CNS Spectrums最新文献

Should Glutamatergic Modulators Be Considered Preferential Treatments for Adults with Major Depressive Disorder and A Reported History of Trauma? Conceptual and Clinical Implications. 谷氨酸调节剂应该被认为是成人重度抑郁症和创伤史患者的优先治疗药物吗？概念和临床意义。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-05-26 DOI: 10.1017/S1092852925100278

Kayla Teopiz, Heidi K Y Lo, Moiz Lakhani, Angela Kwan, Poh Khuen Lim, Melanie Zhang, Sabrina Wong, Gia Han Le, Jennifer Swainson, Bing Cao, Christine Dri, Roger Ho, Kyle Valentino, Roger S McIntyre

引用次数: 0

Exploring the Potential Benefits of Clonidine for Anxiety Disorders. 探索可乐定对焦虑症的潜在益处。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-05-16 DOI: 10.1017/S1092852925100266

Soojae Hollowell, Esha Aneja, Thomas Schwartz

引用次数: 0

An exploration of the determinants of risk formulation, care plan and disposition among older adults in the Ontario forensic psychiatry system: implication for practice. 安大略省法医精神病学系统中老年人风险制定、护理计划和处置决定因素的探索：实践意义。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-05-15 DOI: 10.1017/S1092852925100242

Mark M Kaggwa, Joan Abaatyo, Arianna Davids, Angela Li, Rebecca Marsh, Precious Agboinghale, John M W Bradford, Gary A Chaimowitz, Andrew T Olagunju

{"title":"An exploration of the determinants of risk formulation, care plan and disposition among older adults in the Ontario forensic psychiatry system: implication for practice.","authors":"Mark M Kaggwa, Joan Abaatyo, Arianna Davids, Angela Li, Rebecca Marsh, Precious Agboinghale, John M W Bradford, Gary A Chaimowitz, Andrew T Olagunju","doi":"10.1017/S1092852925100242","DOIUrl":"10.1017/S1092852925100242","url":null,"abstract":"Background: Advances in medicine have led to an improvement in life expectancy, thus increasing the population of older individuals within the criminal justice system. This study investigates the determinants of risk formulation, care plan, and disposition among older adult forensic patients (OAFP) in Ontario, Canada.Methods: This retrospective analysis utilized the Ontario Review Board database, focusing on 161 OAFP, aged 55 years and older. Hierarchical regression was used to analyze the relationship between changes in risk and six blocks of variables: sociodemographic characteristics (Block 1), circumstances during the index offense (Block 2), current clinical profile (Block 3), past psychiatric history and behavioral patterns (Block 4), criminal history and legal status (Block 5), and recent violent events (Block 6).Results: The median age of patients was 61 years (IQR 58-67), with 83.4% being male. Schizophrenia was the most common diagnosis (68.3%), and 9.3% had neurocognitive disorders. The model with six blocks of factors explained 92% of the variability in risk change. Models 2 (blocks 1 and 2) and 4 (blocks 1-4) were statistically significant, explaining 34% (p = 0.010) and 22% (p = 0.018) of the variance in the change in risk of threat to public safety, respectively. OAFP with a significant risk to public safety were more likely to be inpatients and less likely intoxicated during their index offense.Conclusion: Resources, policies, and a supervised model of care to curtail behavioral risks are relevant to the care of OAFP. Innovative risk management models for OAFP are indicated.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e40"},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recreational Drugs Repurposed for Medicinal Use - Cannabis. 重新用于医疗用途的娱乐性药物。大麻

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-04-25 DOI: 10.1017/S109285292500032X

Mike Armour, Justin Sinclair, Hannah Adler

引用次数: 0

Urgency to Treat and Early Optimized Treatment in Major Depressive Disorder: Consequences of Delayed Treatment, Barriers to Implementation, and Practical Strategies for Clinicians. 重度抑郁症的紧急治疗和早期优化治疗：延迟治疗的后果，实施的障碍，临床医生的实用策略。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-04-14 DOI: 10.1017/S1092852925000276

Oloruntoba J Oluboka, Jeffrey Habert, Atul Khullar, David J Robinson, Martin Katzman, Larry J Klassen, Claudio Soares, Pratap Chokka, Margaret A Oakander, Roger S McIntyre, Diane McIntosh, Pierre Blier, Sidney H Kennedy, Matthieu Boucher

引用次数: 0

Associations between subjective sleep quality and inflammatory markers in patients with treatment-resistant depression. 难治性抑郁症患者主观睡眠质量与炎症标志物之间的关系

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-04-11 DOI: 10.1017/S1092852925000227

Mao-Hsuan Huang, Mu-Hong Chen, Pei-Chi Tu, Ya-Mei Bai, Tung-Ping Su, Yee-Lam E Chan, Cheng-Ta Li

引用次数: 0

Neuroethics and treatment without consent. 神经伦理学和未经同意的治疗。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-04-11 DOI: 10.1017/S1092852925000264

Harry G Kennedy, Mary Davoren

{"title":"Neuroethics and treatment without consent.","authors":"Harry G Kennedy, Mary Davoren","doi":"10.1017/S1092852925000264","DOIUrl":"10.1017/S1092852925000264","url":null,"abstract":"Objectives: We consider the neuroethics of treatment without consent from a broader perspective than the accepted starting point of functional mental capacities. Notably, in common law jurisdictions, consciousness is seldom admitted in criminal law as a topic for expert evidence of mentalistic defenses or impairments in civil proceedings, yet consciousness and personality are central in Roman law jurisdictions.Methods: The framework we have adopted is to consider treatment without consent under the headings goals, processes, treatment, and evaluation. The ECHR and the judges of the European Court of Human Rights (ECtHR) are drawn from both common law and Roman law jurisdictions, so that their interpretations and precedents may be informative concerning alternatives to strict application of capacity tests.Results: There are variable thresholds for treating without consent according to the complexity and amount of information involved, the seriousness of the consequences of untreated illness, the effectiveness of the treatments available and the benefits of earlier intervention, particularly for disease-modifying treatments. Theory-driven principled approaches and scientific medical process approaches to ethical treatment are contrasted.Conclusions: Carrara's emphasis on the importance of consciousness and its layered dysfunctions as evidence of competence or impairment appears more robust than a narrow approach based only on functional mental capacity. Capacity-whether general or functional, remains amenable to rules of evidence and legal judgment at the expense of increasingly excessive simplification. Carrara's emphasis on the inherent dignity of the person appears most in keeping with modern human rights principles.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e39"},"PeriodicalIF":3.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which panic-agoraphobic symptoms could be associated with the presence of autistic traits among patients with panic disorder? 在惊恐障碍患者中，哪些惊恐广场恐惧症症状可能与自闭症特征有关？

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-04-10 DOI: 10.1017/S1092852925000240

Barbara Carpita, Chiara Bonelli, Francesca Parri, Gianluca Cerofolini, Cristiana Pronestì, Benedetta Nardi, Diego Laureti, Gabriele Massimetti, Ivan Mirko Cremone, Stefano Pini, Andrea Fiorillo, Lilliana Dell'Osso

引用次数: 0

The behavioral healthcare continuum in the United States: what should it look like and how we can pay for it. 行为保健连续体：它应该是什么样子以及我们如何支付它。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-03-25 DOI: 10.1017/S1092852925000197

Elinore F McCance-Katz

引用次数: 0

The role of previous streptococcal infections in adult patients with obsessive-compulsive disorder: a research study. 既往链球菌感染在成年强迫症患者中的作用：一项研究。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2025-03-24 DOI: 10.1017/S1092852925000203

Donatella Marazziti, Stefania Palermo, Alessandro Arone, Manuel Glauco Carbone, Lucia Massa, Lara Foresi Crowther, Nicola Schulz Bizzozzero Crivelli, Riccardo Gurrieri, Francesco Weiss, Federico Mucci, Liliana Dell'Osso

{"title":"The role of previous streptococcal infections in adult patients with obsessive-compulsive disorder: a research study.","authors":"Donatella Marazziti, Stefania Palermo, Alessandro Arone, Manuel Glauco Carbone, Lucia Massa, Lara Foresi Crowther, Nicola Schulz Bizzozzero Crivelli, Riccardo Gurrieri, Francesco Weiss, Federico Mucci, Liliana Dell'Osso","doi":"10.1017/S1092852925000203","DOIUrl":"10.1017/S1092852925000203","url":null,"abstract":"Introduction: Autoimmune processes have been documented in both childhood and adulthood patients with obsessive-compulsive disorder (OCD), with the pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) representing the paradigm of this model.Given the limited information available, the present study aimed at assessing the characteristics of adult patients with OCD exposed to a previous group A β-hemolytic Streptococcus infection, together with some peripheral inflammatory biomarkers.Materials and methods: Fifty-two subjects displaying antistreptolysin O (ASO) titer positivity were recruited from a sample of 247 adult OCD outpatients, diagnosed according to DSM-5 criteria and assessed by the Yale-Brown Obsessive-Compulsive Scale. Their clinical features were assessed and compared. The possible relationships between the different parameters were also examined.Results: Thirty-six subjects who were on medication for OCD showed significantly lower ASO titers than the other. The neutrophil count was positively and negatively related to, respectively, the \"distress associated with obsessive thoughts\" item and to the patients' age. The lymphocyte count and folic acid levels were higher in 30 subjects with no perinatal insults.Conclusions: These results seem to suggest that OCD subjects with ASO titer-positivity show a chronic inflammatory state, in spite of no symptoms or recall of bacterial infections, that might be involved in both the onset and the maintenance of OCD, with immunological alterations being related to symptom dimension to be identified. They also support the notion of possible anti-inflammatory effects of some psychotropic compounds.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e38"},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0