The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-01-01 DOI:10.1016/j.clinsp.2025.100595

Danielle Borges Germano , Larissa Namie Chiba , Ana Paula Augusto da Cruz Ballerini , Jônatas Bussador do Amaral , Marina Tiemi Shio , Jhefferson Miranda Alves , Daniela Alves de Abreu , Luiz Henrique da Silva Nali , Francisco Antonio Helfenstein Fonseca , Maria Cristina Izar , André Luis Lacerda Bachi , Carolina Nunes França

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引用次数: 0

Abstract

Objective

The aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI).

Method

The authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders – CEAP: C1‒C3).

Results

There were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group.

Conclusions

The inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.