The triglyceride-glucose index, metabolic biomarkers, and olive oil in diabetic patients: Real-world evidence from a propensity-score matched study.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-05-11 eCollection Date: 2025-01-01 DOI:10.1016/j.clinsp.2025.100618

Ge Zhi-Wen, Hong Zhong-Xin

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引用次数: 0

Abstract

Objectives: Using the Triglyceride-Glucose (TyG) index to categorize patients and to compare the effects of different oils on metabolic biomarkers among diabetic patients.

Methods: A total of 98 diabetic patients were included in this retrospective hospital-based study of which data were obtained from medical and dietary records. The participants were divided into soybean oil groups or olive oil groups according to the dietary packages they chose during hospitalization, which merely differed in the kinds of cooking oil (olive oil vs. soybean oil). After being matched based on propensity scores in a 1:1 ratio with a 0.2 caliber width, 70 subjects were finally included in the analysis.

Results: Compared to admission, blood pressure, lipids, and postprandial blood glucose were decreased at discharge in both groups. Grip strength levels of both hands increased in the olive oil group, while no statistical differences were found for these measures in the soybean oil group. In both the soybean oil and olive oil groups, metabolic biomarkers showed broader improvements at discharge for participants with high TyG levels compared to those with low TyG levels. Additionally, patients with high TyG levels in the olive oil group experienced the greatest benefits in terms of blood glucose, lipids, blood pressure, and handgrip strength before and after hospitalization.

Conclusions: Olive oil may have more advantages in improving metabolic risk factors among diabetic patients. The TyG index can be a valuable tool for clinically screening and categorizing patients for personalized precision treatment.

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糖尿病患者的甘油三酯-葡萄糖指数、代谢生物标志物和橄榄油：来自倾向评分匹配研究的真实世界证据

目的：利用甘油三酯-葡萄糖（TyG）指数对糖尿病患者进行分类，并比较不同油脂对糖尿病患者代谢生物标志物的影响。方法：回顾性分析98例糖尿病患者的病历和饮食资料，以医院为基础。根据住院期间选择的饮食包装，参与者被分为大豆油组或橄榄油组，只是食用油的种类不同（橄榄油vs大豆油）。根据倾向得分以1:1的比例匹配0.2口径宽度后，最终纳入70名受试者。结果：与入院时相比，两组患者出院时血压、血脂和餐后血糖均降低。橄榄油组的双手握力水平增加，而大豆油组的这些指标没有统计学差异。在大豆油组和橄榄油组中，代谢生物标志物显示，与TyG水平较低的参与者相比，TyG水平高的参与者出院时的改善范围更广。此外，橄榄油组中TyG水平高的患者在住院前后的血糖、血脂、血压和握力方面受益最大。结论：橄榄油在改善糖尿病患者代谢危险因素方面可能更有优势。TyG指数可以成为临床筛选和分类患者以进行个性化精确治疗的有价值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.