Effect of omega-3 polyunsaturated fatty acid on endometriosis

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-01-01 DOI:10.1016/j.clinsp.2025.100654

Erniao Liu , Qianting Wang , Yaoxian Bai , Xi Zhang , Jingfang Wang

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the effect of Omega-3 Fatty Acids (ω-3 PUFAs) on endometriosis.

Design

The authors conducted a comprehensive search of the PubMed, Embase, Cochrane Library and Web of Science databases, focusing exclusively on Randomised Controlled Trials (RCTs) to study the impact of ω-3 PUFAs on endometriosis. The included studies were assessed for methodological quality using the Cochrane bias risk assessment tool and analyzed using data analysis software.

Results

The search yielded five RCTs conducted between the database's inception and July 2023, with a total sample size of 424 patients with endometriosis. The meta-analysis results showed no statistically significant effects of ω-3 Polyunsaturated Fatty Acids (PUFAs) on pain (Mean Difference [MD = -0.387], 95 % Confidence Interval [95 % CI -1.742–0.967], I² = 93.3 %, z = 0.56, p = 0.575), sexual activity (MD = 0.143, 95 % CI -0.210–0.497, I² = 0 %, z = 0.79, p = 0.427), pain intervention (MD = -0.216, 95 % CI -0.717–0.285, I² = 0.0 %, z = 0.84, p = 0.399), catastrophic thinking (MD = 0.158, 95 % CI -0.315–0.632, I² = 0.0 %, z = 0.66, p = 0.512) and the 12-item short form health survey (MD = 0.001, 95 % CI -0.053–0.503, I² = 0.0 %, z = 0.00, p = 1.000), which were all statistically insignificant. However, ω-3 PUFAs appeared to reduce the inflammatory response in patients with endometriosis (MD = -5.20, 95 % CI -6.21–-4.20, I² = 0 %, z = 10.13, p < 0.001).

Conclusion

Based on the available evidence, ω-3 PUFAs may reduce the inflammatory response in patients with endometriosis, specifically by decreasing levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6 and IL-1, indicating potential anti-inflammatory properties that warrant further investigation.

Trial registration

PROSPERO: CRD42023441699.

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omega-3多不饱和脂肪酸对子宫内膜异位症的影响

目的探讨ω-3脂肪酸（ω-3 PUFAs）对子宫内膜异位症的治疗作用。作者对PubMed、Embase、Cochrane Library和Web of Science数据库进行了全面的检索，专门关注随机对照试验（RCTs），以研究ω-3 PUFAs对子宫内膜异位症的影响。使用Cochrane偏倚风险评估工具对纳入的研究进行方法学质量评估，并使用数据分析软件进行分析。在数据库建立至2023年7月期间进行了5项随机对照试验，总样本量为424例子宫内膜异位症患者。荟萃分析结果无显著影响的ω3多不饱和脂肪酸(欧米伽)疼痛(平均差MD = -0.387, 95%置信区间(95% CI -1.742 - -0.967), I2 = 93.3%, z = 0.56, p = 0.575),性活动(MD = 0.143, 95% CI -0.210 - -0.497, I2 = 0%, z = 0.79, p = 0.427),疼痛干预(MD = -0.216, 95% CI -0.717 - -0.285, I2 = 0.0%, z = 0.84, p = 0.399),灾难性的思维(MD = 0.158, 95% CI -0.315 - -0.632, I2 = 0.0%, z = 0.66,p = 0.512)和12项简短健康调查（MD = 0.001, 95% CI -0.053-0.503, I2 = 0.0%, z = 0.00, p = 1.000），差异均无统计学意义。然而，ω-3 PUFAs似乎可以降低子宫内膜异位症患者的炎症反应(MD = -5.20, 95% CI -6.21 -4.20, I2 = 0%, z = 10.13, p <；0.001)。结论根据现有证据，ω-3 PUFAs可降低子宫内膜异位症患者的炎症反应，特别是通过降低促炎细胞因子（如tnf - α、IL-6和IL-1）的水平，表明其潜在的抗炎特性值得进一步研究。试验注册号prospero: CRD42023441699。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.