High concordance of PET-CT treatment response evaluation according to PERCIST 1.0 when comparing images reconstructed with OSEM vs. BSREM

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2024-09-20 DOI:10.1111/cpf.12907

Tilda Skoglund, David Minarik, Lars Edenbrandt, Elin Trägårdh

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引用次数: 0

Abstract

Background

Positron emission tomography (PET) response criteria in solid tumours (PERCIST 1.0) is a systematic assessment of therapy response with fluorine 18 fluorodeoxyglucose ([¹⁸F]FDG) PET. The ordered subset expectation maximization (OSEM) and block sequential regularized expectation maximization (BSREM) reconstruction algorithms are both commonly used. The impact of using OSEM or BSREM on PERCIST 1.0 is not fully determined. This study aimed to compare treatment response evaluation between the reconstructions OSEM and BSREM according to PERCIST 1.0.

Methods

The highest peak standardized uptake value corrected for lean body mass (SUL_peak) in a lesion were measured in PET-CT scans from 90 patients with metastatic breast cancer or malignant melanoma, who had undergone two [¹⁸F]FDG PET with computer tomography (CT) scans for treatment evaluation purpose. SUL measurements in the reference organ were also calculated. All scans were reconstructed with OSEM and BSREM. Bland Altman plots and Spearman correlation coefficient were used for comparing measurements obtained from OSEM and BSREM images. Patients were categorized as a complete metabolic response (CMR), partial metabolic response (PMR), stable metabolic disease (SMD), or progressive metabolic disease (PMD).

Results

The mean standard deviation (SD) of SUL_mean in the reference organ was slightly lower for BSREM images, resulting in a slightly lower threshold. Lesion SUL_peak was slightly higher for BSREM images compared with OSEM images. Only 5 out of 90 patients had different response evaluations for the different reconstructions.

Conclusion

PERCIST 1.0 serves as a robust response evaluation criterion and is only marginally dependent on the reconstruction used.

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.