CNS Spectrums最新文献

The effects of ECT on cognition: An exploratory retrospective study. 电痉挛疗法对认知的影响：一项探索性回顾性研究。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-10-10 DOI: 10.1017/S1092852925100606

Susanna Rießland, Pia Baldinger-Melich, Nicoletta Margreiter-Neuwirth, Ursula Kainzmayer, Ina Bozic, Rupert Lanzenberger, Richard Frey, Dan Rujescu, Vincent Millischer

引用次数: 0

Efficacy of transcranial direct current stimulation combined with gait training in patients with Parkinson's Disease: Systematic review and meta-analysis. 经颅直流电刺激联合步态训练对帕金森病患者的疗效：系统回顾和meta分析。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-10-09 DOI: 10.1017/S1092852925100618

Ignacio Domínguez-Pera, David Lucena-Anton, Maria-José Estebanez-Perez, Jose-Manuel Pastora-Bernal, Rocío Martín-Valero

引用次数: 0

Efficacy of Lumateperone in Depression Associated With Bipolar II Disorder: A Pooled Analysis of Late-Phase Clinical Trials. Lumateperone治疗双相II型抑郁症的疗效：一项后期临床试验的汇总分析。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-29 DOI: 10.1017/S1092852925100564

Suresh Durgam, Hassan Lakkis, Susan G Kozauer, Changzheng Chen, Roger S McIntyre

引用次数: 0

Clozapine and anti-cancer agents: a systematic literature review of case reports. 氯氮平与抗癌药物：病例报告的系统文献综述。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-24 DOI: 10.1017/S1092852925100576

Amity Honor, Joseph Parmenter, Rodney Marsh, Dan Siskind, Nicola Warren

{"title":"Clozapine and anti-cancer agents: a systematic literature review of case reports.","authors":"Amity Honor, Joseph Parmenter, Rodney Marsh, Dan Siskind, Nicola Warren","doi":"10.1017/S1092852925100576","DOIUrl":"10.1017/S1092852925100576","url":null,"abstract":"Clozapine is the gold standard for treatment-resistant schizophrenia. In the setting of malignancy with concurrent anti-cancer agent use, clozapine use may be of increased concern. Clozapine cessation holds its own risks. This study aims to systematically review all cases of concurrent pharmacotherapy with clozapine and anti-cancer agents and analyze the psychiatric and physical health outcomes. PubMed, EMBASE, CINAHL, and PsycINFO databases were searched from inception to February 2025. Descriptive statistics and narrative analysis of the included cases occurred. There were 53 cases of clozapine use with anti-cancer agents, with a male to female ratio of 1.7:1 and a mean age of 45.0 years. In 30 cases, clozapine was continued without interruption, and in additional 16 cases, clozapine was recommenced after a period of interruption. In cases with clozapine interruption or discontinuation, 90% noted significant deterioration in mental state despite alternative antipsychotic treatments. There were 34 cases of neutropenia, mostly (94%) in the setting of cytotoxic chemotherapy, with low rates of neutropenic complications. The successful continuation of clozapine with anti-cancer agents can occur, although risk-benefit analysis taking into account individual, clozapine, psychiatric, and physical health factors is required. Consideration of prophylactic neutropenia protective measures should form part of the discussion with the individual and their family.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e76"},"PeriodicalIF":4.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomy and compulsory care in the Netherlands. 荷兰的自治和义务医疗。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-19 DOI: 10.1017/S1092852925100370

Esther Nauta, Gerben Meynen

引用次数: 0

Stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and meta-analysis. 应激性生活事件（SLEs）作为强迫症的诱因：系统回顾和荟萃分析。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-19 DOI: 10.1017/S1092852925100497

Veronica Hühne, Samara Dos Santos-Ribeiro, Maria Eduarda Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle

{"title":"Stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and meta-analysis.","authors":"Veronica Hühne, Samara Dos Santos-Ribeiro, Maria Eduarda Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle","doi":"10.1017/S1092852925100497","DOIUrl":"10.1017/S1092852925100497","url":null,"abstract":"Objectives: Much work has been done on the role of trauma in obsessive-compulsive disorder (OCD), but the relationship between stressful life events (SLEs) and the onset of OCD remains poorly studied. This study aims to summarize the evidence about the association between SLEs and OCD development.Methods: For this systematic review, we searched PubMed, Web of Science, Scopus, and PsycINFO databases for studies published from the database's inception to December 12, 2024. We included studies investigating the prevalence of SLEs among individuals diagnosed with OCD compared to other psychiatric disorders or healthy controls.Results: Seven studies met the inclusion criteria and were incorporated. Two studies found that OCD patients suffered more SLEs than healthy controls in the year before the onset of OCD. Two of the included studies showed a higher occurrence of SLEs across the patients' lifetime before the onset of OCD. Three studies were comparable and, therefore, meta-analyzable. Together, they revealed that SLEs in the year before the onset of OCD were associated with a small yet positive pooled effect size.Conclusions: Our review suggests that SLEs may be highly represented among people with OCD both in the year preceding the disorder's onset and throughout their lifetime.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e75"},"PeriodicalIF":4.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Betel Nuts to Cobenfy: How an Ancient Recreational Drug Gave Rise to a New Class of Schizophrenia Medications - ERRATUM. 从槟榔到Cobenfy：一种古老的娱乐性药物如何产生了一类新的精神分裂症药物-勘误。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-17 DOI: 10.1017/S1092852925100539

Justin Fortune Creeden, Siddharth N Machiraju, Johansen B Amin, Stephen M Stahl

引用次数: 0

The Role of Continuous Glucose Monitoring (CGM) in Psychiatric Symptom Management. 持续血糖监测（CGM）在精神症状管理中的作用。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-10 DOI: 10.1017/S1092852925100540

Melanie C Zhang, Roger S McIntyre

引用次数: 0

Identifying neurobiological markers as predictors of antidepressant treatment using diffusion tensor imaging: A tract-based spatial statistical analysis of cingulate bundle. 利用弥散张量成像识别作为抗抑郁治疗预测因子的神经生物学标志物：基于束束的空间统计分析。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-09-01 DOI: 10.1017/S1092852925000252

Chunxia Yang, Jiaxin Han, Ning Sun, Penghong Liu, Kerang Zhang, Aixia Zhang, Zhifen Liu

{"title":"Identifying neurobiological markers as predictors of antidepressant treatment using diffusion tensor imaging: A tract-based spatial statistical analysis of cingulate bundle.","authors":"Chunxia Yang, Jiaxin Han, Ning Sun, Penghong Liu, Kerang Zhang, Aixia Zhang, Zhifen Liu","doi":"10.1017/S1092852925000252","DOIUrl":"https://doi.org/10.1017/S1092852925000252","url":null,"abstract":"It was found that a significant number of patients with major depressive disorder (MDD) did not respond to the treatment, leading to high ongoing costs and disease burden. The main objective of this study was to find neurobiological indicators that can predict the effectiveness of antidepressant treatment using diffusion tensor imaging (DTI). A group of 103 patients who were experiencing their first episode of MDD were included in the study. After 2 weeks of SSRI treatment, the group of patients was split into two categories: ineffectiveand effective. The FMRIB Software Library (FSL) was used for diffusion data preprocessing to obtain tensor-based parameters such as FA, MD, AD, and RD. Tract-Based Spatial Statistical (TBSS) voxel-wise statistical analysis of the tensor-based parameters was carried out using the TBSS procedure in FSL. We conducted an investigation to determine if there were notable variations in neuroimaging attributes among the three groups. Compared to HC, the effective group showed significantly higher AD and MD values in the left CgH. Correlating neuroimaging characteristics and clinical manifestations revealed a significant positive correlation between CgH-l FA and clinical 2-week HAMD-17 total scores and a significant positive correlation between CgH-r FA and clinical 2-week HAMD-17 total scores. Functional damage to the cingulum bundle in the hippocampal region may predispose patients to MDD and predict antidepressant treatment outcomes. More extensive multicenter investigations are necessary to validate these MRI findings that indicate treatment effectiveness and assess their potential significance in practical therapeutic decision-making.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":"30 1","pages":"e68"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical aging diversity of Alzheimer's disease revealed by BrainAGE. BrainAGE揭示阿尔茨海默病的神经解剖学衰老多样性。

IF 4.1 3区医学

CNS Spectrums Pub Date : 2025-08-26 DOI: 10.1017/S1092852925000148

Lemin He, Guodong Sun, Guangyu Zhang, Fei Gao, Xingwei An, Weizhao Lu

引用次数: 0