Tonje Moen Eckhoff, Erik Klepsland Mauland, Anders Verket, Elisabeth Lind Melbye
{"title":"Reliability and Construct Validity of a Questionnaire for Assessment of Patient-Reported Outcomes in Implant Dentistry.","authors":"Tonje Moen Eckhoff, Erik Klepsland Mauland, Anders Verket, Elisabeth Lind Melbye","doi":"10.1111/clr.70110","DOIUrl":"10.1111/clr.70110","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the reliability and construct validity of a questionnaire assessing patient-reported outcomes following dental implant rehabilitation.</p><p><strong>Material and methods: </strong>A questionnaire was mailed to patients 8 years posttreatment to assess experiences with dental implant therapy, including satisfaction, oral function, perceived pretreatment information and complications. Patients completed the questionnaire again during a clinical examination. Internal consistency was evaluated using Cronbach's alpha and corrected item-total correlations (CITC), while test-retest reliability was assessed with intraclass correlation coefficients (ICC). Construct-related validity was examined through associations between questionnaire domains and oral health related quality of life (OHRQoL) measured by OHIP-14.</p><p><strong>Results: </strong>A total of 206 patients completed the questionnaire twice. For individual items, ICCs ranged from 0.39 to 0.75 and CITCs from 0.39 to 0.66. The full questionnaire had an alpha of 0.78 and an ICC of 0.78. Construct-related validity was supported through associations between the questionnaire domains patient satisfaction, pretreatment information and the OHIP-14 sum scores.</p><p><strong>Conclusions: </strong>The questionnaire demonstrated acceptable internal consistency reliability, good test-retest performance, and reasonable construct validity.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":"657-666"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Iorio-Siciliano, Andrea Blasi, Leopoldo Mauriello, Peter Windisch, Giovanni E Salvi, Anton Sculean, Luca Ramaglia
{"title":"Non-Surgical Submarginal Instrumentation of Peri-Implant Mucositis With Delivery of Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid: A Randomized Clinical Trial.","authors":"Vincenzo Iorio-Siciliano, Andrea Blasi, Leopoldo Mauriello, Peter Windisch, Giovanni E Salvi, Anton Sculean, Luca Ramaglia","doi":"10.1111/clr.70109","DOIUrl":"10.1111/clr.70109","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effects of submarginal instrumentation (SI) with or without adjunctive delivery of sodium hypochlorite (NaOCl)/amino acids and cross-linked hyaluronic acid (xHyA) gel in the treatment of peri-implant mucositis (PM).</p><p><strong>Material and methods: </strong>Forty implants supporting single-unit crowns diagnosed with PM in 40 patients were randomly assigned to test (SI + NaOCl/amino acids and xHyA) or control group (SI alone). The primary outcome was mean BoP change. Full-Mouth Plaque Score (FMPS), Full-Mouth Bleeding Score (FMBS), modified plaque index (mPlI), and probing depth (PD) were assessed as secondary outcomes. Clinical parameters were assessed at baseline, 3 and 6 months. Disease resolution was also recorded.</p><p><strong>Results: </strong>Two patients were lost during follow-up while 38 patients completed the study without adverse effects. After 6 months, all clinical parameters improved statistically significantly in both groups (p < 0.05). The change in mean BoP at 1, 3, and 6 months was 72.2% ± 24.3%, 70.4% ± 24.3%, and 63.0% ± 24.6% for test group and 70.0% ± 19.9%, 66.7% ± 24.8%, and 56.7% ± 30.8% for control group. The mean BoP change in experimental procedure was statistically significant at all investigation time points (p < 0.05). Regarding disease resolution, implants with initial PD ≤ 4 mm did not show differences among groups (p > 0.05); conversely, an initial PD = 5 mm yielded a statistically significant difference (p < 0.05). Disease resolution correlation with test group was statistically significant with a 3.77 odds ratio.</p><p><strong>Conclusion: </strong>Within the limitations of the present study, adjunctive delivery of NaOCl/amino acids and xHyA to SI yielded superior clinical outcomes compared with SI alone in the treatment of PM.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT05926297.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":"643-656"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilio A. Cafferata, Frank Schwarz, Ausra Ramanauskaite
{"title":"EAO Monaco 2025—Report From the Joint 32nd EAO and SFPIO Congress","authors":"Emilio A. Cafferata, Frank Schwarz, Ausra Ramanauskaite","doi":"10.1111/clr.70133","DOIUrl":"https://doi.org/10.1111/clr.70133","url":null,"abstract":"","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"65 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Momen A. Atieh, Maanas Shah, Abeer Hakam, Fawaghi AlAli, Samhar AlSayed, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha
{"title":"Diagnostic Accuracy of Deep Learning Models in Detecting Peri-Implant Marginal Bone Loss: A Systematic Review and Meta-Analysis","authors":"Momen A. Atieh, Maanas Shah, Abeer Hakam, Fawaghi AlAli, Samhar AlSayed, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha","doi":"10.1111/clr.70090","DOIUrl":"10.1111/clr.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Peri-implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This review systematically evaluated the diagnostic performance of deep learning models in detecting peri-implant marginal bone loss on radiographic images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A comprehensive search of PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and ProQuest identified studies published between 2010 and July 2025. Two reviewers independently screened studies, extracted data, and assessed methodological quality using QUADAS-2. Diagnostic metrics, including sensitivity, specificity, F1-score, area under the curve (AUC), were synthesized using random-effects meta-analysis. Heterogeneity and publication bias were evaluated using <i>I</i><sup>2</sup> statistics, meta-regression, and funnel plots.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five studies comprising 12,545 periapical and panoramic radiographs met inclusion criteria. Deep learning models achieved pooled sensitivity of 88%, specificity of 91%, and AUC of 0.95, indicating high diagnostic performance. Positive and negative likelihood ratios suggested strong clinical utility. Quality was generally good, though reporting of implant characteristics and data augmentation was inconsistent. Meta-regression revealed that dataset size and unit of analysis influenced accuracy, whereas imaging type did not. No publication bias was found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Deep learning models demonstrate high accuracy in detecting radiographic marginal bone loss, potentially indicating peri-implantitis but cannot substitute for comprehensive clinical assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Relevance</h3>\u0000 \u0000 <p>These models offer a promising adjunct for radiographic detection of marginal bone loss, supporting clinicians in early diagnosis and timely interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 4","pages":"385-401"},"PeriodicalIF":5.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucrezia Paterno Holtzman, Iva Milinkovic, Marija Vuckovic, Chiara Malpassi, Marla Cuppini, Alex Solderer, Zoran Aleksic, Luca Cordaro
{"title":"Effect of Connective Tissue Graft as an Adjunct to Guided Bone Regeneration in the Surgical Treatment of Peri-Implantitis: A Dual-Center Randomized Controlled Trial","authors":"Lucrezia Paterno Holtzman, Iva Milinkovic, Marija Vuckovic, Chiara Malpassi, Marla Cuppini, Alex Solderer, Zoran Aleksic, Luca Cordaro","doi":"10.1111/clr.70093","DOIUrl":"10.1111/clr.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri-implantitis treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-two patients with peri-implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group, CG). Clinical and radiographic parameters were recorded at baseline, 6, and 12 months. The primary outcome was the change in clinical attachment level (CAL), while secondary outcomes included pocket probing depth (PPD), bleeding on probing (BoP), plaque index (PI), keratinized mucosa width (KMW), mucosal thickness (MT), recession (REC), suppuration (SUP), marginal bone levels (MBL), bone defect morphology, and disease resolution (DR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 12 months, CAL gain was significantly higher in TG compared with CG (3.21 ± 1.57 mm vs. 1.65 ± 1.28 mm; <i>p</i> = 0.022), and TG achieved significantly greater increase in KMW (2.25 ± 2.89 mm vs. 0.26 ± 1.49 mm; <i>p</i> = 0.010). Both groups showed significant PPD reduction, with a greater, though not statistically significant, improvement comparing TG with CG (3.25 ± 1.59 mm vs. 1.97 ± 1.23 mm; <i>p</i> = 0.052). Additionally, MBL improved significantly in both groups (<i>p</i> < 0.001), with higher gains in TG (<i>p</i> < 0.001). However, DR was comparable between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>GBR effectively improves peri-implant parameters after 1 year. Adding a CTG enhances CAL and KMW gains and may promote more favorable bone levels, although the impact on DR remains inconclusive. Long-term studies are warranted to confirm these findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov NCT04323540</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 4","pages":"478-495"},"PeriodicalIF":5.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinxin Han, Qian Deng, Qian Ding, Yajin Li, Shaoxia Pan
{"title":"Dietary Experiences and Needs of Edentulous Patients Following Full Arch Implant Surgery: A Qualitative Study","authors":"Xinxin Han, Qian Deng, Qian Ding, Yajin Li, Shaoxia Pan","doi":"10.1111/clr.70092","DOIUrl":"10.1111/clr.70092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to explore the dietary experiences and needs of edentulous patients after full arch implant surgery, and to provide evidence for developing scientific dietary management protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A descriptive qualitative study guided by phenomenological principles was conducted by using purposive sampling. Semi-structured in-depth interviews were performed with participants who underwent full arch implant surgery in edentulous jaws. The data were analyzed using thematic analysis, involving familiarizing oneself with the data, generating initial codes, identifying, reviewing, defining, and naming themes, and producing the report.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one participants, mean age (61.05 ± 7.05) years, were invited and included in the study. Three main themes and nine sub-themes were identified: Functional food intake limitation (changes in food texture, masticatory dysfunction, limited dietary diversity, decreased food intake); Decline in quality of life (loss of eating enjoyment, excessive dietary restrictions, invisible impairment of social functioning); Need for dietary guidance (urgent demand for professional guidance, content of the requirements and formal preference).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Edentulous patients undergoing implant surgery experienced multidimensional eating restrictions and dietary challenges. The majority of patients expressed a pressing need for professional dietary guidance to enhance dietary experience and quality of life. During the critical period of osseointegration following edentulous jaw surgery, a combination of conventional and digital methods can be employed to meet patients' information needs and address existing clinical shortcomings. Based on research findings, future efforts are needed to develop a phased progressive dietary guidance protocol tailored to patient needs, aligned with the biological stages of osseointegration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 4","pages":"468-477"},"PeriodicalIF":5.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Maligno, Ricardo N. M. J. Páscoa, Pedro S. Gomes
{"title":"Peri-Implant Crevicular Fluid Analysis by Mid-Infrared Spectroscopy in Peri-Implantitis—A Pilot Study","authors":"Francisco Maligno, Ricardo N. M. J. Páscoa, Pedro S. Gomes","doi":"10.1111/clr.70091","DOIUrl":"10.1111/clr.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to assess biochemical differences in peri-implant crevicular fluid (PICF) using ATR-FTIR spectroscopy and multivariate analysis, through a between-participant comparison of healthy and peri-implantitis (PI) sites, and a within-participant comparison of PI-PICF and GCF from contralateral periodontal healthy teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Samples were categorized into three groups based on peri-implant status and sampling site: PICF from peri-implant healthy sites, PICF from PI-affected sites, and GCF from contralateral healthy teeth in PI patients, with <i>n</i> = 20/group. Samples were collected and analyzed through ATR-FTIR spectroscopy. Chemometric models were applied for cluster/outlier identification and discrimination. Regression coefficient vectors of PLS-DA models identified key spectral differences between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 40 implants were analyzed; participants had a mean age of 62 years, predominantly female (59%), non-smokers (88%), and most received regular maintenance therapy (82%). PCA revealed subtle cluster formations without clear group separation. Comparing PICF from patients with and without PI, the most important wavenumbers for the PLS-DA model were within 1700–1680 cm<sup>−1</sup>, 1190–1130 cm<sup>−1</sup>, and 1050–980 cm<sup>−1</sup>, associated with protein-related signals and nucleic-acid content. Comparing the GCF and PICF from PI patients, using a split-mouth design, the most important wavenumbers were 3006 cm<sup>−1</sup>, 2982 cm<sup>−1</sup>, and 2900 cm<sup>−1</sup>, related to lipid structures. In terms of accuracy, between-participant assessment achieved 75%, whereas the split-mouth assessment reached 83.4%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FTIR-spectroscopy combined with chemometric modeling effectively discriminates peri-implant health and PI in both inter- and intra-subject comparisons. Higher within-subject accuracy supports FTIR's potential as a site-specific, non-invasive diagnostic tool for peri-implantitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 4","pages":"453-467"},"PeriodicalIF":5.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Flavio Seijas Naya, Juan C. Bernabeu Mira, Alba Pérez Jardón, Mercedes Conde Amboage, David Peñarrocha Oltra, Fabio Camacho Alonso, Mario Pérez Sayáns
{"title":"Influence of Abutment Shape on Implant Marginal Bone Remodeling: A Double-Blind, Randomized 24-Month Clinical Study","authors":"Flavio Seijas Naya, Juan C. Bernabeu Mira, Alba Pérez Jardón, Mercedes Conde Amboage, David Peñarrocha Oltra, Fabio Camacho Alonso, Mario Pérez Sayáns","doi":"10.1111/clr.70085","DOIUrl":"10.1111/clr.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study follows a 2-year evaluation to verify marginal bone remodeling (MBR) trends associated with different abutment designs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A balanced, randomised, double-blind clinical trial with two parallel experimental arms. 68 implants were placed in 9 men and 12 women, 48.5% using the straight abutment and 51.5% the concave abutment. The primary variable was peri-implant tissue stability, measured by marginal bone loss (MBL) or gain (MBG) through digital radiology. Mixed linear regression models and Additive Generalized Additive Models were constructed to estimate MBR, simultaneously considering the variables abutment height, group, and time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 24 months, linear mixed-effects regression models revealed that the concave abutment group exhibited significantly less MBL than the straight abutment group across mesial, distal, and average measurements (<i>p</i> = 0.006–0.026). Significant interactions between abutment type and time at 8 weeks and 6 months suggest early and sustained benefits of the concave design. At 24 months, this effect remained significant except in the mesial model (<i>p</i> = 0.072). Abutment height was positively associated with MBL, particularly in the straight group; however, in the concave group, greater height mitigated bone loss (<i>p</i> < 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Concave abutments demonstrated a potential advantage in reducing early marginal bone loss and promoting mid-term bone stability compared to straight abutments. Their design may enhance soft tissue adaptation, contributing to improved peri-implant bone preservation. While increased abutment height showed a protective effect in the concave group, these findings require confirmation. Further long-term studies are warranted to validate these results and clarify their clinical relevance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 4","pages":"402-412"},"PeriodicalIF":5.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}