CNS Spectrums最新文献_第9页

Towards the correlates of stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and metanalysis. 作为强迫症诱因的生活压力事件的相关性：系统回顾和荟萃分析。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-04-30 DOI: 10.1017/S1092852924000269

Verônica Hühne, Samara Dos Santos-Ribeiro, Maria E Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle

{"title":"Towards the correlates of stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and metanalysis.","authors":"Verônica Hühne, Samara Dos Santos-Ribeiro, Maria E Moreira-de-Oliveira, Gabriela B de Menezes, Leonardo F Fontenelle","doi":"10.1017/S1092852924000269","DOIUrl":"10.1017/S1092852924000269","url":null,"abstract":"Obsessive-compulsive disorder (OCD) is a prevalent condition with multifactorial etiology involving genetic and environmental factors. The present study aims to summarize the correlates of stressful life events (SLEs) in OCD by reviewing studies comparing OCD associated or not with SLEs before its onset. To do so, a systematic review was performed by searching PubMed, Web of Science, Scopus, and PsycINFO databases for studies published between the database's inception and November 27, 2023. Studies including individuals whose OCD was precipitated or not by SLEs (SLEs OCD and NSLEs OCD, respectively) were assessed. Effect sizes or odds ratios were then calculated to identify the strength of association between SLEs and clinical characteristics, such as gender, age of onset, family history of OCD, severity of OCD symptoms, depressive symptoms, and mood comorbidities among patients with OCD. Out of the 4083 records initially identified, 5 studies met the inclusion criteria and 3 were comparable through a meta-analysis. Notably, the analyses were limited by the small number of studies available in the literature. The meta-analysis demonstrated SLEs OCD to be associated with female gender, later OCD onset, and increased comorbidity rates with mood disorders. Despite the cross-sectional nature of the reviewed studies, women may be more vulnerable to develop a later onset of OCD following SLEs, which may also lead to mood disorders. Caution is needed to avoid prematurely classifying this presentation as a distinct subtype of OCD.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"252-260"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response. 终生酗酒和赌博障碍：临床概况和治疗反应。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-05-17 DOI: 10.1017/S1092852924000300

Samuel R Chamberlain, Konstantinos Ioannidis, Jon E Grant

{"title":"Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response.","authors":"Samuel R Chamberlain, Konstantinos Ioannidis, Jon E Grant","doi":"10.1017/S1092852924000300","DOIUrl":"10.1017/S1092852924000300","url":null,"abstract":"Objectives: Gambling disorder affects 0.5-2.4% of the population and shows strong associations with lifetime alcohol use disorder. Very little is known regarding whether lifetime alcohol use disorder can impact the clinical presentation or outcome trajectory of gambling disorder.Methods: Data were pooled from previous clinical trials conducted on people with gambling disorder, none of whom had current alcohol use disorder. Demographic and clinical variables were compared between those who did versus did not have lifetime alcohol use disorder.Results: Of the 621 participants in the clinical trials, 103 (16.6%) had a lifetime history of alcohol use disorder. History of alcohol use disorder was significantly associated with male gender (relative risk [RR] = 1.42), greater body weight (Cohen's D = 0.27), family history of alcohol use disorder in first-degree relative(s) (RR = 1.46), occurrence of previous hospitalization due to psychiatric illness (RR = 2.68), and higher gambling-related legal problems (RR = 1.50). History of alcohol use disorder was not significantly associated with other variables that were examined, such as severity of gambling disorder or extent of functional disability. Lifetime alcohol use disorder was not significantly associated with the extent of clinical improvement in gambling disorder symptoms during the subsequent clinical trials.Conclusions: These data highlight that lifetime alcohol use disorder is an important clinical variable to be considered when assessing gambling disorder because it is associated with several untoward features (especially gambling-related legal problems and prior psychiatric hospitalization). The study design enabled these associations to be disambiguated from current or recent alcohol use disorder.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"273-278"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of akathisia treatments: A network meta-analysis. 眩晕治疗的疗效比较：网络荟萃分析

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-04-29 DOI: 10.1017/S1092852924000233

Luca Gambolò, Dario Bottignole, Marta D'Angelo, Lorenzo Bellini, Giuseppe Stirparo

{"title":"Comparative efficacy of akathisia treatments: A network meta-analysis.","authors":"Luca Gambolò, Dario Bottignole, Marta D'Angelo, Lorenzo Bellini, Giuseppe Stirparo","doi":"10.1017/S1092852924000233","DOIUrl":"10.1017/S1092852924000233","url":null,"abstract":"Objective: Akathisia, a common side effect of psychotropic medications, poses a significant challenge in neuropsychiatry, affecting up to 30% of patients on antipsychotics. Despite its prevalence, akathisia remains poorly understood, with difficulties in diagnosis, patient reporting, and treatment efficacy. This research aimed to shed light on effective interventions to improve akathisia management.Methods: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted, encompassing controlled trials in English and Italian languages. Databases, such asPubMed, Scopus, and EMBASE, were searched until July 9, 2023. Treatment effectiveness was assessed using standardized mean differences (SMDs) in post-treatment akathisia scores.Results: Thirteen studies involving 446 individuals met the inclusion criteria. Benzodiazepines, beta-blockers, and NaSSA demonstrated significant efficacy as compared with placebo. Anticholinergic, anticonvulsant, triptan, and other treatments did not show significant differences. Benzodiazepines ranked highest in P-scores (0.8186), followed by beta-blockers and NaSSA.Conclusions: Effective management of akathisia is crucial, with benzodiazepines, beta-blockers, and NaSSA offering evidence-based options. Treatment rankings provide guidance for clinicians. Future research should prioritize larger, more robust studies to address limitations associated with small sample sizes and publication bias. This research enhances our understanding of interventions for akathisia, offering promising options to improve patient quality of life and prevent complications related to non-adherence and mismanagement.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"243-251"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling shadows: analyzing suicide reporting in Muslim-majority countries vis-à-vis WHO's media guidelines. 揭开阴影：根据世界卫生组织的媒体指南分析穆斯林主要国家的自杀报告。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2023-10-20 DOI: 10.1017/S1092852923006351

Rameez A Mahesar, Sana Shahid, Saba Asif, Abdul K Khoso, Sujita K Kar, Taha Shabbir

引用次数: 0

Poor subjective sleep quality and trait impulsivity in patients with bipolar disorder. 双相情感障碍患者的主观睡眠质量差和特质冲动。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-05-06 DOI: 10.1017/S109285292400021X

Mao-Hsuan Huang, Yi-Hsuan Kuan, Yee-Lam E Chan, Wei-Chung Mao, Tung-Ping Su

{"title":"Poor subjective sleep quality and trait impulsivity in patients with bipolar disorder.","authors":"Mao-Hsuan Huang, Yi-Hsuan Kuan, Yee-Lam E Chan, Wei-Chung Mao, Tung-Ping Su","doi":"10.1017/S109285292400021X","DOIUrl":"10.1017/S109285292400021X","url":null,"abstract":"Background: Sleep disturbance and impulsivity are key components of mood vulnerability in bipolar disorder (BD), but few studies have assessed the association between these two symptoms among patients with BD.Methods: Forty-seven euthymic patients with bipolar I disorder (BDI) or bipolar II disorder (BDII) and 58 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Trait impulsivity was measured using the Barratt Impulsiveness Scale Version 11 (BIS-11), which yielded 3 second-order factors: attention, motor, and non-planning. Subjective sleep quality was assessed using the self-reported Pittsburgh Sleep Quality Index (PSQI). General linear models (GLMs) were used to assess the associations between subjective poor sleep and trait impulsivity with multiple testing corrections.Results: Patients with BD scored higher in BIS-11 and PSQI than healthy controls. PSQI total scores positively correlated with BIS-11 total scores, while sleep disturbance and daytime dysfunction were associated with attentional impulsiveness after controlling for covariates. Participants with higher PSQI total scores (>10) had higher scores in BIS-11 total, attention, and non-planning than those with low PSQI scores (≤5).Conclusion: These findings support the hypothesis that poor sleep quality might lead to impulsivity and add to the growing evidence that improving sleep quality may be a therapeutic target for patients with BD.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"289-295"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation of the experience of control through the sense of agency in people with obsessive-compulsive disorder: a review and meta-analysis. 强迫症患者通过代理感获得控制体验的调查：回顾与元分析

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-03-25 DOI: 10.1017/S1092852924000117

Davide Fausto Borrelli, Matteo Tonna, Reuven Dar

{"title":"An investigation of the experience of control through the sense of agency in people with obsessive-compulsive disorder: a review and meta-analysis.","authors":"Davide Fausto Borrelli, Matteo Tonna, Reuven Dar","doi":"10.1017/S1092852924000117","DOIUrl":"10.1017/S1092852924000117","url":null,"abstract":"The construct of sense of agency (SoA) has proven useful for understanding mechanisms underlying obsessive-compulsive disorder (OCD) phenomenology, especially in explaining the apparent dissociation in OCD between actual and perceived control over one's actions. Paradoxically, people with OCD appear to experience both diminished SoA (feeling unable to control their actions) and inflated SoA (having \"magical\" control over events). The present review investigated the extent to which the SoA is distorted in OCD, in terms of both implicit (ie, inferred from correlates and outcomes of voluntary actions) and explicit (ie, subjective judgment of one's control over an outcome) measures of SoA. Our search resulted in 15 studies that met the criteria for inclusion in a meta-analysis, where we also examined the potential moderating effects of the type of measure (explicit versus implicit) and of the actual control participants had over the outcome. We found that participants with OCD or with high levels of OCD symptoms show lower implicit measures of SoA and at the same time tend to overestimate their control in situations where they do not actually have it. Together, these findings support the hypothesized dissociation in OCD between actual and perceived control over one's actions.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"224-232"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between peritraumatic distress, mental health symptoms, and functioning impairment in healthcare workers during the COVID-19 emergency. 在 COVID-19 紧急事件中，医护人员的创伤周围痛苦、心理健康症状和功能障碍之间的关系。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-02-08 DOI: 10.1017/S1092852923006338

Claudia Carmassi, Carlo Antonio Bertelloni, Valerio Dell'Oste, Virginia Pedrinelli, Sara Fantasia, Anna-Rita Atti, Arianna Goracci, Maria Giulia Nanni, Enrico Massimetti, Lilliana Dell'Osso, Eric Bui

{"title":"The relationship between peritraumatic distress, mental health symptoms, and functioning impairment in healthcare workers during the COVID-19 emergency.","authors":"Claudia Carmassi, Carlo Antonio Bertelloni, Valerio Dell'Oste, Virginia Pedrinelli, Sara Fantasia, Anna-Rita Atti, Arianna Goracci, Maria Giulia Nanni, Enrico Massimetti, Lilliana Dell'Osso, Eric Bui","doi":"10.1017/S1092852923006338","DOIUrl":"10.1017/S1092852923006338","url":null,"abstract":"Objective: Healthcare workers (HCWs) were considered a population at risk for developing psychiatric symptoms during the COVID-19 pandemic, such as anxiety, depression, and post-traumatic stress disorder (PTSD). Peritraumatic distress is associated with post-traumatic psychopathological symptoms; however, little is known about how it may affect functioning. The study aimed at evaluating the level of peritraumatic distress in a sample of HCWs during the first wave of the COVID-19 pandemic and at examining the relationship between peritraumatic distress, mental health symptoms, and functioning impairment.Methods: A sample of 554 frontline HCWs were consecutively enrolled in major university hospitals and community services in Italy. The PDI, IES-R, PHQ-9, and GAD-7 were used to assess peritraumatic distress, symptoms of PTSD, depression, and anxiety, respectively, and the WSAS to investigate functioning impairment. PDI scores were higher among females, community services, physicians, and nurses. Furthermore, the PDI correlated significantly with the GAD-7, PHQ-9, IES-R, and WSAS.Results: In a mediation analysis, the direct effect of PDI on WSAS and the indirect effects through the PHQ-9 and IES-R were statistically significant (P < .001).Conclusion: Peritraumatic distress reported by HCWs was associated with symptoms of PTSD, depression, and anxiety, but the association with reduced functioning may be only partially mediated through symptoms of depression and PTSD.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"261-267"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive cariprazine for major depressive disorder: a systematic review and meta-analysis. 辅助治疗重度抑郁症的卡里普嗪：系统回顾与元分析》。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-08-01 Epub Date: 2024-04-01 DOI: 10.1017/S1092852924000178

Hartej Gill, David C J Chen-Li, Sipan Haikazian, Sam Seyedin, Roger S McIntyre, Rodrigo B Mansur, Joshua D DiVincenzo, Lee Phan, Joshua D Rosenblat

{"title":"Adjunctive cariprazine for major depressive disorder: a systematic review and meta-analysis.","authors":"Hartej Gill, David C J Chen-Li, Sipan Haikazian, Sam Seyedin, Roger S McIntyre, Rodrigo B Mansur, Joshua D DiVincenzo, Lee Phan, Joshua D Rosenblat","doi":"10.1017/S1092852924000178","DOIUrl":"10.1017/S1092852924000178","url":null,"abstract":"Converging evidence has suggested that treatment augmentation with a second-generation atypical antipsychotic (SGA) may improve treatment outcomes in major depressive disorder (MDD) patients after an incomplete response to a first-line antidepressant. Cariprazine is a recently approved SGA for MDD augmentation. Herein, we evaluate both continuous (ie, change in depressive symptom severity scores over time) and categorical (ie, remission and response rates) outcomes. Following a full-text review, four randomized controlled trials (RCTs) were included in our meta-analysis, while five studies were included for a qualitative review. Risk ratios (RRs) were calculated for all included randomized controlled studies to determine the relative response and remission rates of cariprazine compared to placebo augmentation. The RR for all-cause dropout was also determined as a proxy for overall acceptability. Two studies found a statistically significant treatment response using cariprazine augmentation. One study observed depressive symptom remission for cariprazine compared to placebo. Our random-effects model revealed moderate antidepressant effects of cariprazine, with a standardized mean difference (SMD) in Montgomery-Åsberg Depression Rating Scale (MADRS) scores of -1.79 (95% CI): -2.89, -0.69). Our pooled response RR and remission RR were calculated as 1.21 (95% CI: 1.05, 1.39, P=0.008) and 0.99 (95% CI: 0.84, 1.17, P=0.91), respectively. The RR for response was statistically significant (P<0.05). However, the RR for remission was not statistically significant. The findings from our meta-analysis include a variable magnitude of effects. Evidence suggests cariprazine may be an effective treatment for MDD; however, further results are needed to clarify this relation.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"233-242"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Criminal behaviors and substance use disorder in psychiatric patients. 精神病患者的犯罪行为和药物使用障碍。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-06-04 DOI: 10.1017/S1092852924000373

Francesco Achilli, Silvia Leo, Beatrice Benatti, Alice Frediani, Maddalena Cocchi, Laura Molteni, Eleonora Piccoli, Monica Lana, Emma Lucchini, Dario Gobbo, Bernardo M Dell'Osso

{"title":"Criminal behaviors and substance use disorder in psychiatric patients.","authors":"Francesco Achilli, Silvia Leo, Beatrice Benatti, Alice Frediani, Maddalena Cocchi, Laura Molteni, Eleonora Piccoli, Monica Lana, Emma Lucchini, Dario Gobbo, Bernardo M Dell'Osso","doi":"10.1017/S1092852924000373","DOIUrl":"10.1017/S1092852924000373","url":null,"abstract":"Objective: People with mental illness are overrepresented throughout the criminal justice system. In Italy, the Judicial Psychiatric Hospitals are now on the edge of their closure in favor of small-scale therapeutic facilities (REMS). Therefore, when patients end their duty for criminal behaviors, their clinical management moves back to the outpatient psychiatric centers. Elevated risks of rule-violating behavior are not equally shared across the spectrum of psychiatric disorders. To broaden the research in this area, we analyzed sociodemographic, clinical, and forensic variables of a group of psychiatric patients with a history of criminal behaviors, attending an outpatient psychiatric service in Milan, focusing on substance use disorder (SUD).Methods: This is a cross-sectional single center study, conducted from 2020. Seventy-six subjects with a history of criminal behaviors aged 18 years or older and attending an outpatient psychiatric service were included. Demographic and clinical variables collected during clinical interviews with patients were retrospectively retrieved from patients' medical records. Appropriate statistical analyses for categorical and continuous variables were conducted.Results: Data were available for 76 patients, 51.3% of them had lifetime SUD. Lifetime SUD was significantly more common in patients with long-acting injectable antipsychotics therapy, a history of more than 3 psychiatric hospitalizations, and a history of previous crimes, particularly economic crimes. Additionally, this last potential correlation was confirmed by logistic regression.Conclusions: Data emerging from this survey provide new information about offenders with lifetime SUD attending an Italian mental health service. Our preliminary results should be confirmed in larger sample sizes.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"1-8"},"PeriodicalIF":3.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of the cognitive effects of the COMT inhibitor, tolcapone, in adult humans. 关于 COMT 抑制剂托卡朋对成年人认知能力影响的系统性综述。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI: 10.1017/S1092852924000130

Emilia Kings, Konstantinos Ioannidis, Jon E Grant, Samuel R Chamberlain

{"title":"A systematic review of the cognitive effects of the COMT inhibitor, tolcapone, in adult humans.","authors":"Emilia Kings, Konstantinos Ioannidis, Jon E Grant, Samuel R Chamberlain","doi":"10.1017/S1092852924000130","DOIUrl":"10.1017/S1092852924000130","url":null,"abstract":"Objective: The catechol-o-methyltransferase (COMT) inhibitor tolcapone constitutes a potentially useful probe of frontal cortical dopaminergic function. The aim of this systematic review was to examine what is known of effects of tolcapone on human cognition in randomized controlled studies.Methods: The study protocol was preregistered on the Open Science Framework. A systematic review was conducted using PubMed to identify relevant randomized controlled trials examining the effects of tolcapone on human cognition. Identified articles were then screened against inclusion and exclusion criteria.Results: Of the 22 full-text papers identified, 13 randomized control trials were found to fit the pre-specified criteria. The most consistent finding was that tolcapone modulated working memory; however, the direction of effect appeared to be contingent on the COMT polymorphism (more consistent evidence of improvement in Val-Val participants). There were insufficient nature and number of studies for meta-analysis.Conclusion: The cognitive improvements identified upon tolcapone administration, in some studies, are likely to be due to the level of dopamine in the prefrontal cortex being shifted closer to its optimum, per an inverted U model of prefrontal function. However, the results should be interpreted cautiously due to the small numbers of studies. Given the centrality of cortical dopamine to understanding human cognition, studies using tolcapone in larger samples and across a broader set of cognitive domains would be valuable. It would also be useful to explore the effects of different dosing regimens (different doses; and single versus repeated administration).","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":" ","pages":"166-175"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0