Clinical, Cosmetic and Investigational Dentistry最新文献

{"title":"Effect of Fluoride Varnish on Enamel Microhardness: An in vitro Study.","authors":"Tesa Waluya, Irmaleny, Denny Nurdin","doi":"10.2147/CCIDE.S526038","DOIUrl":"10.2147/CCIDE.S526038","url":null,"abstract":"<p><strong>Background: </strong>Remineralization counteracts demineralization, which is the loss of mineral ions from dental enamel, by restoring the mineral. Remineralization itself could be enhanced by external factors such as fluoride contained in fluoride varnish. This study aimed to determine the difference in enamel microhardness before and after applying 5% sodium fluoride (NaF) fluoride varnish.</p><p><strong>Materials and methods: </strong>This experimental laboratory in vitro study used 40 premolar crowns as samples. All samples were demineralized in a pH 4 demineralizing solution for 6 hours. The samples were split into two groups, each containing 20 samples. Group I (Control) acted as a control and Group II (Fluoride Varnish) was treated with 5% NaF (fluoride varnish). Then all samples were immersed in artificial saliva for seven days. A Vickers microhardness tester measured the samples' pre-demineralization, post-demineralization, and post-remineralization microhardness. The dependent sample <i>t</i>-test analysis was used to determine the difference in microhardness in each group. The two sample <i>t</i>-test analysis was used to determine the difference in microhardness between groups.</p><p><strong>Results: </strong>The findings indicated that fluoride varnish application increases the demineralized enamel microhardness in Group II (Fluoride Varnish) from 174.63 VHN (SD = 23.12; 95% CI: 163.81-185.44) to 270.58 VHN (SD = 26.52; 95% CI: 258.17-282.99) (p-value = 0.000). The increase in Group II (Fluoride Varnish) was higher than in Group I (Control) after remineralization of seven days (p-value = 0.002).</p><p><strong>Conclusion: </strong>The findings show a significant increase in enamel microhardness following fluoride varnish application, measured on the seventh day (p-value 0.000). This demonstrates the effectiveness of fluoride varnish in increasing enamel hardness under these in vitro experimental conditions. This study can serve as a reference for clinicians selecting fluoride varnish as a caries prevention effort.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"269-275"},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Parenting Stress and Parents' Level of Education, Knowledge, and Attitude Regarding Dental and Oral Health Maintenance in Children with Intellectual Disabilities.","authors":"Munawar Chalid, Eriska Riyanti, Willyanti Soewondo, Prima Andisetyanto, Rasmi Rikmasari, Yunia Dwi Rakhmatia, Sri Tjahajawati","doi":"10.2147/CCIDE.S520832","DOIUrl":"10.2147/CCIDE.S520832","url":null,"abstract":"<p><strong>Background: </strong>Parenting stress is an unpleasant psychological reaction to the demands of being a parent. It affects parents who raise children with developmental disabilities and presents unique challenges, the impact of which is exacerbated by socio-economic status, age, income, and parental education level. Individuals with intellectual disabilities have poorer general health and oral hygiene compared to the general population. Parenting stress can influence parents' knowledge and attitudes about maintaining oral health. This research aimed to determine whether there was a relationship between parenting stress and the level of education, knowledge, and attitudes of parents toward maintaining oral health in children with intellectual disabilities.</p><p><strong>Methods: </strong>This research used a cross-sectional analytical method. The total sample was 104 parents of children with intellectual disabilities in two special schools in Bandung Regency, Indonesia. Data was collected and then tested for correlation with Spearman's Rank and Kendall Coefficient of Concordance.</p><p><strong>Results: </strong>The majority of parents described their level of parenting stress as moderate (51%), with the highest level of education being high school (36.5%), a sufficient level of knowledge (48.1%), and an adequate attitude towards maintaining dental and oral health (46.2%). Multivariate analysis showed a relationship between parenting stress and parents' level of education, knowledge, and attitudes, with a p-value of 0.0008 and W=0.205.</p><p><strong>Conclusion: </strong>There is a relationship between parenting stress and the level of education, knowledge, and attitudes of parents regarding the maintenance of the oral health of children with intellectual disabilities (whether it is related between parenting stress and each variable or when parenting stress is related to all three).</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"259-267"},"PeriodicalIF":1.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cariostatic Agents: From Silver Diamine Fluoride to Emerging Bioactive Compounds.","authors":"Edisson-Mauricio Pacheco-Quito, Daniel Avila-Cunalata, Katherine Cuenca-León","doi":"10.2147/CCIDE.S502433","DOIUrl":"10.2147/CCIDE.S502433","url":null,"abstract":"<p><p>Cariostatic agents are bioactive compounds that inhibit the progression of dental caries by promoting enamel and dentin remineralization while mitigating dentin hypersensitivity. This review conducted an extensive bibliographic search across specialized databases, including Web of Science, PubMed, Cochrane Library, and Scopus, to present a comprehensive and up-to-date analysis of the clinical applications of cariostatic agents. A critical appraisal of the available scientific evidence was performed to evaluate their efficacy and potential as adjunctive therapeutic strategies in caries management. Among the most well-documented agents, silver diamine fluoride (SDF) demonstrates superior efficacy in arresting active carious lesions and preventing lesion progression. Furthermore, emerging bioactive compounds, such as remineralizing peptides and phytochemicals, have exhibited promising anticariogenic properties, though their long-term clinical effectiveness remains under investigation. This review synthesizes key findings from recent research, underscoring the pivotal role of cariostatic agents in evidence-based caries prevention and management. The results highlight the necessity of integrating these agents into a minimally invasive and patient-centered approach, particularly for high-risk populations, to optimize long-term oral health outcomes.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"237-257"},"PeriodicalIF":1.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hyaluronic Acid Gel on Initial Wound Healing Following Tooth Extraction and Crown Lengthening Procedures: A Retrospective Analysis.","authors":"Suhailah AlShaali, Momen Atieh, Abeer Hakam, Nabeel H M Alsabeeha, Maanas Shah","doi":"10.2147/CCIDE.S513987","DOIUrl":"10.2147/CCIDE.S513987","url":null,"abstract":"<p><strong>Aim: </strong>There is limited evidence highlighting the implications of adjunctive topical application of wound healing agents on clinical and patient-related outcomes in surgical procedures. The aim of the retrospective analysis was to evaluate the effects of 0.8% hyaluronic acid (HA) gel on wound healing following tooth extraction and crown lengthening procedures using the Inflammatory Proliferative and Remodeling (IPR) scale in a postgraduate clinical setting.</p><p><strong>Methods: </strong>A retrospective assessment of medical record database related to clinical and patient-related outcomes of patients who received tooth extraction or crown lengthening procedures was conducted. Wound healing was assessed using the IPR scale providing scores for patient-reported postoperative pain, bleeding, granulation tissue, hematoma, tissue color compared to unaffected site, complete/incomplete flap closure, suppuration, and edema. The test group included participants who received an adjuvant application of 1mL of 0.8% HA gel <i>versus</i> control group participants receiving the same procedures without HA gel application.</p><p><strong>Results: </strong>Overall, no statistically significant differences were observed between the total IPR wound healing scores for test (5.54 ±1.02) <i>versus</i> control (5.19 ±1.21, P=0.30) groups. Bleeding and hematoma were less frequent in participants receiving 0.8% HA gel, though the differences were not statistically significant (bleeding: P=0.09, hematoma: P=0.12). Of the 45 participants analysed, 79.2% in the test group achieved successful inflammatory phase scores (5-8), compared to 76.2% in the control group (P = 0.81). More sites with a successful inflammatory phase (score 5-8) were observed in systemically healthy, male, non-smokers, and those with posterior mandibular surgeries, though without statistical significance.</p><p><strong>Conclusion: </strong>Although 0.8% HA gel did not significantly improve early wound healing, well-designed clinical trials are necessary to evaluate its safety and potential benefits in routine periodontal surgeries. The IPR wound healing index demonstrated high reliability with excellent inter- and intra-examiner agreement in assessing the initial healing process after periodontal surgery.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"225-236"},"PeriodicalIF":1.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Periapical Lesion and Discoloration with Periapical Microsurgery Followed up by Internal-External Bleaching and Direct Composite Restoration: One-Year Clinical Evaluation.","authors":"Opik Taofik Hidayat, Suhardjo Sitam, Irmaleny Irmaleny, Setyo Harnowo, Wawan Suridwan","doi":"10.2147/CCIDE.S516207","DOIUrl":"10.2147/CCIDE.S516207","url":null,"abstract":"<p><strong>Background: </strong>Endodontic treatment outcomes may change over time. Factors such as compromised coronal seal and inadequate obturation can lead to canal reinfection and often periapical infection, thus developing into periapical lesions. Biofilm occupying the surface of the root tip can cause failure of conventional endodontic treatment or retreatment. Healing is achievable depending on the success of efforts to eradicate the biofilm layer from the site. Tooth discoloration after a root canal treatment can also be concerning, with several causes and treatment options. One of the minimally invasive aesthetic treatment options for discolored anterior teeth is dental bleaching or direct composite veneers.</p><p><strong>Case report: </strong>A 22-year-old patient experienced pain in the right maxillary lateral and central incisors with a history of trauma at the age of six. Both teeth have undergone root canal treatment at the age of ten years. Clinically, the teeth were discolored with visible old composite restorations. Radiological finding shows radiolucency in the periapical and compromised apical structure. Endodontic retreatment and periapical microsurgery were performed to remove the periapical lesion, followed by internal-external bleaching and direct composite veneer to restore the aesthetics.</p><p><strong>Results: </strong>The procedure was successful, and a one-year follow-up recall revealed bone regeneration around their apices and esthetic outcomes that satisfied the patient.</p><p><strong>Conclusion: </strong>The technique described is an excellent approach in conserving the tooth with periapical lesions and compromised apical structure due to root resorption and internally stained teeth.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"217-223"},"PeriodicalIF":1.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Prophylaxis in Patients with Joint Prostheses: Variability in Dentists' Practices and the Need for Guidance.","authors":"Mohamed Rahhali, Majid Sakout","doi":"10.2147/CCIDE.S526588","DOIUrl":"https://doi.org/10.2147/CCIDE.S526588","url":null,"abstract":"<p><strong>Background and objective: </strong>With increasing life expectancy, the incidence of degenerative and inflammatory joint diseases continues to rise. These conditions are major indications for orthopedic prostheses, which pose risks of postoperative complications, particularly infections of orthopedic prostheses (IPO). Dental infections have been considered a potential source of these infections, and recommendations regarding the use of antibiotic prophylaxis (AP) during dental procedures have evolved over time. Current guidelines discourage the routine use of AP. This study aims to assess the knowledge, attitudes, and practices (KAP) of private-sector dentists in the cities of Rabat, Temara, and Salé (Morocco) regarding the dental management of patients with orthopedic prostheses, particularly the use of AP.</p><p><strong>Methodology: </strong>An anonymous 21-question survey was distributed to 310 dentists practicing in these cities. The collected responses were analyzed using JamoviR software (version 2.3.25), with a significance threshold set at p < 0.05. Chi-square and Fisher's exact tests were employed to compare different groups.</p><p><strong>Results: </strong>Out of 310 distributed questionnaires, 102 valid responses were retained (response rate: 32.9%). Among respondents, 53.9% considered patients with joint prostheses at risk of infection, yet only 47.1% reported prescribing AP. Female practitioners and those with over 20 years of experience were significantly more likely to prescribe AP (p=0.047 and p=0.002, respectively). Dentists who did not consult guidelines or attend professional conferences were also more prone to prescribing AP during endodontic procedures (p=0.017 and p=0.018).</p><p><strong>Conclusion: </strong>This study reveals inconsistent knowledge and practices among dentists regarding AP use for patients with joint prostheses. Given the misalignment with current guidelines and the influence of outdated sources of information, targeted educational interventions and updated clinical guidelines are urgently needed to promote evidence-based practices. Clear, standardized guidelines are also essential to prevent the unjustified overprescription of antibiotics and to address the growing concern of antimicrobial resistance.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"209-215"},"PeriodicalIF":1.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Stage Crestal Sinus Elevation Using Osseodensification Technique for Single Molar Restoration: A Case Report.","authors":"Raed AlRowis","doi":"10.2147/CCIDE.S515234","DOIUrl":"10.2147/CCIDE.S515234","url":null,"abstract":"<p><p>This report presents a two-stage approach for crestal sinus elevation using the osseodensification technique in a case of severe vertical bone deficiency (<3 mm). Traditional approaches to maxillary sinus elevation with less than 3 mm of residual bone height typically require a lateral window technique. A 55-year-old male patient presented with a missing maxillary right first molar with residual bone height of 2 mm. The treatment involved: Stage 1: Crestal sinus elevation using osseodensification with Versah burs and allograft placement. Stage 2: After 6 months of healing, placement of a Straumann Bone Level Tapered implant (4.1 × 10mm) with 35 Ncm insertion torque and final prosthetic restoration was started 4 months after implant placement. Then, follow-up at 12 months demonstrated stable peri-implant tissues, maintained bone levels, and excellent patient satisfaction. Radiographic evaluation showed uniform bone formation around the implant and maintained sinus floor elevation. The case demonstrates that osseodensification can provide a predictable alternative to lateral window approaches even in cases with severe vertical bone deficiency (<3 mm), offering reduced invasiveness with enhanced bone density and favorable clinical outcomes.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"201-207"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Much is Stable the Bonding of CAD-CAM Implant-Supported All-Ceramic Restorations to Titanium Bases Clinically? A Systematic Review.","authors":"Rola Muhammed Shadid","doi":"10.2147/CCIDE.S510760","DOIUrl":"10.2147/CCIDE.S510760","url":null,"abstract":"<p><p>The rapid advancement of digital technologies and the introduction of new ceramic materials have largely attributed to the notable transition from metal-ceramic to all-ceramic implant restorations bonded to Ti-bases. The purpose of this review was to evaluate all clinical studies reporting on the bond stability between CAD-CAM implant-supported all-ceramic restorations and Ti-bases. The review was directed according to the PRISMA guidelines to answer the focused question \"How much is the stability and durability of the resin bond between implant-supported fixed CAD-CAM ceramic restorations and Ti- bases clinically?\". The PubMed, Google Scholar, and Cochrane databases were investigated to identify related clinical studies. Human studies assessing at least 10 patients restored with implant-supported fixed CAD-CAM ceramic restorations luted to prefabricated Ti-bases with a mean follow-up of at least 1 year and published in an English-language up to Sep. 2024 were included. The restorations could be single crown, fixed dental prosthesis, or full-arch fixed prosthesis. The search yielded 5,190 records; of these, 59 full-text articles were evaluated based on eligibility criteria. Ultimately, 40 studies were included. All 40 studies demonstrated low debonding rates from Ti-bases for single copings, multi-unit fixed dental prostheses, and full arch zirconia prostheses. Based on the limited evidence available, different factors were blamed for the debonding incidence, such as Ti-base height, geometry, luting agent, inadequacy of passive fit and biomechanical patient- and prosthesis-related factors. CAD-CAM implant-supported all-ceramic restorations bonded to Ti-bases demonstrated relatively high bond stability during observation period ranging from 1 to 7.5 years. More well-designed clinical research with long-term observation periods is highly recommended.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"181-200"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic Assessment of the Quality of Post and Core Restorations and the Effect of the Gap Between the Post-Restoration and the Remaining Root Canal Filling on the Apical Status in a Saudi Subpopulation.","authors":"Sami A Almohefer, Rana Alkattan, Ruqayyah H Alshubrami, Fajr Y Alshammari, Nawal M Alnaseeb, Hani Tamim, Ahmed A Madfa","doi":"10.2147/CCIDE.S514108","DOIUrl":"10.2147/CCIDE.S514108","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to assess the quality of post and core restorations carried out by general dentists in the Hail region of Saudi Arabia using periapical radiographs. Additionally, the assessment included the examination of periapical lesions.</p><p><strong>Methods: </strong>A comprehensive analysis was conducted on 301 periapical digital radiographs to assess various factors including the type of post, type of coronal restoration, post length in relation to crown and root length, presence of any abnormalities in the post space, condition of the remaining gutta-percha (GP), gap between the end of the post and the GP, and the presence of apical lesions. Analysis was conducted to determine the frequency distribution and cross-tabulation of the variables.</p><p><strong>Results: </strong>Prefabricated metallic posts were most commonly used (62.1%), followed by metal posts which were found in 28.9% of the cases, and fiber posts which were used in 9.0% of the cases. The length of the posts in relation to the tooth were 2:1 in 32.6%, followed by 1:1 (27.9%) and 1:2 (23.6%). Parallel posts were used in 54.2% of cases, while the remaining 45.8% used tapered posts. Smooth posts were utilized in 77.1% of the cases, while serrated posts were utilized in 22.9%. Approximately 54.2% of the cases exhibited remaining GP of more than 5 mm, whereas 35.2% demonstrated adequate GP between 3-5 mm and 8.0% with remaining GP less than 3 mm. According to the study's findings, 65.1% of the samples under investigation had full coverage indirect restorations placed.</p><p><strong>Conclusion: </strong>It was found that the post and core procedures' quality was comparable to earlier epidemiological studies. However, a significant proportion of posts were deemed to have poor technical quality, and apical periodontitis was seen in slightly more than one-third of the cases.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"169-179"},"PeriodicalIF":1.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Mucosal Wetting Capacity of Novel and Commercial Saliva Substitute Formulations: An in vitro Study.","authors":"Wipaporn Kajornwongwattana, Nutchaporn Sanguansin, Thanapat Songsak, Suchada Vuddhakanok, Supanee Thanakun","doi":"10.2147/CCIDE.S514583","DOIUrl":"10.2147/CCIDE.S514583","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the effectiveness of novel, inexpensive saliva substitute formulas (Rangsit University (RSU) preparation) in maintaining mucosal wetness compared with commercial products.</p><p><strong>Materials and methods: </strong>In vitro experiments were conducted using swine tongues to assess the wetness of various RSU saliva substitute solutions and gels, with four flavors each (sweet mint, sweet vanilla, sweet-sour mint, and sweet-sour lemon), compared with water, hospital-based mouth rinse from a government dental school, and commercial products (Biotene^® mouthwash and GC Dry Mouth Gel^®). The wetness was measured at baseline and at 0, 10, 20, 30, 60, and 120 minutes using a digital moisture analyzer.</p><p><strong>Results: </strong>All saliva substitutes consistently maintained a higher relative wetness than water, particularly beyond 60 minutes (<i>p</i> < 0.001). RSU solutions with a sour flavor (sweet-sour mint and sweet-sour lemon) had a similar wetness to commercial saliva substitute mouthwash at all times. These solutions were more effective in maintaining higher relative wetness over time than those without a sour flavor (sweet mint and sweet vanilla) (<i>p</i> < 0.05) and provided more wetness than the hospital-based mouth rinse at 120 minutes. The RSU solution formula also provided comparable wetness to RSU gel preparation at every time point. While RSU gel formulas initially provided comparable wetness to water, they maintained significantly higher wetness at 60 minutes (<i>p</i> = 0.029) and 120 minutes (<i>p</i> = 0.002). These results were similar to those of commercial saliva substitute gel, which maintained stable wetness since application up to 120 minutes (<i>p</i> = 0.052).</p><p><strong>Conclusion: </strong>Our novel saliva substitute formulas show similar effectiveness to commercial products in maintaining mucosal wetness. These inexpensive products could be a viable alternative for patients with dry mouth who cannot afford commercial formulations.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"17 ","pages":"159-167"},"PeriodicalIF":1.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}