CNS Spectrums最新文献_第10页

Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice. 精确精神病学和研究领域标准：对临床试验和未来实践的启示。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-07 DOI: 10.1017/S1092852923002420

Leanne M Williams, William T Carpenter, Carrie Carretta, Evangelos Papanastasiou, Uma Vaidyanathan

{"title":"Precision psychiatry and Research Domain Criteria: Implications for clinical trials and future practice.","authors":"Leanne M Williams, William T Carpenter, Carrie Carretta, Evangelos Papanastasiou, Uma Vaidyanathan","doi":"10.1017/S1092852923002420","DOIUrl":"10.1017/S1092852923002420","url":null,"abstract":"Psychiatric disorders are associated with significant social and economic burdens, many of which are related to issues with current diagnosis and treatments. The coronavirus (COVID-19) pandemic is estimated to have increased the prevalence and burden of major depressive and anxiety disorders, indicating an urgent need to strengthen mental health systems globally. To date, current approaches adopted in drug discovery and development for psychiatric disorders have been relatively unsuccessful. Precision psychiatry aims to tailor healthcare more closely to the needs of individual patients and, when informed by neuroscience, can offer the opportunity to improve the accuracy of disease classification, treatment decisions, and prevention efforts. In this review, we highlight the growing global interest in precision psychiatry and the potential for the National Institute of Health-devised Research Domain Criteria (RDoC) to facilitate the implementation of transdiagnostic and improved treatment approaches. The need for current psychiatric nosology to evolve with recent scientific advancements and increase awareness in emerging investigators/clinicians of the value of this approach is essential. Finally, we examine current challenges and future opportunities of adopting the RDoC-associated translational and transdiagnostic approaches in clinical studies, acknowledging that the strength of RDoC is that they form a dynamic framework of guiding principles that is intended to evolve continuously with scientific developments into the future. A collaborative approach that recruits expertise from multiple disciplines, while also considering the patient perspective, is needed to pave the way for precision psychiatry that can improve the prognosis and quality of life of psychiatric patients.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"26-39"},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from a multicenter, international, large sample size analysis of patients with obsessive-compulsive disorders: an overview of the ICOCS Snapshot studies. 一项针对强迫症患者的多中心、国际、大样本分析的经验教训：ICOCS快照研究综述。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-11 DOI: 10.1017/S1092852923002432

Matteo Vismara, Beatrice Benatti, Naomi A Fineberg, Eric Hollander, Michael Van Ameringen, Jose M Menchon, Joseph Zohar, Bernardo Dell'Osso

引用次数: 0

The relationship among posttraumatic stress disorder, posttraumatic growth, and suicidal ideation among Italian healthcare workers during the first wave of COVID-19 pandemic. 新冠肺炎第一波疫情期间意大利医护人员创伤后应激障碍、创伤后成长和自杀念头之间的关系。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-27 DOI: 10.1017/S1092852923002493

Camilla Gesi, Rita Cafaro, Francesco Achilli, Maria Boscacci, Matteo Cerioli, Giovanna Cirnigliaro, Fotios Loupakis, Massimo Di Maio, Bernardo Dell'Osso

{"title":"The relationship among posttraumatic stress disorder, posttraumatic growth, and suicidal ideation among Italian healthcare workers during the first wave of COVID-19 pandemic.","authors":"Camilla Gesi, Rita Cafaro, Francesco Achilli, Maria Boscacci, Matteo Cerioli, Giovanna Cirnigliaro, Fotios Loupakis, Massimo Di Maio, Bernardo Dell'Osso","doi":"10.1017/S1092852923002493","DOIUrl":"10.1017/S1092852923002493","url":null,"abstract":"Objective: The COVID-19 pandemic impacted mental health across different groups, including healthcare workers (HWs). To date, few studies focused on potential positive aspects that may follow the exposure to the pandemic. We investigated the prevalence of posttraumatic stress disorder (PTSD) in Italian HWs and whether posttraumatic growth (PTG) dimensions affected the risk of suicidal ideation (SI) during the first COVID-19 wave.Methods: An online self-report survey was conducted between April and May 2020. Sociodemographic data, information about COVID-19-related stressful events, Impact of the Event Scale-revised, and Post-Traumatic Growth Inventory-Short Form (PTGI-SF) scores were collected and compared between participants. Patient Health Questionnaire-9 scores were also collected to assess SI through item 9. Multivariate logistic regression was used to assess the relationship between PTGI and SI.Results: Among 948 HWs, 257 (27.0%) reported a provisional PTSD diagnosis. The median PTGI-SF score was 24. Participants reporting PTSD symptoms had higher scores in the Spiritual change, Appreciation of life, and New possibilities domains, and in the total PTG scale. A total of 100 HWs (10.8%) screened positive for SI. Improvements in Relating to others domain of PTGI-SF (odds ratioOR: .46; 95% confidence interval: .25-.85) were associated with lower odds of SI.Conclusions: COVID-19 pandemic has been indicated as a risk factor for SI, also among HWs. PTG may have a protective role on suicide risk. Improvements in Relating to others domain reduced odds of SI, consistently with the role of loneliness and lack of connectedness with others in enhancing suicidal risk.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"60-64"},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duration of untreated illness in gambling disorder. 赌博障碍未经治疗的疾病持续时间。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-11 DOI: 10.1017/S1092852923002444

Jon E Grant, Samuel R Chamberlain

{"title":"Duration of untreated illness in gambling disorder.","authors":"Jon E Grant, Samuel R Chamberlain","doi":"10.1017/S1092852923002444","DOIUrl":"10.1017/S1092852923002444","url":null,"abstract":"Objective: Gambling disorder is common, affects 0.5-2% of the population, and is under-treated. Duration of untreated illness (DUI) has emerged as a clinically important concept in the context of other mental disorders, but DUI in gambling disorder, has received little research scrutiny.Methods: Data were aggregated from previous clinical trials in gambling disorder with people who had never previously received any treatment. DUI was quantified, and clinical characteristics were compared as a function of DUI status.Results: A total of 298 individuals were included, and the mean DUI (standard deviation) was 8.9 (8.4) years, and the median DUI was 6 years. Longer DUI was significantly associated with male gender, older age, earlier age when the person first started to gamble, and family history of alcohol use disorder. Longer DUI was not significantly associated with racial-ethnic status, gambling symptom severity, current depressive or anxiety severity, comorbidities, or disability/functioning. The two groups did not differ in their propensity to drop out of the clinical trials, nor in overall symptom improvement associated with participation in those trials.Conclusions: These data suggest that gambling disorder has a relatively long DUI and highlight the need to raise awareness and foster early intervention for affected and at-risk individuals. Because earlier age at first gambling in any form was strongly linked to longer DUI, this highlights the need for more rigorous legislation and education to reduce exposure of younger people to gambling.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"54-59"},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10202284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric providers' attitudes toward patients with borderline personality disorder and possible ways to improve them. 精神科医生对边缘型人格障碍患者的态度及可能的改善方法。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-11-23 DOI: 10.1017/S1092852923006326

Diane U Ukwuoma, Kachikwulu A Ajulu, Dongliang Wang, Sergey Golovko, Jarred Marks, Luba Leontieva

{"title":"Psychiatric providers' attitudes toward patients with borderline personality disorder and possible ways to improve them.","authors":"Diane U Ukwuoma, Kachikwulu A Ajulu, Dongliang Wang, Sergey Golovko, Jarred Marks, Luba Leontieva","doi":"10.1017/S1092852923006326","DOIUrl":"10.1017/S1092852923006326","url":null,"abstract":"Objective: Tending to patients with a diagnosis of borderline personality disorder (BPD) is a challenging task for clinicians due to stigma and differences in opinion within the psychiatric community. Various symptoms of BPD including affective instability, mood reactivity, and extremes of idealization are associated with challenging emotions toward patients with BPD. This observational research study utilized an adaptation of the 37-question Attitude to Personality Disorder Questionnaire (APDQ) to assess the attitudes of clinicians toward patients with BPD.Methods: This questionnaire was distributed to 139 clinicians including psychiatry attendings, psychiatry residents, registered nurses, nurse practitioners, social workers, recreation and art therapists, and psychologists who worked with patients diagnosed with BPD on an inpatient unit. Responses of participants were compared based on occupation, gender, and duration of years worked on an inpatient psychiatric unit.Results: Results show that individuals employed in occupations under the \"other health professionals\" category had more positive transference (which included feelings of respect toward BPD patients along with feelings of closeness and warmth) toward patients with BPD, and nurses had an increased total score for lack of valid difficulties compared with other health professionals. When grouping by gender and duration of year spent working on an inpatient unit, there were no significant differences in the response toward patients with BPD in affective situations.Conclusion: Clinical implications are discussed, as well as the need for training to help improve staff attitudes toward this patient population.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"65-75"},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138294858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lumateperone monotherapy for treatment-resistant obsessive-compulsive disorder in an adolescent. Lumateperone单药治疗青少年顽固性强迫症。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-02-01 Epub Date: 2023-09-14 DOI: 10.1017/S1092852923002468

Ahmed Naguy, Saxby Pridmore, Mohamed Y Abuzeid, Dalal Elsori, Bibi Alamiri

引用次数: 0

Cognition in adults with borderline personality disorder. 边缘型人格障碍成人的认知。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2023-12-01 Epub Date: 2023-03-16 DOI: 10.1017/S1092852923001177

Ibrahim H Aslan, Jon E Grant, Samuel R Chamberlain

{"title":"Cognition in adults with borderline personality disorder.","authors":"Ibrahim H Aslan, Jon E Grant, Samuel R Chamberlain","doi":"10.1017/S1092852923001177","DOIUrl":"10.1017/S1092852923001177","url":null,"abstract":"Objective: Borderline personality disorder (BPD) is a common and disabling mental health disorder and has detrimental effects on affected individuals across multiple domains. We aimed to investigate whether individuals with BPD differ from control subjects in terms of cognitive functions, and to see if there is a relationship between cognitive functions, impulsivity, and BPD symptom severity.Methods: BPD individuals (n = 26; mean age = 26.7; 69.2% female) and controls (n = 58; mean age = 25.3; 51.7% female) were enrolled. Intra/Extra-Dimensional Set Shift (IED) and One Touch Stockings of Cambridge (OTS) tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were used to assess cognitive functions. Barratt Impulsivity Scale-version 11 (BIS-11) was administered to measure impulsivity and both the Zanarini Scale for Borderline Personality Disorder self-report and the clinician-administered versions were used to assess BPD symptom severity.Results: BPD group showed significantly impaired cognitive performance on the IED task versus controls, but there was not a significant difference in the OTS task. BPD symptom severity was positively correlated with trait (BIS-11) impulsivity and no correlation was found between BPD symptom severity and cognitive functions.Conclusions: This study suggests people with BPD experience impaired cognitive flexibility and heightened impulsivity. Only impulsivity appeared to be directly related to symptom severity, perhaps indicating that cognitive inflexibility could be a vulnerability marker. Future research should focus on a longitudinal approach to extend clinical and theoretical knowledge in this area.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"674-679"},"PeriodicalIF":3.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9492008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Price of Love: how sleep, and dysregulated clocks may account for its obsessive-compulsive related behaviors? 爱的代价：睡眠和时钟失调如何解释其强迫症相关行为？

IF 3.3 3区医学

CNS Spectrums Pub Date : 2023-12-01 Epub Date: 2023-02-14 DOI: 10.1017/S1092852923000056

Miguel Meira E Cruz

引用次数: 0

Pro-inflammatory markers are associated with response to sequential pharmacotherapy in major depressive disorder: a CAN-BIND-1 report. 前炎症标志物与重度抑郁症患者对连续药物治疗的反应有关：CAN-BIND-1 报告。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2023-12-01 Epub Date: 2023-05-23 DOI: 10.1017/S109285292300233X

M Ishrat Husain, Jane A Foster, Brittany L Mason, Sheng Chen, Haoyu Zhao, Wei Wang, Susan Rotzinger, Sakina Rizvi, Keith Ho, Raymond Lam, Glenda MacQueen, Roumen Milev, Benicio N Frey, Daniel Müller, Gustavo Turecki, Manish Jha, Madhukar Trivedi, Sidney H Kennedy

{"title":"Pro-inflammatory markers are associated with response to sequential pharmacotherapy in major depressive disorder: a CAN-BIND-1 report.","authors":"M Ishrat Husain, Jane A Foster, Brittany L Mason, Sheng Chen, Haoyu Zhao, Wei Wang, Susan Rotzinger, Sakina Rizvi, Keith Ho, Raymond Lam, Glenda MacQueen, Roumen Milev, Benicio N Frey, Daniel Müller, Gustavo Turecki, Manish Jha, Madhukar Trivedi, Sidney H Kennedy","doi":"10.1017/S109285292300233X","DOIUrl":"10.1017/S109285292300233X","url":null,"abstract":"Objective: There is limited literature on associations between inflammatory tone and response to sequential pharmacotherapies in major depressive disorder (MDD).Methods: In a 16-week open-label clinical trial, 211 participants with MDD were treated with escitalopram 10-20 mg daily for 8 weeks. Responders continued escitalopram while non-responders received adjunctive aripiprazole 2-10 mg daily for 8 weeks. Plasma levels of pro-inflammatory markers-C-reactive protein, interleukin (IL)-1β, IL-6, IL-17, interferon-gamma (IFN)-Γ, tumor necrosis factor (TNF)-α, and Chemokine C-C motif ligand-2 (CCL-2)-measured at baseline, and after 2, 8 and 16 weeks were included in logistic regression analyzes to assess associations between inflammatory markers and treatment response.Results: Pre-treatment IFN-Γ and CCL-2 levels were significantly associated with a lower of odds of response to escitalopram at 8 weeks. Increases in CCL-2 levels from weeks 8 to 16 in escitalopram non-responders were significantly associated with higher odds of non-response to adjunctive aripiprazole at week 16.Conclusion: Higher pre-treatment levels of IFN-Γ and CCL-2 were associated with non-response to escitalopram. Increasing levels of these pro-inflammatory markers may be associated with non-response to adjunctive aripiprazole. These findings require validation in independent clinical populations.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"739-746"},"PeriodicalIF":3.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical benefits of vortioxetine 20 mg/day in patients with major depressive disorder. 伏替西汀 20 毫克/天对重度抑郁症患者的临床疗效。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2023-12-01 Epub Date: 2023-04-18 DOI: 10.1017/S1092852923002249

Michael C Christensen, Roger S McIntyre, Michael Adair, Ioana Florea, Henrik Loft, Andrea Fagiolini

{"title":"Clinical benefits of vortioxetine 20 mg/day in patients with major depressive disorder.","authors":"Michael C Christensen, Roger S McIntyre, Michael Adair, Ioana Florea, Henrik Loft, Andrea Fagiolini","doi":"10.1017/S1092852923002249","DOIUrl":"10.1017/S1092852923002249","url":null,"abstract":"Background: Vortioxetine has demonstrated dose-dependent efficacy in patients with major depressive disorder (MDD), with the greatest effect observed with vortioxetine 20 mg/day. This analysis further explored the clinical relevance of the more rapid and greater improvement in depressive symptoms observed with vortioxetine 20 mg/day vs 10 mg/day.Methods: Analysis of pooled data from six short-term (8-week), randomized, placebo-controlled, fixed-dose studies of vortioxetine 20 mg/day in patients with MDD (N = 2620). Symptomatic response (≥50% decrease in Montgomery-Åsberg Depression Rating Scale [MADRS] total score), sustained symptomatic response, and remission (MADRS total score ≤10) were assessed by vortioxetine dosage (20 or 10 mg/day).Results: After 8 weeks, 51.4% of patients receiving vortioxetine 20 mg/day had achieved symptomatic response vs 46.0% of those receiving vortioxetine 10 mg/day (P < .05). Significantly more patients achieved symptomatic response vs placebo from week 2 onwards for vortioxetine 20 mg/day and from week 6 onwards for vortioxetine 10 mg/day (both P ≤ .05). Sustained response was achieved from week 4 for 26.0% of patients receiving vortioxetine 20 mg/day vs 19.1% of those receiving vortioxetine 10 mg/day (P < .01), increasing to 36.0% and 29.8%, respectively, over the 8-week treatment period (P < .05). At week 8, 32.0% of patients receiving vortioxetine 20 mg/day were in remission vs 28.2% of those receiving vortioxetine 10 mg/day (P = .09). Rates of adverse events and treatment withdrawal were not increased during the week following vortioxetine dose up-titration to 20 mg/day.Conclusion: Vortioxetine 20 mg/day provides more rapid and more sustained symptomatic response than vortioxetine 10 mg/day in patients with MDD, without compromising tolerability.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"693-701"},"PeriodicalIF":3.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9528380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0