Clinics最新文献

{"title":"RPS27A as a potential clock-related diagnostic biomarker for myocardial infarction: Comprehensive bioinformatics analysis and experimental validation.","authors":"Rui Xu, Changshun Yan, GuiQiu Cao","doi":"10.1016/j.clinsp.2025.100677","DOIUrl":"10.1016/j.clinsp.2025.100677","url":null,"abstract":"<p><strong>Background: </strong>The circadian system plays a crucial role in managing cardiovascular functions, with disturbances in this system associated with Myocardial Infarction (MI). Despite this connection, the exact mechanisms by which clock genes influence MI occurrence are not well-defined. This research focused on investigating the link between clock genes and MI.</p><p><strong>Methods: </strong>The authors examined MI microarray datasets (GSE151412 and GSE60993) from the GEO database, concentrating on Differentially Expressed Genes (DEGs) associated with the circadian system. To clarify critical biological functions and pathways, the authors performed enrichment analyses using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Through Lasso regression, the authors pinpointed hub genes and confirmed their relevance using both the GSE66360 dataset and quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR). Furthermore, the authors conducted single-Gene Set Enrichment Analysis (GSEA) to reveal pathways linked to the hub gene. The analysis extended to exploring drug interactions and networks involving competing endogenous RNA (ceRNA).</p><p><strong>Results: </strong>The present analysis identified ten clock genes associated with circadian rhythms that showed differential expression between MI patients and healthy controls. Enrichment analysis suggested these genes' roles in pathways like the Gap junction and circadian rhythm pathways. Following Lasso regression and validation, RPS27A was identified as the main hub gene. GSEA further highlighted enriched pathways, such as mismatch repair. Additionally, immune infiltration analysis revealed notable differences in B-cell and CD4+ T-cell populations between the MI group and the control group.</p><p><strong>Conclusion: </strong>The present findings suggest that the clock-related gene RPS27A is associated with MI, potentially influencing its development through circadian rhythm regulation. These results enhance the understanding of MI pathogenesis and may offer new avenues for therapeutic intervention.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100677"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new option of reconstruction after extensive chest wall resection.","authors":"João Paulo Cassiano de Macedo, Pedro Henrique Xavier Nabuco-de-Araujo, José Ribas M de Campos, Paulo M Pêgo-Fernandes, Ricardo M Terra","doi":"10.1016/j.clinsp.2025.100679","DOIUrl":"10.1016/j.clinsp.2025.100679","url":null,"abstract":"<p><strong>Objective: </strong>Chest wall reconstruction plays an important role in the outcomes of chest wall resection. However, there being a huge variety of materials at disposable, the best option has not yet been well defined. The Vitagraft® is a synthetic and absorbable material, that works as an osteoinduction and osteoconduction for bone regeneration. It consists of a β-phase Tricalcium Phosphate Ceramic (β-TCP) and the Polylactic Glycolic Acid Polymer (PLGA). Therefore, this study intends to assess the safety of Vitagraft® use in the chest wall.</p><p><strong>Methods: </strong>A prospective study, in which the patient's chest was reconstructed with Vitagraft®. Each patient was followed after the procedure for at least three months. The following variables were considered: KPS, ECOG, preoperative treatment, defect size, myocutaneous flap, the time between surgeries, complications, and mortality.</p><p><strong>Results: </strong>Eight resections were performed due to tumor findings. One reconstruction was a treatment for sternal cleft, another for Poland's syndrome, and finally as a consequence of late sternal dehiscence. Primary closure was performed in 63.6 % of the patients. Vitagraft® was used in association with mesh in eight cases. Reoperation was required in two cases, and prosthesis removal for one of them. Respiratory failure and major systemic complications were not evidenced.</p><p><strong>Conclusion: </strong>In the present study, the first to assess Vitagraft® in chest wall reconstruction, the second operation was necessary for 28 %, and removal was mandatory for 14 %. Until now, chest postoperative tomography has been showing good prosthesis biocompatibility. The authors need further details about the ossification time especially relating to the size of the resection.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100679"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the art therapy interventions to alleviate depression symptoms among children and adolescents: a systematic review and meta-analysis.","authors":"Bo Zhang, Lifang Yang, Wen Sun, Peng Xu, Hui Ma, Azizah Binti Abdullah","doi":"10.1016/j.clinsp.2025.100683","DOIUrl":"10.1016/j.clinsp.2025.100683","url":null,"abstract":"<p><strong>Background: </strong>Existing systematic reviews provide evidence that art therapy is an effective intervention for reducing symptoms of depression in children and adolescents. This study aims to systematically review and quantify the impact of art-based interventions on depressive symptoms in this demographic through meta-analysis.</p><p><strong>Method: </strong>A systematic search of databases and journals identified eligible studies for inclusion in a meta-analysis examining the efficacy of art therapy interventions on depressive symptom reduction. A random-effects meta-analysis was conducted using the Standardized Mean Difference (SMD).</p><p><strong>Results: </strong>The meta-analysis of twelve (randomized) controlled trials revealed a significant effect (SMD = -0.72; 95 % CI [-1.28, -0.16], p = 0.01), indicating that children and adolescents (n = 333) who received art therapy experienced a more significant reduction in depressive symptoms compared to those (n = 344) in the control groups.</p><p><strong>Limitations: </strong>The existing evidence is limited to studies with low statistical power and methodological quality. Furthermore, the included studies were highly heterogeneous in terms of the intervention type, measurement tools, participant samples, and study designs.</p><p><strong>Conclusions: </strong>The findings suggest that art-based interventions can be effective in reducing depressive symptoms in children and adolescents. However, future research requires more methodologically rigorous and well-controlled studies to strengthen the evidence base.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100683"},"PeriodicalIF":2.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of using electromyographic biofeedback on pelvic floor rehabilitation in men with post-prostatectomy urinary incontinence: a meta-analysis.","authors":"Camila Chaves Dos Santos Novais, Adélia Regina Oliveira da Rosa Santana, Alisson Rodrigo Moura da Paz, Aline Tenório Lins Carnaúba, Kelly Cristina Lira de Andrade, Pedro de Lemos Menezes","doi":"10.1016/j.clinsp.2025.100687","DOIUrl":"10.1016/j.clinsp.2025.100687","url":null,"abstract":"<p><strong>Objective: </strong>To identify the impact of using electromyographic biofeedback on pelvic floor rehabilitation in men with post-prostatectomy urinary incontinence.</p><p><strong>Materials and methods: </strong>Searches in the databases were carried out: Pubmed/Medline, Latin American and Caribbean Literature in Health Sciences, Physiotherapy Evidence Database, Cochrane Library, Embase, Scopus, Web of Science, and in gray literature. The study included randomized clinical trials that treated men with post-prostatectomy urinary incontinence using electromyographic biofeedback in pelvic rehabilitation compared to other resources or no treatment. Studies including incontinent men with sphincter implants, pharmacological treatments, or studies with incomplete data were excluded. Assessment of risk of bias using the Critical Appraisal Tool developed by Joanna Briggs Institute for randomized clinical trials and the GRADE approach to assess the certainty of evidence of meta-analysis results were used.</p><p><strong>Results: </strong>16 articles were included, of which, 7 studies were subjected to two meta-analyses to assess the relative risk of men becoming continent and the reduction of urine loss through pad. Participants who received treatment showed a 1.78 times greater risk of achieving continence compared to those who did not receive treatment (RR = 1.78; 95% CI 1.29‒2.45; I² = 77%). The limitations of the present study are the lack of high-quality evidence, in which existing trials suffered from a lack of standardized outcome measures.</p><p><strong>Conclusion: </strong>Electromyographic biofeedback in pelvic rehabilitation seems to contribute to the faster achievement of continence in prostatectomized men compared to those who did not undergo any intervention. Additionally, helps to reduce pad weight.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100687"},"PeriodicalIF":2.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and gender differences in cancer research and its application to clinical oncology and therapeutics.","authors":"Rut Lucas-Domínguez, Cristina Rius, Yiming Liu, Andrea Sixto-Costoya, Juan Carlos Valderrama-Zurián","doi":"10.1016/j.clinsp.2025.100670","DOIUrl":"10.1016/j.clinsp.2025.100670","url":null,"abstract":"<p><strong>Objectives: </strong>Oncology has exhibited gender inequalities in leadership and authorship, alongside significant differences in cancer incidence, mortality, and survival rates between sexes. These disparities highlight the urgent need for sex- and gender-specific scientific reporting to improve research accuracy and clinical applications and encourage the same opportunities in research careers.</p><p><strong>Methods: </strong>The integration of gender perspective in cancer was assessed by analyzing scientific publications comparing 2011 and 2021. The correlation between the gender of the authors and the different types of cancer studied was examined, as well as the inclusion of the sex and gender variables in the content of the research. The study was STROBE compliant.</p><p><strong>Results: </strong>3,194 papers were published in 2011 and 6,781 in 2021, signed by at least one Spanish institution. The ratio of female authors per article was 0.39 in 2011 compared to 0.43 in 2021, reaching parity. Gender bias in the content of scientific articles, as measured by a 10-item checklist, showed an unfavorable score for perspective integration in both years (1.7/10 and 1.8/10, respectively). In terms of the Gender Balance Index in the analyzed samples of the papers (cells, animals or volunteers/patients), there was an increase from 29 % in 2011 to 43 % in 2021. Breast cancer research was dominated by female authors, whereas lung cancer research was predominantly by parity or male authorship, and no differences in author groups in colorectal cancer research were observed.</p><p><strong>Conclusions: </strong>Greater efforts and commitments are needed from government institutions, funding agencies, and academic structures to promote sex/gender integration in cancer research.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100670"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats.","authors":"Edmundo L R Pereira, Raul C Maranhão, Michelle N C Dias, Ijair R Dos Santos, Carolina Ramos Dos Santos, Moisés Hamoy, Danielle Cristine A Feio, Priscila O Carvalho, Jaqueline M Bazioli, Aleksandra T Morikawa, Walace Gomes-Leal","doi":"10.1016/j.clinsp.2025.100676","DOIUrl":"10.1016/j.clinsp.2025.100676","url":null,"abstract":"<p><p>Background This study aimed to investigate the effects of LDE-MTX on acute cerebral infarction. The study focuses on how LDE-MTX can influence the outcomes of ischemic stroke in a rat model, specifically examining its neuroprotective properties. Methods Radioactively labeled LDE uptake by brain tissue was determined after IV injection in rats with Endothelin-1 (ET-1)-induced cortical ischemic stroke (n = 11) and controls (n = 18). Two groups of 5 animals were treated with LDE-MTX (1 mg/kg, IV) or LDE-alone 4 h post-stroke induction. After 7days, tissues were analyzed by immunohistochemistry for neuronal bodies, astrocytes, and microglia. Results LDE uptake was fivefold higher in ischemic rats than in controls (p = 0.0003). LDE-MTX significantly inhibited microglial activation, resulting in a tenfold decrease in activated macrophages, and increased neuronal survival by 319 % in the periinfarct area. LDE-MTX had no effect on astrocytosis or primary infarct size. Conclusions LDE-MTX demonstrated neuroprotective effects and shows potential as a novel strategy to limit ischemic stroke damage. The results suggest that LDE-MTX could be a promising treatment option for reducing ischemic damage in stroke patients, particularly through its effect on microglial activation and neuronal survival.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100676"},"PeriodicalIF":2.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the monocyte Chemoattractant protein-1-2518A/G polymorphism and the risk of tuberculosis in the Chinese population: A meta-analysis and systematic review.","authors":"Hongfang Lu, Jingang Wang, Xinyu Song, Xiaoqi Xiong","doi":"10.1016/j.clinsp.2025.100685","DOIUrl":"10.1016/j.clinsp.2025.100685","url":null,"abstract":"<p><strong>Objectives: </strong>No meta-analysis has been conducted on the relationship between the MCP-1-2518A/G gene polymorphism and tuberculosis susceptibility in the Chinese population. The aim of this study was to investigate whether MCP-1-2518A/G polymorphism is associated with susceptibility to TB in Chinese.</p><p><strong>Method: </strong>Publications addressing the association between the MCP-1-2518A/G polymorphism and TB risk were selected from the PubMed, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.1 and STATA 12 software.</p><p><strong>Results: </strong>Ten case-control studies were extracted from 10 articles on polymorphisms involving 1634 TB patients and 1768 controls. The results of the meta-analysis showed that a significantly increased risk for TB was found for Chinese individuals with the polymorphism as follows: dominant model (GG+GA vs. AA Odds Ratio [OR = 1.53], 95 % CI 1.14‒2.07, p = 0.000); recessive model (GG vs. GA+AA Odds Ratio [OR = 1.63], 95 % CI 1.13‒2.35, p = 0.009); and a homozygote comparison (GG vs. AA Odds Ratio [OR = 1.93], 95 % CI 1.19‒3.13, p = 0.008). In the subgroup analysis by ethnicity, significantly elevated risks were found in non-Han Chinese individuals but not in Han Chinese individuals (mutant homozygous GG vs. AA: OR = 3.81, 95 % CI 2.07‒7.00, p = 0.000).</p><p><strong>Conclusions: </strong>This meta-analysis suggested that the -2518A/G polymorphism of the MCP-1 gene is a risk factor for TB in Chinese individuals. In the GG vs. AA model, non-Han Chinese individuals had a higher risk of tuberculosis than Han Chinese individuals.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100685"},"PeriodicalIF":2.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of multiple ultrasonic modalities for prostate cancer.","authors":"Yushan Liu, Shi Zeng, Dan Zhou, Haiqing He, Shuiqing Wu, Changkun Huang, Kai Ai, Xuan Zhu, Ran Xu","doi":"10.1016/j.clinsp.2025.100680","DOIUrl":"10.1016/j.clinsp.2025.100680","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of Grayscale Ultrasound (GSU), Color Doppler Ultrasound/Power Doppler Ultrasound (CDU/PDU), Transrectal Real-Time Tissue Elastography (TRTE) and Contrast-Enhanced Ultrasound (CEUS) in the diagnosis of Prostate Cancer (PCa).</p><p><strong>Method: </strong>All analyzed patients underwent GSU, CDU/PDU, TRTE and CEUS examinations before radical prostatectomy. Receiver Operating Characteristic (ROC) curves were drawn, and the Areas Under the Curve (AUCs) were calculated for the four ultrasonic modalities alone and in combination. Binary logistic analysis was used to evaluate the predictive value of lesion features observed with the 4 modalities.</p><p><strong>Results: </strong>The results of the chi-square test showed that the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of TRTE for diagnosing PCa were higher than those of CEUS (p-values were < 0.05 for all). The ROC curves analysis showed that the diagnostic performance of TRTE for PCa was better than that of CEUS (p = 0.046). Moreover, the diagnostic performance of the combination of four ultrasonic technologies (AUC = 0.873) was significantly better than that of any technology alone. Multivariate binary logistic regression analysis showed that enhancement strength on CEUS, presence of a blue area on TRTE and total serum Prostate Specific Antigen (PSA) level were independent predictors for prostate malignancy.</p><p><strong>Conclusions: </strong>The diagnostic performance of TRTE was higher than that of CEUS. Early hyperenhancement on CEUS and stiffness on TRTE had high predictive value for the diagnosis of PCa. The combination of multiple ultrasonic modalities can significantly improve the positive diagnostic rate for PCa over that of a single ultrasonic mode.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100680"},"PeriodicalIF":2.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triglyceride-glucose index, metabolic biomarkers, and olive oil in diabetic patients: Real-world evidence from a propensity-score matched study.","authors":"Ge Zhi-Wen, Hong Zhong-Xin","doi":"10.1016/j.clinsp.2025.100618","DOIUrl":"10.1016/j.clinsp.2025.100618","url":null,"abstract":"<p><strong>Objectives: </strong>Using the Triglyceride-Glucose (TyG) index to categorize patients and to compare the effects of different oils on metabolic biomarkers among diabetic patients.</p><p><strong>Methods: </strong>A total of 98 diabetic patients were included in this retrospective hospital-based study of which data were obtained from medical and dietary records. The participants were divided into soybean oil groups or olive oil groups according to the dietary packages they chose during hospitalization, which merely differed in the kinds of cooking oil (olive oil vs. soybean oil). After being matched based on propensity scores in a 1:1 ratio with a 0.2 caliber width, 70 subjects were finally included in the analysis.</p><p><strong>Results: </strong>Compared to admission, blood pressure, lipids, and postprandial blood glucose were decreased at discharge in both groups. Grip strength levels of both hands increased in the olive oil group, while no statistical differences were found for these measures in the soybean oil group. In both the soybean oil and olive oil groups, metabolic biomarkers showed broader improvements at discharge for participants with high TyG levels compared to those with low TyG levels. Additionally, patients with high TyG levels in the olive oil group experienced the greatest benefits in terms of blood glucose, lipids, blood pressure, and handgrip strength before and after hospitalization.</p><p><strong>Conclusions: </strong>Olive oil may have more advantages in improving metabolic risk factors among diabetic patients. The TyG index can be a valuable tool for clinically screening and categorizing patients for personalized precision treatment.</p>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100618"},"PeriodicalIF":2.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond non-inferiority: Exploring the full potential of virtual reality in surgical training.","authors":"Brijesh Sathian, Hanadi Al Hamad, Javed Iqbal","doi":"10.1016/j.clinsp.2025.100675","DOIUrl":"10.1016/j.clinsp.2025.100675","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"100675"},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}