Clinics最新文献

{"title":"Multi-omics model is an effective means to diagnose benign and malignant pulmonary nodules","authors":"Yunzeng Zhang ,&nbsp;Fan Zhang ,&nbsp;Changming Shen ,&nbsp;Gaofeng Qiao ,&nbsp;Cheng Wang ,&nbsp;Feng Jin ,&nbsp;Xiaogang Zhao","doi":"10.1016/j.clinsp.2025.100599","DOIUrl":"10.1016/j.clinsp.2025.100599","url":null,"abstract":"<div><div>In response to the high false positive rate of traditional Low-Dose Computed Tomography (LDCT) in diagnosing pulmonary malignant nodules, this study aimed to investigate the effectiveness of scoring of blood-based non-invasive biological metabolite detection combined with artificial intelligent scoring of non-invasive imaging in the clinical diagnosis of Pulmonary Nodules (PNs). In this retrospective study, risk scoring was performed in patients positive for pulmonary nodules and subsequently, PNs were sampled by invasive procedures for pathological examinations. The pathological classification was used as the gold standard, and statistical and machine learning methods showed, that in 210 patients (23 benign PN and 187 malignant PN), the risk score of Metabonomics, radiomics, and multi-omics had different levels of performance in different risk groups based on various predictive models. The Area Under the receiver operating Characteristic Curve (AUC) of the multi-omics model was 0.823. The present results indicate that a multi-omics model is more effective than a single model in the non-invasive diagnosis of pulmonary malignant nodules.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100599"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression","authors":"AiYuan Cai ,&nbsp;HuiShi Ye ,&nbsp;YuanHong Lin ,&nbsp;JinYun Li ,&nbsp;DongSheng Fang ,&nbsp;ZhongBin Pan ,&nbsp;ZhiWei Li ,&nbsp;GuangLiang Luo ,&nbsp;YanFang Huang ,&nbsp;CiAi Lai","doi":"10.1016/j.clinsp.2025.100594","DOIUrl":"10.1016/j.clinsp.2025.100594","url":null,"abstract":"<div><h3>Background and objective</h3><div>Colon Cancer (CC) is a common malignant tumor. The aim of this study was to investigate the role and regulatory mechanism of circular RNA pappalysin-1 (circ-PAPPA; hsa_circ_0088233) in CC.</div></div><div><h3>Methods</h3><div>In cancer tissues from CC patients, circ-PAPPA expression was measured and its relationship with patients’ clinical features was analyzed. Plasmid vectors or oligonucleotides interfering with the expression of circ-PAPPA, microRNA (miR)-656–3p or G-protein subunit Gamma-5 (GNG5) were transfected into CC cells. Cell viability was detected by MTT and colony formation assay; apoptosis was detected by flow cytometry; and cell migration and invasion were detected by wound healing assay and Transwell. Glycolytic capacity of CC cells was assessed by measuring glucose uptake and lactate production using commercial kits. The targeting relationship between miR-656–3p and circ-PAPPA or GNG5 was verified by bioinformatics website starBase and dual luciferase reporter gene assay assays.</div></div><div><h3>Results</h3><div>Circ-PAPPA was upregulated in CC and was negatively correlated with benign pathological features and 5-year survival rates of CC patients. Circ-PAPPA silencing inhibited the growth and glycolysis of CC cells through upregulating miR-656–3p. GNG5, a target of miR-656–3p, could reverse the impacts of silencing circ-PAPPA on CC cells.</div></div><div><h3>Conclusion</h3><div>Circ-PAPPA may play an oncogenic role in CC by promoting cell growth and glycolysis through the miR-656–3p/GNG5 axis.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100594"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Gastric adenocarcinoma and periodontal disease: a systematic review and meta-analysis”","authors":"Shubham Kumar ,&nbsp;Nosaibah Razaqi ,&nbsp;Rachana Mehta ,&nbsp;Ranjana Sah","doi":"10.1016/j.clinsp.2025.100596","DOIUrl":"10.1016/j.clinsp.2025.100596","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100596"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive model for pulmonary arterial hypertension in adult idiopathic-inflammatory-myopathy patients: A cross-sectional study","authors":"Junyu Liang ,&nbsp;Xiaoqun Ba ,&nbsp;Liyan Wan ,&nbsp;Xiao Cui ,&nbsp;Ye He ,&nbsp;Lanlan Xiao ,&nbsp;Yini Ke ,&nbsp;Hanyin Zhang ,&nbsp;Heng Cao ,&nbsp;Jin Lin","doi":"10.1016/j.clinsp.2025.100621","DOIUrl":"10.1016/j.clinsp.2025.100621","url":null,"abstract":"<div><h3>Objective</h3><div>To identify clinical and laboratory risk factors for Pulmonary Arterial Hypertension (PAH) in Idiopathic-Inflammatory-Myopathy (IIM) patients as well as construct a predicting model for PAH.</div></div><div><h3>Methods</h3><div>An IIM cohort in southeastern China was established, including 504 adult IIM patients who met the inclusion and exclusion criteria, and were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU) from January 1st, 2018, to April 30st 2022. Serum cytokine profiles, myositis-specific antibodies as well as other factors of patients who met the inclusion and exclusion criteria were collected and analyzed.</div></div><div><h3>Results</h3><div>Of the 504 adult IIM patients, 25 IIM patients developed PAH and 48.0 % of them deceased within six months. IIM patients complicated with PAH were found to suffer from worse outcome (<em>p</em> &lt; 0.001). After multivariate logistic regression analysis, age (<em>p</em> &lt; 0.001), bacterial infection (<em>p</em> = 0.005), MYOACT score (<em>p</em> = 0.009), Interleukin (IL)-17A (<em>p</em> = 0.017), anti-SRP antibody (<em>p</em> = 0.011) and steroid monotherapy (<em>p</em> = 0.001) were identified as factors significantly associated with PAH in IIM patients. A “BAIMS” model was constructed by including the above six items to predict PAH with a cut-off value of ≥ 3 and an Area Under the Curve (AUC) of 0.877.</div></div><div><h3>Conclusion</h3><div>PAH is a rare but potentially fatal complication in IIM patients. Aging, complication of bacterial infection, elevated disease activity, increased serum IL-17A level, positivity of anti-SRP antibody and steroid monotherapy were significantly correlated with development of PAH in IIM patients. In addition, the BAIMS model was found valuable in prediction and early-identification of PAH in IIM patients.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100621"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases","authors":"Arthur Henrique Cunha-Volpato ,&nbsp;Carlos Izaias Sartorão Neto ,&nbsp;Luiz Fernando Ferraz da Silva ,&nbsp;Paulo Campos Carneiro","doi":"10.1016/j.clinsp.2024.100539","DOIUrl":"10.1016/j.clinsp.2024.100539","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of Hormone Dosage (HD) in Fine Needle Aspiration Biopsy (FNA) needle washout fluid, introduced in the 1990s, initially aimed at measuring Thyroglobulin (TG). Elevated TG concentration in an extrathyroidal cervical lesion suggests metastases of Well-Differentiated Thyroid Carcinomas (WDTC). Over the years, HD has evolved to incorporate Calcitonin (CT) and Parathormone (PTH), improving sensitivity and specificity in diverse clinical scenarios. Despite varying cutoffs in the literature, existing data underscore significant advancements in diagnostic accuracy.</div></div><div><h3>Methods</h3><div>This paper presents a case series of 762 cervical lesions with FNA cytology and HD in different cervical regions.</div></div><div><h3>Results</h3><div>It was possible to establish the histogenesis of the lesion based on a combination of the FNA cytology and PTH HD findings, so PTH was useful to determine parathyroid origin in all regions, Thyroglobulin (TG) and PTH together provide insights on cell origin in difficult cases. Thyroglobulin (TG) dosage enhances the accuracy of detecting well-differentiated thyroid carcinomas. In post-thyroidectomy by bed lesions, dosages help to determine non-thyroid/parathyroid lesions.</div></div><div><h3>Discussion</h3><div>The case series and review underscore the valuable contribution of HD in fine-needle aspiration for the evaluation of cervical lesions. By integrating HD with cytological, ultrasound, and clinical data, clinicians can enhance the accuracy and specificity of FNA in diagnosing various cervical lesions, ultimately improving patient care and management.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100539"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactylated histone H3K18 as a potential biomarker for the diagnosis and prediction of the severity of pancreatic cancer","authors":"Jinping Hou ,&nbsp;Mingsong Guo ,&nbsp;Yongqiong Li ,&nbsp;Yijin Liao","doi":"10.1016/j.clinsp.2024.100544","DOIUrl":"10.1016/j.clinsp.2024.100544","url":null,"abstract":"<div><h3>Background</h3><div>Lactylation plays an essential role in pancreatic cancer, but the precise role of lactylated histone in the diagnosis and prognosis of pancreatic cancer remains to be further clarified.</div></div><div><h3>Methods</h3><div>Twenty-one patients diagnosed with pancreatic cancer were enrolled in this study, and the clinicopathologic characteristics were collected. Lactylation levels of total proteins and histone H3 Lysine-18 (H3K18) of tissues were determined by western blotting and laboratory indicators including serum levels of lactate, Cancer Antigen 19–9 (CA19–9), and Carcinoembryogenic Antigen (CEA) were obtained.</div></div><div><h3>Results</h3><div>Total protein lactylation was found in both pancreatic cancer tissues and para-carcinoma normal tissues, and was more potent in tumor tissues. H3K18la was also highly expressed tumor tissues. Furthermore, H3K18la protein expression correlated positively with serum lactate (<em>r</em> = 0.774, <em>p</em> &lt; 0.001), CA19–9 (<em>r</em> = 0.744, <em>p</em> &lt; 0.001), and CEA (<em>r</em> = 0.589, <em>p</em> &lt; 0.01). The Area Under the Curve (AUC) of H3K18la for the diagnosis of pancreatic cancer was 0.848 in serum (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The present findings suggested that H3K18 may be used as a novel potential biomarker for the diagnosis and prognosis of pancreatic cancer patients.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100544"},"PeriodicalIF":2.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with rare diseases are responsible for the majority of hospitalizations in a Brazilian tertiary pediatric hospital: Preliminary data.","authors":"Cristina Grassiotto, Simone Pavani, Nara Vasconcelos Cavalcanti, Angelina Gonçalves, Andreia Watanabe, Vicente Odone-Filho, Ana Cristina Aoun Tannuri, Clovis Artur A Silva, Magda Carneiro-Sampaio","doi":"10.1016/j.clinsp.2024.100535","DOIUrl":"10.1016/j.clinsp.2024.100535","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100535"},"PeriodicalIF":2.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of heart rate variability with cardiorespiratory fitness and muscle strength in patients after hospitalization for COVID-19: An analytical cross-sectional study.","authors":"Daniele Ferreira Rodrigues, Victor Ribeiro Neves, Ulisses Ramos Montarroyos, Washington José Dos Santos, Isabelle Carolline Verissimo de Farias, Dário Celestino Sobral Filho","doi":"10.1016/j.clinsp.2024.100534","DOIUrl":"10.1016/j.clinsp.2024.100534","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with a moderate to severe clinical condition of COVID-19 who need hospitalization may have dysfunction in Cardiac Autonomic Control (CAC) and functional capacity.</p><p><strong>Objective: </strong>To assess the association of HRV with cardiorespiratory fitness and respiratory and peripheral muscle strength in patients after hospitalization for COVID-19.</p><p><strong>Method: </strong>Cross-sectional study with individuals > 18-years old, post-hospitalization for COVID-19, with a positive RT-PCR test. Data on clinical condition and hospital admission were collected, and parameters of respiratory and peripheral muscle strength and functional capacity were evaluated with the 6-Minute Walk Test (6MWT). CAC was assessed by analyzing (Heart Rate Variability) HRV in the time (SDNN, RMSSD) and frequency domains (HF, LF, HF/LF ratio). Pearson correlation was performed between HRV measures and functional parameters.</p><p><strong>Results: </strong>The results showed low HRV in study participants, with positive correlations between 6MWT and RMSSD and between SDNN and HF power and negative correlations between Heart Rate and the LF/HF ratio. On the other hand, respiratory and peripheral muscle strength correlated positively with parameters that represent sympathetic nervous system expression (LF nu and LF power) and negatively with the LF/HF ratio. However, changes in HRV parameters were not associated with disease severity.</p><p><strong>Conclusion: </strong>The dysautonomia of COVID-19 patients was correlated with functional sequelae, though not associated with disease severity parameters. There was low HRV, with low vagal expression, and imbalance in sympathetic/parasympathetic modulation in the study group.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100534"},"PeriodicalIF":2.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of NGF, proNGF, p75^NTR in lung injury induced by cerebral ischemia-reperfusion in young and elderly rats.","authors":"Hong Chen, Qiang Du, Jie Chen, Qiang Tian, Lei Xu, Ying Wang, Xiaoyan Gu","doi":"10.1016/j.clinsp.2024.100532","DOIUrl":"10.1016/j.clinsp.2024.100532","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the expression levels of Nerve Growth Factor (NGF), the precursor form of NGF (proNGF), and p75 neurotrophin receptor (p75^NTR) in lung injury induced by cerebral Ischemia-Reperfusion (I/R) in both young and elderly rats.</p><p><strong>Methods: </strong>Male Sprague-Dawley rats, categorized as young (3-months-old) and elderly (16-months-old), were divided into four experimental groups: Young Sham, Young I/R, Elderly Sham, and Elderly I/R. Each group underwent either sham surgery or ischemia-reperfusion treatment. Following 24 h post-procedure, the severity of cerebral ischemia was assessed using the Zea Longa 5-point scoring system, and lung tissue pathological changes were examined using Hematoxylin and Eosin (HE) staining. Western blot analysis was utilized to measure the expression levels of NGF, proNGF, and p75^NTR proteins in lung tissue.</p><p><strong>Results: </strong>Both young and elderly I/R groups exhibited lung tissue congestion and edema compared to their respective sham groups, with a significant increase in pathological scores (p < 0.05). Furthermore, the elderly I/R group demonstrated a significantly higher pathological score compared to the young I/R group (p < 0.05). Western blot analysis revealed that compared to the young sham group, the expression of NGF in the lung tissue of elderly sham rats decreased (p < 0.05), while proNGF and p75^NTR increased (p < 0.05). Additionally, compared to the sham group, the levels of NGF, proNGF, and p75^NTR in lung tissue were elevated in both young and elderly I/R groups of rats (p < 0.05). Moreover, the expression of proNGF and p75^NTR in lung tissue was higher in the elderly I/R group than in the young I/R group (p < 0.05).</p><p><strong>Conclusion: </strong>Cerebral ischemia-reperfusion-induced lung injury was associated with increased expression of proNGF and p75^NTR, as well as decreased NGF expression in lung tissue. These alterations in NGF, proNGF, and p75^NTR may contribute to the susceptibility to age-related lung injury.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100532"},"PeriodicalIF":2.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the collection, packaging, and transportation of preterm newborn stool samples.","authors":"Jessica Santos Passos Costa, Heli Vieira Brandão, Mara Viana Cardoso Amaral, Gabriela Cintra Dos Santos, Camilla da Cruz Martins, Michelle de Santana Xavier Ramos, Tatiana de Oliveira Vieira, Raquel Guimarães Benevides, Graciete Oliveira Vieira","doi":"10.1016/j.clinsp.2024.100531","DOIUrl":"10.1016/j.clinsp.2024.100531","url":null,"abstract":"<p><strong>Background: </strong>The newborn's intestinal microbiota can vary with gestational age. Reliable analyses of stool samples require establishing the steps of collection, packaging, transportation, and storage.</p><p><strong>Objective: </strong>To describe the development of a protocol and test an algorithm for the sequence of actions and procedures for the collection, packaging, transportation, and storage of stool samples from Preterm Newborn (PTNB) admitted to a Neonatal Intensive Care Unit (NICU).</p><p><strong>Materials and methods: </strong>This is a descriptive, observational study linked to a non-randomized controlled clinical trial conducted in the NICU of two public hospitals covenanted to the Unified Health System of a large city in inland northeastern Brazil. The methodology adopted in its development followed the Brazilian Ministry of Health Preparation Guide recommendations.</p><p><strong>Results: </strong>The flow of actions and procedures was consistent with scientific evidence. The sequence of work process steps to implement the proposed protocol was tested and resulted in a graphical representation of an algorithm compatible with the reality of Brazilian public hospitals.</p><p><strong>Conclusion: </strong>Following the protocol steps with the description of the rules of conduct and recommendations regarding the collection, packaging, transportation, and storage of stool samples from PTNBs ensured the preservation and integrity of the bacterial DNA in the stools sample. The details of the recommendations will allow their reproducibility and improvement by professionals and researchers with similar study objects.</p><p><strong>Trial registration: </strong>World Health Organization (WHO) under Universal Trial Number (UTN) code U1111-1266-2295, under register RBR-3mm7cs in the Brazilian Registry of Clinical Trials (REBEC).</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"79 ","pages":"100531"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}