Clinics最新文献

{"title":"Innovation in reconstructive plastic surgery","authors":"Fábio F. Busnardo, Nivaldo Alonso, Rolf Gemperli","doi":"10.1016/j.clinsp.2026.101108","DOIUrl":"10.1016/j.clinsp.2026.101108","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 101108"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different acupuncture strategies on the prognosis and inflammatory factor levels associated with the treatment of knee osteoarthritis","authors":"Jun Li ,&nbsp;Di Wu ,&nbsp;Xueli Chen ,&nbsp;Guanhua Li","doi":"10.1016/j.clinsp.2026.100871","DOIUrl":"10.1016/j.clinsp.2026.100871","url":null,"abstract":"<div><h3>Background</h3><div>Knee osteoarthritis is a degenerative joint condition characterized by the progressive degeneration of knee cartilage. Acupuncture therapy, as an alternative treatment, has shown significant efficacy in managing joint disorders. In the current study, the effects of four acupuncture strategies in treating knee osteoarthritis were compared and analyzed.</div></div><div><h3>Methods</h3><div>123 cases diagnosed with knee osteoarthritis were included in the current study at the First People's Hospital of Jiujiang City from May 2022 to May 2023. The patients received different acupuncture strategies, including traditional acupuncture, electroacupuncture, warm acupuncture, and fire acupuncture. Then the information regarding the treatment effects on physical function and inflammatory cytokines was collected and analyzed.</div></div><div><h3>Results</h3><div>The data showed that all four treatment strategies could improve the life quality of the patients, but the effects of electroacupuncture were stronger. The effects of warm acupuncture and fire acupuncture were weaker than electroacupuncture, but were stronger than traditional acupuncture. Regarding the effects on knee physical function and inflammatory indicators, electroacupuncture also showed better treatment effects than the other three treatments. The overall efficacy in treating knee osteoarthritis was comparable between different treating strategies, even though the effects of different acupuncture strategies on detailed items might be different.</div></div><div><h3>Conclusions</h3><div>Collectively, the current study demonstrated that all the acupuncture strategies could improve the physical function and reduce pain in the knee, thereby improving the life quality of patients, with electroacupuncture showing the strongest effects on certain detecting items.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100871"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation study on different types of chronic sinusitis and eustachian tube dysfunction: analysis of prevalence and risk factors","authors":"Qihang Zhang ,&nbsp;Qianjin Zeng ,&nbsp;Jingtao Wang ,&nbsp;Fu Feng ,&nbsp;Guangke Wang","doi":"10.1016/j.clinsp.2026.100890","DOIUrl":"10.1016/j.clinsp.2026.100890","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;This study investigated the Eustachian Tube Dysfunction (ETD) prevalence and its influencing factors in Chronic Rhinosinusitis (CRS) patients undergoing Functional Endoscopic Sinus Surgery (FESS), based on postoperative histopathological subtypes. The findings may aid in the diagnosis and individualized management of CRS with comorbid ETD.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;This study included 92 patients who underwent FESS surgery for CRS and were hospitalized in the Otolaryngology Head and Neck Surgery Department of Zhengzhou University People's Hospital from January 2024 to May 2024. According to the postoperative pathological results, the patients were divided into the Chronic Rhinosinusitis without Nasal Polyps (CRSsNP) group and the Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) group. The CRSwNP group was further divided into an Eosinophilic Chronic Rhinosinusitis with Nasal Polyps (EosCRSwNP) subgroup. General information, imaging examination data, 7-item symptom score scale for eustachian tube dysfunction (Eustachian Tube Dysfunction Questionnaire-7, ETDQ-7), and eustachian tube pressure score (Eustachian Tube Score, ETS) of all included patients were collected. The prevalence of ETD in patients with different pathological types of CRS, the influencing factors of eustachian tube function in preoperative CRS patients, and the consistency of the two eustachian tube function detection methods and the test efficacy of the two eustachian tube function detection methods were analyzed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Correlations &amp; Risk Factors: CRSwNP: Serum total IgE moderately correlated with preop ETDQ-7 (ρ = 0.497, p = 0.001). EosCRSwNP: Age (γ = 0.534, p &lt; 0.01) and IgE (ρ = 0.506, p &lt; 0.05) strongly correlated with ETDQ-7. IgE was an independent risk factor (OR = 1.010). Using the ETDQ-7 score and ETS score as the main diagnostic methods for ETD indicates that there is no statistically significant difference in the prevalence of ETD among the three groups of patients (CRSsNP, CRSwNP, and EosCRSwNP) (p &gt; 0.05). Two types of examination methods were used to test the preoperative eustachian tube function of patients with different pathological types of CRS. The consistency degree of the results of the ETDQ-7 score and the ETS score was different. Among them, the patients in the EosCRSwNP group had the highest score, while those in the CRSsNP group had the lowest score (CRSsNP group: κ = 0.396, p &lt; 0.01; CRSwNP group: κ = 0.421, p &lt; 0.01; EosCRSwNP group: κ = 0.563, p &lt; 0.01).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;ETD Incidence &amp; Correlation: ETD occurrence in CRS varies slightly by subtype but remains comparable overall. CRSwNP patients show a significant association between ETD symptoms and serum total IgE levels. The ETDQ-7 score and the ETS score, as subjective and objective methods for evaluating the function of the eustachian tube, have good consistency in results and ca","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100890"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the efficacy and safety of lenvatinib vs. sorafenib as first-line treatments for hepatocellular carcinoma","authors":"Wentao Bo ,&nbsp;Zhenguo Wang ,&nbsp;Xiuhua Dong ,&nbsp;Jing Zou","doi":"10.1016/j.clinsp.2026.100869","DOIUrl":"10.1016/j.clinsp.2026.100869","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the efficacy and safety of lenvatinib and sorafenib as first-line treatments for hepatocellular carcinoma.</div></div><div><h3>Method</h3><div>The authors searched PubMed, Web of Science, Cochrane, CNKI, Wanfang, and other databases and compared the clinical efficacy of lenvatinib and sorafenib as first-line treatments for hepatocellular carcinoma. Two participants screened the literature, collated the data, and evaluated the literature according to the inclusion and exclusion criteria. RevMan 5.4 software was used for meta-analysis of the included studies.</div></div><div><h3>Results</h3><div>Ten studies were included in the meta-analysis. The results of the meta-analysis showed that, in terms of efficacy, compared with sorafenib, lenvatinib prolongs PFS in patients with hepatocellular carcinoma (HR = 85.50, 95 % CI: 38.53‒189.73, <em>p</em> &lt; 0.00001) and OS (HR = 36.73, 95 % CI: 20.28–66.52, <em>p</em> &lt; 0.00001), and the differences were statistically significant. In terms of safety, the risk of toxicities in the lenvatinib group at any level of gastrointestinal toxicities, metabolism/nutrition toxicities, hematological toxicities, Renal/Urinary, Vascular toxicities, and endocrine toxicities was significantly higher in the lenvatinib group than in the sorafenib group. The risks of metabolism/nutrition toxicities, renal/urinary toxicities, and vascular toxicities above grade III were significantly higher than those in the sorafenib group. The Skin/Subcutaneous Tissue toxicities of any grade and above were significantly lower than those in the sorafenib group.</div></div><div><h3>Conclusions</h3><div>As a first-line treatment for hepatocellular carcinoma, lenvatinib can prolong PFS and OS and improve the clinical benefit rate and quality of life of patients. The increased risk of specific adverse events with lenvatinib requires diligent clinical oversight.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100869"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Δ9-tetrahydrocannabinol and cannabidiol on myofascial pain modulation in patients with temporomandibular disorder: a prospective crossover study","authors":"Francisco Gomes Bonetto Schinko ,&nbsp;Luiz Renato Paranhos ,&nbsp;Lucas Gonçalves de Sousa ,&nbsp;Gabriel Phelipe de Paula Santos ,&nbsp;Sigmar de Mello Rode ,&nbsp;Antonio Sergio Guimarães ,&nbsp;Juliana Cama Ramacciato","doi":"10.1016/j.clinsp.2026.100885","DOIUrl":"10.1016/j.clinsp.2026.100885","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular Disorder (TMD) often causes chronic orofacial pain and functional limitations, with conventional treatments providing suboptimal results. Phytocannabinoids such as Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) have analgesic and anti-inflammatory properties, but evidence in TMD is scarce.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of Δ9-THC/CBD therapy in reducing pain and improving mandibular function in TMD patients.</div></div><div><h3>Methods</h3><div>Twenty adults with chronic myofascial pain (DC/TMD diagnosis) participated in a blinded, crossover, non-randomized study. Participants underwent two consecutive 90-day phases: placebo followed by Δ9-THC/CBD therapy (1:1 ratio, starting with a dose of 2 mg/day in the first week, gradually adjusting an increase of 2 mg/week until reaching 10 mg/day in the fifth week, sublingually), without washout. Outcomes included pain intensity (VAS), muscle sensitivity (algometry), mandibular function (mouth opening, protrusion, laterality) and pain sensitivity (allodynia/hyperalgesia). Data were analyzed using linear mixed models for repeated measures.</div></div><div><h3>Results</h3><div>Δ9-THC/CBD improved all outcomes versus baseline and post-placebo (<em>p</em> &lt; 0.001; Cohen’s <em>d</em> &gt; 0.8). Mouth opening increased from 45.9 mm to 49.9 mm; VAS pain decreased from 7.35 to 3.50. Functional pain dropped by ∼90%, with near elimination of allodynia and hyperalgesia. Placebo effects were minimal.</div></div><div><h3>Conclusion</h3><div>Δ9-THC/CBD therapy provided substantial analgesic and functional benefits in TMD patients, supporting its potential as a therapeutic alternative. Larger randomized studies are recommended to validate these findings and explore underlying mechanisms.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100885"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition paradox: high muscle mass and adiposity jointly predict incident chronic kidney disease in a Korean cohort","authors":"Eun Young Lee ,&nbsp;Choon Hee Chung ,&nbsp;Tae Hwa Go ,&nbsp;Sang Baek Koh ,&nbsp;Jung Ran Choi","doi":"10.1016/j.clinsp.2026.100879","DOIUrl":"10.1016/j.clinsp.2026.100879","url":null,"abstract":"<div><h3>Objective</h3><div>Diabetes, hypertension, and obesity are common traditional risk factors for Chronic Kidney Disease (CKD). In this population-based longitudinal study, the authors identified risk factors associated with CKD development.</div></div><div><h3>Method</h3><div>A total of 6,238 Korean adults aged 40- to 69-years without baseline CKD were included. Among them, 4,057 participants with baseline estimated Glomerular Filtration Rate (eGFR) measurements were analyzed. Logistic regression models were used to evaluate significant predictors of CKD.</div></div><div><h3>Results</h3><div>Over a 10-year follow-up period, CKD developed in 354 subjects (8.7 %). Leptin levels were significantly higher in participants who developed CKD compared to those who did not (8.89 ± 8.00 vs. 6.44 ± 5.52, <em>p</em> &lt; 0.001). After adjusting for confounding factors, logistic regression analysis indicated that participants in the highest quartile of muscle mass were 2.314-times more likely to develop CKD compared to those in the lowest quartile (Odds Ratio [OR = 2.314]; 95 % Confidence Interval [95 % CI: 1.372–3.902]; p = 0.014). In multivariable-adjusted models, the OR for incident CKD when comparing the lowest to the highest quartiles of body fat was 2.166 in men; however, the significance disappeared after adjusting for eGFR. Among women, higher leptin levels and lower adiponectin levels were independently associated with incident CKD (<em>p</em> = 0.003 and <em>p</em> = 0.038, respectively), regardless of traditional CKD risk factors. Furthermore, compared to subjects without CKD, those with metabolic syndrome had an OR (95 % CI) of 5.256 (2.813–9.820) for incident CKD after controlling for confounding factors.</div></div><div><h3>Conclusion</h3><div>These findings suggest that muscle mass and body fat may serve as better predictors of incident CKD.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100879"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prometheus’ fire and Brazilian universities: A decade of the quota law","authors":"Lucas Leite Cunha,&nbsp;Laura Sterian Ward","doi":"10.1016/j.clinsp.2026.101058","DOIUrl":"10.1016/j.clinsp.2026.101058","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 101058"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onlay versus Inlay Lower Trapezius Tendon transfer for posterosuperior functional irreparable rotator cuff tears: a 2-year clinical and imaging study","authors":"Cheng-Pang Yang,&nbsp;Tung-Lung Wu,&nbsp;Louis Yi Lu,&nbsp;Lei Hsia,&nbsp;Poyu Chen,&nbsp;Joe Chih-Hao Chiu","doi":"10.1016/j.clinsp.2026.100934","DOIUrl":"10.1016/j.clinsp.2026.100934","url":null,"abstract":"<div><h3>Background</h3><div>This study compared the clinical and radiological outcomes of Onlay and Inlay Lower Trapezius Tendon (LTT) transfer techniques in managing posterosuperior Functional Irreparable Rotator Cuff Tears (FIRCTs).</div></div><div><h3>Methods</h3><div>This retrospective comparative study included patients who underwent Onlay and Inlay LTT transfer. The inclusion criteria were FIRCTs defined by tendon retraction to the glenoid, fatty infiltration &gt; 2 grade according to Goutallier, and with a positive External Rotation (ER) lag sign. Patients with irreparable subscapularis, dysfunctional deltoid, advanced glenohumeral osteoarthritis, cuff tear arthropathy, and revision surgeries were excluded. Outcomes measures included the active Range Of Motion (ROM), Acromiohumeral Distance (AHD), American Shoulder and Elbow Surgeons (ASES) score, Single Assessment Numeric Evaluation (SANE) score and Constant score.</div></div><div><h3>Results</h3><div>The study included 39 patients (21 Onlay and 18 Inlay LTT) with at least 2-year follow-up. Both groups achieved significant improvement in active forward elevation from 118.6 ± 57.6° to 145.7 ± 18° in the Onlay group (<em>p</em> = 0.046) and 112.2 ± 49.2° to 140.6 ± 30.6° in the Inlay group (<em>p</em> = 0.046). The ER improved from 31 ± 21.2°to 44.3 ± 16° in the Onlay (<em>p</em> = 0.027) and 29.4 ± 27.1° to 45 ± 16.9° in the Inlay group (<em>p</em> = 0.046). The postoperative AHD was better in the Onlay group (7.3 ± 2.5 vs. 4.8 ± 3.2 mm, <em>p</em> = 0.001). The ASES, SANE, and Constant scores all improved significantly at final follow-up (all <em>p</em> &lt; 0.001) in both groups and reached the Minimal Clinically Important Difference.</div></div><div><h3>Conclusion</h3><div>Both the onlay and Inlay techniques of LTT transfer effectively improved shoulder function in patients with irreparable posterosuperior rotator cuff tears. The Onlay technique resulted in better AHD at final follow-up.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100934"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based physiological responses to a 750-m swim at critical velocity estimated by the three-parameter model","authors":"Vinícius Ribeiro dos Anjos Souza ,&nbsp;Lavínia Vivan ,&nbsp;Paulo Engelke ,&nbsp;Claudio Andre Barbosa de Lira ,&nbsp;Rodrigo Luiz Vancini ,&nbsp;Katja Weiss ,&nbsp;Beat Knechtle ,&nbsp;Marilia Santos Andrade","doi":"10.1016/j.clinsp.2026.100943","DOIUrl":"10.1016/j.clinsp.2026.100943","url":null,"abstract":"<div><h3>Introduction</h3><div>Critical Velocity (CV) is widely used to assess aerobic performance in endurance sports. Studies have compared protocols for CV determination in elite athletes. However, knowledge on the influence of the assessment protocol on CV and sex-based differences on metabolic responses at critical swimming velocity is limited.</div></div><div><h3>Objective</h3><div>This study aims to compare different protocols for determining CV in swimming among male and female triathletes and to compare sex-based differences in the metabolic and perceived exertion responses after swimming 750 m at CV estimated by the three-parameter model.</div></div><div><h3>Methods</h3><div>Highly trained amateur triathletes (12 men, 35.7 ± 11.0 years; 10 women, 38.1 ± 6.0 years) performed maximal swimming tests (50, 100, 200, and 400 m) to estimate Critical Velocity (CV). Each completed a 750 m swim at the CV determined by the three-parameter protocol (100–200–400 m), with monitoring of metabolic responses (lactate level and heart rate) and pain, dyspnea, and subjective perceived exertion.</div></div><div><h3>Results</h3><div>The four-distance protocol yielded the highest CV in both sexes, whereas the protocol based on 92% of the 400 m time produced the lowest values (p &lt; 0.001). After the 750 m swim, men showed higher ratings of perceived exertion (p = 0.005), pain (p &lt; 0.001), dyspnea (p &lt; 0.001), and blood lactate concentration (p &lt; 0.001) than women.</div></div><div><h3>Conclusion</h3><div>The protocol used to determine CV significantly influences estimated values. Importantly, all findings related to physiological and perceptual responses during the 750 m swim are specific to the CV determined by the three-parameter protocol and should not be generalized to other CV determination methods. Under this protocol, CV may be associated with an exercise intensity approaching the severe domain; however, this interpretation should be made with caution.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100943"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of an interdisciplinary research model at a tertiary University Hospital in São Paulo, Brazil: post-COVID-19 cohort study","authors":"Laura Sampaio de Moura Azevedo ,&nbsp;Marina Pires do Rio Caldeira ,&nbsp;Moises Victor Ribeiro Nunes ,&nbsp;Carolina Monteiro Lobato Del Villar ,&nbsp;Denise Lungwtz Ramalho ,&nbsp;Thais Suemi Yokoyama ,&nbsp;Pedro Rizzi de Oliveira ,&nbsp;Thais Mauad ,&nbsp;Orestes Vicente Forlenza ,&nbsp;Linamara Rizzo Battistella ,&nbsp;Emmanuel A. Burdmann ,&nbsp;Marcia Thereza Couto ,&nbsp;Carlos Roberto Ribeiro Carvalho","doi":"10.1016/j.clinsp.2026.100925","DOIUrl":"10.1016/j.clinsp.2026.100925","url":null,"abstract":"<div><div>This study describes the implementation of an interdisciplinary model within the COVID-19 cohort at Hospital das Clínicas, Universidade de São Paulo (HCFMUSP). Among 1957 survivors, 749 attended the first follow-up (6‒11 months), revealing that 83% reported persistent symptoms ‒ mainly fatigue, dizziness, pain, and dyspnea ‒ highlighting the need for extended monitoring. A four-year program involving 22 study groups was established to characterize symptom frequency, severity and disability, explore clinical and sociodemographic associations, and evaluate the potential for recovery through multidisciplinary approaches. A dedicated team coordinated recruitment, teleconsultations, in-person assessments and database management. Of 749 patients, 523 completed teleconsultations, 433 attended the first visit, and 367 the second. The implementation demonstrated that interdisciplinary research enhances patient engagement, reduces fragmentation, and supports efficient and high-quality research in complex human-based studies.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100925"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}