in those trials.Conclusions: These data suggest that gambling disorder has a relatively long DUI and highlight the need to raise awareness and foster early intervention for affected and at-risk individuals. Because earlier age at first gambling in any form was strongly linked to longer DUI, this highlights the need for more rigorous legislation and education to reduce exposure of younger people to gambling.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10202284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric providers' attitudes toward patients with borderline personality disorder and possible ways to improve them. 精神科医生对边缘型人格障碍患者的态度及可能的改善方法。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-11-23 DOI: 10.1017/S1092852923006326

Diane U Ukwuoma, Kachikwulu A Ajulu, Dongliang Wang, Sergey Golovko, Jarred Marks, Luba Leontieva

{"title":"Psychiatric providers' attitudes toward patients with borderline personality disorder and possible ways to improve them.","authors":"Diane U Ukwuoma, Kachikwulu A Ajulu, Dongliang Wang, Sergey Golovko, Jarred Marks, Luba Leontieva","doi":"10.1017/S1092852923006326","DOIUrl":"10.1017/S1092852923006326","url":null,"abstract":"Objective: Tending to patients with a diagnosis of borderline personality disorder (BPD) is a challenging task for clinicians due to stigma and differences in opinion within the psychiatric community. Various symptoms of BPD including affective instability, mood reactivity, and extremes of idealization are associated with challenging emotions toward patients with BPD. This observational research study utilized an adaptation of the 37-question Attitude to Personality Disorder Questionnaire (APDQ) to assess the attitudes of clinicians toward patients with BPD.Methods: This questionnaire was distributed to 139 clinicians including psychiatry attendings, psychiatry residents, registered nurses, nurse practitioners, social workers, recreation and art therapists, and psychologists who worked with patients diagnosed with BPD on an inpatient unit. Responses of participants were compared based on occupation, gender, and duration of years worked on an inpatient psychiatric unit.Results: Results show that individuals employed in occupations under the \"other health professionals\" category had more positive transference (which included feelings of respect toward BPD patients along with feelings of closeness and warmth) toward patients with BPD, and nurses had an increased total score for lack of valid difficulties compared with other health professionals. When grouping by gender and duration of year spent working on an inpatient unit, there were no significant differences in the response toward patients with BPD in affective situations.Conclusion: Clinical implications are discussed, as well as the need for training to help improve staff attitudes toward this patient population.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138294858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CNS volume 29 issue 1 Cover and Front matter CNS 第 29 卷第 1 期封面和封底

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 DOI: 10.1017/s109285292400004x

引用次数: 0

Lumateperone monotherapy for treatment-resistant obsessive-compulsive disorder in an adolescent. Lumateperone单药治疗青少年顽固性强迫症。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-14 DOI: 10.1017/S1092852923002468

Ahmed Naguy, Saxby Pridmore, Mohamed Y Abuzeid, Dalal Elsori, Bibi Alamiri

引用次数: 0