Clinics最新文献

{"title":"Nomogram prediction model for the clinical efficacy of flunarizine hydrochloride in patients with vertigo based on 5-HT and oxidative stress indicators✰","authors":"Hua Zhang,&nbsp;Xu Pan,&nbsp;Dan Lin,&nbsp;Xiaogang Yang,&nbsp;Puzhao Liu","doi":"10.1016/j.clinsp.2026.100936","DOIUrl":"10.1016/j.clinsp.2026.100936","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and validate a nomogram model integrating 5-Hydroxytryptamine (5-HT) and oxidative stress markers to predict the efficacy of flunarizine hydrochloride in treating vertigo.</div></div><div><h3>Methods</h3><div>A retrospective study included 244 vertigo patients treated with flunarizine hydrochloride from September 2022 to December 2024. Patients were divided into training (70%) and validation (30%) sets. Clinical data, 5-HT levels, and oxidative stress indicators (Superoxide Dismutase [SOD], Malondialdehyde [MDA], Glutathione Peroxidase [GSH-Px]) were collected and analyzed. The influencing factors of treatment efficacy were screened using univariate and multivariate logistic regression. Least Absolute Shrinkage and Selection Operator (LASSO) regression was implemented using the R 'glmnet' package with 10-fold cross-validation. A nomogram model was constructed by integrating the independent influencing factors of treatment efficacy. Model performance was assessed via calibration curves, Consistency index (C-index), Decision Curve Analysis (DCA), and Receiver Operating Characteristic (ROC) curve.</div></div><div><h3>Results</h3><div>There were 176 cases in the effective group and 68 cases in the ineffective group. Age, 5-HT, SOD, MDA, and GSH-Px were identified as independent predictors of treatment efficacy (<em>p</em> &lt; 0.05). After variable selection via LASSO regression, the reduced nomogram demonstrated strong discriminative ability, with C-indexes of 0.862 (in the training set) and 0.874 (in the validation set), and average absolute errors of 0.144 and 0.138, respectively. Hosmer-Lemeshow tests confirmed good fit of the model (training: χ² = 9.061, <em>p</em> = 0.337; validation: χ² = 8.034, <em>p</em> = 0.430). ROC analysis yielded Area Under the Curve (AUC) values of 0.861 (95% CI: 0.797–0.925) and 0.870 (95% CI: 0.798–0.973) for training and validation sets, with sensitivity/specificity values of 0.892/0.711 and 1.000/0.650, respectively.</div></div><div><h3>Conclusion</h3><div>The simplified nomogram incorporating age and oxidative stress markers demonstrates robust predictive accuracy while enhancing clinical feasibility. Actionable thresholds were established, such that patients with a score &gt; 70-points should be considered for alternative therapies due to a high predicted risk of treatment non-response.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100936"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT grading combined with inflammatory markers for predicting the efficacy of conservative treatment in acute appendicitis","authors":"Zhizun Lin","doi":"10.1016/j.clinsp.2026.100929","DOIUrl":"10.1016/j.clinsp.2026.100929","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the clinical characteristics of patients with first-episode acute appendicitis and explore the value of CT imaging grading combined with inflammatory markers in evaluating the cure and relapse of conservative treatment.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted to collect the clinical data of 482 patients with acute appendicitis diagnosed in the Emergency Department of the Second Affiliated Hospital of Fujian Medical University from October 2021 to February 2024. The imaging features of these patients were evaluated using Computed Tomography (CT) scans. Descriptive analysis, chi-square test, ordinal logistic regression model, Kaplan-Meier curve, and COX regression analysis were used to analyze the data.</div></div><div><h3>Results</h3><div>Elevated levels of Procalcitonin (PCT) and C-Reactive Protein (CRP) were associated with higher CT grades. Acute appendicitis patients with higher CT grades had a poor prognosis with antibiotic treatment. CT grade was a predictor of the prognosis of antibiotic treatment, and a high CT grade was an independent risk factor for relapse.</div></div><div><h3>Conclusion</h3><div>CT grade combined with inflammatory markers (PCT and CRP) can effectively predict the prognosis of conservative treatment for acute appendicitis, and CT grade can be used to predict the risk of relapse.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100929"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective analysis of post-COVID-19 hospitalization: Impact on pulmonary function, physical performance and overall functionality","authors":"Danielle Brancolini de Oliveira,&nbsp;Gabriela Sayuri Ochiai,&nbsp;Elizabeth Mendes da Silva,&nbsp;Camila Machado de Campos,&nbsp;Caroline Gil de Godoy,&nbsp;Erika Christina Gouveia e Silva,&nbsp;Celso Ricardo Fernandes Carvalho,&nbsp;Jose Eduardo Pompeu","doi":"10.1016/j.clinsp.2026.100938","DOIUrl":"10.1016/j.clinsp.2026.100938","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 can lead to enduring long-term effects, particularly in severe cases requiring hospitalization. This study contrasts Normal lung Patterns (NP) with Restrictive lung Disease (RD) regarding the evolution of physical performance and functionality post-COVID-19 hospitalization.</div></div><div><h3>Methods</h3><div>This is a prospective cohort study. Individuals post-COVID-19 were evaluated at 1- and 12-months post-discharge. Data collection included analysis of lung function, physical performance, functionality, and clinical data.</div></div><div><h3>Results</h3><div>Of the 185 participants initially assessed, 62 attended the final evaluation. At 1 month post-discharge, 57 (92%) had been admitted to the ICU and 47 (76%) exhibited RD. After 12-months, RD decreased to 20 (32%). Both groups showed improved Sit-to-Stand repetitions (p = 0.002). A substantial percentage (28%) of participants with RD experienced functional impairments at one month, with a notable proportion maintaining these limitations after one year (15%).</div></div><div><h3>Conclusions</h3><div>Almost half of individuals with RD (43%) still exhibited this pulmonary alteration after one year (RD 20/47). Additionally, RD participants demonstrated decreased physical performance at one month (15%), with only a fraction (5%) showing improvement after one year. Finally, these results pointed out the necessity of long-term follow-up regarding the recovery trajectory of post-COVID patients. Furthermore, there is a clear need to offer specific rehabilitation focusing on pulmonary, physical performance and functionality.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100938"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From diagnosis to daily life: A comparative pilot study on healthcare access and challenges for neurofibromatosis type 1 in public systems of Brazil and Portugal","authors":"Déborah Domeneghetti de Francisco ,&nbsp;Isabela Mayá Wayhs Silva ,&nbsp;Jorge M. Saraiva ,&nbsp;Carlos Eduardo Steiner ,&nbsp;Vera Lúcia Gil-da-Silva-Lopes","doi":"10.1016/j.clinsp.2026.100875","DOIUrl":"10.1016/j.clinsp.2026.100875","url":null,"abstract":"<div><h3>Background</h3><div>Neurofibromatosis type 1 is a systemic genetic disease with manifestations that include neurocognitive alterations. The disease's characteristics influence various areas of the lives of affected individuals, regardless of their place of residence.</div></div><div><h3>Objectives</h3><div>This study compares the experiences of a small group of patients with type 1 neurofibromatosis in two public hospitals in Brazil and Portugal.</div></div><div><h3>Methods</h3><div>This is an exploratory, cross-sectional, and descriptive study. Patients of legal age or those responsible for underage patients were included in a health service in the Clinical Hospital of the State University of Campinas in Brazil and the Clinical Academic Center of Coimbra in Portugal. They answered an online form about quality of life and access to health.</div></div><div><h3>Results</h3><div>18 participants were included, 13 Brazilians and 5 Portuguese. Most were female and had a mean age at diagnosis of 8.2-years. The mean age of Brazilians was 9.1-years for the first consultation with a geneticist and 15.5-years among Portuguese. The average number of professionals accessed was 4.5 among Brazilians and 3.8 among Portuguese.</div></div><div><h3>Limitations</h3><div>Small sample size, restricted temporal aspect, convenience bias of participants with internet access, and self-declaration of data by participants.</div></div><div><h3>Conclusions</h3><div>Both Brazilians and Portuguese participants with neurofibromatosis type 1 presented similar difficulties regarding access to health. The differences found between the participants from both countries focus on access to medical geneticists and their health literacy. Expanding studies would help identify care priorities related to the specificities of NF1 that could improve the quality of life of affected individuals.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100875"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance and mechanistic role of Hsa_circ_0005075 in recurrent spontaneous abortion: Regulation of trophoblast proliferation and invasion through the Wnt/β-catenin pathway","authors":"Meng Li ,&nbsp;Shuyuan Liu ,&nbsp;Xuan Du","doi":"10.1016/j.clinsp.2025.100816","DOIUrl":"10.1016/j.clinsp.2025.100816","url":null,"abstract":"<div><h3>Objective</h3><div>Given the current lack of diagnostic markers with high sensitivity and specificity, the diagnosis and treatment of Recurrent Spontaneous Abortion (RSA) have always presented significant difficulties. To analyze the relationship between hsa_circ_0005075 and RSA and conduct a preliminary exploration of its mechanism.</div></div><div><h3>Methods</h3><div>Fifty-eight RSA patients admitted to the studied hospital from March 2022 to January 2024 (research group) and 52 normal pregnant women (control group) were selected as the research subjects. Peripheral blood hsa_circ_0005075 expression was detected to determine the difference between the two groups. In addition, the evaluation value of hsa_circ_0005075 for RSA, miscarriage, and adverse pregnancy outcomes was analyzed through Receiver Operating Characteristic (ROC) curves. Furthermore, human placental Trophoblast Cells (TBCs) HTR8/SVneowere purchased and transfected with abnormal hsa_circ_0005075 expression sequences to identify changes in HTR8/SVneoproliferation, invasion, and apoptosis, and alterations in Wnt/β-catenin pathway expression.</div></div><div><h3>Results</h3><div>hsa_circ_0005075 was higher in the research group than in the control group (4.00 ± 0.93 vs. 2.78 ± 0.94, <em>p</em> &lt; 0.05). ROC curves indicated the excellent diagnostic effect of hsa_circ_0005075 on the occurrence of RSA (Area Under Curve [AUC = 0.820]), miscarriage (AUC = 0.744), and adverse pregnancy outcomes (AUC = 0.726). In vitro, increasing hsa_circ_0005075 inhibited HTR8/SVneogrowth, decreased cell clones and cell invasion number, increased apoptosis, shortened the G0/G1 phase, and activated the Wnt/β-catenin pathway; the opposite results were observed after silencing hsa_circ_0005075 expression. Mechanistically, gain and loss-of-function experiments revealed that hsa_circ_0005075 acts as a negative regulator of trophoblast proliferation, invasion, and cell cycle progression, and induces apoptosis by suppressing the Wnt/β-catenin signaling pathway.</div></div><div><h3>Conclusions</h3><div>The present findings identify hsa_circ_0005075 as a promising circulating biomarker for RSA and demonstrate that it contributes to RSA pathogenesis by impairing trophoblast function through inhibition of the Wnt/β-catenin pathway, suggesting its potential as a therapeutic target.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100816"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy of the treat-to-close strategy for patients with atrial septal defect-pulmonary artery hypertension and characteristics of indicated populations","authors":"Jianing Fan ,&nbsp;Yuliang Long ,&nbsp;Jin Qi ,&nbsp;Dawei Lin ,&nbsp;Feng Zhang ,&nbsp;Zhi Zhan ,&nbsp;Dandan Chen ,&nbsp;Wenzhi Pan ,&nbsp;Lihua Guan ,&nbsp;Daxin Zhou ,&nbsp;Junbo Ge","doi":"10.1016/j.clinsp.2026.100861","DOIUrl":"10.1016/j.clinsp.2026.100861","url":null,"abstract":"<div><h3>Objective</h3><div>“Treat-to-close” strategy in the treatment of patients with Atrial Septal Defects (ASD) combined with severe Pulmonary Hypertension (PAH). This study explored the long-term survival of patients undergoing the “treat-to-close” strategy and the characteristics of the applicable population.</div></div><div><h3>Methods</h3><div>A total of 141 ASD-PAH patients were collected. Patients were classified as “Occlusion Group” (OG) and “Conservative Treatment Group” (CTG) depending on the suitability of ASD occlusion after drug treatment. The baseline characteristics and long-term follow-up outcomes of the two groups were recorded.</div></div><div><h3>Results</h3><div>Patients in the OG underwent 5 (3.8) months of Pulmonary Artery-targeted Drug Therapy (PADT) before ASD occlusion. OG patients had better long-term survival (<em>p</em> = 0.043). Pulmonary Vascular Resistance (PVR): Area Under the Curve (AUC) 0.813 (0.726‒0.899, <em>p</em> &lt; 0.001), Pulmonary Arterial Oxygen Saturation (PASO2): AUC = 0.794 (95% CI: 0.682‒0.904 <em>p</em> &lt; 0.001), Pulmonary Artery Systolic Pressure (PASP): AUC = 0.808 (95% Confidence Interval [95% CI]: 0.733‒0.883 <em>p</em> &lt; 0.001) and PASO2 combined with PASP: 0.918 (95% CI: 0.854‒0.979 <em>p</em> &lt; 0.001) contribute to the screening of drug-sensitive populations.</div></div><div><h3>Conclusions</h3><div>The treat-to-close strategy significantly improves long-term patient survival. Initial intraoperative indications can help screen the beneficiary population. Larger-scale prospective studies are needed to validate the present findings.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100861"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective single embryo transfer in in vitro fertilization cycles with or without preimplantation genetic testing using next-generation sequencing: A randomized clinical trial","authors":"Pedro Felipe Magalhães Peregrino,&nbsp;Carlos Augusto Z. Nissel,&nbsp;Patricia Florido,&nbsp;Mayara Satiko Nakano,&nbsp;Marcos de Lorenzo Messina,&nbsp;José Maria Soares Júnior,&nbsp;Edmund Chada Baracat,&nbsp;Pedro Augusto Araujo Monteleone","doi":"10.1016/j.clinsp.2026.100870","DOIUrl":"10.1016/j.clinsp.2026.100870","url":null,"abstract":"<div><h3>Introduction</h3><div>Preimplantation Genetic Testing (PGT-A) has been increasingly used in IVF to improve embryo selection. However, its clinical utility in patients with a good prognosis remains debated. There is a lack of robust scientific evidence about the benefits of preimplantation genetic testing Next-Generation Sequencing (NGS) on the clinical pregnancy and live birth rates in good-prognosis IVF patients undergoing elective Single Embryo Transfer (eSET) testing.</div></div><div><h3>Objective</h3><div>To compare the clinical pregnancy rate after IVF treatment in patients with a good prognosis between groups that receive the transfer of a single embryo with or without pre-implantation genetic embryo analysis.</div></div><div><h3>Methods</h3><div>This work was a prospective randomized clinical study that evaluated 206 patients to compare the clinical pregnancy rate after the first elective transfer of an embryo, associated or not with pre-implantation genetic embryo analysis using Next-Generation Sequencing (NGS). Patients were randomized into groups: SET group ‒ patients undergoing the transfer of a single embryo (eSET, elective Single Embryo Transfer) without embryo genetic analysis (SET group, <em>n</em> = 103); and NGS + SET group ‒ patients undergoing eSET with embryo genetic analysis (NGS + SET group, <em>n</em> = 103).</div></div><div><h3>Results</h3><div>The clinical pregnancy rate after the first transfer was similar between the two groups (SET: 76.7 % and NGS + SET: 79.6 %; <em>p</em> = 0.613). There was also no statistical difference in live birth rates or abortion rates between the groups analyzed.</div></div><div><h3>Conclusion</h3><div>This clinical trial suggests no significant improvement in the embryo genetic analysis in IVF treatments for infertile couples with a good prognosis</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100870"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck cancer patients present late cancer cachexia two years after curative chemoradiotherapy","authors":"Willian das Neves,&nbsp;Thomás Giollo Rivelli,&nbsp;Eduardo Furquim Simão,&nbsp;Marco Aurélio Vamondes Kulcsar,&nbsp;Gilberto de Castro Junior","doi":"10.1016/j.clinsp.2025.100851","DOIUrl":"10.1016/j.clinsp.2025.100851","url":null,"abstract":"<div><h3>Introduction</h3><div>Over 90% of Head and Neck Cancers are Squamous Cell Carcinoma (HNSCC). HNSCC patients with no evidence of disease after treatment completion usually present a high frequency of late treatment-related toxicities. Here, we aimed to evaluate the prevalence of cachexia among head and neck squamous cell carcinoma patients treated with cisplatin-based chemoradiation with curative intent and presenting no evidence of disease. We hypothesize that even patients post long-term follow-up and curative-intention treatment present a high frequency of cancer cachexia.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional observational study included 120 patients with HNSCC who had previously received definitive or adjuvant chemoradiation. Eligible patients were in regular follow-up for at least 2-years, with no evidence of disease. We assessed clinical characteristics, body composition, muscle strength, nutritional status, and blood tests. The primary outcome was the prevalence of cachexia, and the secondary outcome was an association between cachexia and self-reported dysphagia.</div></div><div><h3>Results</h3><div>Using two different diagnostic criteria (Fearon and Evans criteria), we found that 20.7% and 8.6% of patients presented cancer cachexia after more than two years of follow-up after curative chemoradiation treatment. As expected, cachectic patients presented lower mid-arm muscle circumference, with dysphagia in 73%. In addition, in cachectic patients diagnosed according to Evans's cancer cachexia criteria, we found lower muscle strength levels. There is no association between dysphagia and cancer cachexia, regardless of the diagnostic criteria.</div></div><div><h3>Conclusion</h3><div>In long-term follow-up, head and neck squamous cell carcinoma patients with no evidence of disease frequently present with cachexia after curative chemoradiation.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100851"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of serum TBL1XR1, MFAP5, and PSA as diagnostic biomarkers for prostate cancer","authors":"Xianxian Wu,&nbsp;Xiuping Lin,&nbsp;Jiejun Lin","doi":"10.1016/j.clinsp.2026.100868","DOIUrl":"10.1016/j.clinsp.2026.100868","url":null,"abstract":"<div><h3>Objective</h3><div>Advanced prostate cancer (PCa) remains a leading cause of cancer-related mortality in men. While Prostate-Specific Antigen (PSA)-based early screening has demonstrated mortality reduction, its diagnostic accuracy remains limited. This study aimed to evaluate the potential of serum transducin (beta)-like-1 X-linked Receptor-1 (TBL1XR1) and Microfibrillar-Associated Protein-5 (MFAP5) as novel diagnostic biomarkers for supplementing PSA-based detection.</div></div><div><h3>Method</h3><div>Through bioinformatic analysis, TBL1XR1 and MFAP5 were identified as candidate markers, with their expression validated using reverse transcription-quantitative polymerase chain reaction. Diagnostic performance was assessed via Receiver Operating Characteristic (ROC) curve analysis, while Pearson correlation coefficients evaluated biomarker associations.</div></div><div><h3>Results</h3><div>Serum TBL1XR1 and MFAP5 levels were elevated in PCa patients, both exhibiting positive correlations with PSA concentrations. Individual AUC values reached 0.8197 (TBL1XR1) and 0.8139 (MFAP5). The free PSA (fPSA)/total PSA (tPSA) ratio showed decreased values in PCa cases, demonstrating superior diagnostic utility compared to total PSA alone. A combined panel of TBL1XR1, MFAP5, and PSA achieved an AUC of 0.939 with a Youden index of 0.756.</div></div><div><h3>Conclusions</h3><div>TBL1XR1 and MFAP5 have the potential for PCa diagnosis. The synergistic application of TBL1XR1, MFAP5, and PSA significantly enhances diagnostic accuracy. These findings indicate that serum TBL1XR1 and MFAP5 represent promising diagnostic markers for PCa. The combination of serum TBL1XR1 and MFAP5 with PSA for diagnosis may potentially reduce unnecessary biopsies in clinical practice.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100868"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-session music therapy reduces anxiety and depression among hospitalized adults in an endocrinology ward","authors":"Veronique Lima ,&nbsp;Izabel Cristina Rios ,&nbsp;Marlene Inacio ,&nbsp;Vinicius Nahime Brito ,&nbsp;Berenice B. Mendonca","doi":"10.1016/j.clinsp.2026.100922","DOIUrl":"10.1016/j.clinsp.2026.100922","url":null,"abstract":"<div><h3>Introduction</h3><div>Hospitalization can generate stress and anxiety and lead to depression. Music therapy has been used in hospital environments to promote patient well-being. However, scarce research has examined heterogeneous groups using the single-session format. This controlled clinical trial aimed to compare the effects of three methods of single-session music therapy on reducing anxiety and depression in hospitalized adult patients with diverse endocrine disorders.</div></div><div><h3>Method</h3><div>Participants (<em>n</em> = 222) were non-randomly distributed into three experimental music therapy groups (compositional, songwriting, and receptive) and a control group. The instruments used were the Hospital Anxiety and Depression Scale (HADS; pre-and post-test).</div></div><div><h3>Results</h3><div>The experimental groups presented a statistically significant decrease in the HADS scores (<em>p</em> &lt; 0.05) compared with the control group. Participants in the experimental groups reported an enhancement in well-being.</div></div><div><h3>Discussion</h3><div>Single-session music therapy interventions, mainly the receptive method, had a positive impact on reducing anxiety and depression in a heterogeneous group of hospitalized adult patients with endocrinopathies.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"81 ","pages":"Article 100922"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}