Clinics最新文献

{"title":"Doctor competencies, patient expectations and healthcare context: connecting communication to satisfaction and trust","authors":"Carlos Frederico Confort Campos ,&nbsp;Clarice Rosa Olivo ,&nbsp;Gabrielle Leite Silveira ,&nbsp;Milton de Arruda Martins ,&nbsp;Patricia Zen Tempski","doi":"10.1016/j.clinsp.2026.100903","DOIUrl":"10.1016/j.clinsp.2026.100903","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate which factors mediate the association between doctors’ communication behaviours and patients’ satisfaction with care and trust placed in their doctors.</div></div><div><h3>Methods</h3><div>Qualitative descriptive study conducted in a tertiary teaching hospital in São Paulo, Brazil, with 60 patients enrolled in the preoperative risk assessment clinic. They underwent a semi-structured interview, which was analysed using a reflexive thematic analysis approach.</div></div><div><h3>Results</h3><div>Patients' satisfaction with care and trust placed in their doctors were analysed. The main themes identified as mediating factors were doctors' competencies, patients subjectiveness, and healthcare context.</div></div><div><h3>Conclusion</h3><div>Better understanding the mediators involved in the association between communication and patients’ satisfaction and trust allows the creation of specific educational actions targeted at doctors.</div></div><div><h3>Innovation</h3><div>We use a qualitative approach to identify mediating factors and shed light on how what happens in the “doctor’s office” can mediate the connection between communication, satisfaction and trust.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100903"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circ-RERE promotes autophagy and immune escape in acute myeloid leukemia involving the miR-128-3p/ZEB1/PD-L1 axis","authors":"XiaoWei Shi,&nbsp;TianTian Wang,&nbsp;KeYa Sha,&nbsp;ShuangYue Li,&nbsp;RenZhi Pei,&nbsp;Ying Lu","doi":"10.1016/j.clinsp.2025.100850","DOIUrl":"10.1016/j.clinsp.2025.100850","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the role of circular RNA derived from RERE (circ-RERE) in regulating Programmed Death-Ligand-1 (PD-L1) expression and microRNA-128–3p (miR-128–3p)/Zinc finger e-box Binding homeobox-1 (ZEB1) axis in Acute Myeloid Leukemia (AML).</div></div><div><h3>Methods</h3><div>AML cell viability, proliferation, apoptosis, the ratio of microtubule-associated protein 1A/1B-Light Chain 3-phosphatidylethanolamine conjugate (LC3-II) to free LC3 (LC3-I) (LC3-II/LC3-I), and PD-L1 expression, as well as CD8⁺ <em>T</em>-cell cytotoxicity, were correspondingly analyzed. The targeting relationship between miR-128–3p and circ-RERE or ZEB1 was verified.</div></div><div><h3>Results</h3><div>As detected, suppressing circ-RERE or overexpressing miR-128–3p significantly blocked the proliferation, migration, invasion, and autophagy of AML cells, promoted cell apoptosis, suppressed PD-L1 expression, and increased CD8+ <em>T</em>-cell cytotoxicity. circ-RERE competed with miR-128–3p to regulate ZEB1. Forced expression of ZEB1 did a reversal of circ-RERE suppression-induced effects.</div></div><div><h3>Conclusion</h3><div>In a word, circ-RERE promotes autophagy and immune escape in AML by regulating PD-L1 expression through the miR-128–3p/ZEB1 axis, which may provide a new target for AML therapy.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100850"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological evaluation of the auditory pathway in newborns and infants with peri-intraventricular hemorrhage and/or periventricular leukomalacia","authors":"Rosanna Giaffredo Angrisani ,&nbsp;Natalia Olival Balzarini ,&nbsp;Carla Regina Tragante ,&nbsp;Valdenise Martins Laurindo Tuma Calil ,&nbsp;Werther Brunow de Carvalho ,&nbsp;Carla Gentile Matas","doi":"10.1016/j.clinsp.2025.100853","DOIUrl":"10.1016/j.clinsp.2025.100853","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate and monitor, through electrophysiological assessment of hearing, the integrity of the peripheral and central auditory pathways in infants with Peri-intraventricular hemorrhage and/or Periventricular Leukomalacia (PIVH/PVL) who stayed in a Neonatal Intensive Care Unit (NICU), aiming to verify the occurrence of possible neural dysfunctions in this system.</div></div><div><h3>Material and methods</h3><div>This prospective longitudinal study evaluated preterm Newborns (NBs) and infants at the time of hospital discharge and after 3- and 6-months. The Study Group (SG) had 12 females and 11 males, with gestational age between 25- and 33-weeks, and a mean gestational age of 29.82-weeks at birth. The Control Group (CG) had 26 healthy NBs, distributed in 13 females and 13 males, with gestational age between 27- and 33-weeks and a mean of 30.67-weeks of gestational age at birth. All participants underwent Auditory Brainstem Response (ABR) and Cortical Auditory Evoked Potentials (CAEP) P1, N1, P2, at the time of hospital discharge, and 3- and 6-months after discharge. Each group’s results were compared using statistical tests.</div></div><div><h3>Results</h3><div>Evolutionary study of mean ABR and CAEP latencies in infants in the study and control group showed a similar pattern over the six months after hospital discharge.</div></div><div><h3>Conclusion</h3><div>The comparison of brainstem and cortical potentials showed that auditory function is symmetrical in the peripheral and central portions of the auditory pathway in both groups. The maturation of the ABR and CAEP waves in both groups developed in a very similar way over the six months after hospital discharge.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100853"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limits of life and ethical imperatives: A synthesis between principlism and moral deliberation in periviability","authors":"Fábio Roberto Cabar","doi":"10.1016/j.clinsp.2026.101031","DOIUrl":"10.1016/j.clinsp.2026.101031","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 101031"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xerostomia in the menopausal transition: are we measuring menopause or its comorbidities?","authors":"Giovanna P. Florezi,&nbsp;Lara Vanelli,&nbsp;Fernanda Pereira de Moraes,&nbsp;Isabel Cristina Esposito Sorpreso,&nbsp;José Maria Soares-Junior,&nbsp;Silvia Vanessa Lourenço","doi":"10.1016/j.clinsp.2026.101154","DOIUrl":"10.1016/j.clinsp.2026.101154","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 101154"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From diagnosis to daily life: A comparative pilot study on healthcare access and challenges for neurofibromatosis type 1 in public systems of Brazil and Portugal","authors":"Déborah Domeneghetti de Francisco ,&nbsp;Isabela Mayá Wayhs Silva ,&nbsp;Jorge M. Saraiva ,&nbsp;Carlos Eduardo Steiner ,&nbsp;Vera Lúcia Gil-da-Silva-Lopes","doi":"10.1016/j.clinsp.2026.100875","DOIUrl":"10.1016/j.clinsp.2026.100875","url":null,"abstract":"<div><h3>Background</h3><div>Neurofibromatosis type 1 is a systemic genetic disease with manifestations that include neurocognitive alterations. The disease's characteristics influence various areas of the lives of affected individuals, regardless of their place of residence.</div></div><div><h3>Objectives</h3><div>This study compares the experiences of a small group of patients with type 1 neurofibromatosis in two public hospitals in Brazil and Portugal.</div></div><div><h3>Methods</h3><div>This is an exploratory, cross-sectional, and descriptive study. Patients of legal age or those responsible for underage patients were included in a health service in the Clinical Hospital of the State University of Campinas in Brazil and the Clinical Academic Center of Coimbra in Portugal. They answered an online form about quality of life and access to health.</div></div><div><h3>Results</h3><div>18 participants were included, 13 Brazilians and 5 Portuguese. Most were female and had a mean age at diagnosis of 8.2-years. The mean age of Brazilians was 9.1-years for the first consultation with a geneticist and 15.5-years among Portuguese. The average number of professionals accessed was 4.5 among Brazilians and 3.8 among Portuguese.</div></div><div><h3>Limitations</h3><div>Small sample size, restricted temporal aspect, convenience bias of participants with internet access, and self-declaration of data by participants.</div></div><div><h3>Conclusions</h3><div>Both Brazilians and Portuguese participants with neurofibromatosis type 1 presented similar difficulties regarding access to health. The differences found between the participants from both countries focus on access to medical geneticists and their health literacy. Expanding studies would help identify care priorities related to the specificities of NF1 that could improve the quality of life of affected individuals.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100875"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance and mechanistic role of Hsa_circ_0005075 in recurrent spontaneous abortion: Regulation of trophoblast proliferation and invasion through the Wnt/β-catenin pathway","authors":"Meng Li ,&nbsp;Shuyuan Liu ,&nbsp;Xuan Du","doi":"10.1016/j.clinsp.2025.100816","DOIUrl":"10.1016/j.clinsp.2025.100816","url":null,"abstract":"<div><h3>Objective</h3><div>Given the current lack of diagnostic markers with high sensitivity and specificity, the diagnosis and treatment of Recurrent Spontaneous Abortion (RSA) have always presented significant difficulties. To analyze the relationship between hsa_circ_0005075 and RSA and conduct a preliminary exploration of its mechanism.</div></div><div><h3>Methods</h3><div>Fifty-eight RSA patients admitted to the studied hospital from March 2022 to January 2024 (research group) and 52 normal pregnant women (control group) were selected as the research subjects. Peripheral blood hsa_circ_0005075 expression was detected to determine the difference between the two groups. In addition, the evaluation value of hsa_circ_0005075 for RSA, miscarriage, and adverse pregnancy outcomes was analyzed through Receiver Operating Characteristic (ROC) curves. Furthermore, human placental Trophoblast Cells (TBCs) HTR8/SVneowere purchased and transfected with abnormal hsa_circ_0005075 expression sequences to identify changes in HTR8/SVneoproliferation, invasion, and apoptosis, and alterations in Wnt/β-catenin pathway expression.</div></div><div><h3>Results</h3><div>hsa_circ_0005075 was higher in the research group than in the control group (4.00 ± 0.93 vs. 2.78 ± 0.94, <em>p</em> &lt; 0.05). ROC curves indicated the excellent diagnostic effect of hsa_circ_0005075 on the occurrence of RSA (Area Under Curve [AUC = 0.820]), miscarriage (AUC = 0.744), and adverse pregnancy outcomes (AUC = 0.726). In vitro, increasing hsa_circ_0005075 inhibited HTR8/SVneogrowth, decreased cell clones and cell invasion number, increased apoptosis, shortened the G0/G1 phase, and activated the Wnt/β-catenin pathway; the opposite results were observed after silencing hsa_circ_0005075 expression. Mechanistically, gain and loss-of-function experiments revealed that hsa_circ_0005075 acts as a negative regulator of trophoblast proliferation, invasion, and cell cycle progression, and induces apoptosis by suppressing the Wnt/β-catenin signaling pathway.</div></div><div><h3>Conclusions</h3><div>The present findings identify hsa_circ_0005075 as a promising circulating biomarker for RSA and demonstrate that it contributes to RSA pathogenesis by impairing trophoblast function through inhibition of the Wnt/β-catenin pathway, suggesting its potential as a therapeutic target.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100816"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy of the treat-to-close strategy for patients with atrial septal defect-pulmonary artery hypertension and characteristics of indicated populations","authors":"Jianing Fan ,&nbsp;Yuliang Long ,&nbsp;Jin Qi ,&nbsp;Dawei Lin ,&nbsp;Feng Zhang ,&nbsp;Zhi Zhan ,&nbsp;Dandan Chen ,&nbsp;Wenzhi Pan ,&nbsp;Lihua Guan ,&nbsp;Daxin Zhou ,&nbsp;Junbo Ge","doi":"10.1016/j.clinsp.2026.100861","DOIUrl":"10.1016/j.clinsp.2026.100861","url":null,"abstract":"<div><h3>Objective</h3><div>“Treat-to-close” strategy in the treatment of patients with Atrial Septal Defects (ASD) combined with severe Pulmonary Hypertension (PAH). This study explored the long-term survival of patients undergoing the “treat-to-close” strategy and the characteristics of the applicable population.</div></div><div><h3>Methods</h3><div>A total of 141 ASD-PAH patients were collected. Patients were classified as “Occlusion Group” (OG) and “Conservative Treatment Group” (CTG) depending on the suitability of ASD occlusion after drug treatment. The baseline characteristics and long-term follow-up outcomes of the two groups were recorded.</div></div><div><h3>Results</h3><div>Patients in the OG underwent 5 (3.8) months of Pulmonary Artery-targeted Drug Therapy (PADT) before ASD occlusion. OG patients had better long-term survival (<em>p</em> = 0.043). Pulmonary Vascular Resistance (PVR): Area Under the Curve (AUC) 0.813 (0.726‒0.899, <em>p</em> &lt; 0.001), Pulmonary Arterial Oxygen Saturation (PASO2): AUC = 0.794 (95% CI: 0.682‒0.904 <em>p</em> &lt; 0.001), Pulmonary Artery Systolic Pressure (PASP): AUC = 0.808 (95% Confidence Interval [95% CI]: 0.733‒0.883 <em>p</em> &lt; 0.001) and PASO2 combined with PASP: 0.918 (95% CI: 0.854‒0.979 <em>p</em> &lt; 0.001) contribute to the screening of drug-sensitive populations.</div></div><div><h3>Conclusions</h3><div>The treat-to-close strategy significantly improves long-term patient survival. Initial intraoperative indications can help screen the beneficiary population. Larger-scale prospective studies are needed to validate the present findings.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100861"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective single embryo transfer in in vitro fertilization cycles with or without preimplantation genetic testing using next-generation sequencing: A randomized clinical trial","authors":"Pedro Felipe Magalhães Peregrino,&nbsp;Carlos Augusto Z. Nissel,&nbsp;Patricia Florido,&nbsp;Mayara Satiko Nakano,&nbsp;Marcos de Lorenzo Messina,&nbsp;José Maria Soares Júnior,&nbsp;Edmund Chada Baracat,&nbsp;Pedro Augusto Araujo Monteleone","doi":"10.1016/j.clinsp.2026.100870","DOIUrl":"10.1016/j.clinsp.2026.100870","url":null,"abstract":"<div><h3>Introduction</h3><div>Preimplantation Genetic Testing (PGT-A) has been increasingly used in IVF to improve embryo selection. However, its clinical utility in patients with a good prognosis remains debated. There is a lack of robust scientific evidence about the benefits of preimplantation genetic testing Next-Generation Sequencing (NGS) on the clinical pregnancy and live birth rates in good-prognosis IVF patients undergoing elective Single Embryo Transfer (eSET) testing.</div></div><div><h3>Objective</h3><div>To compare the clinical pregnancy rate after IVF treatment in patients with a good prognosis between groups that receive the transfer of a single embryo with or without pre-implantation genetic embryo analysis.</div></div><div><h3>Methods</h3><div>This work was a prospective randomized clinical study that evaluated 206 patients to compare the clinical pregnancy rate after the first elective transfer of an embryo, associated or not with pre-implantation genetic embryo analysis using Next-Generation Sequencing (NGS). Patients were randomized into groups: SET group ‒ patients undergoing the transfer of a single embryo (eSET, elective Single Embryo Transfer) without embryo genetic analysis (SET group, <em>n</em> = 103); and NGS + SET group ‒ patients undergoing eSET with embryo genetic analysis (NGS + SET group, <em>n</em> = 103).</div></div><div><h3>Results</h3><div>The clinical pregnancy rate after the first transfer was similar between the two groups (SET: 76.7 % and NGS + SET: 79.6 %; <em>p</em> = 0.613). There was also no statistical difference in live birth rates or abortion rates between the groups analyzed.</div></div><div><h3>Conclusion</h3><div>This clinical trial suggests no significant improvement in the embryo genetic analysis in IVF treatments for infertile couples with a good prognosis</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100870"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck cancer patients present late cancer cachexia two years after curative chemoradiotherapy","authors":"Willian das Neves,&nbsp;Thomás Giollo Rivelli,&nbsp;Eduardo Furquim Simão,&nbsp;Marco Aurélio Vamondes Kulcsar,&nbsp;Gilberto de Castro Junior","doi":"10.1016/j.clinsp.2025.100851","DOIUrl":"10.1016/j.clinsp.2025.100851","url":null,"abstract":"<div><h3>Introduction</h3><div>Over 90% of Head and Neck Cancers are Squamous Cell Carcinoma (HNSCC). HNSCC patients with no evidence of disease after treatment completion usually present a high frequency of late treatment-related toxicities. Here, we aimed to evaluate the prevalence of cachexia among head and neck squamous cell carcinoma patients treated with cisplatin-based chemoradiation with curative intent and presenting no evidence of disease. We hypothesize that even patients post long-term follow-up and curative-intention treatment present a high frequency of cancer cachexia.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional observational study included 120 patients with HNSCC who had previously received definitive or adjuvant chemoradiation. Eligible patients were in regular follow-up for at least 2-years, with no evidence of disease. We assessed clinical characteristics, body composition, muscle strength, nutritional status, and blood tests. The primary outcome was the prevalence of cachexia, and the secondary outcome was an association between cachexia and self-reported dysphagia.</div></div><div><h3>Results</h3><div>Using two different diagnostic criteria (Fearon and Evans criteria), we found that 20.7% and 8.6% of patients presented cancer cachexia after more than two years of follow-up after curative chemoradiation treatment. As expected, cachectic patients presented lower mid-arm muscle circumference, with dysphagia in 73%. In addition, in cachectic patients diagnosed according to Evans's cancer cachexia criteria, we found lower muscle strength levels. There is no association between dysphagia and cancer cachexia, regardless of the diagnostic criteria.</div></div><div><h3>Conclusion</h3><div>In long-term follow-up, head and neck squamous cell carcinoma patients with no evidence of disease frequently present with cachexia after curative chemoradiation.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100851"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}