Can total electrical energy (TEED) after subthalamic DBS alter verbal fluency in Parkinson's disease patients? A preliminary evidence.

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2024-10-28 DOI:10.1017/S1092852924000439

Fabiana Ruggiero, Francesca Mameli, Edoardo Nicolò Aiello, Eleonora Zirone, Filippo Cogiamanian, Linda Borellini, Elena Pirola, Antonella Ampollini, Barbara Poletti, Angelica De Sandi, Marco Prenassi, Sara Marceglia, Nicola Ticozzi, Vincenzo Silani, Marco Locatelli, Giordano D'Urso, Sergio Barbieri, Alberto Priori, Roberta Ferrucci

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引用次数: 0

Abstract

Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor outcomes in Parkinson's disease (PD) but may have adverse long-term effects on specific cognitive domains. The aim of this study was to investigate the association between total electrical energy (TEED) delivered by DBS and postoperative changes in verbal fluency.

Methods: Seventeen PD patients undergoing bilateral STN-DBS were assessed with the Alternate Verbal Fluency Battery (AVFB), which includes phonemic (PVF), semantic (SVF), and alternate verbal fluency (AVF) tests, before surgery (T0) and after 6 (T1) and 12 months (T2). Bilateral TEED and average TEEDM were recorded at T1 and T2. For each AVFB measurement, changes from T0 to T1 (Δ-01) and from T0 to T2 (Δ-02) were calculated.

Results: At T1, PVF (p = 0.007) and SVF scores (p = 0.003) decreased significantly. TEED measures at T1 and T2 were unrelated to Δ-01 and Δ-02 scores, respectively. However, an inverse, marginally significant association was detected between the TEEDM and Δ-01 scores for the AVF (p = 0.041, against an α_adjusted = 0.025).

Conclusions: In conclusion, the present reports provide preliminary evidence that TEED may not be responsible or only slightly responsible for the decline in VF performance after STN-DBS in PD.

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帕金森病患者脑下垂体电刺激术后的总电能（TEED）会改变其言语流畅性吗？初步证据。

目的：眼下核（STN）深部脑刺激（DBS）可改善帕金森病（PD）的运动疗效，但可能对特定认知领域产生长期不利影响。本研究的目的是调查 DBS 提供的总电能（TEED）与术后言语流利性变化之间的关系：17名接受双侧STN-DBS手术的帕金森病患者在术前（T0）、术后6个月（T1）和12个月（T2）接受了交替言语流利性电池（AVFB）评估，其中包括音位（PVF）、语义（SVF）和交替言语流利性（AVF）测试。在 T1 和 T2 阶段记录了双侧 TEED 和平均 TEEDM。计算每次 AVFB 测量从 T0 到 T1（Δ-01）和从 T0 到 T2（Δ-02）的变化：结果：在 T1，PVF（p = 0.007）和 SVF 分数（p = 0.003）显著下降。T1 和 T2 的 TEED 测量值分别与 Δ-01 和 Δ-02 分数无关。然而，在 TEEDM 和 AVF 的 Δ-01 分数之间发现了反向的、略微显著的关联（p = 0.041，而 α 调整后 = 0.025）：总之，本报告提供的初步证据表明，TEED 可能不是导致或仅是轻微导致 STN-DBS 治疗后脊髓灰质炎患者 VF 性能下降的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.