Clinics最新文献

{"title":"Prognostic impact of sarcomatous component in patients with localized and locally advanced uterine carcinosarcoma: a retrospective study in Latin America","authors":"Daniel Santos Rocha Sobral Filho ,&nbsp;Giulia Mazaro de Oliveira ,&nbsp;Letícia Vecchi Leis ,&nbsp;Mariana de Paiva Batista ,&nbsp;Vanessa da Costa Miranda ,&nbsp;Renata Colombo Bonadio ,&nbsp;Maria del Pilar Estevez Diz ,&nbsp;Samantha Cabral Severino da Costa","doi":"10.1016/j.clinsp.2025.100854","DOIUrl":"10.1016/j.clinsp.2025.100854","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the prognostic of the sarcomatous component (homologous vs heterologous).</div></div><div><h3>Methods</h3><div>This retrospective study evaluated patients with FIGO I‒IVA Uterine Carcinosarcoma (UCS) treated at a single cancer center. The endpoints were Overall Survival (OS) and Disease-Free Survival (DFS) according to the sarcomatous component. The Kaplan-Meier was used for survival analyses. Hazard Ratio (HR) and 95% Confidence Interval (95% CI) were calculated using Cox regression.</div></div><div><h3>Results</h3><div>61 patients with localized/locally advanced disease (34 homologous vs. 27 heterologous) were included. The most common pathological subtype was Rhabdomyosarcoma (60%) in the heterologous and endometrial stromal sarcoma (95%) in the homologous group. All patients underwent surgery. Adjuvant Chemotherapy (CT) was indicated for approximately 70%. A difference was observed between patients who did not complete adjuvant CT: 32.0% vs. 57.9% in homologous and heterologous groups, respectively (p = 0.03). The main reason for this was recurrence during treatment. Comparing homologous vs. heterologous group, median DFS was 143.2 months vs. 18.0 months (HR = 3.72, 95% CI 1.73‒8.02; p = 0.001) and median OS was 143.2 months vs. 34.4 months (HR = 2.79, 95% CI 1.27‒6.13; p = 0.001), respectively. Heterologous subtype (HR = 4.34, 95% CI 1.59‒11.85, p = 0.004) and FIGO stage III (HR = 3.33, 95% CI 1.18–9.39, p = 0.023) were associated with inferior DFS and OS, while completing adjuvant CT (HR = 0.22, 95% CI 0.07‒0.69, p = 0.009) was associated with superior outcomes.</div></div><div><h3>Conclusions</h3><div>The sarcomatous component has a relevant prognostic impact in localized/locally advanced UCS. The heterologous component was associated with a worse DFS and OS. Other negative prognostic factors were FIGO stage III and not completing adjuvant CT.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100854"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limb remote ischemic preconditioning attenuates biomarkers of acute lung injury and inflammation during thoracoscopic lobectomy: a randomized controlled trial","authors":"Wenfu Zhang ,&nbsp;Mingwang Zeng ,&nbsp;Chao Yang ,&nbsp;Lijun Yang ,&nbsp;Juan Yang ,&nbsp;Yi Wang ,&nbsp;Haiyu Xie ,&nbsp;Lifeng Wang ,&nbsp;Maolin Zhong ,&nbsp;Fuzhou Hua ,&nbsp;Weidong Liang","doi":"10.1016/j.clinsp.2026.100883","DOIUrl":"10.1016/j.clinsp.2026.100883","url":null,"abstract":"<div><h3>Background</h3><div>One-Lung Ventilation (OLV), though essential for thoracic surgery, triggers inflammation and oxidative stress that may lead to Acute Lung Injury (ALI). Remote Ischemic Preconditioning (RIPC) is a simple, non-invasive intervention that may activate protective pathways and reduce ischemia-reperfusion injury. This randomized controlled trial assessed whether limb RIPC attenuates OLV-induced lung injury during thoracoscopic lobectomy.</div></div><div><h3>Methods</h3><div>Fifty-four patients undergoing thoracoscopic lobectomy with OLV were randomized to the RIPC (<em>n</em> = 27) or Control (NC, <em>n</em> = 27) group. RIPC consisted of five cycles of 5-min ischemia and 5-min reperfusion using a lower limb tourniquet before OLV. Blood samples were collected at T0 (post-induction), T1 (30-min after OLV), T2 (90-min after OLV), and T3 (30-min after resumption two-lung ventilation). The primary endpoint was plasma CC16. Secondary endpoints included IL-6, MDA, arterial blood gases, Intraoperative Oxygenation Indices (OI, RI, A-aDO₂, a/A), and hospital stay.</div></div><div><h3>Results</h3><div>Plasma CC16, IL-6, and MDA levels were significantly lower in the RIPC group from T1 to T3 (all <em>p</em> &lt; 0.001). In contrast, oxygenation indices, blood gas parameters, and hospital stay did not differ significantly between groups (all <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Limb RIPC effectively reduced systemic markers of lung injury (CC16), inflammation and oxidative stress during OLV but not in short-term improvements in oxygenation or clinical recovery. These findings suggest that RIPC confers molecular protection, with potential functional benefits requiring longer follow-up or evaluation in high-risk populations. Larger multicenter trials are warranted.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100883"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol protects against isoflurane-induced testicular injury: a stereological and molecular study in mice","authors":"Zahra Mohammadi ,&nbsp;Sanaz Alaee ,&nbsp;Majid Kamali-Dolat Abadi ,&nbsp;Somayyeh Karami-Mohajeri ,&nbsp;Zahra Khodabandeh ,&nbsp;Saeed Shokri ,&nbsp;Sulagna Dutta ,&nbsp;Pallav Sengupta ,&nbsp;Hesam Kamyab","doi":"10.1016/j.clinsp.2026.100878","DOIUrl":"10.1016/j.clinsp.2026.100878","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the therapeutic effects of resveratrol, known for its antioxidant and anti-inflammatory properties, in mitigating the harmful effects of isoflurane, an inhalation anesthetic, on testicular tissues in mice.</div></div><div><h3>Methods</h3><div>Sixty adult male C57BL/6 mice were grouped into six categories: control (normal saline), isoflurane only (1.5% for 1-hour/day), low-dose Resveratrol (RSV, 50 mg/kg/day), high-dose RSV (100 mg/kg/day), isoflurane combined with low-dose RSV, and isoflurane combined with high-dose RSV. After 35-days, the mice were euthanized, and their testes were harvested for stereological analysis and the assessment of antioxidant and apoptotic markers.</div></div><div><h3>Results</h3><div>Exposure to isoflurane resulted in decreased seminiferous tubule volume and length, along with increased interstitial tissue volume of the testis. Co-treatment with resveratrol, especially at higher doses, mitigated these changes. Additionally, resveratrol modulated the expression of the apoptotic genes <em>Bcl2l1, Bax</em>, and <em>Caspase-3</em>, and enhanced the expression of antioxidant genes <em>GPX1, Sod1</em>, and <em>catalase</em> in mice that received isoflurane.</div></div><div><h3>Conclusions</h3><div>The findings suggest that resveratrol effectively counters isoflurane-induced damage in testicular structures and gene expression, enhancing tubular integrity and antioxidant defense. This indicates a potential therapeutic approach to protect against isoflurane-induced testicular toxicity.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100878"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcome of totally laparoscopic gastrectomy for gastric cancer: a comparative study","authors":"Liu Liu ,&nbsp;Shijie Feng ,&nbsp;Haiyan Wang ,&nbsp;Lin Liu","doi":"10.1016/j.clinsp.2026.100887","DOIUrl":"10.1016/j.clinsp.2026.100887","url":null,"abstract":"<div><h3>Objective</h3><div>Whether Totally Laparoscopic Gastrectomy (TLG) is beneficial for patients with gastric cancer remains not fully understood. This study was to evaluate the advantages of Totally Laparoscopic Gastrectomy (TLG) for treating Gastric Cancer (GC).</div></div><div><h3>Methods</h3><div>From January 2019 to December 2021, 380 patients with gastric cancer were included into this study (190 per group). The outcomes of interest, including postoperative recovery, inflammation, and oncological results, were compared between the two groups.</div></div><div><h3>Results</h3><div>The patient baselines between the two groups were comparable. The TLG group had lower risks of wound infection (<em>p</em> = 0.02) and total complications (<em>p</em> = 0.03) compared to LAG. The TLG group exhibited significantly shorter operative time (median: 215 vs. 240 min, <em>p</em> &lt; 0.001), less intraoperative blood loss (median: 50 vs. 100 mL, <em>p</em> &lt; 0.001), shorter time to first flatus (median: 3 vs. 4 days, <em>p</em> &lt; 0.001), and reduced length of postoperative hospital stay (<em>p</em> &lt; 0.001). Furthermore, patients in the TLG group exhibited lower White Blood Cell (WBC) counts on POD 1 compared to patients in the LAG group (mean 11.74 vs. 12.75 × 10^9/L; <em>p</em> = 0.003). Multivariate logistic regression analysis revealed that TLG was an independent predictor of shorter postoperative hospitalization (OR (95% CI): 0.54 (0.30‒0.95), <em>p</em> = 0.03). Interestingly, the TLG group had more lymph nodes harvested than the LAG group (median (range): 23 (2‒88) vs. 23 (2‒88), <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This study demonstrates that TLG has a lower risk of complications and faster postoperative recovery, thus TLG is superior to LAG for the treatment of gastric cancer.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100887"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effects of a 12-week Zumba program on thyroid and cardiometabolic markers in overweight/obese postmenopausal women: A randomized pilot study","authors":"Hanen Saadouni ,&nbsp;Okba Selmi ,&nbsp;Nejmeddine Ouerghi ,&nbsp;Hamza Marzouki ,&nbsp;Soukaina Hattabi ,&nbsp;Lamia Attig ,&nbsp;Katja Weiss ,&nbsp;Thomas Rosemann ,&nbsp;Beat Knechtle ,&nbsp;Anissa Bouassida","doi":"10.1016/j.clinsp.2026.100880","DOIUrl":"10.1016/j.clinsp.2026.100880","url":null,"abstract":"<div><h3>Objective</h3><div>This pilot study aimed to investigate the effects of a 12-week Zumba training program on Thyroid-Stimulating Hormone (TSH), Free Thyroxine (FT4), lipid profile, and anthropometric parameters in overweight and obese postmenopausal women.</div></div><div><h3>Methods</h3><div>Twenty-two women (aged 44‒60 years) were randomly assigned to a Zumba training group (ZG; <em>n</em> = 11) or a control group (CG; <em>n</em> = 11). The ZG participated in 60-min Zumba sessions three times per week for 12-weeks, while the CG maintained their usual lifestyle. Before and after the intervention, participants underwent assessments of body composition, blood pressure, and circulating levels of TSH, FT4, Total Cholesterol (TC), and Triglycerides (TG).</div></div><div><h3>Results</h3><div>Following the intervention, the ZG showed significant reductions in TSH (<em>p</em> = 0.001; Cohen’s d (<em>d)</em> = 0.90), TG levels (<em>p</em> = 0.043; <em>d</em> = 0.75), body fat percentage, body mass index, waist and hip circumference, and both systolic and diastolic blood pressure (all <em>p</em> &lt; 0.05). No significant changes were observed for FT4 and TC levels. No notable changes were recorded in the CG.</div></div><div><h3>Conclusions</h3><div>The 12-week Zumba program can serve as a feasible and enjoyable strategy for promoting physical activity in overweight and obese postmenopausal women, leading to improvements in thyroid function, TG levels, body composition, and blood pressure. These preliminary findings support the potential of Zumba for enhancing cardiometabolic health during menopause, though larger, long-term trials are needed to confirm these effects and investigate their durability.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100880"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POEM for Zenker’s diverticulum (Z-POEM): Technical advances, challenges and complications – a narrative review","authors":"Ygor Rocha Fernandes ,&nbsp;Mateus Pereira Funari ,&nbsp;Christiano Makoto Sakai ,&nbsp;Fauze Maluf-Filho","doi":"10.1016/j.clinsp.2026.100897","DOIUrl":"10.1016/j.clinsp.2026.100897","url":null,"abstract":"<div><h3>Background/Aims</h3><div>Zenker's Diverticulum (ZD) is a pharyngoesophageal pulsion diverticulum traditionally managed with open surgical or endoscopic (rigid and flexible) techniques. Zenker’s Peroral Endoscopic Myotomy (Z-POEM) has recently emerged as a minimally invasive alternative demonstrating promising efficacy and safety. This narrative review aims to synthesize current evidence regarding the technical evolution of Z-POEM, its indications, procedural nuances, long-term outcomes, cost-effectiveness, and future directions.</div></div><div><h3>Methods</h3><div>A structured narrative review was conducted in accordance with SANRA guidelines to assess the technical modifications, clinical outcomes, and complications of Zenker’s Per-Oral Endoscopic Myotomy (Z-POEM). Relevant literature published between January 2016 and September 2025 was systematically searched across PubMed, Scopus, and EMBASE, supplemented by manual citation tracing. Eligible studies included clinical trials, cohorts, observational reports, and technical notes focusing on Z-POEM or its variants. Data extraction and synthesis were performed independently by two reviewers, with findings organized into thematic domains comprising procedural techniques, efficacy, safety, adverse events, recurrence, and follow-up.</div></div><div><h3>Results</h3><div>Proper patient selection is critical for technical success. Factors such as diverticulum size, symptom severity, and anatomical features guide the optimal technique. Long-term studies report sustained clinical success exceeding 85% over 30‒40 months. Repeat Z-POEM procedures have shown high efficacy in managing recurrence. Comparative data indicate Z-POEM achieves superior clinical outcomes compared with flexible endoscopic septotomy, with comparable safety and procedure times.</div></div><div><h3>Conclusions</h3><div>Z-POEM demonstrates high safety and efficacy, though long-term durability may favor Z-POEM in larger or fibrotic diverticula. Further research should focus on cost-effectiveness, technique standardization, and long-term comparative outcomes to refine patient selection criteria and consolidate Z-POEM as a first-line therapy for ZD.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100897"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological evaluation of the auditory pathway in newborns and infants with peri-intraventricular hemorrhage and/or periventricular leukomalacia","authors":"Rosanna Giaffredo Angrisani ,&nbsp;Natalia Olival Balzarini ,&nbsp;Carla Regina Tragante ,&nbsp;Valdenise Martins Laurindo Tuma Calil ,&nbsp;Werther Brunow de Carvalho ,&nbsp;Carla Gentile Matas","doi":"10.1016/j.clinsp.2025.100853","DOIUrl":"10.1016/j.clinsp.2025.100853","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate and monitor, through electrophysiological assessment of hearing, the integrity of the peripheral and central auditory pathways in infants with Peri-intraventricular hemorrhage and/or Periventricular Leukomalacia (PIVH/PVL) who stayed in a Neonatal Intensive Care Unit (NICU), aiming to verify the occurrence of possible neural dysfunctions in this system.</div></div><div><h3>Material and methods</h3><div>This prospective longitudinal study evaluated preterm Newborns (NBs) and infants at the time of hospital discharge and after 3- and 6-months. The Study Group (SG) had 12 females and 11 males, with gestational age between 25- and 33-weeks, and a mean gestational age of 29.82-weeks at birth. The Control Group (CG) had 26 healthy NBs, distributed in 13 females and 13 males, with gestational age between 27- and 33-weeks and a mean of 30.67-weeks of gestational age at birth. All participants underwent Auditory Brainstem Response (ABR) and Cortical Auditory Evoked Potentials (CAEP) P1, N1, P2, at the time of hospital discharge, and 3- and 6-months after discharge. Each group’s results were compared using statistical tests.</div></div><div><h3>Results</h3><div>Evolutionary study of mean ABR and CAEP latencies in infants in the study and control group showed a similar pattern over the six months after hospital discharge.</div></div><div><h3>Conclusion</h3><div>The comparison of brainstem and cortical potentials showed that auditory function is symmetrical in the peripheral and central portions of the auditory pathway in both groups. The maturation of the ABR and CAEP waves in both groups developed in a very similar way over the six months after hospital discharge.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100853"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doctor competencies, patient expectations and healthcare context: connecting communication to satisfaction and trust","authors":"Carlos Frederico Confort Campos ,&nbsp;Clarice Rosa Olivo ,&nbsp;Gabrielle Leite Silveira ,&nbsp;Milton de Arruda Martins ,&nbsp;Patricia Zen Tempski","doi":"10.1016/j.clinsp.2026.100903","DOIUrl":"10.1016/j.clinsp.2026.100903","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate which factors mediate the association between doctors’ communication behaviours and patients’ satisfaction with care and trust placed in their doctors.</div></div><div><h3>Methods</h3><div>Qualitative descriptive study conducted in a tertiary teaching hospital in São Paulo, Brazil, with 60 patients enrolled in the preoperative risk assessment clinic. They underwent a semi-structured interview, which was analysed using a reflexive thematic analysis approach.</div></div><div><h3>Results</h3><div>Patients' satisfaction with care and trust placed in their doctors were analysed. The main themes identified as mediating factors were doctors' competencies, patients subjectiveness, and healthcare context.</div></div><div><h3>Conclusion</h3><div>Better understanding the mediators involved in the association between communication and patients’ satisfaction and trust allows the creation of specific educational actions targeted at doctors.</div></div><div><h3>Innovation</h3><div>We use a qualitative approach to identify mediating factors and shed light on how what happens in the “doctor’s office” can mediate the connection between communication, satisfaction and trust.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100903"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circ-RERE promotes autophagy and immune escape in acute myeloid leukemia involving the miR-128-3p/ZEB1/PD-L1 axis","authors":"XiaoWei Shi,&nbsp;TianTian Wang,&nbsp;KeYa Sha,&nbsp;ShuangYue Li,&nbsp;RenZhi Pei,&nbsp;Ying Lu","doi":"10.1016/j.clinsp.2025.100850","DOIUrl":"10.1016/j.clinsp.2025.100850","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the role of circular RNA derived from RERE (circ-RERE) in regulating Programmed Death-Ligand-1 (PD-L1) expression and microRNA-128–3p (miR-128–3p)/Zinc finger e-box Binding homeobox-1 (ZEB1) axis in Acute Myeloid Leukemia (AML).</div></div><div><h3>Methods</h3><div>AML cell viability, proliferation, apoptosis, the ratio of microtubule-associated protein 1A/1B-Light Chain 3-phosphatidylethanolamine conjugate (LC3-II) to free LC3 (LC3-I) (LC3-II/LC3-I), and PD-L1 expression, as well as CD8⁺ <em>T</em>-cell cytotoxicity, were correspondingly analyzed. The targeting relationship between miR-128–3p and circ-RERE or ZEB1 was verified.</div></div><div><h3>Results</h3><div>As detected, suppressing circ-RERE or overexpressing miR-128–3p significantly blocked the proliferation, migration, invasion, and autophagy of AML cells, promoted cell apoptosis, suppressed PD-L1 expression, and increased CD8+ <em>T</em>-cell cytotoxicity. circ-RERE competed with miR-128–3p to regulate ZEB1. Forced expression of ZEB1 did a reversal of circ-RERE suppression-induced effects.</div></div><div><h3>Conclusion</h3><div>In a word, circ-RERE promotes autophagy and immune escape in AML by regulating PD-L1 expression through the miR-128–3p/ZEB1 axis, which may provide a new target for AML therapy.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100850"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six IL-8 gene polymorphisms and the entire cancer susceptibility according to a comprehensive analysis especially in prostate cancer","authors":"Xiao Zhang ,&nbsp;Jian Sun ,&nbsp;Xiqi Ding","doi":"10.1016/j.clinsp.2026.100862","DOIUrl":"10.1016/j.clinsp.2026.100862","url":null,"abstract":"<div><h3>Objectives</h3><div>Interleukin-8 (IL-8) is a key cytokine regulating immunity and inflammation, and its genetic polymorphisms have been increasingly linked to cancer susceptibility. However, findings on the role of specific IL-8 polymorphisms across different cancers remain inconsistent, necessitating a comprehensive meta-analysis.</div></div><div><h3>Methods</h3><div>The authors systematically searched Embase, PubMed, Chinese databases, Google Scholar, and Web of Science up to June 25, 2023. A total of 104 case-control studies (26,029 cases and 31,577 controls) were included in a high-powered meta-analysis. Summary Odds Ratios (ORs) with 95% Confidence Intervals (95% CIs) were calculated using Stata. Additionally, the authors performed an ELISA-based validation study to measure serum IL-8 levels in Prostate Cancer (PCa) patients grouped by genotype.</div></div><div><h3>Results</h3><div>The +2767 polymorphism was associated with a significant reduction in overall cancer risk. The +781 polymorphism increased cancer risk specifically in Caucasian populations. In contrast, the -251 polymorphism demonstrated a strong pan-cancer risk association, particularly in Mixed/Asian ethnicities, gastric cancer, lung cancer, and hospital-based studies. Mechanistically, patients with the -251 AA/AC genotypes had elevated serum IL-8 levels, which were linked to more aggressive PCa pathogenesis.</div></div><div><h3>Conclusion</h3><div>This pioneering meta-analysis identifies the IL-8 -251 polymorphism as a high-risk biomarker and +2767 as a protective variant. By functionally validating that the -251 risk allele promotes PCa progression via IL-8 overexpression, the present study establishes IL-8 genotyping as a potential tool for ethnic-specific risk stratification and prognostic prediction, with broad implications for precision oncology.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100862"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}