Clinics最新文献

{"title":"Pharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials","authors":"Antonio Carlos Queiroz de Aquino ,&nbsp;Ayane Cristine Alves Sarmento ,&nbsp;Raphaell Lucas de Araújo Teixeira ,&nbsp;Tâmilly Nascimento Batista ,&nbsp;Cijara Leonice de Freitas ,&nbsp;José Manuel Pérez Mármol ,&nbsp;Lucia Alves Silva Lara ,&nbsp;Ana Katherine Gonçalves","doi":"10.1016/j.clinsp.2025.100602","DOIUrl":"10.1016/j.clinsp.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>Antidepressant-Induced Sexual Dysfunction (AISD) is a significant public health concern, and pharmacological treatments may offer potential solutions for managing this side effect. This study aims to assess the efficacy of these therapies in treating AISD in women, as well as their impact on improving depressive symptoms.</div></div><div><h3>Methods</h3><div>The authors conducted a search of PubMed, Cochrane, Scopus, Web of Science, Embase, and ClinicalTrials.gov databases up to July 3, 2024, including Randomized Controlled Trials (RCTs) comparing pharmacological treatments with placebo. The risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2.0). Data synthesis was performed with RevMan 5.4, and the certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.</div></div><div><h3>Results</h3><div>Eleven studies, with 859 women, were included in the review. Two studies were used in the meta-analysis. The participants' ages ranged from 28 to 48 years. The interventions studied included <em>Aphrodite</em>, bupropion SR, ephedrine, <em>maca root, rosa damascena, saffron</em>, sildenafil, testosterone, and the compound VML-670. Bupropion SR 150 mg/b.i.d. showed improvements in three sexual function domains: desire (1.74 [1.03, 2.44], p = 0.00001), arousal (1.30 [1.16, 1.43], p = 0.00001), and orgasm (1.90 [1.78, 2.02], p = 0.00001) compared to placebo. However, it did not improve depressive symptoms (0.46 [-0.71, 1.63], p = 0.44). The GRADE rating for the evidence quality was low.</div></div><div><h3>Conclusions</h3><div>Bupropion SR 150 mg/b.i.d. is the most effective pharmacological treatment for AISD in women, though the evidence quality is low. Further clinical trials focusing on women with rigorous methodologies are needed to strengthen these findings.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42024496931.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100602"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019 infection severity among different variants in children under 2-years old in Brazil","authors":"Beatriz Martinelli Menezes Gonçalves ,&nbsp;Rossana P.V. Francisco ,&nbsp;Ágatha S. Rodrigues ,&nbsp;José Carlos Soares Junior","doi":"10.1016/j.clinsp.2025.100592","DOIUrl":"10.1016/j.clinsp.2025.100592","url":null,"abstract":"<div><div>To analyze whether there is a significant difference in the virulence, symptoms, and outcomes of different Coronavirus Disease 2019 (COVID-19) variants in children under 2-years of age. We collected data from the <em>Sistema de Informação de Vigilância Epidemiológica</em> da <em>Gripe</em>, a nationwide Brazilian database on severe acute respiratory syndrome. The patients were classified according to four variants of concern: wild-type, gamma, delta, and omicron. The wild-type variant was defined as the baseline. A total of 11,153 patients were analyzed. The risk of presenting dyspnea (adjusted Odds Ratio[Aor = 1.20], 95 % Confidence Interval [95 % CI 1.07–1.34]) was higher in patients with gamma infection. Respiratory discomfort was more likely to be present for the omicron (Aor = 1.29, 95 % CI 1.15–1.43) and gamma (aOR = 1.26, 95 % CI 1.13–1.41) infections. Desaturation was more likely to be present for the omicron (aOR = 1.67, 95 % CI 1.50–1.86), gamma (aOR = 1.16, 95 % CI 1.43–1.79), and delta (aOR 1.41, CI 95 % 1.18–1.68) infections. Infection by the omicron variant was a protective factor for intubation (aOR = 0.78, 95 % CI 0.67–0.91) and death (aOR = 0.43, 95 % CI 0.35–0.53). Additionally, delta infection was a protective factor against death (aOR = 0.60, 95 % CI 0.43–0.85). The wild-type variant was responsible for most of the cases that evolved with death. Omicron appears to be responsible for milder symptoms than delta. Children between 1 and 6 months of age account for most cases, which is a concern because there is no vaccination coverage.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100592"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency","authors":"Danielle Borges Germano ,&nbsp;Larissa Namie Chiba ,&nbsp;Ana Paula Augusto da Cruz Ballerini ,&nbsp;Jônatas Bussador do Amaral ,&nbsp;Marina Tiemi Shio ,&nbsp;Jhefferson Miranda Alves ,&nbsp;Daniela Alves de Abreu ,&nbsp;Luiz Henrique da Silva Nali ,&nbsp;Francisco Antonio Helfenstein Fonseca ,&nbsp;Maria Cristina Izar ,&nbsp;André Luis Lacerda Bachi ,&nbsp;Carolina Nunes França","doi":"10.1016/j.clinsp.2025.100595","DOIUrl":"10.1016/j.clinsp.2025.100595","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI).</div></div><div><h3>Method</h3><div>The authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders – CEAP: C1‒C3).</div></div><div><h3>Results</h3><div>There were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group.</div></div><div><h3>Conclusions</h3><div>The inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100595"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for depression in peritoneal dialysis patients and establishment of a risk nomogram model","authors":"Ming Yang ,&nbsp;Xinhai Tang ,&nbsp;Yehua Fang","doi":"10.1016/j.clinsp.2025.100600","DOIUrl":"10.1016/j.clinsp.2025.100600","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyze the risk factors for depression in peritoneal dialysis patients and to develop a predictive nomogram model for assessing these risks.</div></div><div><h3>Methods</h3><div>A total of 326 peritoneal dialysis patients treated between August 2021 and December 2023 were selected as the training set. These patients were categorized into a non-depression group (229 cases) and a depression group (97 cases) based on the presence of depression. Additionally, 104 peritoneal dialysis patients from the same period were selected as the validation set. Clinical data were collected from all patients for analysis.</div></div><div><h3>Results</h3><div>The depression group had higher proportions of female patients, non-employed individuals, those with a per capita monthly income of &lt;2000-yuan, cardiovascular complications, cerebrovascular complications, and sleep disorders compared to the non-depression group. Additionally, the levels of hemoglobin and blood uric acid were lower in the depression group than in the non-depression group (<em>p</em> &lt; 0.05). Gender, work status, per capita monthly income, cardiovascular complications, cerebrovascular complications, and sleep disorders are risk factors for depression in peritoneal dialysis patients (<em>p</em> &lt; 0.05), while hemoglobin and blood uric acid are protective factors for depression in peritoneal dialysis patients (<em>p</em> &lt; 0.05). Calibration curve analysis results showed that the predicted probability was basically consistent with the actual incidence rate. The results of the Decision Curve Analysis (DCA) demonstrated that the nomogram model developed in this study has strong clinical applicability.</div></div><div><h3>Conclusion</h3><div>The nomogram model for predicting depression in peritoneal dialysis patients, which incorporates factors such as gender, work status, per capita monthly income, cardiovascular complications, cerebrovascular complications, sleep disorders, hemoglobin levels, and blood uric acid levels, demonstrates excellent calibration and discrimination. Additionally, it has high clinical applicability.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100600"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brugada pattern changes during tilt table test with high precordial leads. An exploratory data to better understand the dynamic profile","authors":"Eduardo Nolla Silva Pereira,&nbsp;Luciana Sacilotto,&nbsp;Tan Chen Wu,&nbsp;Gabriele D'Arezzo Pessente,&nbsp;Denise Tessariol Hachul,&nbsp;Mauricio Ibrahim Scanavacca,&nbsp;Francisco Carlos da Costa Darrieux","doi":"10.1016/j.clinsp.2025.100647","DOIUrl":"10.1016/j.clinsp.2025.100647","url":null,"abstract":"<div><h3>Introduction</h3><div>Brugada Syndrome (BrS) typically manifests with a dynamic type 1 Brugada pattern (Br1ECGp) that depends on the dominance of the sympathetic or parasympathetic nervous system. This pattern is more prominent during activities that stimulate the vagus nerve, such as sleeping and after meals. By conducting the tilt table test and adding high precordial leads to the standard protocol, it is possible to provoke sympathetic or parasympathetic responses, providing valuable information.</div></div><div><h3>Materials and methods</h3><div>This was an observational, cross-sectional and hypothesis-generating pilot study. The tilt table test was performed with high precordial leads on three Brugada patients to assess the Br1ECGp during the test. The ECG features were continuously recorded to analyze variations during all phases of the test.</div></div><div><h3>Results</h3><div>The first patient exhibited a significant Br1ECGp that disappeared during the upward phase of the tilt table test and reappeared during the recovery phase. The second patient had a Br1ECGp in three leads that persisted during both the upward and recovery phases of the tilt table test. The third patient displayed a Br1ECGp in three leads, which was maintained during the upward phase in two leads and recovered during the recovery phase. The third patient was the only one to experience cardioinhibitory syncope.</div></div><div><h3>Conclusion</h3><div>This study provided insights into the dynamics of the Br1ECGp during the tilt table test when enhanced by high precordial leads. It reaffirmed that the Brugada ECG pattern is influenced by sympathetic or parasympathetic dominance.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100647"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR","authors":"Pedro Andrade ,&nbsp;Aline Boveto Santamarina ,&nbsp;Jéssica Alves de Freitas ,&nbsp;Annete Bressan Rente Ferreira Marum ,&nbsp;Ana Flávia Marçal Pessoa","doi":"10.1016/j.clinsp.2024.100549","DOIUrl":"10.1016/j.clinsp.2024.100549","url":null,"abstract":"<div><div>This mini-review explores the potential of precision medicine and personalized nutrition in addressing health challenges faced by perimenopausal women, focusing on the role of genetic polymorphisms in key metabolic pathways. Specifically focus on the single nucleotide polymorphisms (SNPs) in the COMT, FUT2, and MTHFR genes, which influence neurotransmitter metabolism, gut microbiota composition, and folate homeostasis, respectively. These polymorphisms are critical in modulating hormonal fluctuations, metabolic imbalances, and nutrient absorption during perimenopause. The review highlights the impact of COMT rs4680 on stress response and mood disorders, FUT2 rs602662 and rs601338 on vitamin B12 absorption and cortisol metabolism, and MTHFR rs1801133 and rs1801131 on homocysteine levels and cardiovascular risk. Furthermore, the integration of machine learning in precision medicine is discussed, offering insights into how genetic data can optimize personalized interventions. This approach enables targeted nutritional and therapeutic strategies to mitigate the metabolic and psychological effects of perimenopause. Overall, this review underscores the importance of incorporating genetic testing into preventive care for perimenopausal women to enhance quality of life and promote healthy aging.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100549"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Licochalcone A on proliferation, invasion, and drug resistance of glioma cells by regulating TLR4/NF-κB signaling pathway","authors":"Baigui Zhou ,&nbsp;Kun Mu ,&nbsp;Xuzhou Yu ,&nbsp;Xu Chen ,&nbsp;Xiaoying Shi","doi":"10.1016/j.clinsp.2024.100542","DOIUrl":"10.1016/j.clinsp.2024.100542","url":null,"abstract":"<div><h3>Objective</h3><div>Based on Toll Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Exploring the effects of Licochalcone A (LCA) on the proliferation, invasion, and drug resistance of glioma cells through signaling pathways.</div></div><div><h3>Methods</h3><div>Cultivate human glioma cell line U251 in vitro, induce drug-resistant cell line U251/TMZ with Temozolomide (TMZ), and validate the results. Different concentrations of licorice chalcone A were used to treat U251 cells and U251/TMZ cells, and were named as control group, low-dose group, medium-dose group, and high-dose group, respectively. CCK-8 assay, cell adhesion assay, and Transwell assay were used to detect cell survival rate, cell adhesion rate, number of migrating cells, and number of invading cells, respectively.</div></div><div><h3>Results</h3><div>The cell survival rate, cell adhesion rate, number of migrating and invading cells in the high-dose group were lower than those in the medium-dose group and lower than those in the control group. High-dose group TLR4, NF-κB mRNA and protein levels were lower than those in the medium dose group and lower than those in the control group (<em>p</em> &lt; 0.05). Compared with the si-NC group, the si-TLR4 group showed a decrease in cell survival rate and adhesion rate, as well as a decrease in the number of migrating and invading cells, the levels of CyclinD1 and N-cadherin proteins decreased, while the levels of E-cadherin protein increased (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>LCA could inhibit the proliferation and metastasis of glioma cells and reverse drug resistance, possibly by inhibiting the TLR4/NF-κB signaling pathway.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100542"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitude of deaf women in relation to contraceptive methods: A systematic review","authors":"Gabriela Fuster Barbosa ,&nbsp;Edson Santos Ferreira-Filho ,&nbsp;Lais Abdo Quintão ,&nbsp;Laura Fernandes Berto ,&nbsp;Patrícia Gonçalves de Almeida ,&nbsp;Edmund Chada Baracat ,&nbsp;Luis Bahamondes ,&nbsp;José Maria Soares-Junior ,&nbsp;Isabel Cristina Esposito Sorpreso","doi":"10.1016/j.clinsp.2024.100558","DOIUrl":"10.1016/j.clinsp.2024.100558","url":null,"abstract":"<div><h3>Background</h3><div>Communication barriers make it difficult for deaf women to access information about contraceptive methods, making them vulnerable to unplanned pregnancies.</div></div><div><h3>Objective</h3><div>To identify knowledge and attitudes of deaf women in relation to contraceptive methods.</div></div><div><h3>Method</h3><div>The authors conducted a systematic review of the literature, PROSPERO registry (CRD42021277635), conducted from August 2021 to April 2024. The included studies focused on knowledge and attitudes about contraception among women with deafness.</div></div><div><h3>Results</h3><div>Twelve articles were included, with a total of 2,641 participants and those reported low knowledge about contraceptive methods. Nine studies showed withdrawal, condoms, and oral contraceptives as the best methods that deaf women know. Five studies showed low knowledge about intrauterine devices and subdermal implants. The main reasons given for abandoning the method were reproductive desire and fear of side effects. The use of hormonal contraceptives was higher among adult women and, two studies showed that among teenagers the practice of withdrawal was higher than the use of condoms. The barriers most mentioned in the eight articles for the use of contraceptives were those of communication.</div></div><div><h3>Conclusion</h3><div>Knowledge of contraceptives among deaf women was low; however, the attitude of acceptance of the use of contraceptive methods was favorable, despite the little access to more effective methods, especially among adolescents. The factor associated with low knowledge evidenced in the systematic review was communication barriers.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100558"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small fiber neuropathy with dysautonomia and positive GPCR and FGFR-3 antibodies after the first BNT162b2 dose","authors":"Josef Finsterer ,&nbsp;Carla Alexandra Scorza ,&nbsp;Fulvio Alexandre Scorza ,&nbsp;Ana C. Fiorini","doi":"10.1016/j.clinsp.2024.100557","DOIUrl":"10.1016/j.clinsp.2024.100557","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100557"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of dry eye in Brazil: Home survey reveals differences in urban and rural regions","authors":"Leidiane Adriano Pereira,&nbsp;Laura Braga Arantes,&nbsp;Etiene Lorriane de Souza Persona,&nbsp;Denny Marcos Garcia,&nbsp;Isvander Gustavo de Souza Persona,&nbsp;Regina Celia Nucci Pontelli,&nbsp;Eduardo M. Rocha","doi":"10.1016/j.clinsp.2025.100578","DOIUrl":"10.1016/j.clinsp.2025.100578","url":null,"abstract":"<div><h3>Purpose</h3><div>A random home visit search investigated the prevalence and predictors of Dry Eye (DE) symptoms in Brazil.</div></div><div><h3>Methods</h3><div>Through home visits to 420 urban and 180 rural residences in the countryside of Southeast Brazil, the Dry Eye Disease Short Questionnaire (DEDSQ) was applied to volunteers 40 years and older. The predictive value of the DEDSQ and the risk factors were investigated.</div></div><div><h3>Results</h3><div>DE is more frequent in the urban population (38.1 % vs. 20 %; <em>p</em> &lt; 0.0001) and was higher in females (37.5 % and 21.5 %; <em>p</em> &lt; 0.0001). In the urban area, DE is associated with dyslipidemia (<em>p</em> &lt; 0.0001), visual display terminal use &gt; 2 h/day (<em>p</em> &lt; 0.0001), and pterygium (<em>p</em> &lt; 0.001), and in the rural area with dyslipidemia (<em>p</em> &lt; 0.01) and prior ocular surgery (<em>p</em> &lt; 0.05). In women, the predictors are antiallergics, chronic pelvic pain, fibromyalgia, and visual display terminal use &gt; 2h/day. Aging was associated with distinct risk factors. DEDSQ showed 78.5 % of sensitivity and 71.1 % specificity.</div></div><div><h3>Conclusion</h3><div>This first domiciliary study in Brazil reveals that DE symptoms were more prevalent in the urban area and among women. DE has distinct risk factors and a high prevalence in Brazil.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100578"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}