Agreement analysis and associated factors of SARC-F and SARC-CALF in screening of risk sarcopenia in people living with human immunodeficiency virus

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-01-01 DOI:10.1016/j.clinsp.2024.100565

Lara Cristina Vieira , Jaine Alves Ximenez , Maria Claudia Bernardes Spexoto

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Abstract

Introduction

People Living with Human Immunodeficiency Virus (PLHIV) appear to be at a higher risk of developing sarcopenia. Various factors seem to influence the risk of sarcopenia, and its prevalence may differ depending on the screening tool used. This study aimed to (i) Screen the risk of sarcopenia in PLHIV using the SARC-F and SARCCalf and identify associated factors; (ii) Analyze the agreement between the instruments in PLHIV.

Methods

Cross-sectional study including PLHIV taking antiretroviral therapy. The authors assessed sarcopenia risk using the SARC-F and SARCCalf tools with ≥4 and ≥11 cutoff points, respectively, and a wide spectrum of variables was analyzed.

Results

Participated 76 patients (44.9 ± 12.7 years). Sarcopenia risk, according to the SARC-F, was 27.6 % and was associated with socioeconomic status (p = 0.004), smoking (p = 0.001), disease status (p < 0.001), opportunistic infections (p = 0.001), CD4 T-cell count (p < 0.001), Handgrip Strength (HGS) (p < 0.001), and Gait Speed (GS) (p = 0,001). Using the SARCCalf, sarcopenia risk was 36.8 % and was associated with work activity (p = 0.029), socioeconomic status (p = 0.004), smoking (p = 0.009), disease status (p < 0.001), opportunistic infections (p = 0.015), CD4 T-cell count (p = 0.002), HGS (p = 0.001), Appendicular Skeletal Muscle Mass Index (ASMMI) (p = 0.009), and GS (p < 0.001). The agreement between tools was moderate (k = 0.49).

Conclusion

Sarcopenia risk, as determined by both tools, was higher in low-income PLHIV with opportunistic infections, CD4 T-cell count ≤ 200 cells/mm³, low HGS, and low GS, and lower in asymptomatic and non-smoking individuals. The authors recommend investigating these factors in hospital and outpatient settings. The SARCCalf proved to be more appropriate for screening sarcopenia risk in PLHIV.

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SARC-F和SARC-CALF筛查人类免疫缺陷病毒感染者危险肌少症的一致性分析及相关因素

人类免疫缺陷病毒（PLHIV）感染者出现肌肉减少症的风险较高。各种因素似乎会影响肌肉减少症的风险，其患病率可能因使用的筛查工具而异。本研究旨在(i)使用SARC-F和SARCCalf筛选PLHIV患者肌肉减少的风险，并确定相关因素；（ii）分析PLHIV检测仪器之间的一致性。方法：包括接受抗逆转录病毒治疗的艾滋病毒感染者的横断面研究。作者使用SARC-F和SARCCalf工具评估肌肉减少症风险，分别有≥4和≥11个截止点，并分析了广泛的变量。结果：76例患者（44.9±12.7岁）。根据SARC-F，骨骼肌减少的风险为27.6%，与社会经济地位（p = 0.004）、吸烟（p = 0.001）、疾病状况（p < 0.001）、机会性感染（p = 0.001）、CD4 t细胞计数（p < 0.001）、握力（p < 0.001）和步态速度（p = 0.001）相关。使用SARCCalf，肌肉减少的风险为36.8%，与工作活动（p = 0.029）、社会经济地位（p = 0.004）、吸烟（p = 0.009）、疾病状况（p < 0.001）、机会性感染（p = 0.015）、CD4 t细胞计数（p = 0.002）、HGS （p = 0.001）、阑尾骨骼肌质量指数（ASMMI）（p = 0.009）和GS （p < 0.001）相关。工具间的一致性中等（k = 0.49）。结论：这两种工具确定的肌少症风险在低收入PLHIV伴机会性感染、CD4 t细胞计数≤200细胞/mm3、低HGS和低GS人群中较高，在无症状和非吸烟人群中较低。作者建议在医院和门诊环境中调查这些因素。sarcalf被证明更适合于筛查PLHIV患者的肌肉减少症风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.