Cognitive Neurodynamics最新文献_第9页

Setting a double-capacitive neuron coupled with Josephson junction and piezoelectric source 设置与约瑟夫森结和压电源耦合的双电容神经元

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-07-02 DOI: 10.1007/s11571-024-10145-6

Yixuan Chen, Feifei Yang, Guodong Ren, Chunni Wang

{"title":"Setting a double-capacitive neuron coupled with Josephson junction and piezoelectric source","authors":"Yixuan Chen, Feifei Yang, Guodong Ren, Chunni Wang","doi":"10.1007/s11571-024-10145-6","DOIUrl":"https://doi.org/10.1007/s11571-024-10145-6","url":null,"abstract":"Perception of voice means acoustic electric conversion in the auditory system, and changes of external magnetic field can affect the neural activities by taming the channel current via some field components including memristor and Josephson junction. Combination of two capacitors via an electric component is effective to describe the physical property of artificial cell membrane, which is often used to reproduce the characteristic of electric activities in cell membrane. Involvement of two capacitive variables for two capacitors in the neural circuit can discern the effect of field diversity in the media in two sides of the cell membrane in theoretical way. A Josephson junction is used to couple a piezoelectric neural circuit composed of two capacitors, one inductor and one nonlinear resistor. Field energy is mainly kept in the capacitive and inductive components, and it is obtained and converted into dimensionless energy function. The Hamilton energy function in an equivalent auditory neuron is verified by using the Helmholtz theorem. Noisy excitation on the neural circuit can be detected via the Josephson junction channel and similar stochastic resonance is detected by regulating the noise intensity, as a result, the average energy reaches a peak value under stochastic resonance. An adaptive law controls the bifurcation parameter, which is relative to the membrane property, and energy shift controls the mode selection during continuous growth of the bifurcation parameter. That is, external energy injection derived from acoustic wave or magnetic field will control the energy level, and then suitable firing patterns are controlled effectively.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"18 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141523667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagus nerve electrical stimulation in the recovery of upper limb motor functional impairment after ischemic stroke 迷走神经电刺激在缺血性中风后上肢运动功能障碍恢复中的作用

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-07-01 DOI: 10.1007/s11571-024-10143-8

Long Chen, Huixin Gao, Zhongpeng Wang, Bin Gu, Wanqi Zhou, Meijun Pang, Kuo Zhang, Xiuyun Liu, Dong Ming

{"title":"Vagus nerve electrical stimulation in the recovery of upper limb motor functional impairment after ischemic stroke","authors":"Long Chen, Huixin Gao, Zhongpeng Wang, Bin Gu, Wanqi Zhou, Meijun Pang, Kuo Zhang, Xiuyun Liu, Dong Ming","doi":"10.1007/s11571-024-10143-8","DOIUrl":"https://doi.org/10.1007/s11571-024-10143-8","url":null,"abstract":"Ischemic stroke (IS) is characterized by high mortality, disability rates, and a high risk of recurrence. Motor dysfunction, such as limb hemiparesis, dysphagia, auditory disorders, and speech disorders, usually persists after stroke, which imposes a heavy burden on society and the health care system. Traditional rehabilitation therapies may be ineffective in promoting functional recovery after stroke, and alternative strategies are urgently needed. The Food and Drug Administration (FDA) has approved invasive vagus nerve stimulation (iVNS) for the improvement of refractory epilepsy, treatment-resistant depression, obesity, and moderate to severe upper limb motor impairment following chronic ischemic stroke. Additionally, the FDA has approved transcutaneous vagus nerve stimulation (tVNS) for the improvement of cluster headaches and acute migraines. Recent studies have demonstrated that vagus nerve stimulation (VNS) has neuroprotective effects in both transient and permanent cerebral ischemia animal models, significantly improving upper limb motor impairments, auditory deficits, and swallowing difficulties. Firstly, this article reviews two potential neuronal death pathways following IS, including autophagy and inflammatory responses. Then delves into the current status of preclinical and clinical research on the functional recovery following IS with VNS, as well as the potential mechanisms mediating its neuroprotective effects. Finally, the optimal parameters and timing of VNS application are summarized, and the future challenges and directions of VNS in the treatment of IS are discussed. The application of VNS in stroke rehabilitation research has reached a critical stage, and determining how to safely and effectively translate this technology into clinical practice is of utmost importance. Further preclinical and clinical studies are needed to elucidate the therapeutic mechanisms of VNS.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"31 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141529971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the impact of hearing loss on attentional networks among older individuals: an event-related potential study 调查听力损失对老年人注意力网络的影响：事件相关电位研究

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-21 DOI: 10.1007/s11571-024-10140-x

Sankalpa Madashetty, Hari Prakash Palaniswamy, Bellur Rajashekhar

{"title":"Investigating the impact of hearing loss on attentional networks among older individuals: an event-related potential study","authors":"Sankalpa Madashetty, Hari Prakash Palaniswamy, Bellur Rajashekhar","doi":"10.1007/s11571-024-10140-x","DOIUrl":"https://doi.org/10.1007/s11571-024-10140-x","url":null,"abstract":"Attention is a core cognitive domain crucial in facilitating day-to-day life. Using an attention network test (ANT) along with event-related potentials (ERPs) in older individuals with hearing loss would provide excellent information about the impact of hearing loss on attentional processes. Thus, the current study aims to understand the attentional deficits and its cortical dynamics in older individuals with and without hearing loss. The study recruited 40 participants, 20 older individuals with hearing loss and 20 age and education-matched controls with normal hearing. All the participants underwent cognitive assessment using ANT with simultaneous 32-channel EEG recording. Results revealed significant impairment in executive attention and subtle alterations in alerting and orienting attention among older individuals with hearing loss compared to their normal-hearing counterparts. These findings suggest the negative impact of hearing loss on attentional networks. In addition, ANT and ERPs provide insight into the underlying neural mechanisms in specific attention network deficits associated with hearing loss.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"197 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memristive leaky integrate-and-fire neuron and learnable straight-through estimator in spiking neural networks 尖峰神经网络中的 Memristive 渗漏整合发射神经元和可学习直通估计器

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-20 DOI: 10.1007/s11571-024-10133-w

Tao Chen, Chunyan She, Lidan Wang, Shukai Duan

{"title":"Memristive leaky integrate-and-fire neuron and learnable straight-through estimator in spiking neural networks","authors":"Tao Chen, Chunyan She, Lidan Wang, Shukai Duan","doi":"10.1007/s11571-024-10133-w","DOIUrl":"https://doi.org/10.1007/s11571-024-10133-w","url":null,"abstract":"Compared to artificial neural networks (ANNs), spiking neural networks (SNNs) present a more biologically plausible model of neural system dynamics. They rely on sparse binary spikes to communicate information and operate in an asynchronous, event-driven manner. Despite the high heterogeneity of the neural system at the neuronal level, most current SNNs employ the widely used leaky integrate-and-fire (LIF) neuron model, which assumes uniform membrane-related parameters throughout the entire network. This approach hampers the expressiveness of spiking neurons and restricts the diversity of neural dynamics. In this paper, we propose replacing the resistor in the LIF model with a discrete memristor to obtain the heterogeneous memristive LIF (MLIF) model. The memristance of the discrete memristor is determined by the voltage and flux at its terminals, leading to dynamic changes in the membrane time parameter of the MLIF model. SNNs composed of MLIF neurons can not only learn synaptic weights but also adaptively change membrane time parameters according to the membrane potential of the neuron, enhancing the learning ability and expression of SNNs. Furthermore, since the proper threshold of spiking neurons can improve the information capacity of SNNs, a learnable straight-through estimator (LSTE) is proposed. The LSTE, based on the straight-through estimator (STE) surrogate function, features a learnable threshold that facilitates the backward propagation of gradients through neurons firing spikes. Extensive experiments on several popular static and neuromorphic benchmark datasets demonstrate the effectiveness of the proposed MLIF and LSTE, especially on the DVS-CIFAR10 dataset, where we achieved the top-1 accuracy of 84.40(%).","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"23 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time–frequency–space transformer EEG decoding for spinal cord injury 用于脊髓损伤的时频空间变压器脑电图解码

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-18 DOI: 10.1007/s11571-024-10135-8

Fangzhou Xu, Ming Liu, Xinyi Chen, Yihao Yan, Jinzhao Zhao, Yanbing Liu, Jiaqi Zhao, Shaopeng Pang, Sen Yin, Jiancai Leng, Yang Zhang

{"title":"Time–frequency–space transformer EEG decoding for spinal cord injury","authors":"Fangzhou Xu, Ming Liu, Xinyi Chen, Yihao Yan, Jinzhao Zhao, Yanbing Liu, Jiaqi Zhao, Shaopeng Pang, Sen Yin, Jiancai Leng, Yang Zhang","doi":"10.1007/s11571-024-10135-8","DOIUrl":"https://doi.org/10.1007/s11571-024-10135-8","url":null,"abstract":"Transformer neural networks based on multi-head self-attention are effective in several fields. To capture brain activity on electroencephalographic (EEG) signals and construct an effective pattern recognition model, this paper explores the multi-channel deep feature decoding method utilizing the self-attention mechanism. By integrating inter-channel features with intra-channel features, the self-attention mechanism generates a deep feature vector that encompasses information from all brain activities. In this paper, a time-frequency-spatial domain analysis of motor imagery (MI) based EEG signals from spinal cord injury patients is performed to construct a transformer neural network-based MI classification model. The proposed algorithm is named time-frequency-spatial transformer. The time-frequency and spatial domain feature vectors extracted from the EEG signals are input into the transformer neural network for multiple self-attention depth feature encoding, a peak classification accuracy of 93.56% is attained through the fully connected layer. By constructing the attention matrix brain network, it can be inferred that the channel connections constructed by the attention heads have similarities to the brain networks constructed by the EEG raw signals. The experimental results reveal that the self-attention coefficient brain network holds significant potential for brain activity analysis. The self-attention coefficient brain network can better illustrate correlated connections and show sample differences. Attention coefficient brain networks can provide a more discriminative approach for analyzing brain activity in clinical settings.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"68 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data-driven natural computational psychophysiology in class 课堂上的数据驱动自然计算心理生理学

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-04 DOI: 10.1007/s11571-024-10126-9

Yong Huang, Yuxiang Huan, Zhuo Zou, Yijun Wang, Xiaorong Gao, Lirong Zheng

{"title":"Data-driven natural computational psychophysiology in class","authors":"Yong Huang, Yuxiang Huan, Zhuo Zou, Yijun Wang, Xiaorong Gao, Lirong Zheng","doi":"10.1007/s11571-024-10126-9","DOIUrl":"https://doi.org/10.1007/s11571-024-10126-9","url":null,"abstract":"Objective. The assessment of mental fatigue (MF) and attention span in educational and healthcare settings frequently relies on subjective scales or methods such as induced-task interruption tools. However, these approaches are deficient in real-time evaluation and dynamic definitions. To address this gap, this paper proposes a Continuous Quantitative Scale (CQS) that allows for the natural and real-time measurement of MF based on group-synchronized electroencephalogram (EEG) data. Approach. In this study, computational psychophysiology was used to measure MF scores during a realistic class. Our methodology continuously monitored participants’ psychological states without interrupting their regular routines, providing an objective evaluation. By analyzing multi-subject brain-computer interface (mBCI) data with a collaborative computing approach, the group-synchronized data were obtained from 10 healthy participants to assess MF levels. Each participant wore an EEG headset for only 10 min of preparation before performing a sustained task for 80 min. Main results. Our findings indicate that a lecture duration of 18.9 min is most effective, while a duration of 43.1 min leads to heightened MF levels. By focusing on the group-level simultaneous data analysis, the effects of individual variability were mitigated and the efficiency of cognitive computing was improved. From the perspective of a neurocomputational measure, these results confirm previous research. Significance. The proposed CQS provides a reliable, objective, memory- and emotion-free approach to the assessment of MF and attention span. These findings have significant implications not only for education, but also for the study of group cognitive mechanisms and for improving the quality of mental healthcare.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"12 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141252742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells. GABA受体介导小鼠视网膜神经节细胞的适应和致敏过程

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-01 Epub Date: 2023-04-08 DOI: 10.1007/s11571-023-09950-2

Min Dai, Pei-Ji Liang

{"title":"GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.","authors":"Min Dai, Pei-Ji Liang","doi":"10.1007/s11571-023-09950-2","DOIUrl":"10.1007/s11571-023-09950-2","url":null,"abstract":"Two coordinated dynamic properties (adaptation and sensitization) are observed in retinal ganglion cells (RGCs) under the contrast stimulation. During sustained high-contrast period, adaptation decreases RGCs' responses while sensitization increases RGCs' responses. In mouse retina, adaptation and sensitization respectively show OFF- and ON-pathway-dominance. However, the mechanisms which drive the differentiation between adaptation and sensitization remain unclear. In the present study, multi-electrode recordings were conducted on isolated mouse retina under full-field contrast stimulation. Dynamic property was quantified based on the trend of RGC's firing rate during high-contrast period, light sensitivity was estimated by linear-nonlinear analysis and coding ability was estimated through stimulus reconstruction algorism. γ-Aminobutyric acid (GABA) receptors were pharmacologically blocked to explore the relation between RGCs' dynamic property and the activity of GABA receptors. It was found that GABAA and GABAC receptors respectively mediated the adaptation and sensitization processes in RGCs' responses. RGCs' dynamic property changes occurred after the blockage of GABA receptors were related to the modulation of the cells' light sensitivity. Further, the blockage of GABAA (GABAC) receptor significantly decreased RGCs' overall coding ability and eliminated the functional benefits of adaptation (sensitization). Our work suggests that the dynamic property of individual RGC is related to the balance between its GABAA-receptor-mediated inputs and GABAC-receptor-mediated inputs. Blockage of GABA receptors breaks the balance of retinal circuitry for signal processing, and down-regulates the visual information coding ability.Supplementary information: The online version contains supplementary material available at 10.1007/s11571-023-09950-2.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"1 1","pages":"1021-1032"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41430758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Population and individual firing behaviors in sparsely synchronized rhythms in the hippocampal dentate gyrus. Correction to：海马齿状回稀疏同步节律中的群体和个体点火行为

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-06-01 Epub Date: 2023-03-29 DOI: 10.1007/s11571-023-09949-9

Sang-Yoon Kim, Woochang Lim

引用次数: 0

Short-length SSVEP data extension by a novel generative adversarial networks based framework 通过基于生成式对抗网络的新型框架扩展短时长 SSVEP 数据

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-05-31 DOI: 10.1007/s11571-024-10134-9

Yudong Pan, Ning Li, Yangsong Zhang, Peng Xu, Dezhong Yao

{"title":"Short-length SSVEP data extension by a novel generative adversarial networks based framework","authors":"Yudong Pan, Ning Li, Yangsong Zhang, Peng Xu, Dezhong Yao","doi":"10.1007/s11571-024-10134-9","DOIUrl":"https://doi.org/10.1007/s11571-024-10134-9","url":null,"abstract":"Steady-state visual evoked potentials (SSVEPs) based brain–computer interface (BCI) has received considerable attention due to its high information transfer rate (ITR) and available quantity of targets. However, the performance of frequency identification methods heavily hinges on the amount of user calibration data and data length, which hinders the deployment in real-world applications. Recently, generative adversarial networks (GANs)-based data generation methods have been widely adopted to create synthetic electroencephalography data, holds promise to address these issues. In this paper, we proposed a GAN-based end-to-end signal transformation network for Time-window length Extension, termed as TEGAN. TEGAN transforms short-length SSVEP signals into long-length artificial SSVEP signals. Additionally, we introduced a two-stage training strategy and the LeCam-divergence regularization term to regularize the training process of GAN during the network implementation. The proposed TEGAN was evaluated on two public SSVEP datasets (a 4-class and 12-class dataset). With the assistance of TEGAN, the performance of traditional frequency recognition methods and deep learning-based methods have been significantly improved under limited calibration data. And the classification performance gap of various frequency recognition methods has been narrowed. This study substantiates the feasibility of the proposed method to extend the data length for short-time SSVEP signals for developing a high-performance BCI system. The proposed GAN-based methods have the great potential of shortening the calibration time and cutting down the budget for various real-world BCI-based applications.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"101 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141190568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington’s disease and treatment 基底神经节直接和间接通路之间和谐关系的打破和恢复：亨廷顿氏病与治疗

IF 3.7 3区工程技术

Cognitive Neurodynamics Pub Date : 2024-05-30 DOI: 10.1007/s11571-024-10125-w

Sang-Yoon Kim, Woochang Lim

{"title":"Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington’s disease and treatment","authors":"Sang-Yoon Kim, Woochang Lim","doi":"10.1007/s11571-024-10125-w","DOIUrl":"https://doi.org/10.1007/s11571-024-10125-w","url":null,"abstract":"The basal ganglia (BG) in the brain exhibit diverse functions for motor, cognition, and emotion. Such BG functions could be made via competitive harmony between the two competing pathways, direct pathway (DP) (facilitating movement) and indirect pathway (IP) (suppressing movement). As a result of break-up of harmony between DP and IP, there appear pathological states with disorder for movement, cognition, and psychiatry. In this paper, we are concerned about the Huntington’s disease (HD), which is a genetic neurodegenerative disorder causing involuntary movement and severe cognitive and psychiatric symptoms. For the HD, the number of D2 SPNs ((N_{rm D2})) is decreased due to degenerative loss, and hence, by decreasing (x_{rm D2}) (fraction of (N_{rm D2})), we investigate break-up of harmony between DP and IP in terms of their competition degree (mathcal{C}_d), given by the ratio of strength of DP ((mathcal{S}_{DP})) to strength of IP ((mathcal{S}_{IP})) (i.e., (mathcal{C}_d = mathcal{S}_{DP} / mathcal{S}_{IP})). In the case of HD, the IP is under-active, in contrast to the case of Parkinson’s disease with over-active IP, which results in increase in (mathcal{C}_d) (from the normal value). Thus, hyperkinetic dyskinesia such as chorea (involuntary jerky movement) occurs. We also investigate treatment of HD, based on optogenetics and GP ablation, by increasing strength of IP, resulting in recovery of harmony between DP and IP. Finally, we study effect of loss of healthy synapses of all the BG cells on HD. Due to loss of healthy synapses, disharmony between DP and IP increases, leading to worsen symptoms of the HD.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"53 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141190676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0