Clinics最新文献

{"title":"Difference among frailty assessment tools in predicating postoperative prognosis of elderly patients with mild traumatic brain injury","authors":"Chunhua Ni ,&nbsp;Chen Gu ,&nbsp;Hua Liu ,&nbsp;Feng Cheng ,&nbsp;Chao Cheng ,&nbsp;Xiaohua Xia","doi":"10.1016/j.clinsp.2024.100554","DOIUrl":"10.1016/j.clinsp.2024.100554","url":null,"abstract":"<div><h3>Objectives</h3><div>Mild Traumatic Brain Injury (mTBI) is quite prevalent in the elderly population, and the authors performed a retrospective analysis regarding the predictive value of frailty assessing tools regarding the prognosis of elderly mTBI patients.</div></div><div><h3>Methods</h3><div>All the patients underwent assessment of frailty upon admission using five tools including Frailty Phenotype (FP), FRAIL Scale (FS), Edmonton Frailty Scale (EFS), Groningen Frailty Indicator (GFI), and Clinical Frailty Scale (CFS). The predicting potential of tools was analyzed against the prognosis defined by the extended Glasgow Outcome Scale (GOSE).</div></div><div><h3>Results</h3><div>The incidence of frailty in elderly patients varies widely among the tools. Multivariate logistic regression analysis showed that only frail conditions defined by FP (p-value = 0.014) and FS (p-value = 0.004) could be employed for predicting unfavorable prognosis defined by GOSE, while frailty defined by CFS (p-value = 0.683), EFS (p-value = 0.301) and GFI (p-value = 0.925) could not. The ROC further showed that FP (AUC = 73.2 %) and FS (AUC = 76.2 %) had moderate power in predicting unfavorable conditions, while CFS (AUC = 46.1 %), EFS (AUC = 55.6 %), and GFI (AUC = 51.5 %) only had low or even no power.</div></div><div><h3>Conclusions</h3><div>FP and FS could be used to predict the unfavorable prognosis associated with mTBI in the elderly population.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100554"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of tomography in the screening at the emergency room during pandemics","authors":"Marcel Lima Albuquerque ,&nbsp;Ricardo D'Oliveira Vieira ,&nbsp;Luiz Eduardo Fonteles Ritt","doi":"10.1016/j.clinsp.2024.100559","DOIUrl":"10.1016/j.clinsp.2024.100559","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100559"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics model is an effective means to diagnose benign and malignant pulmonary nodules","authors":"Yunzeng Zhang ,&nbsp;Fan Zhang ,&nbsp;Changming Shen ,&nbsp;Gaofeng Qiao ,&nbsp;Cheng Wang ,&nbsp;Feng Jin ,&nbsp;Xiaogang Zhao","doi":"10.1016/j.clinsp.2025.100599","DOIUrl":"10.1016/j.clinsp.2025.100599","url":null,"abstract":"<div><div>In response to the high false positive rate of traditional Low-Dose Computed Tomography (LDCT) in diagnosing pulmonary malignant nodules, this study aimed to investigate the effectiveness of scoring of blood-based non-invasive biological metabolite detection combined with artificial intelligent scoring of non-invasive imaging in the clinical diagnosis of Pulmonary Nodules (PNs). In this retrospective study, risk scoring was performed in patients positive for pulmonary nodules and subsequently, PNs were sampled by invasive procedures for pathological examinations. The pathological classification was used as the gold standard, and statistical and machine learning methods showed, that in 210 patients (23 benign PN and 187 malignant PN), the risk score of Metabonomics, radiomics, and multi-omics had different levels of performance in different risk groups based on various predictive models. The Area Under the receiver operating Characteristic Curve (AUC) of the multi-omics model was 0.823. The present results indicate that a multi-omics model is more effective than a single model in the non-invasive diagnosis of pulmonary malignant nodules.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100599"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression","authors":"AiYuan Cai ,&nbsp;HuiShi Ye ,&nbsp;YuanHong Lin ,&nbsp;JinYun Li ,&nbsp;DongSheng Fang ,&nbsp;ZhongBin Pan ,&nbsp;ZhiWei Li ,&nbsp;GuangLiang Luo ,&nbsp;YanFang Huang ,&nbsp;CiAi Lai","doi":"10.1016/j.clinsp.2025.100594","DOIUrl":"10.1016/j.clinsp.2025.100594","url":null,"abstract":"<div><h3>Background and objective</h3><div>Colon Cancer (CC) is a common malignant tumor. The aim of this study was to investigate the role and regulatory mechanism of circular RNA pappalysin-1 (circ-PAPPA; hsa_circ_0088233) in CC.</div></div><div><h3>Methods</h3><div>In cancer tissues from CC patients, circ-PAPPA expression was measured and its relationship with patients’ clinical features was analyzed. Plasmid vectors or oligonucleotides interfering with the expression of circ-PAPPA, microRNA (miR)-656–3p or G-protein subunit Gamma-5 (GNG5) were transfected into CC cells. Cell viability was detected by MTT and colony formation assay; apoptosis was detected by flow cytometry; and cell migration and invasion were detected by wound healing assay and Transwell. Glycolytic capacity of CC cells was assessed by measuring glucose uptake and lactate production using commercial kits. The targeting relationship between miR-656–3p and circ-PAPPA or GNG5 was verified by bioinformatics website starBase and dual luciferase reporter gene assay assays.</div></div><div><h3>Results</h3><div>Circ-PAPPA was upregulated in CC and was negatively correlated with benign pathological features and 5-year survival rates of CC patients. Circ-PAPPA silencing inhibited the growth and glycolysis of CC cells through upregulating miR-656–3p. GNG5, a target of miR-656–3p, could reverse the impacts of silencing circ-PAPPA on CC cells.</div></div><div><h3>Conclusion</h3><div>Circ-PAPPA may play an oncogenic role in CC by promoting cell growth and glycolysis through the miR-656–3p/GNG5 axis.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100594"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Gastric adenocarcinoma and periodontal disease: a systematic review and meta-analysis”","authors":"Shubham Kumar ,&nbsp;Nosaibah Razaqi ,&nbsp;Rachana Mehta ,&nbsp;Ranjana Sah","doi":"10.1016/j.clinsp.2025.100596","DOIUrl":"10.1016/j.clinsp.2025.100596","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100596"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive model for pulmonary arterial hypertension in adult idiopathic-inflammatory-myopathy patients: A cross-sectional study","authors":"Junyu Liang ,&nbsp;Xiaoqun Ba ,&nbsp;Liyan Wan ,&nbsp;Xiao Cui ,&nbsp;Ye He ,&nbsp;Lanlan Xiao ,&nbsp;Yini Ke ,&nbsp;Hanyin Zhang ,&nbsp;Heng Cao ,&nbsp;Jin Lin","doi":"10.1016/j.clinsp.2025.100621","DOIUrl":"10.1016/j.clinsp.2025.100621","url":null,"abstract":"<div><h3>Objective</h3><div>To identify clinical and laboratory risk factors for Pulmonary Arterial Hypertension (PAH) in Idiopathic-Inflammatory-Myopathy (IIM) patients as well as construct a predicting model for PAH.</div></div><div><h3>Methods</h3><div>An IIM cohort in southeastern China was established, including 504 adult IIM patients who met the inclusion and exclusion criteria, and were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU) from January 1st, 2018, to April 30st 2022. Serum cytokine profiles, myositis-specific antibodies as well as other factors of patients who met the inclusion and exclusion criteria were collected and analyzed.</div></div><div><h3>Results</h3><div>Of the 504 adult IIM patients, 25 IIM patients developed PAH and 48.0 % of them deceased within six months. IIM patients complicated with PAH were found to suffer from worse outcome (<em>p</em> &lt; 0.001). After multivariate logistic regression analysis, age (<em>p</em> &lt; 0.001), bacterial infection (<em>p</em> = 0.005), MYOACT score (<em>p</em> = 0.009), Interleukin (IL)-17A (<em>p</em> = 0.017), anti-SRP antibody (<em>p</em> = 0.011) and steroid monotherapy (<em>p</em> = 0.001) were identified as factors significantly associated with PAH in IIM patients. A “BAIMS” model was constructed by including the above six items to predict PAH with a cut-off value of ≥ 3 and an Area Under the Curve (AUC) of 0.877.</div></div><div><h3>Conclusion</h3><div>PAH is a rare but potentially fatal complication in IIM patients. Aging, complication of bacterial infection, elevated disease activity, increased serum IL-17A level, positivity of anti-SRP antibody and steroid monotherapy were significantly correlated with development of PAH in IIM patients. In addition, the BAIMS model was found valuable in prediction and early-identification of PAH in IIM patients.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100621"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases","authors":"Arthur Henrique Cunha-Volpato ,&nbsp;Carlos Izaias Sartorão Neto ,&nbsp;Luiz Fernando Ferraz da Silva ,&nbsp;Paulo Campos Carneiro","doi":"10.1016/j.clinsp.2024.100539","DOIUrl":"10.1016/j.clinsp.2024.100539","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of Hormone Dosage (HD) in Fine Needle Aspiration Biopsy (FNA) needle washout fluid, introduced in the 1990s, initially aimed at measuring Thyroglobulin (TG). Elevated TG concentration in an extrathyroidal cervical lesion suggests metastases of Well-Differentiated Thyroid Carcinomas (WDTC). Over the years, HD has evolved to incorporate Calcitonin (CT) and Parathormone (PTH), improving sensitivity and specificity in diverse clinical scenarios. Despite varying cutoffs in the literature, existing data underscore significant advancements in diagnostic accuracy.</div></div><div><h3>Methods</h3><div>This paper presents a case series of 762 cervical lesions with FNA cytology and HD in different cervical regions.</div></div><div><h3>Results</h3><div>It was possible to establish the histogenesis of the lesion based on a combination of the FNA cytology and PTH HD findings, so PTH was useful to determine parathyroid origin in all regions, Thyroglobulin (TG) and PTH together provide insights on cell origin in difficult cases. Thyroglobulin (TG) dosage enhances the accuracy of detecting well-differentiated thyroid carcinomas. In post-thyroidectomy by bed lesions, dosages help to determine non-thyroid/parathyroid lesions.</div></div><div><h3>Discussion</h3><div>The case series and review underscore the valuable contribution of HD in fine-needle aspiration for the evaluation of cervical lesions. By integrating HD with cytological, ultrasound, and clinical data, clinicians can enhance the accuracy and specificity of FNA in diagnosing various cervical lesions, ultimately improving patient care and management.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100539"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactylated histone H3K18 as a potential biomarker for the diagnosis and prediction of the severity of pancreatic cancer","authors":"Jinping Hou ,&nbsp;Mingsong Guo ,&nbsp;Yongqiong Li ,&nbsp;Yijin Liao","doi":"10.1016/j.clinsp.2024.100544","DOIUrl":"10.1016/j.clinsp.2024.100544","url":null,"abstract":"<div><h3>Background</h3><div>Lactylation plays an essential role in pancreatic cancer, but the precise role of lactylated histone in the diagnosis and prognosis of pancreatic cancer remains to be further clarified.</div></div><div><h3>Methods</h3><div>Twenty-one patients diagnosed with pancreatic cancer were enrolled in this study, and the clinicopathologic characteristics were collected. Lactylation levels of total proteins and histone H3 Lysine-18 (H3K18) of tissues were determined by western blotting and laboratory indicators including serum levels of lactate, Cancer Antigen 19–9 (CA19–9), and Carcinoembryogenic Antigen (CEA) were obtained.</div></div><div><h3>Results</h3><div>Total protein lactylation was found in both pancreatic cancer tissues and para-carcinoma normal tissues, and was more potent in tumor tissues. H3K18la was also highly expressed tumor tissues. Furthermore, H3K18la protein expression correlated positively with serum lactate (<em>r</em> = 0.774, <em>p</em> &lt; 0.001), CA19–9 (<em>r</em> = 0.744, <em>p</em> &lt; 0.001), and CEA (<em>r</em> = 0.589, <em>p</em> &lt; 0.01). The Area Under the Curve (AUC) of H3K18la for the diagnosis of pancreatic cancer was 0.848 in serum (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The present findings suggested that H3K18 may be used as a novel potential biomarker for the diagnosis and prognosis of pancreatic cancer patients.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100544"},"PeriodicalIF":2.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with rare diseases are responsible for the majority of hospitalizations in a Brazilian tertiary pediatric hospital: Preliminary data.","authors":"Cristina Grassiotto, Simone Pavani, Nara Vasconcelos Cavalcanti, Angelina Gonçalves, Andreia Watanabe, Vicente Odone-Filho, Ana Cristina Aoun Tannuri, Clovis Artur A Silva, Magda Carneiro-Sampaio","doi":"10.1016/j.clinsp.2024.100535","DOIUrl":"10.1016/j.clinsp.2024.100535","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100535"},"PeriodicalIF":2.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of heart rate variability with cardiorespiratory fitness and muscle strength in patients after hospitalization for COVID-19: An analytical cross-sectional study.","authors":"Daniele Ferreira Rodrigues, Victor Ribeiro Neves, Ulisses Ramos Montarroyos, Washington José Dos Santos, Isabelle Carolline Verissimo de Farias, Dário Celestino Sobral Filho","doi":"10.1016/j.clinsp.2024.100534","DOIUrl":"10.1016/j.clinsp.2024.100534","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with a moderate to severe clinical condition of COVID-19 who need hospitalization may have dysfunction in Cardiac Autonomic Control (CAC) and functional capacity.</p><p><strong>Objective: </strong>To assess the association of HRV with cardiorespiratory fitness and respiratory and peripheral muscle strength in patients after hospitalization for COVID-19.</p><p><strong>Method: </strong>Cross-sectional study with individuals > 18-years old, post-hospitalization for COVID-19, with a positive RT-PCR test. Data on clinical condition and hospital admission were collected, and parameters of respiratory and peripheral muscle strength and functional capacity were evaluated with the 6-Minute Walk Test (6MWT). CAC was assessed by analyzing (Heart Rate Variability) HRV in the time (SDNN, RMSSD) and frequency domains (HF, LF, HF/LF ratio). Pearson correlation was performed between HRV measures and functional parameters.</p><p><strong>Results: </strong>The results showed low HRV in study participants, with positive correlations between 6MWT and RMSSD and between SDNN and HF power and negative correlations between Heart Rate and the LF/HF ratio. On the other hand, respiratory and peripheral muscle strength correlated positively with parameters that represent sympathetic nervous system expression (LF nu and LF power) and negatively with the LF/HF ratio. However, changes in HRV parameters were not associated with disease severity.</p><p><strong>Conclusion: </strong>The dysautonomia of COVID-19 patients was correlated with functional sequelae, though not associated with disease severity parameters. There was low HRV, with low vagal expression, and imbalance in sympathetic/parasympathetic modulation in the study group.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100534"},"PeriodicalIF":2.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}