Early or recent trauma in treatment-resistant depression: a systematic review.

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2025-03-12 DOI:10.1017/S1092852925000185

Sara Fantasia, Lorenzo Conti, Debora Andreoli, Andrea Bordacchini, Berenice Rimoldi, Valerio Dell'Oste, Virginia Pedrinelli, Claudia Carmassi

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引用次数: 0

Abstract

Background: Increasing attention has been recently devoted to treatment-resistant depression (TRD); however, its clinical characteristics, potential risk factors, and course are still debated. Most recently, childhood trauma exposure has been correlated to TRD, but systematic investigation on the role of lifetime trauma is still lacking. The aim of this paper was to revise current evidence on early and recent trauma exposure in TRD.

Methods: A systematic search was conducted from the 1st of June to the 20th of February 2024 in accordance with the PRISMA 2020 guidelines and using the electronic databases PubMed, Web of Science, and Embase.

Results: The primary database search produced a total of 1998 record, and finally, the search yielded a total of 22 publications, including 18 clinical studies, 3 case reports, and 1 case series, all from the period 2014 to 2024.

Limitations: Limitations include a small sample size of some studies and the lack of homogeneity in the definition of TRD. Furthermore, we only considered articles in English, we excluded preprints or abstracts, and we included case reports.

Conclusions: This review highlights the role of early and recent trauma in TRD, even in the absence of a full-blown post-traumatic stress disorder (PTSD), highlighting the need for a thorough assessment of trauma in patients with TRD and of its role as a therapeutic target.

查看原文本刊更多论文

难治性抑郁症的早期或近期创伤：系统回顾。

背景：近年来，人们越来越关注难治性抑郁症（TRD）；然而，其临床特征、潜在危险因素和病程仍有争议。最近，儿童创伤暴露与TRD相关，但对终身创伤的作用仍缺乏系统的调查。本文的目的是修订目前的证据早期和近期创伤暴露在TRD。方法：根据PRISMA 2020指南，利用PubMed、Web of Science和Embase电子数据库，于2024年6月1日至2月20日进行系统检索。结果：初检索数据库共检索到1998条记录，最终检索到22篇出版物，其中临床研究18篇，病例报告3篇，病例系列1篇，时间均为2014 - 2024年。局限性：局限性包括一些研究的样本量小，TRD的定义缺乏同质性。此外，我们只考虑英文文章，我们排除了预印本或摘要，我们纳入了病例报告。结论：本综述强调了早期和近期创伤在TRD中的作用，即使在没有完全的创伤后应激障碍（PTSD）的情况下，也强调了对TRD患者创伤及其作为治疗靶点的作用进行彻底评估的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.