Clinics最新文献

{"title":"Plants used by Brazilian communities of African descent for women's health","authors":"Letícia Francine Silva Ramos ,&nbsp;Ananda Gomes de Sousa ,&nbsp;Rebeca de Siqueira Amorim ,&nbsp;Alan de Araújo Roque ,&nbsp;Israel Luís Diniz Carvalho ,&nbsp;Ana Laura Vilela de Carvalho ,&nbsp;Maiara Bernardes Marques ,&nbsp;Milena Evangelista dos Santos ,&nbsp;Moan Jéfter Fernandes Costa ,&nbsp;Luiza Rayanna Amorim de Lima ,&nbsp;Pedro Henrique Sette-de-Souza","doi":"10.1016/j.clinsp.2024.100513","DOIUrl":"10.1016/j.clinsp.2024.100513","url":null,"abstract":"<div><div>Quilombola women are primarily responsible for maintaining ethnopharmacological knowledge. Their knowledge is transmitted orally to their descendants, preserving cultural identity and ensuring the survival of Quilombola communities. Was conducting a scoping review on the use of medicinal plants by Quilombola women. Based on the PPC strategy (population, concept, and context) and the “Joanna Briggs Institute Reviewer's Manual”, this systematic scoping review sought to answer the guiding question: which medicinal plants are used for diseases that compromise women's health in Brazilian communities of African descent? The article has registered this research in the Open Science Framework available at osf.io/eb2nc, at identifier DOI <span><span>https://doi.org/10.17605/OSF.IO/5N24Y</span><svg><path></path></svg></span>. Using the search keys, 888 studies were found. After reading the titles and abstracts, 38 studies moved on to the next stage. During the reading of the texts in full, 32 were excluded for not meeting all the inclusion criteria and six studies were included in the research. In all, 44 plants, belonging to 23 families, were mentioned in the studies. The plants reported by the study have a plurality in their therapeutic use, the form of preparation, and part of the plant used. Regarding women's health, plants were recorded for sexual, menstrual, and postpartum care. The appreciation and recognition of this ancestral knowledge contribute not only to Women's health but also to strengthening the identity and rescuing the cultural roots of these communities.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100513"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The educational impact of medical students’ participation in a short-term health expedition: The Iguape one health experience","authors":"Marcelo Arruda Candido ,&nbsp;Vinicius Venturini ,&nbsp;Matheus Polly ,&nbsp;Matheus Belloni Torsani ,&nbsp;Alexandre Sizilio ,&nbsp;João Mitsuji Sakô ,&nbsp;Wen-Jan Tuan ,&nbsp;Robert Patrick Lennon ,&nbsp;Anna Sara Shafferman Levin ,&nbsp;Iolanda de Fátima Lopes Calvo Tibério","doi":"10.1016/j.clinsp.2025.100601","DOIUrl":"10.1016/j.clinsp.2025.100601","url":null,"abstract":"<div><h3>Objectives</h3><div>The primary goal of this study is to evaluate the educational effects of medical students' participation in a health expedition project. Specific objectives include assessing students' perceptions of the educational value of the program, measuring gains in clinical knowledge and skills, evaluating behavioral changes, professional orientation, and students' willingness to work within the public health system (SUS) after graduation.</div></div><div><h3>Methods</h3><div>A quantitative methodology was employed, following Kirkpatrick's four-level evaluation model. Questionnaires were administered before and after participation in the expedition to assess students' reactions, learning, and empathy. The sample comprised all 15 students who participated in the expedition, with data analysis performed using R software.</div></div><div><h3>Results</h3><div>The analysis highlighted that the expedition experience significantly impacted student's career trajectories. Approximately 80 % of participants reported that the expedition positively influenced their career decisions, and 60 % expressed interest in working within the SUS. These findings suggest that while expeditions may not yield quantifiable gains in clinical competence in the short term, they can be catalysts in forming physicians oriented towards public service and social sensitivity.</div></div><div><h3>Conclusions</h3><div>Health expeditions like the one conducted may not offer significant improvements in measurable clinical competencies in the short term but have a substantial effect on students' career decisions, aligning with public health needs and reinforcing commitment to service in vulnerable contexts. This influence suggests that practical experiences in community settings play a crucial role in shaping medical students' professional aspirations, emphasizing the importance of such programs in medical education aimed at social responsibility and health equity.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100601"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of MicroRNA-519d-3p in enhancing chemosensitivity of colorectal cancer cells to 5-Fluorouracil through PFKFB3 targeting","authors":"Yangyang Zhang ,&nbsp;Yiqing Zhang ,&nbsp;Yanan Xiao ,&nbsp;Shufen Xu ,&nbsp;Jie Li ,&nbsp;Juan Li ,&nbsp;Lisha Chang ,&nbsp;Jie Ding ,&nbsp;Di Wu ,&nbsp;Li Wang ,&nbsp;Guangxu Xu ,&nbsp;Keming Wang","doi":"10.1016/j.clinsp.2025.100606","DOIUrl":"10.1016/j.clinsp.2025.100606","url":null,"abstract":"<div><h3>Objective</h3><div>In the fight against Colorectal Cancer (CRC), chemotherapy resistance is a major obstacle. Therefore, it is imperative to identify effective biomarker therapeutics. Despite microRNAs (miRs) playing a crucial role in drug resistance, the mechanisms comprising miR-519d-3p's role in CRC drug resistance have not been fully understood. Therefore, the present study aimed to investigate the biological function of miR-519d-3p in the chemosensitivity of CRC cells to 5-Fluorouracil (5-FU).</div></div><div><h3>Methods</h3><div>CRC cells were treated with 5-FU and transfected. Cellular proliferation, invasion, and apoptosis were evaluated. The relationship between miR-519d-3p and 6-Phosphofructokinase-2/Frucose-2, 6-Biphosphatase-3 (PFKFB3) was analyzed, and their interaction in CRC was further investigated. In vivo tumor experiments were conducted to investigate the function of miR-519d-3p and 5-FU in CRC.</div></div><div><h3>Results</h3><div>As determined, CRC cells overexpressing miR-519d-3p were more sensitive to 5-FU in vitro, as miR-519d-3p inhibits proliferation and invasion and stimulates apoptosis. miR-519d-3p directly targeted PFKFB3. In CRC cells, PFKFB3 overexpression rescued miR-519d-3p-induced 5-FU toxicity. In vivo results showed that mice co-treated with miR-519d-3p mimics and 5-FU showed higher antitumor activity.</div></div><div><h3>Conclusion</h3><div>Overall, it may be possible to improve 5-FU chemosensitivity of CRC cells by targeting miR-519d-3p and PFKFB3.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100606"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eugenol alleviates renal ischemia-reperfusion injury induced-endoplasmic reticulum stress via activating Sestrin2","authors":"Jingwei Liu,&nbsp;Xujie Sun,&nbsp;Junfeng Liang,&nbsp;Shiqiang Song","doi":"10.1016/j.clinsp.2025.100627","DOIUrl":"10.1016/j.clinsp.2025.100627","url":null,"abstract":"<div><h3>Introduction</h3><div>Renal Ischemia-Reperfusion Injury (RIRI) often arises due to heightened oxidative stress, rendering it a central focus of research. Sestrin2 plays a pivotal role in regulating oxidative stress; nevertheless, its impact on the renoprotective properties of Eugenol (EU) during RIRI warrants further investigation.</div></div><div><h3>Methods</h3><div>Mice and TCMK-1 cells were categorically assigned into six groups: Sham/Control, Ischemia-Reperfusion (IR)/HR (Hypoxia-Reoxygenation), IR/HR+EU, Sham/Control+Sestrin2-KO, IR/HR+Sestrin2-KO, and IR/HR+EU+Sestrin2-KO. The effects of EU and the involvement of Sestrin2 in RIRI/HR were evaluated using Urea Nitrogen (BUN), Creatinine (Scr), Superoxide Dismutase (SOD), Glutathione (GSH), Catalase (CAT), and Malondialdehyde (MDA) assay kits; western blotting; cell viability assays; HE-staining; and Reactive Oxygen Species (ROS) detection.</div></div><div><h3>Results</h3><div>Following RIRI/HR, a marked deterioration in kidney function and a significant surge in oxidative stress levels were observed. However, EU treatment ameliorated renal injury and inhibited oxidative stress. Additionally, EU upregulated Sestrin2 expression, and the renoprotective effects of EU were reversed upon Sestrin2 knockdown.</div></div><div><h3>Conclusion</h3><div>The present study posits that EU effectively mitigates RIRI/HRI (Hypoxia-Reoxygenation Injury), and its mechanism of renal protection potentially involves the upregulation of Sestrin2, coupled with the inhibition of oxidative and Endoplasmic Reticulum Stress (ERS).</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100627"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olanzapine as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anesthesia: A systematic review and meta-analysis","authors":"Thiago Ramos Grigio ,&nbsp;Hans Timmerman ,&nbsp;Angela Maria Sousa ,&nbsp;André Paul Wolff","doi":"10.1016/j.clinsp.2025.100645","DOIUrl":"10.1016/j.clinsp.2025.100645","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100645"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kynurenine promotes the immune escape of colorectal cancer cells via NAT10-mediated ac4C acetylation of PD-L1","authors":"Zaibiao Wang ,&nbsp;Manman Yin ,&nbsp;Ruhang Zhou ,&nbsp;Ming Li ,&nbsp;Jie Peng ,&nbsp;Zhengguang Wang","doi":"10.1016/j.clinsp.2025.100658","DOIUrl":"10.1016/j.clinsp.2025.100658","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the role of kynurenine in Colorectal Cancer (CRC) and the underlying mechanism.</div></div><div><h3>Methods</h3><div>Enzyme-linked immunosorbent assay was employed to assess the kynurenine concentration. Flow cytometry was utilized to analyze the percentages of CD3+CD4+ and CD3+CD8+ <em>T</em>-cells. Immunofluorescence was used to measure the expression of Programmed Death-Ligand 1 (PD-L1). RNA modification levels in CRC cells were analyzed using a dot blot assay. The interaction between NAT10 and PD-L1 was assessed via RNA immunoprecipitation, dual-luciferase reporter, and immunofluorescence assays. A xenograft tumor rat model was established.</div></div><div><h3>Results</h3><div>Results indicated that kynurenine suppressed T-cell activation and promoted immune escape. Besides, kynurenine promoted N-Acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac⁴C) modification. Moreover, NAT10 inhibition improved T-cell activation and suppressed immune escape. Mechanically, NAT10 is bound with the mRNA of PD-L1. Rescue experiments showed that PD-L1 inhibitor treatment reversed the suppressed T-cell activation and the promoted immune escape induced by NAT10 overexpression. In vivo, studies indicated that NAT10 deficiency reversed the promoted tumor growth induced by kynurenine treatment.</div></div><div><h3>Conclusion</h3><div>In conclusion, kynurenine promoted the immune escape of CRC cells via NAT10-mediated ac⁴C acetylation of PD-L1.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100658"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding in patients hospitalized with acute pulmonary embolism in Brazil","authors":"Leonardo Jordan Hansen Vizzotto,&nbsp;Corina dos Reis Sepeda,&nbsp;Carlos Henrique Miranda","doi":"10.1016/j.clinsp.2024.100573","DOIUrl":"10.1016/j.clinsp.2024.100573","url":null,"abstract":"<div><h3>Objective</h3><div>Acute Pulmonary Embolism (APE) is a disease with increasing incidence worldwide. Antithrombotics are the cornerstone of the treatment. Bleeding is an adverse event related to this therapy. The objective was to evaluate the prevalence of bleeding in a sample of Brazilian patients hospitalized with APE and the impact of this complication on mortality. Additionally, the performance of some bleeding predictive scores was evaluated in this sample.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was carried out on patients hospitalized with APE from January 2009 through August 2017. The medical records of these patients were reviewed, and the bleeding recorded during hospital stay was classified according to the “Thrombolysis in Myocardial Infarction (TIMI) bleeding risk.” Five different predictive scores for bleeding after APE (RIETE, PE-SARD, VTE-BLEED, Kuijer, and ATRIA) were applied. Overall mortality at 30 days and one year were assessed.</div></div><div><h3>Results</h3><div>One hundred fifty-nine patients were included. The prevalence of any bleeding was 36/159 (23 %), major bleeding was 10/159 (06 %), minor bleeding was 11/159 (07 %), and bleeding requiring attention was 15/159 (10 %). Only major bleeding was associated with higher mortality at one-year follow-up with a Relative Risk (RR) of 2.00 (95 % CI 1.16–3.57; <em>p</em> = 0.044). All bleeding predictive scores evaluated showed low accuracy in identifying patients at higher risk of bleeding.</div></div><div><h3>Conclusion</h3><div>Patients hospitalized with APE in Brazil had a high prevalence of bleeding. The major bleeding increased the one-year mortality. The bleeding predictive scores assessed showed limited accuracy in identifying patients at high risk of bleeding.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100573"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of photodynamic therapy on cellular immune function in patients with cervical HPV infection","authors":"Yan Ju ,&nbsp;Qunyan Zhou","doi":"10.1016/j.clinsp.2024.100537","DOIUrl":"10.1016/j.clinsp.2024.100537","url":null,"abstract":"<div><h3>Introduction</h3><div>Cervical Human Papillomavirus (HPV) infection, a common sexually transmitted infection, can lead to cervical cancer. This study investigates the impact of Photodynamic Therapy (PDT) on cellular immune function in cervical HPV-infected patients.</div></div><div><h3>Methods</h3><div>From October 2022 to February 2023, 60 patients with cervical HPV infection were randomly assigned to a control group (conventional treatment) or a PDT group (PDT treatment), each with 30 patients. Peripheral blood samples and cervical tissue were collected before treatment, at 3 months, and at 6 months post-treatment. Flow cytometry assessed T-cell subsets (CD4⁺, CD8⁺, CD3⁺), and ELISA measured cytokine levels (TNF-α, IL-6, IL-8).</div></div><div><h3>Results</h3><div>Baseline characteristics were similar between the PDT and control groups. The PDT group showed significantly higher HPV clearance rates at 3-months (70.00 %) and 6 months (100.00 %) compared to the control group 43.33 % and 80.00 %, respectively (p &lt; 0.05). PDT significantly increased CD3⁺ and CD4⁺ cell levels at 3- and 6-months post-treatment compared to controls (p &lt; 0.05). CD8⁺ levels and the CD4⁺/CD8⁺ ratio also significantly increased in the PDT group at 6 months. Additionally, PDT significantly reduced IL-6, IL-8, and TNF-α levels at 3- and 6-months post-treatment (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>PDT enhances cellular immune function in cervical HPV-infected patients by increasing CD4⁺ and CD8⁺ T-cells and reducing pro-inflammatory cytokines. These findings highlight the potential of PDT in modulating immune responses and improving therapeutic strategies for cervical HPV infection.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100537"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia","authors":"Cristiane Tavares ,&nbsp;Cláudia Maia Memória ,&nbsp;Luiz Guilherme Villares da Costa ,&nbsp;Vinícius Caldeira Quintão ,&nbsp;Alberto Azoubel Antunes ,&nbsp;Deborah Teodoro ,&nbsp;Maria José Carvalho Carmona","doi":"10.1016/j.clinsp.2024.100562","DOIUrl":"10.1016/j.clinsp.2024.100562","url":null,"abstract":"<div><h3>Background</h3><div>Hospitalization for Transurethral Prostate Resection (TURP) involves circadian rhythm disturbance – a possible cause of Postoperative Neurocognitive Disorder (POCD) in elderly patients. This study investigated whether melatonin ameliorated this effect.</div></div><div><h3>Methods</h3><div>A double-blind, randomized clinical trial used a battery of neuropsychological tests to evaluate cognitive performance of 118 patients aged ≥ 60, before TURP with spinal anesthesia, and at 21- and 180-days PO. Patients received 10 mg of melatonin, or a placebo, on the night before surgery and 1-, 2- and 3-days PO. Delayed neurocognitive recovery in the two groups at 21 days PO was compared using the Chi-Squared test; individual performances in each test at each date were compared using the General Mixed Model. Results with p &lt; 0.05 were considered significant.</div></div><div><h3>Results</h3><div>Pre-surgery, both groups had significant cognitive deficits. Delayed cognitive recovery at 21 days PO was the same in both. There were no cases of POCD at 180 days. The melatonin group performed better in the delayed-recall FOME, which assesses memory, and in the Digit Span test, which assesses attention and cognitive flexibility. Unexpectedly, global neurocognitive performance was improved at 180 PO in both groups.</div></div><div><h3>Conclusions</h3><div>Melatonin had no statistical effect on POCD, but a selective beneficial effect was observed in two cognitive areas. The high prevalence of preoperative cognitive impairment may be related to the lower urinary tract symptoms which were reasons for the surgery; the unexpected improvement of cognitive performance in all patients at 180 days PO may reflect alleviation of these symptoms.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100562"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do not expect an endoluminal complete response to identify a pathologic complete response in rectal cancer!","authors":"Alexandre Gheller ,&nbsp;Guilherme Inácio Bertoldo de Melo e Patriarca da Silva Neiva ,&nbsp;Mario Nóbrega de Araújo Neto ,&nbsp;Fernando Gonçalves Lyrio ,&nbsp;Dunya Bachour Basílio ,&nbsp;Marília Cristina Roda da Costa ,&nbsp;Douglas Vieira Mourão ,&nbsp;Paulo Gonçalves de Oliveira ,&nbsp;João Batista de Sousa","doi":"10.1016/j.clinsp.2025.100587","DOIUrl":"10.1016/j.clinsp.2025.100587","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the relationship between endoluminal and pathologic complete response after chemoradiotherapy for rectal cancer and identify predictors of a pathologic complete response.</div></div><div><h3>Method</h3><div>The anatomic pathology reports of 102 consecutive patients with rectal cancer who underwent neoadjuvant chemoradiotherapy followed by proctectomy between 2013 and 2017 were reviewed for the presence or absence of endoluminal complete response. The presence of endoluminal complete response was compared with the anatomopathological stage. The residual lesion area was compared with the final pathologic stage to identify predictors of complete response.</div></div><div><h3>Results</h3><div>Of 102 patients, 20 (19.6 %) achieved a pathologic complete response (ypT0N0). Of these, 9 (45 %) did not achieve an endoluminal complete response. The presence of endoluminal complete response had a sensitivity of 55.00 %, specificity of 96.34 %, and accuracy of 88.24 % to identify ypT0N0. The presence of endoluminal complete response, residual lesion area ≤ 4 cm², and tumor located in the mid-rectum were associated with pathologic complete response (ypT0N0).</div></div><div><h3>Conclusion</h3><div>Almost half of the patients who had a pathologic complete response did not achieve an endoluminal complete response. Tumors located in the mid-rectum with a residual size of ≤ 4 cm² and the presence of endoluminal complete response were significantly associated with the achievement of ypT0N0.</div></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":"80 ","pages":"Article 100587"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}