Stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and meta-analysis.

IF 4.1 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2025-09-19 DOI:10.1017/S1092852925100497

Veronica Hühne, Samara Dos Santos-Ribeiro, Maria Eduarda Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle

{"title":"Stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and meta-analysis.","authors":"Veronica Hühne, Samara Dos Santos-Ribeiro, Maria Eduarda Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle","doi":"10.1017/S1092852925100497","DOIUrl":null,"url":null,"abstract":"Objectives: Much work has been done on the role of trauma in obsessive-compulsive disorder (OCD), but the relationship between stressful life events (SLEs) and the onset of OCD remains poorly studied. This study aims to summarize the evidence about the association between SLEs and OCD development.Methods: For this systematic review, we searched PubMed, Web of Science, Scopus, and PsycINFO databases for studies published from the database's inception to December 12, 2024. We included studies investigating the prevalence of SLEs among individuals diagnosed with OCD compared to other psychiatric disorders or healthy controls.Results: Seven studies met the inclusion criteria and were incorporated. Two studies found that OCD patients suffered more SLEs than healthy controls in the year before the onset of OCD. Two of the included studies showed a higher occurrence of SLEs across the patients' lifetime before the onset of OCD. Three studies were comparable and, therefore, meta-analyzable. Together, they revealed that SLEs in the year before the onset of OCD were associated with a small yet positive pooled effect size.Conclusions: Our review suggests that SLEs may be highly represented among people with OCD both in the year preceding the disorder's onset and throughout their lifetime.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"e75"},"PeriodicalIF":4.1000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CNS Spectrums","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S1092852925100497","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Much work has been done on the role of trauma in obsessive-compulsive disorder (OCD), but the relationship between stressful life events (SLEs) and the onset of OCD remains poorly studied. This study aims to summarize the evidence about the association between SLEs and OCD development.

Methods: For this systematic review, we searched PubMed, Web of Science, Scopus, and PsycINFO databases for studies published from the database's inception to December 12, 2024. We included studies investigating the prevalence of SLEs among individuals diagnosed with OCD compared to other psychiatric disorders or healthy controls.

Results: Seven studies met the inclusion criteria and were incorporated. Two studies found that OCD patients suffered more SLEs than healthy controls in the year before the onset of OCD. Two of the included studies showed a higher occurrence of SLEs across the patients' lifetime before the onset of OCD. Three studies were comparable and, therefore, meta-analyzable. Together, they revealed that SLEs in the year before the onset of OCD were associated with a small yet positive pooled effect size.

Conclusions: Our review suggests that SLEs may be highly represented among people with OCD both in the year preceding the disorder's onset and throughout their lifetime.

查看原文本刊更多论文

应激性生活事件（SLEs）作为强迫症的诱因：系统回顾和荟萃分析。

目的：关于创伤在强迫症（OCD）中的作用已经做了很多工作，但压力生活事件（SLEs）与强迫症发病之间的关系研究仍然很少。本研究旨在总结关于SLEs与强迫症发展之间关系的证据。方法：在本系统综述中，我们检索了PubMed、Web of Science、Scopus和PsycINFO数据库，检索了从该数据库建立到2024年12月12日发表的研究。我们纳入了调查强迫症患者与其他精神疾病或健康对照者之间的SLEs患病率的研究。结果：7项研究符合纳入标准并被纳入。两项研究发现，在强迫症发病前一年，强迫症患者比健康对照组遭受更多的SLEs。其中两项研究表明，在强迫症发病前的整个患者一生中，SLEs的发生率较高。三项研究具有可比性，因此可进行荟萃分析。总之，他们揭示了强迫症发病前一年的SLEs与一个小而积极的综合效应大小有关。结论：我们的综述表明，在强迫症患者中，无论是在发病前一年还是在其一生中，SLEs都可能具有很高的代表性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.