The association between the monocyte Chemoattractant protein-1-2518A/G polymorphism and the risk of tuberculosis in the Chinese population: A meta-analysis and systematic review.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-05-11 eCollection Date: 2025-01-01 DOI:10.1016/j.clinsp.2025.100685

Hongfang Lu, Jingang Wang, Xinyu Song, Xiaoqi Xiong

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引用次数: 0

Abstract

Objectives: No meta-analysis has been conducted on the relationship between the MCP-1-2518A/G gene polymorphism and tuberculosis susceptibility in the Chinese population. The aim of this study was to investigate whether MCP-1-2518A/G polymorphism is associated with susceptibility to TB in Chinese.

Method: Publications addressing the association between the MCP-1-2518A/G polymorphism and TB risk were selected from the PubMed, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.1 and STATA 12 software.

Results: Ten case-control studies were extracted from 10 articles on polymorphisms involving 1634 TB patients and 1768 controls. The results of the meta-analysis showed that a significantly increased risk for TB was found for Chinese individuals with the polymorphism as follows: dominant model (GG+GA vs. AA Odds Ratio [OR = 1.53], 95 % CI 1.14‒2.07, p = 0.000); recessive model (GG vs. GA+AA Odds Ratio [OR = 1.63], 95 % CI 1.13‒2.35, p = 0.009); and a homozygote comparison (GG vs. AA Odds Ratio [OR = 1.93], 95 % CI 1.19‒3.13, p = 0.008). In the subgroup analysis by ethnicity, significantly elevated risks were found in non-Han Chinese individuals but not in Han Chinese individuals (mutant homozygous GG vs. AA: OR = 3.81, 95 % CI 2.07‒7.00, p = 0.000).

Conclusions: This meta-analysis suggested that the -2518A/G polymorphism of the MCP-1 gene is a risk factor for TB in Chinese individuals. In the GG vs. AA model, non-Han Chinese individuals had a higher risk of tuberculosis than Han Chinese individuals.

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单核细胞趋化蛋白-1- 2518a /G多态性与中国人群结核病风险的关系：荟萃分析和系统评价

目的：尚未对中国人群MCP-1-2518A/G基因多态性与结核病易感性的关系进行meta分析。本研究旨在探讨中国人MCP-1-2518A/G多态性是否与结核病易感性相关。方法：选择PubMed、Embase、CNKI和万方数据库中有关MCP-1-2518A/G多态性与结核病风险关系的文献。数据由两名独立审稿人从研究中提取。采用RevMan 5.1和STATA 12软件进行统计分析。结果：从10篇关于多态性的文章中提取了10项病例对照研究，涉及1634例结核病患者和1768例对照。meta分析结果显示，中国人患TB的风险显著增加，其多态性如下：显性模型（GG+GA vs. AA优势比[OR = 1.53], 95% CI 1.14-2.07, p = 0.000）；隐性模型（GG vs. GA+AA优势比[OR = 1.63], 95% CI 1.13-2.35, p = 0.009）；纯合子比较（GG与AA比值比[OR = 1.93], 95% CI 1.19-3.13, p = 0.008）。在种族亚组分析中，非汉族个体的风险显著升高，汉族个体的风险显著升高（突变纯合子GG vs. AA: OR = 3.81, 95% CI 2.07-7.00, p = 0.000）。结论：本荟萃分析提示MCP-1基因-2518A/G多态性是中国人结核病的危险因素。在GG与AA模型中，非汉族个体患结核病的风险高于汉族个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.