Clinical Physiology and Functional Imaging最新文献

{"title":"Switch to gliflozins and biventricular function improvement in patients with chronic heart failure and diabetes mellitus","authors":"Michele Correale,&nbsp;Pietro Mazzeo,&nbsp;Martino Fortunato,&nbsp;Matteo Paradiso,&nbsp;Andrea Furore,&nbsp;Angela I. Fanizzi,&nbsp;Lucia Tricarico,&nbsp;Giuseppe Pastore,&nbsp;Simona Alfieri,&nbsp;Natale D. Brunetti,&nbsp;Olga Lamacchia","doi":"10.1111/cpf.12857","DOIUrl":"10.1111/cpf.12857","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>SGLT2 inhibitors have been shown to reduce hospitalisation in patients with chronic heart failure (CHF). The cardioprotective mechanisms of gliflozins however have not been fully elucidated. The aim of this study was therefore to evaluate the effect of SGLT2 inhibitors on right and left ventricular function in patients with diabetes and HF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventy-eight patients with diabetes and CHF were enroled in the study and followed up; 38 started treatment with SGLT2i, while the remaining 40 continued their previous antidiabetic therapy. All patients underwent conventional, TDI and strain echocardiography in an ambulatory setting, at the beginning and after 3 months of therapy with SGLT2i.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 3 months of therapy with SGLT2i, echocardiographic parameters assessing both left and right ventricular dimensions and function were found as significantly improved in patients switching to SGLT2i than control group: LVEF (45 ± 9% vs. 40 ± 8%, <i>p</i> &lt; 0.001), LVEDD (54 ± 6.5 vs. 56 ± 6.5 mm, <i>p</i> &lt; 0.01), GLS (−13 ± 4% vs. −10 ± 3%, <i>p</i> &lt; 0.001), TAPSE (21 ± 3 vs. 19 ± 3 mm, <i>p</i> &lt; 0.001), RV S' (12.9 ± 2.5 vs 11.0 ± 1.9 cm/sec, <i>p</i> &lt; 0.001) and PAsP (24 ± 8 vs. 31 ± 9 mmHg, <i>p</i> &lt; 0.001). Also mitral (1.0 ± 0.5 vs. 1.3 ± 0.5, <i>p</i> &lt; 0.01) and tricuspid regurgitation (1.0 ± 0.5 vs. 1.3 ± 0.5, <i>p</i> &lt; 0.01) improved after SGLT2i therapy. Changes were not statistically significant in patients not treated with SGLT2i (p n.s. in all cases).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In a real-world scenario, treatment with SGLT2i in patients with CHF and diabetes is associated with an improvement in both left and right ventricular function assessed at echocardiography. These data may explain potential anti-remodelling effects of gliflozins.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in muscle thickness, echo intensity and shear modulus of the iliocapsularis","authors":"Haruka Sakata,&nbsp;Hiroshige Tateuchi,&nbsp;Masahide Yagi,&nbsp;Kotono Kobayashi,&nbsp;Noriaki Ichihashi","doi":"10.1111/cpf.12858","DOIUrl":"10.1111/cpf.12858","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to clarify age-related changes in the iliocapsularis (IC) using indicators of quantity, quality, and mechanical properties. We also compared the age-related changes in the IC and other hip muscles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-seven healthy women (ages: 21–82 years, mean age: 45.9 ± 15.7 years) participated in the experiment. We measured thickness, echo intensity, and shear modulus of the IC, iliacus muscle, rectus femoris, and the thickness and shear modulus of the hip joint capsule. Spearman's rank correlation coefficient was used to measure the association of age with variables measured in the muscles and joint capsule.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thickness of the iliacus muscle and rectus femoris decreased significantly with age, but the thickness of the IC and hip joint capsule showed no significant correlation. The echo intensities of the IC, iliacus muscle, and rectus femoris were positively correlated, which increased with age. Furthermore, the shear modulus of the iliacus, rectus femoris, and hip joint capsule showed an increase with age, whereas the shear modulus of the IC exhibited no correlation with age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The muscle quality of the IC changed significantly, unlike that of the iliacus or rectus femoris. Additionally, the correlation with echo intensity was relatively weaker in the IC compared with the iliacus or rectus femoris.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12858","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41109683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of physical post-exercise recovery techniques on vagally-mediated heart rate variability: A systematic review and meta-analysis","authors":"Sylvain Laborde,&nbsp;Jannik Wanders,&nbsp;Emma Mosley,&nbsp;Florian Javelle","doi":"10.1111/cpf.12855","DOIUrl":"10.1111/cpf.12855","url":null,"abstract":"<p>In sports, physical recovery following exercise-induced fatigue is mediated via the reactivation of the parasympathetic nervous system (PNS). A noninvasive way to quantify the reactivation of the PNS is to assess vagally-mediated heart rate variability (vmHRV), which can then be used as an index of physical recovery. This systematic review and meta-analysis investigated the effects of physical recovery techniques following exercise-induced fatigue on vmHRV, specifically via the root mean square of successive differences (RMSSD). Randomized controlled trials from the databases <i>PubMed, WebOfScience</i>, and <i>SportDiscus</i> were included. Twenty-four studies were part of the systematic review and 17 were included in the meta-analysis. Using physical post-exercise recovery techniques displayed a small to moderate positive effect on RMSSD (<i>k</i> = 22, Hedges' <i>g</i> = 0.40, 95% confidence interval [CI] = 0.20–0.61, <i>p</i> = 0.04) with moderate heterogeneity. In the subgroup analyses, cold water immersion displayed a moderate to large positive effect (<i>g</i> = 0.75, 95% CI: 0.42–1.07) compared with none for other techniques. For exercise type, physical recovery techniques performed after resistance exercise (<i>g</i> = 0.69, 95% CI: 0.48–0.89) demonstrated a larger positive effect than after cardiovascular intermittent (<i>g</i> = 0.52, 95% CI: 0.06–0.97), while physical recovery techniques performed after cardiovascular continuous exercise had no effect. No significant subgroup differences for training status and exercise intensity were observed. Overall, physical post-exercise recovery techniques can accelerate PNS reactivation as indexed by vmHRV, but the effectiveness varies with the technique and exercise type.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low workload respiratory training with steam inhalation on lung function in stable asthma: A controlled clinical study","authors":"Ilpo Kuronen,&nbsp;Jukka Heinijoki,&nbsp;Anssi Sovijärvi","doi":"10.1111/cpf.12856","DOIUrl":"10.1111/cpf.12856","url":null,"abstract":"<p>To investigate effects of low workload respiratory muscle training (RMT) on respiratory muscle power and lung function in asthmatics, we recruited asthmatic persons who performed a 4-week training programme. The training included 20 daily ex- and inhalations with counter pressure 30% from the individual maximal expiratory pressure (MEP). Lung function was measured before and after the training programme and a follow-up period. The study also included several subjective endpoints for respiratory symptoms. A significant increase in a training group (<i>n</i> = 27) compared with a control group (<i>n</i> = 20) was seen in MEP (+12.4%, vs. +3.5%, <i>p</i> = 0.086), maximal inspiratory pressure (MIP) (+21.1% vs. +0.82%, <i>p</i> = 0.023), slow vital capacity (VC) (+3.7% vs. +1.5%, <i>p</i> = 0.023) and in forced expiratory time (FET, +15.5%, vs. −5.0%, <i>p</i> = 0.022). After being a control for group A, also group B performed similar RMT as group A. In the combined group (A and B, <i>n</i> = 47) MEP (11.3%, <i>p</i> = 0.003), MIP (19.73%, <i>p</i> &lt; 0.001), VC (4.1%, <i>p</i> &lt; 0.001) and FET (14.7%, <i>p</i> &lt; 0.001) increased significantly from the baseline. Changes in other lung function variables were not indicative. On a scale of 1–5, the subjects perceived improvement in reduction of mucus secretion in the airways (median 3, <i>p</i> &lt; 0.001), alleviation of coughing (median 3, <i>p</i> &lt; 0.001) and reduction in dyspnoea (median 3, <i>p</i> &lt; 0.001). As a conclusion, low workload respiratory training of 4 weeks improved respiratory muscle power and increased VC in patients with stable asthma.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative myocardial perfusion should be interpreted in the light of sex and comorbidities in patients with suspected chronic coronary syndrome: A cardiac positron emission tomography study","authors":"Anna Székely,&nbsp;Katarina Steding-Ehrenborg,&nbsp;Daniel Ryd,&nbsp;Fredrik Hedeer,&nbsp;Kristian Valind,&nbsp;Shahnaz Akil,&nbsp;Cecilia Hindorf,&nbsp;Erik Hedström,&nbsp;David Erlinge,&nbsp;Håkan Arheden,&nbsp;Henrik Engblom","doi":"10.1111/cpf.12854","DOIUrl":"10.1111/cpf.12854","url":null,"abstract":"<p>Diagnosis and treatment of patients with suspected chronic coronary syndrome (CCS) currently relies on the degree of coronary artery stenosis and its significance for myocardial perfusion. However, myocardial perfusion can be affected by factors other than coronary stenosis. The aim of this study was to investigate to what extent sex, age, diabetes, hypertension and smoking affect quantitative myocardial perfusion, beyond the degree of coronary artery stenosis, in patients with suspected or established CCS. Eighty-six patients [median age 69 (range 46−86) years, 24 females] planned for elective coronary angiography due to suspected or established CCS were included. All patients underwent cardiac ¹³N-NH₃ positron emission tomography to quantify myocardial perfusion at rest and stress. Lowest myocardial perfusion (perfusion_min) at stress and rest and lowest myocardial perfusion reserve (MPR_min) for all vessel territories was used as dependent variables in a linear mixed model. Independent variables were vessel territory, degree of coronary artery stenosis (as a continuous variable of 0%−100% stenosis), sex, age, diabetes, hypertension and smoking habits. Degree of coronary artery stenosis (<i>p</i> &lt; 0.001), male sex (1.8 ± 0.6 vs. 2.3 ± 0.6 mL/min/g, <i>p</i> &lt; 0.001), increasing age (<i>p</i> = 0.025), diabetes (1.6 ± 0.5 vs. 2.0 ± 0.6 mL/min/g, <i>p</i> = 0.023) and smoking (1.9 ± 0.6 vs. 2.1 ± 0.6 mL/min/g, <i>p</i> = 0.052) were independently associated with myocardial perfusion_min at stress. Degree of coronary artery stenosis (<i>p</i> &lt; 0.001), age (<i>p</i> = 0.040), diabetes (1.8 ± 0.6 vs. 2.3 ± 0.7, <i>p</i> = 0.046) and hypertension (2.2 ± 0.7 vs. 2.5 ± 0.6, <i>p</i> = 0.033) were independently associated with MPR_min. Sex, increasing age, diabetes, hypertension and smoking affect myocardial perfusion independent of coronary artery stenosis in patients with suspected or established CCS. Thus, these factors need to be considered when assessing the significance of reduced quantitative myocardial perfusion of patients with suspected or established CCS.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12854","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10235112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First clinical experience of a ring-configured cadmium zinc telluride camera: A comparative study versus conventional gamma camera systems","authors":"Irma Cerić Andelius,&nbsp;David Minarik,&nbsp;Eva Persson,&nbsp;Henrik Mosén,&nbsp;Kristian Valind,&nbsp;Elin Trägårdh,&nbsp;Jenny Oddstig","doi":"10.1111/cpf.12853","DOIUrl":"10.1111/cpf.12853","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A novel semiconductor cadmium zinc telluride (CZT) gamma camera system using a block sequential regularized expectation maximization (BSREM) reconstruction algorithm is now clinically available. Here we investigate how a multi-purpose ring-configurated CZT system can be safely applied in clinics and describe the initial optimization process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Seventy-six patients (bone-, cardiac- and lung scan) were scanned on a conventional gamma camera (planar and/or single-photon emission computed tomography [SPECT]/SPECT-CT) used in clinical routine and on the ring-configurated CZT camera Starguide (GE Healthcare). These data were used to validate and optimize the Starguide system for routine clinical use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparable image quality for the Starguide system, to that of the conventional gamma camera, was achieved for bone scan (4 min/bed position [BP] using a relative difference prior [RDP] with gamma 2 and beta 0.4, along with 10 iterations and 10 subsets), cardiac scan (8 min [stress] and 3 min 20 s [rest] using median root prior [MRP] with beta 0.07 non attenuation corrected and 0.008 attenuation corrected and 50 interations and 10 subsets for both stress and rest) and lung scan (10 min [vent] and 5 min [perf] using RDP with gamma 0.5 and beta 0.03 [vent] and 0.02 [perf] and 20 interations and 10 subsets for both vent and perf).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It was possible to transition from a conventional gamma camera to the Starguide system as part of the clinical routine, with acceptable image quality. Images from the Starguide system were deemed to be at least as good as those from a conventional gamma camera.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10113844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of blood flow restriction with low-load exercise on muscle damage in healthy adults: A systematic review of randomized controlled trials","authors":"Jinchao Yang,&nbsp;Fenghao Ma,&nbsp;Qian Wang,&nbsp;Yuanfen Cui,&nbsp;Jun Zheng","doi":"10.1111/cpf.12852","DOIUrl":"10.1111/cpf.12852","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Blood flow restriction (BFR) is a relatively new rehabilitative technique and low-load exercise combined with BFR (LL-BFR) can increase muscle strength and muscle mass. However, it is currently unknown whether LL-BFR causes muscle damage. Therefore, the aim of this study is to investigate the effects of LL-BFR on muscle damage and provide recommendations for sports training and physical exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A systematic search was conducted using PubMed, Web of Science, Medline, Cochrane Library and Physiotherapy Evidence Database (PEDro) with a cut-off of March 2022. Randomized controlled trials (RCTs) and English-language studies were selected. Two independent assessors used the PEDro scoring scale to evaluate the methodological quality and risk of bias of the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 2935 articles identified, 15 RCTs were included in this systematic review. Two studies demonstrated that LL-BFR could induce muscle damage in healthy individuals; however, two studies presented contrasting findings in the short term. Four studies found that no muscle damage occurred after LL-BFR in the long term. The remaining seven articles showed that it was unclear if LL-BFR could cause muscle damage, regardless of whether these participants were trained or not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although LL-BFR may induce muscle damage within 1 week, it will help gain long-term muscle strength and muscle hypertrophy. However, the lack of sufficient evidence on the effect of LL-BFR on muscle damage in clinical practice warrants additional RCTs with large sample sizes in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12852","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10030498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective head-to-head comparison of the Lugano classification and PERCIST for FDG-PET/CT response assessment in diffuse large B-cell lymphoma","authors":"Nicklas B. Nielsen,&nbsp;Oke Gerke,&nbsp;Anne L. Nielsen,&nbsp;Karen Juul-Jensen,&nbsp;Thomas S. Larsen,&nbsp;Michael B. Møller,&nbsp;Malene G. Hildebrandt","doi":"10.1111/cpf.12851","DOIUrl":"10.1111/cpf.12851","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma. European guidelines recommend FDG-PET/CT for staging and end of treatment (EOT) response assessment, mid-treatment response assessment is optional. We compared the Lugano classification and PET Response Criteria In Solid Tumours (PERCIST) for FDG-PET/CT response assessment in DLBCL head-to-head.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively included patients with DLBCL who underwent first-line R-CHOP(-like) therapy (2013−2020). Interim and EOT FDG-PET/CT response were reevaluated using the Lugano classification and PERCIST. Response was dichotomized into complete metabolic response (CMR) versus non-CMR (interim and EOT) and responders versus nonresponders (interim only). The cutoff for nonresponse at interim was a Deauville score of 5 (DS5) with the Lugano classification and a partial metabolic response with ≤66% reduction in SUL_peak using PERCIST (PERCIST66).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In multivariable Cox regression (<i>N</i> = 170), DS5 at interim, PERCIST66 at interim, non-CMR at EOT with the Lugano classification and non-CMR at EOT with PERCIST were predictive of progression-free survival (PFS). The Lugano classification and PERCIST agreed perfectly at interim and EOT and with 98.4% for the identification of nonresponders at interim. The accuracy for predicting events within 2 years of diagnosis was 84.2% for DS-5 at interim, 87.6% for PERCIST66 at interim, 86% for non-CMR with the Lugano classification at EOT and 83.3% for non-CMR with PERCIST at EOT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Lugano classification and PERCIST were equally predictive of PFS. Nonresponse at interim and non-CMR at EOT were predictive of poor PFS with comparable accuracy for predicting events within 2 years.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10330159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers","authors":"Fleur W. H. Wildenbeest,&nbsp;Gert-Jan Hassing,&nbsp;Michiel J. B. Kemme,&nbsp;Matthijs Moerland,&nbsp;Pim Gal","doi":"10.1111/cpf.12846","DOIUrl":"10.1111/cpf.12846","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Limited data exist on heart rate stabilization in the domiciled nature of phase I clinical studies, particularly when frequent measurements of QT intervals are involved. The present analysis aimed to evaluate heart rate stability in the domiciled nature of, and stabilization after a short exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-six healthy male subjects were included in this analysis. Data during a domiciled clinical setting and after a short exercise were analysed. Mean values of 30 s intervals of collected electrocardiographical data (PR, RR, QT and QTcF intervals) during a 10-min supine resting period in a domiciled nature or after walking up and down three stories (100 steps) were compared to baseline values using paired <i>t</i>-tests or compared to the intrasubject standard deviation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stable heart rates and stable QTcF intervals observed immediately upon assuming a supine position in the domiciled clinical setting. After the short exercise, PR interval and RR interval were significantly (<i>p</i> &lt; 0.05) shorter for up to 120 s (mean value −9.8 ± 7.2 ms) and 30 s (−160 ± 165 ms, <i>p</i> &lt; 0.05), respectively. QT and QTcF intervals were significantly (<i>p</i> &lt; 0.05) shorter for up to 90 and 120 s postexercise, respectively. Both QT and QTcF intervals stabilized after 2 min, but QT interval remained prolonged while QTcF interval returned to baseline levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In a clinical setting, male volunteers do not require a waiting period for electrocardiographic parameter normalization. However, accurate measurement of these parameters following a short exercise necessitates a minimum 2-min resting interval.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10318238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young type 1 diabetes subjects sway more than healthy persons when somatosensory system is challenged in static standing postural stability tests","authors":"Kim J. Lesch,&nbsp;Vesa V. Hyrylä,&nbsp;Timo Eronen,&nbsp;Saana Kupari,&nbsp;Lauri Stenroth,&nbsp;Mika Venojärvi,&nbsp;Mika P. Tarvainen,&nbsp;Heikki O. Tikkanen","doi":"10.1111/cpf.12849","DOIUrl":"10.1111/cpf.12849","url":null,"abstract":"<p>In type 1 diabetes, it is important to prevent diabetes-related complications and postural instability may be one clinically observable manifestation early on. This study was set to investigate differences between type 1 diabetics and healthy controls in variables of instrumented posturography assessment to inform about the potential of the assessment in early detection of diabetes-related complications. Eighteen type 1 diabetics with no apparent complications (HbA1c = 58 ± 9 mmol/L, diabetes duration = 15 ± 7 years) and 35 healthy controls underwent six 1-min two feet standing postural stability tests on a force plate. Study groups were comparable in age and anthropometric and performed the test with eyes open, eyes closed (EC), and EC head up with and without unstable padding. Type 1 diabetics exhibited greater sway (path length, <i>p</i> = 0.044 and standard deviation of velocity, <i>p</i> = 0.039) during the EC test with the unstable pad. Also, power spectral density indicated greater relative power (<i>p</i> = 0.043) in the high-frequency band in the test with EC head up on the unstable pad and somatosensory activity increased more (<i>p</i> = 0.038) when the unstable pad was added to the EC test. Type 1 diabetes may induce subtle changes in postural control requiring more active balancing when stability is challenged. Postural assessment using a portable easy-to-use force plate shows promise in detecting a diabetes-related decline in postural control that may be used as a sensitive biomarker of early-phase diabetes-related complications.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}