Clinical, Cosmetic and Investigational Dentistry最新文献

{"title":"A Narrative Review of the Material Properties, Clinical Efficacy, and Developmental Prospects of Bulk-Fill Resin-Based Composites.","authors":"Fahad Bakitian","doi":"10.2147/CCIDE.S583379","DOIUrl":"https://doi.org/10.2147/CCIDE.S583379","url":null,"abstract":"<p><p>Bulk-fill resin-based composites (RBCs) have been developed as alternatives to conventional RBCs, offering advantages such as simplified clinical handling, reduced polymerisation shrinkage, improved restoration integrity, and increased resistance to microleakage that can compromise long-term clinical outcomes. These materials are applied in a single increment of 4-5 mm during restorative procedures, thereby minimising chair time and technique sensitivity without compromising restoration quality. Nonetheless, their clinical performance can be influenced by several factors, including material type and inherent properties (mechanical, optical, biocompatibility, polymerisation shrinkage, and conversion rate), curing parameters, the restorative technique used, storage conditions, the external oral environment, and preheating treatments. This article presents a comprehensive review of bulk-fill RBCs, discussing their concept, classifications, clinical applications, principal properties, and the critical factors that affect successful clinical outcomes. Additionally, it addresses the clinical limitations of bulk-fill RBCs and explores potential future developments. By synthesising the current evidence, this article aims to serve as a practical guide for clinicians and researchers, promoting informed decision-making and effective application of bulk-fill RBCs in restorative dentistry.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"583379"},"PeriodicalIF":1.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Insights into Association of Growth Factors with Hypodontia: A Clinical Study.","authors":"Rana H Alenzi, Abdullah F Alshammari, Mashan L Abdullah, Sultan M Aldukhyeel, Mohammed N Aldosari, Yousef I Aljameel","doi":"10.2147/CCIDE.S573457","DOIUrl":"https://doi.org/10.2147/CCIDE.S573457","url":null,"abstract":"<p><strong>Purpose: </strong>Hypodontia, defined as the congenital absence of teeth, may reflect underlying disturbances in molecular pathways regulating odontogenesis. This pilot cross-sectional study aimed to investigate whether systemic levels of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and human growth hormone (HGH) differ between individuals with congenital bilateral absence of mandibular second premolars and individuals with normal dentition.</p><p><strong>Methods: </strong>Twenty-two participants aged 12-31 years were included and allocated into two groups: individuals with congenital bilateral absence of mandibular second premolars (n = 11) and age- and sex-matched controls (n = 11). Hypodontia was confirmed using panoramic radiographs. Plasma concentrations of IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-6, and HGH were measured via multiplex magnetic bead assays. Between-group comparisons were performed using the Mann-Whitney <i>U</i>-test.</p><p><strong>Results: </strong>No statistically significant differences in the IGF-I (p = 0.897), IGF-II (p = 0.519), IGFBP-2 (p = 0.573), IGFBP-3 (p = 0.189), IGFBP-4 (p = 0.380), IGFBP-6 (p = 0.193), or HGH levels (p = 0.747) were observed between the hypodontia and control groups. Exploratory analyses suggested age- and body mass index-related variability in the IGF-I levels, indicating potential metabolic influences on circulating growth factor profiles.</p><p><strong>Conclusion: </strong>In this small exploratory cohort, the systemic IGF, IGFBP, and HGH levels did not differ significantly between the individuals with and without hypodontia. These findings suggest that circulating growth factor alterations are unlikely to play a dominant role in nonsyndromic mandibular second premolar agenesis. Larger, well-controlled studies incorporating tissue-specific or genetic analyses are required to clarify the biological mechanisms underlying hypodontia.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"573457"},"PeriodicalIF":1.8,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cephalometric Study of the Effect of \"Maxillary Splint with High Pull Headgear\" for the Treatment of Class II Division 1 Malocclusion - A 12-18 Months Retrospective Matched-Control Study.","authors":"Divya Siddalingappa, Divya Pai, Chetan Kumar Chiniwalar, Kalyana C Pentapati, Arun S Urala","doi":"10.2147/CCIDE.S562357","DOIUrl":"https://doi.org/10.2147/CCIDE.S562357","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effect of maxillary splint high pull head gear (MSHPH) on dentoskeletal structures in growing Class II division 1 patients with a matched control group.</p><p><strong>Methods: </strong>The treatment group (MSHPH) comprised 20 patients who were evaluated at two stages: pretreatment (T1) and post orthopaedic (T2). The control group consisted of 20 untreated class II patients under observation. Intra-group comparisons were done with paired <i>t</i> test and the inter-group comparisons were analyzed with \"Mann-Whitney <i>U</i>-test\".</p><p><strong>Results: </strong>Intra-group comparisons in the treated group showed significant decrease in the mean SNA, ANB, N perpendicular to Point A, Point A vertical, PNS vertical, U1 - NA (angular), U1 - SN, U1 - NA (linear), U1 - NF, PtV - U6, overjet and overbite at T2 when compared to T1. However, there was a significant increase in the mean SNB, N-Pog, EMnL, LAFH, at T2. The control group showed significant increase in the mean SNA, ANB, N perpendicular to Pogonion, Effective MxL, Effective MnL, LAFH, Point A vertical, ANS vertical, PNS vertical, U1 - NA (angular), U1 - SN, U1 - NA (linear), U1 - NF, PtV - U6, and overjet at T2 when compared to T1. Inter-group comparisons (T2-T1) showed significantly higher mean in treated group for SNA, SNB, ANB, N perpendicular to Point A, N perpendicular to Pogonion, Effective MnL, U1 - NA (angular), U1 - SN, U1 - NA (linear), U1 - NF, PtV - U6, overjet, overbite, S line Upper Lip and S line to Lower Lil. However, significantly lower values were seen in treated group for Effective MxL, LAFH, Point A vertical, ANS vertical, and PNS vertical.</p><p><strong>Conclusion: </strong>MSHPH held the maxilla without changes in the palatal plane. Thus, normal skeletal relationships resulted from inhibiting maxillary growth and preserving natural mandibular development in the treatment group.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"562357"},"PeriodicalIF":1.8,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Thermal Cycling and Cyclic Loading on The Flexural Strength of Milled PMMA Versus 3D Printed PEEK as a Provisional Restorative Restoration.","authors":"Noor Al Mortadi, Lina Khasawneh, Karem H Alzoubi, Omar F Khabour, Rami Saleh Al Fodeh, Rania Mahafdeh","doi":"10.2147/CCIDE.S570687","DOIUrl":"10.2147/CCIDE.S570687","url":null,"abstract":"<p><strong>Background: </strong>Temporary restorations play a crucial role in oral rehabilitation. The development of CAD/CAM technology and 3D printing has expanded the use of polymethyl methacrylate (PMMA) and polyetheretherketone (PEEK) in the fabrication of provisional restorations. While both materials are widely used, their mechanical behavior under simulated long-term clinical conditions remains largely ununderstood.</p><p><strong>Aim: </strong>This study aims to compare the flexural strength of CAD/CAM milled PMMA and CAD/CAM 3D-printed PEEK provisional crowns that were subjected to thermocycling and cyclic loading, simulating the aging protocols designed to replicate long-term clinical use.</p><p><strong>Materials and methods: </strong>A total of 54 provisional crowns (n = 27 per group) were fabricated from PMMA and PEEK. All specimens underwent an aging protocol consisting of 2500 thermal cycles (5°C-55°C) and 600,000 mechanical loading cycles (50 N, 1.6 Hz). Flexural strength was assessed using a universal testing machine. Fracture load values were analyzed using descriptive statistics and compared using the Mann-Whitney <i>U</i>-test (p < 0.05).</p><p><strong>Results: </strong>PEEK crowns exhibited significantly higher mean fracture load values (2.441 ± 0.573 kN) than PMMA (1.860 ± 0.517 kN), with a statistically significant difference (p = 0.0004). PEEK specimens demonstrated consistent mechanical performance and ductile failure patterns, while PMMA crowns showed brittle fractures and greater variability.</p><p><strong>Conclusion: </strong>3D printing PEEK provisional crowns demonstrated superior flexural strength compared to milled PMMA under simulated aging conditions. PEEK represents a promising material for long-term provisional use, particularly in high-load clinical scenarios.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"570687"},"PeriodicalIF":1.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitating Patients with Atrophic Maxillae via Zygomatic Implants.","authors":"Sami A Almohefer","doi":"10.2147/CCIDE.S565674","DOIUrl":"10.2147/CCIDE.S565674","url":null,"abstract":"<p><strong>Background: </strong>Significant maxillary atrophy poses a considerable obstacle for oral restoration with standard dental implants because of insufficient bone supply. Zygomatic implants provide alternative treatments without a graft by being secured into the sturdy zygomatic bone, enabling support for prosthetic restoration. Thus, zygomatic implants were proposed in this case report as a substitute for costly and lengthy grafting techniques for rehabilitating patients with insufficient bone.</p><p><strong>Case presentation: </strong>We describe a 62-year-old male who was diagnosed with maxillary atrophy and who underwent a rehabilitation protocol involving zygomatic implants. Two bilateral zygomatic implants were planned as free-hand surgical procedures because of the lack of a supporting structure to stabilize the surgical template. Prostheses were then placed after 48 hours, and a radiographic follow-up occurred at 24 months. Regular check-ups and proper oral hygiene were maintained. The clinical data and radiographs for the control treatment were obtained throughout the two years following treatment. Patients achieved functional and aesthetic rehabilitation with no major complications reported during the follow-up period. High levels of patient satisfaction and prosthetic function were observed.</p><p><strong>Conclusion: </strong>This case report highlights the effective rehabilitation of a severely atrophic maxilla using quad zygomatic implants, achieving immediate function and aesthetics with no major complications over two years. Compared with traditional bone grafting, the graftless approach is less invasive, leading to faster recovery and greater patient satisfaction.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"681-689"},"PeriodicalIF":1.8,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative MultiOmics and Machine Learning Reveal Peroxiredoxin 4 as a Critical Hub Governing Mitochondrial Dysfunction and B Cell Differentiation in Periodontitis.","authors":"Congyi Tu, Yaxian Luo, Tianle Jiang, Zhan Yang, Bingqian Yang, Kechen Zhang, Jingyu Zhang, Chaoming Hu, Lijun Zhou, Tao Qiu, Haorong Xia, Ziyu Xi, Rongdang Hu, Mouyuan Sun","doi":"10.2147/CCIDE.S560013","DOIUrl":"10.2147/CCIDE.S560013","url":null,"abstract":"<p><strong>Aim: </strong>Periodontitis, a highly prevalent chronic inflammatory disease, progressively destroys tooth-supporting tissues, ultimately leading to tooth loss, and significantly increases systemic risks such as cardiovascular disease and diabetic complications. Current mechanical therapies effectively control clinical symptoms but fail to eradicate pathogenic microenvironments or restore periodontal homeostasis. Mitochondrial dysfunction is a critical driver of periodontitis progression; however, the regulatory mechanisms of mitochondria-related genes remain poorly defined.</p><p><strong>Materials and methods: </strong>This study integrated bulk transcriptome sequencing (bulk RNA-seq) and single-cell RNA-seq (scRNA-seq) analyses to identify mitochondrial dysfunction-associated immune cell alterations in periodontitis. Key mitochondria-related genes inducing disease progression were pinpointed through non-negative matrix factorization (NMF) and weighted gene coexpression network analysis (WGCNA). By integrating ten machine learning algorithms with experimental validation using real-time quantitative polymerase chain reaction (qPCR) and immunofluorescence, peroxiredoxin 4 (PRDX4) was identified as the most crucial hub gene governing mitochondrial homeostasis in periodontitis.</p><p><strong>Results: </strong>Patient stratification based on PRDX4 expression revealed upregulated B cell-related pathways. Pseudotime analysis demonstrated a synchronized upregulation of PRDX4 and B cell signature genes during late-stage disease progression. scRNA-seq and immunofluorescence confirmed PRDX4 upregulation in B cells, particularly in plasma cells and memory B cells, and indicated its involvement in B cell differentiation. Experiments in a mouse model further validated the conserved functional role of PRDX4 in regulating B cells during periodontitis. Finally, we screened traditional Chinese medicinal compounds and identified aloe as a potential PRDX4 inhibitor.</p><p><strong>Conclusion: </strong>These findings establish PRDX4 as a key regulatory node linking mitochondrial dysfunction to periodontitis pathogenesis, providing insights into mitochondria-related genes and potential therapeutic strategies.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"661-680"},"PeriodicalIF":1.8,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Custom Sleeve Parameters in Static Guided Endodontic Access: Influence on Deviation Control in Pulp Canal Obliteration.","authors":"Anna Muryani, Dudi Aripin, Hendra Dian Adhita Dharsono, Satrio Wicaksono, Zainul Ahmad Rajion, Wandi Prasetia","doi":"10.2147/CCIDE.S563295","DOIUrl":"10.2147/CCIDE.S563295","url":null,"abstract":"<p><strong>Purpose: </strong>Pulp canal obliteration (PCO) narrows the root canal, complicating access and increasing treatment risks. This study aims to evaluate the accuracy of static guided endodontic access (SGEA) using custom sleeves of different materials and heights compared to conventional freehand access (FHA) in pulp canal obliteration.</p><p><strong>Methods: </strong>An in vitro experimental study was conducted using 48 resin maxillary incisors modeled to simulate pulp canal obliteration via CBCT, intraoral scanner, and 3D printing. The samples were divided into eight groups (n=6): a negative control (freehand access-FHA), a positive control (Titanium Steco 5 mm sleeve), and six static guided endodontic access (SGEA) groups using custom inner sleeves made of Chrome-Cobalt (CoCr) and Zirconia at three heights (3 mm, 5 mm, and 7 mm). Coronal and sagittal deviations between pre- and postoperative CBCT scans were analyzed using one-way ANOVA and Bonferroni post hoc tests (α=0.05).</p><p><strong>Results: </strong>All SGEA groups demonstrated significantly lower deviation values compared to freehand access (p < 0.05). The mean coronal deviation ranged from 1.83° to 6.90°, with the lowest value observed in the Zirconia 7 mm sleeve group (1.83°±1.84°). Sagittal deviation ranged from 2.48° to 30.08°, also lowest in the Zirconia 7 mm group (2.48°±2.43°) and highest in the freehand access group (30.08°±5.93°). Increased sleeve height improved angular precision, and zirconia demonstrated superior dimensional stability compared to chrome-cobalt and titanium.</p><p><strong>Conclusion: </strong>The SGEA technique provided higher accuracy than freehand access in controlling drilling deviation. Among the tested parameters, the custom 3D-printed zirconia sleeve with a 7 mm height yielded the best precision, supporting its potential use in minimizing iatrogenic risk during endodontic access of obliterated canals. This in vitro study on resin models requires further in vivo validation for clinical application.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"691-701"},"PeriodicalIF":1.8,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Sonic, Ultrasonic, and Diode Laser-Activated Irrigation with Combination of NaOCl/EDTA/CHX Solutions Against <i>Fusobacterium nucleatum</i> in Dentinal Tubules: A Confocal Microscopy Study.","authors":"Eddie Nagadi, Dudi Aripin, Diani Prisinda, Indra Primathena, Fitria Dwi Ayuningtyas, Alfina Gracia Feronytha","doi":"10.2147/CCIDE.S567977","DOIUrl":"10.2147/CCIDE.S567977","url":null,"abstract":"<p><strong>Purpose: </strong>This research evaluated the effectiveness of sonic, ultrasonic, and diode laser irrigation techniques with a final irrigation protocol of 3% NaOCl, 17% EDTA, and 2% CHX in eliminating <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>) from dentinal tubules.</p><p><strong>Materials and methods: </strong>The research method utilized 38 human lower premolar teeth inoculated with <i>F. nucleatum</i>, which were divided into four groups: conventional needle irrigation (positive control), sonic irrigation (EDDY^® tips), ultrasonic irrigation (IrriSafe™), and diode laser (SOLASE, 976 nm). Bacterial viability was assessed using confocal laser scanning microscopy with the LIVE/DEAD™ <i>Bac</i>Light™ Bacterial Viability Kits. Data were analyzed using the Kruskal-Wallis and post-hoc Mann-Whitney tests.</p><p><strong>Results: </strong>The results demonstrated that the diode laser irrigation technique achieved the highest effectiveness, with an average penetration depth of 1045.55 (740.00-1420.00) µm, significantly outperforming sonic (751.11 [480.00-1170.00] µm; p-value = 0.024) and ultrasonic (617.77 [450.00-1090.00] µm; p-value = 0.002) irrigation techniques. The control group exhibited the lowest effectiveness (243.33 [150.00-330.00] µm).</p><p><strong>Conclusion: </strong>Diode laser irrigation with the final irrigation protocol provided the highest efficacy against <i>F. nucleatum</i> in dentinal tubules, highlighting its superiority over other irrigation techniques for disinfection in endodontic treatment.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"651-660"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Depression on Gingival Health and C-Reactive Protein Among Female Students in Iraq: A Cross-Sectional Study.","authors":"Ahmed Satea Raafat, Farah Abdul Razzak Mahmood Al Bazaza, Hashim Mueen Hussein, Athraa Ali Mahmood, Maha Jamal Abbas","doi":"10.2147/CCIDE.S559611","DOIUrl":"10.2147/CCIDE.S559611","url":null,"abstract":"<p><strong>Background: </strong>Gingival health is considered an important concern in dentistry and can affect people, especially females. Depression plays a crucial role in the gingival state.</p><p><strong>Aim of the study: </strong>This study aimed to test the consequences of a depressive state on gingival health status in women in association with C-reactive protein in saliva.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted using a sample of 500 randomly selected women. All chosen females in the sample suffered from depression, but in different grades, and this was achieved using Beck's Depression Inventory II questionnaire. Plaque and gingival indices were used to assess the oral health. Salivary flow rate and C-reactive protein levels were examined in the high- and low-depression subsamples.</p><p><strong>Results: </strong>Participants were divided into three grades based on the depression scale (mild, moderate, and severe). The severe depression grades had higher plaque and gingival indices, and the mean C-reactive protein concentration was higher in the severe depression grade, with a highly significant difference (P =0.000).</p><p><strong>Conclusion: </strong>Depression has an actual biological relationship with the health of the oral cavity; it increases gingival inflammatory illnesses and similarly disturbs typical salivary constituents. Increased C-reactive protein levels correlate with psychosomatic depressive illnesses.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"633-640"},"PeriodicalIF":1.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12730150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Insertion Challenges That Complete Denture Patients Present to Dental Practitioners in Uganda: A Qualitative Inquiry.","authors":"David Nono, Godfrey Bagenda, Isaac Okullo, Charles Mugisha Rwenyonyi","doi":"10.2147/CCIDE.S576790","DOIUrl":"10.2147/CCIDE.S576790","url":null,"abstract":"<p><strong>Background: </strong>Edentulism is a major global burden that contributes to disability and impairment. Globally, edentulous patients frequently receive removable complete dentures because they are still a preferred treatment modality. However, effective adaptation to removable complete dentures remains challenging. This study explored the post-insertion challenges patients present to dental practitioners after receiving and wearing removable complete dentures.</p><p><strong>Methods: </strong>This was a qualitative exploratory study conducted at Makerere University Dental Hospital in Kampala, Uganda. Twenty-five key informant interviews were conducted with dental surgeons and dental technologists, who were purposively selected based on their training, years of practice and roles in removable complete denture fabrication and fitting. Audio recordings were transcribed verbatim. Data were analyzed using inductive thematic analysis. The analysis was managed using NVivo software.</p><p><strong>Results: </strong>Dental technologists and dental surgeons revealed that patients commonly reported substantial post-insertion challenges like pain and discomfort, drooling, difficulty speaking, eating, oral hygiene and salivating. They also noted that patients' confidence and self-esteem were severely influenced by their displeasure with the way their dentures looked. Furthermore, they stated that patients frequently experienced denture instability. Dental technologists and dental surgeons reported providing post-insertion advice on hygiene, oral care adaptation. They encouraged patients to keep wearing their dentures despite all inconveniences and assured them that they would eventually get used and become comfortable with wearing the dentures.</p><p><strong>Conclusion: </strong>Patients presented several post insertion challenges relating to pain, discomfort, speech, drooling, salivating and hygiene which consequently affected their self-esteem. Post insertion advice and assurance was key in restoring confidence to patients to adapt to the removable complete dentures.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"623-632"},"PeriodicalIF":1.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12730182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}