Clinical, Cosmetic and Investigational Dentistry最新文献

{"title":"Prevalence of Partial Edentulism Based on Kennedy Classification in a Teaching Hospital: A Retrospective Study.","authors":"Sayed Yasir Torabi, Ali Maisam Eshraqi","doi":"10.2147/CCIDE.S607554","DOIUrl":"https://doi.org/10.2147/CCIDE.S607554","url":null,"abstract":"<p><strong>Background: </strong>Partial edentulism remains a common oral health condition with significant functional and prosthodontic implications. The Kennedy classification system is widely used for categorizing partially edentulous arches due to its simplicity and clinical applicability.</p><p><strong>Objective: </strong>To determine the prevalence and distribution of Kennedy Class I-IV partial edentulism according to age, gender, and jaw involvement among patients attending a teaching hospital in Kabul, Afghanistan.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted using secondary data obtained from hospital records. The study included 328 patients diagnosed with Kennedy Class I-IV partial edentulism who attended the Prosthodontics Department between January 2023 and December 2023. Data were analyzed using IBM SPSS software. Descriptive statistics were used to determine frequencies and percentages.</p><p><strong>Results: </strong>Among 328 partially edentulous patients, Kennedy Class I was the most prevalent (46.3%), followed by Class III (25.6%) and Class II (21.3%), while Class IV was the least frequent (6.7%). Class I and II were more commonly observed in the mandible, whereas Class III and IV predominated in the maxilla. Females showed a higher prevalence of Class I and III, while Class II and IV were more frequent among males. The highest proportion of partial edentulism was observed in the 41-50-year age group.</p><p><strong>Conclusion: </strong>Kennedy Class I was the most prevalent pattern of partial edentulism in the studied population, while Class IV was the least common. Distribution patterns varied according to age, gender, and jaw involvement. These findings provide useful epidemiological data for prosthodontic treatment planning and oral health service development.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"607554"},"PeriodicalIF":1.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Diode Laser Treatment in Managing Dentin Hypersensitivity in Vietnamese Adults: A Six-Month Prospective Study.","authors":"Hong Loi Nguyen, Nguyet Tu Ha Anh","doi":"10.2147/CCIDE.S599840","DOIUrl":"https://doi.org/10.2147/CCIDE.S599840","url":null,"abstract":"<p><strong>Background: </strong>Dentin hypersensitivity (DH) is a prevalent oral complaint that negatively affects patients' quality of life. Although various desensitising agents exist, their effect is often short‑lived. Diode laser irradiation has been proposed as a minimally invasive alternative. This study aims to evaluate the short‑ and medium‑term effectiveness and safety of 810‑nm diode laser therapy for cervical DH in Vietnamese adults.</p><p><strong>Materials and methods: </strong>This prospective single-arm clinical study included 57 patients contributing 180 hypersensitive teeth with Smith and Knight tooth-wear scores of 1-2. Sensitive teeth were treated with an 810-nm diode laser at 0.5 W in continuous-wave mode using a standardized non-contact protocol. Pain intensity was assessed using a 10-cm visual analogue scale (VAS) at baseline, immediately after treatment, and at 1, 3, and 6 months. Baseline-to-follow-up comparisons were performed using paired analyses.</p><p><strong>Results: </strong>Mean VAS scores decreased immediately after treatment and remained lower than baseline at all follow-up time points. The reduction was most pronounced at 3 months and remained clinically relevant at 6 months. Greater absolute reductions were observed in teeth with more severe baseline sensitivity. Patient satisfaction exceeded 90%, and no adverse effects were observed during follow-up.</p><p><strong>Conclusion: </strong>Within the limitations of this single-arm study, 810-nm diode laser treatment was associated with immediate and sustained reduction in dentin hypersensitivity over 6 months. Randomized controlled studies with sham or active comparators are required to confirm efficacy.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"599840"},"PeriodicalIF":1.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Modulation of Orthodontic Tooth Movement: Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. A Review.","authors":"Edisson-Mauricio Pacheco-Quito, Carol Flores-Regalado, Miriam Lima-Illescas, Jessica Sarmiento-Ordoñez, Katherine Cuenca-León","doi":"10.2147/CCIDE.S595185","DOIUrl":"https://doi.org/10.2147/CCIDE.S595185","url":null,"abstract":"<p><strong>Introduction: </strong>Orthodontic tooth movement is a biologically mediated process involving inflammatory signaling and coordinated bone remodeling in response to mechanical force. Increasing evidence suggests that systemic and locally administered pharmacological agents can modulate this process by influencing cellular and molecular pathways regulating osteoclastogenesis and osteogenesis.</p><p><strong>Objective: </strong>To analyze the role of various medications in orthodontic tooth movement by describing their mechanisms of action, clinical implications, and emerging therapeutic applications.</p><p><strong>Methods: </strong>A narrative literature review was conducted using PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library databases. Publications in English from January 2010 to October 2025 were screened. Original studies in humans and animal models, in vitro investigations, clinical trials, and relevant systematic reviews addressing drug-related modulation of OTM were included. Non-peer-reviewed publications, incomplete reports, and unrelated studies were excluded. A total of 70 studies met the inclusion criteria and were analyzed through qualitative synthesis.</p><p><strong>Results: </strong>Pharmacological agents were categorized as inhibitors or accelerators of OTM. Nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, corticosteroids, and certain hormonal therapies were consistently associated with reduced osteoclastic activity and slower tooth movement. Conversely, prostaglandins, vitamin D metabolites, thyroid hormones, and selected molecular modulators demonstrated acceleration effects, primarily in preclinical models. Emerging approaches, including selective estrogen receptor modulators, monoclonal antibodies, and localized drug delivery systems, show promising potential; however, most evidence remains experimental and heterogeneous.</p><p><strong>Conclusion: </strong>Pharmacological modulation represents a biologically relevant adjunct to orthodontic biomechanics. Nevertheless, current evidence is predominantly derived from animal and preclinical studies, limiting direct clinical extrapolation. Careful assessment of patients' pharmacological profiles is essential for individualized treatment planning, and further controlled clinical trials are required before routine therapeutic implementation.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"595185"},"PeriodicalIF":1.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Assessment of Open-Access Digital Workflow for Presurgical Nasoalveolar Molding in Unilateral Cleft Lip and Palate.","authors":"Emily A Genovesi, Jessica E Canallatos, Laxmi Deepak Hulyalkar, Ridham V Varsani, Steven Makowka, Dany Atalla, Praveen Arany","doi":"10.2147/CCIDE.S588444","DOIUrl":"https://doi.org/10.2147/CCIDE.S588444","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate digitally fabricated nasoalveolar molding (NAM) prostheses using open-source software against conventionally manufactured prostheses using an in vitro assessment of material mechanical properties, and fabrication efficiency.</p><p><strong>Materials and methods: </strong>Following IRB approval, a retrospective, in vitro comparative study was conducted using previously obtained, deidentified neonatal maxillary gypsum casts from patients with unilateral cleft lip and palate. NAM prostheses were fabricated using either conventional cold-cure acrylic resin or a digital workflow using open-access software (Meshmixer, Autodesk) and stereolithography 3D printing (Formlabs). Surface deviation relative to reference casts, fabrication time, flexural strength, flexural modulus, and microscopic structural analysis of 3D printed resin versus conventional materials were evaluated.</p><p><strong>Results: </strong>Digital NAM prostheses demonstrated significantly (n = 17, p = 0.038) reduced surface cast-based deviation compared to conventional prostheses (mean deviation: 1.53 ± 0.19 mm vs. 1.69 ± 0.25 mm), reflecting nearly 10% improvement in fit relative to the reference cast with the digital method. Materials analysis revealed that 3D-printed resin blocks of standardized testing dimension demonstrated significantly higher flexural strength (n = 7, p < 0.0001) at 67.17 ± 4.8 MPa compared to conventional acrylic blocks at 28.7 ± 3.32 MPa. Flexural modulus was also significantly (n = 7, p < 0.0001) different between groups, with values of 1713 ± 131.6 MPa for 3D printed resin and 797.5 ± 99.0 MPa for conventional acrylic, indicating greater stiffness in the 3D printed resin material. Microscopic analysis revealed a uniform, void-free structure in 3D printed resin blocks in contrast to visible air entrapment in conventional cold-cure acrylic blocks.</p><p><strong>Conclusion: </strong>Within the limitations of this in-vitro study using gypsum casts as a reference standard, this work validates a digital workflow for NAM prosthesis fabrication using freely available open-source software (Meshmixer). By providing a reproducible, cost-free workflow, this study offers a practical guide for clinicians initiating digital NAM design and future sequential treatments, supporting wider accessibility and precision in presurgical NAM therapy, particularly in resource-limited settings.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"588444"},"PeriodicalIF":1.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Cold-Sensitivity in Root Canal Treated Teeth: Mechanisms, Cracked Roots, and Clinical Implications.","authors":"Dennis Flanagan","doi":"10.2147/CCIDE.S585681","DOIUrl":"https://doi.org/10.2147/CCIDE.S585681","url":null,"abstract":"<p><p>Root canal treatment (RCT) removes necrotic and inflamed pulp tissue with the objective of eliminating pain and sensitivity. Nonetheless, some treated teeth may have persistent sensitivity to cold. This symptom is counterintuitive and poses a diagnostic challenge. This article reviews current knowledge base on how cold sensitivity can persist in RCT teeth. Cold sensitivity may indicate residual neural tissue, periodontal/periapical innervation, altered sensations, cracked roots, and restoration marginal leakage. Cracked roots may indeed induce \"cold-only\" sensitivity. A narrative review, diagnostic and clinical management considerations are presented as well.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"585681"},"PeriodicalIF":1.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Dental Service Utilization Among Adults in Akure Metropolis, Nigeria: A Cross-Sectional Study.","authors":"Adebayo Adeneye Sheyin, David Nono","doi":"10.2147/CCIDE.S608045","DOIUrl":"https://doi.org/10.2147/CCIDE.S608045","url":null,"abstract":"<p><strong>Background: </strong>Utilization of dental services remains low in many developing countries despite the availability of oral-health facilities. This study assessed barriers to and identified predictors of dental service utilization among adults in Akure Metropolis, Ondo State, Nigeria.</p><p><strong>Methods: </strong>A descriptive cross-sectional survey was conducted among 480 adults selected using a multistage sampling technique. Data were collected using a structured interviewer-administered questionnaire and analyzed with SPSS version 26. Dental-service utilization was defined as having visited a dental clinic at least once within the preceding 12 months. Descriptive statistics summarized variables, while Chi-square tests and binary logistic regression identified factors associated with utilization at a significance level of p < 0.05.</p><p><strong>Results: </strong>Although 81.7% of respondents were aware of dental clinics, only 39.0% were aware of preventive dental services. While 57.1% had ever visited a dentist, only 27.9% reported utilization within the past 12 months, with most visits being symptom-driven. Major barriers included high cost of care (73.1%), fear of dental pain (62.1%), and long waiting times (51.0%). Educational level and monthly income were significantly associated with service utilization (p < 0.05). Logistic regression analysis showed that higher education, higher income, and awareness of preventive services significantly increased the likelihood of utilization, whereas fear of dental pain reduced it.</p><p><strong>Conclusion: </strong>Dental service utilization in Akure Metropolis appears low and largely ymptom-driven. Financial, informational, and psychological factors may act as barriers; however, given the cross-sectional design, these associations do not imply causality. Improving oral-health education, financial access, and service delivery may enhance utilization.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"608045"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of Local Bone Grafting Combined with Implant Restoration in Patients with Diabetes Mellitus and Partial Edentulism.","authors":"Xin Wang, Quan-Hua Shi","doi":"10.2147/CCIDE.S598579","DOIUrl":"https://doi.org/10.2147/CCIDE.S598579","url":null,"abstract":"<p><strong>Background: </strong>Patients with diabetes mellitus are at increased risk of partial edentulism, which may lead to tooth loss, compromised masticatory function, and dietary restrictions. Delayed or inadequate treatment can cause complications and sequelae that severely reduce quality of life. This study aimed to explore the clinical efficacy of local bone grafting combined with implant restoration in diabetic patients with partial edentulism, to provide evidence for clinical treatment strategies.</p><p><strong>Objective: </strong>To assess the clinical efficacy and safety of local bone grafting combined with implant restoration in diabetic patients with partial edentulism.</p><p><strong>Methods: </strong>A total of 122 eligible patients were randomly divided into control and observation groups (n=61 each). The control group received conventional implant restoration, while the observation group underwent local autogenous bone grafting combined with implant restoration. Outcomes included peri-implant bone mineral density, new bone formation, bone-to-implant contact, inflammatory cytokines in peri-implant crevicular fluid, periodontal indicators, serum bone metabolic markers, and postoperative soft tissue complications.</p><p><strong>Results: </strong>Preoperative baseline values were comparable between groups (P > 0.05). At 6 months postoperatively, the observation group exhibited significantly higher bone mineral density, new bone area percentage, and bone-to-implant contact, along with lower levels of TNF-α, IL-8, and IFN-γ. Periodontal status, implant stability, and bone metabolism markers were also improved, and the overall complication rate was significantly lower (P < 0.05).</p><p><strong>Conclusion: </strong>Local bone grafting combined with implant restoration effectively improves early implant stability and osseointegration, reduces inflammatory responses, and lowers the incidence of postoperative complications in diabetic patients with partial edentulism. The method is safe and effective and holds high clinical application value.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"598579"},"PeriodicalIF":1.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.","authors":"Patrick Unterbrink, Erik Schulze Zur Wiesche, Bennett Tochukwu Amaechi, Joachim Enax","doi":"10.2147/CCIDE.S586895","DOIUrl":"https://doi.org/10.2147/CCIDE.S586895","url":null,"abstract":"<p><strong>Objective: </strong>To systematically identify and evaluate clinical trials assessing the caries-preventive efficacy of fluoride-free active ingredients in toothpaste formulations.</p><p><strong>Data: </strong>Randomized clinical trials analyzing the caries preventive effect of fluoride-free active ingredients in toothpastes.</p><p><strong>Sources: </strong>A PRISMA-related systematic review of MEDLINE and Embase was conducted. Inclusion criteria were human in vivo clinical trials on toothpastes, fluoride-free interventions, and caries-focused outcomes; exclusion criteria were in vitro or animal studies, non-toothpaste products, fluoride-only products, and non-English publications. The review followed the PICO framework: Population - participants of all ages with primary, mixed, or permanent dentition; Intervention - use of a toothpaste with a non-fluoride active ingredient; Comparison - a fluoride-containing toothpaste as control; Outcome - a measurable oral health effect based on in vivo caries estimation.</p><p><strong>Study selection: </strong>Fifteen clinical trials met the inclusion criteria. Eleven used fluoride-free, non-therapeutic abrasive toothpastes as placebo controls. Three trials evaluated the caries-preventing efficacy of fluoride-free hydroxyapatite toothpastes across children, adolescents, and adults; one trial evaluated the caries-preventive efficacy of fluoride-free arginine toothpaste in children.</p><p><strong>Conclusion: </strong>Caries prevention relies on reducing sugar intake and thorough daily oral care, with toothpaste, containing evolving combinations of remineralizing agents, antibacterials, and abrasives, playing a central role. With growing global interest in fluoride-free options, this literature review shows that clinically proven fluoride alternatives are already in use.</p><p><strong>Clinical significance: </strong>This review provides evidence-based guidance for dentists when recommending fluoride-free toothpastes to patients.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"586895"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal Contact Loss and Interproximal Caries in Natural Teeth Adjacent to Dental Implants. A Review.","authors":"Mohammed Alsaloum, Sami A Almohefer, Abdulaziz Alzaid, Faey Alburidy, Fatimah Alanazi, Layan Tarabzoni, Rana K Alkattan, Ahmed A Madfa, Ahmad Alkhodair","doi":"10.2147/CCIDE.S585610","DOIUrl":"https://doi.org/10.2147/CCIDE.S585610","url":null,"abstract":"<p><p>Proximal contact loss (PCL) between implant restorations and neighboring natural teeth can lead to interproximal caries and other dental problems. This review assessed the frequency of interproximal caries on teeth adjacent to implants and implant infraocclusion across different age groups. Factors influencing PCL, including implant placement and adjustments for patient age and gender, were evaluated. The review also examined the impact of implants on surrounding bone and oral microbiota. Understanding these effects helps guide implant planning and follow-up care, aiming to reduce complications, preserve the integrity of neighboring teeth, and maintain overall oral health. Implants can trigger local inflammation and microbial imbalance, leading to bone loss around adjacent natural teeth and potentially increasing caries risk. Interproximal contact loss (PCL) between implants and neighboring teeth is common and heightens susceptibility to interproximal caries, affecting oral health. Factors such as implant placement, follow-up duration, and microbial changes influence PCL development and its consequences. Timely implant placement and consideration of patient age and gender are essential to manage growth-related changes. Proper treatment strategies combined with regular monitoring help minimize risks, maintain interproximal integrity, and protect oral health, ensuring implant restorations function effectively without compromising adjacent natural teeth.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"585610"},"PeriodicalIF":1.8,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Comparison of Third Molar Agenesis Among Indian and Malaysian Subpopulations: A Retrospective Orthopantomographic Study.","authors":"Mehul Saha, Sreea Roy, Murali Venkata Rama Mohan Kodali, Shreyosi Banik, Srikanth Gadicherla, Thrishma Gauri, Pavithra Varchas, Lisamarie S L Colaco, Lakshmi Priya, Aditi Kumar, Aditya John, Gowri Kamath, Kalyana Chakravarthy Pentapati, Komal Smriti, Nandita Shenoy","doi":"10.2147/CCIDE.S579884","DOIUrl":"https://doi.org/10.2147/CCIDE.S579884","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and establish the prevalence of third molar (M3) agenesis among Indian and Malaysian subpopulations.</p><p><strong>Material and methods: </strong>This cross-sectional observational study was conducted as a collaborative study between Manipal College of Dental Sciences, Manipal and Melaka Medical and Dental College, Malaysia (Manipal branch). Following Ethical Committee clearance, digital orthopantomograms (OPG) of students who visited the Dental OPD of Manipal College of Dental Sciences, Manipal for orthodontic treatment or M3 disimpactions were included in the study. The data collected from the OPGs included demographic information (age and sex) and information about the presence or absence of M3. Descriptive statistics were presented as frequencies for categorical variables and as mean ± standard deviation for age. Additionally, Fisher's exact test and chi-square test were conducted to evaluate differences within and between the two ethnic groups.</p><p><strong>Results: </strong>Hundred OPGs each of Malaysian and Indian origin students met the inclusion criteria and were included in the study. The mean age of the study population was 15.8 ± 2.8 years (range: 13-21 years). The Indian group comprised 52 females and 48 males, while the Malaysian group included 49 females and 51 males. Among the Indian subjects, 7% had M3 present in all four quadrants, whereas 93% exhibited agenesis of M3 in at least one quadrant. Similarly, 8% of Malaysian subjects had M3 present in all four quadrants, and 92% demonstrated agenesis in at least one quadrant. Overall, M3 agenesis was observed in 77.5% of the 200 study participants.</p><p><strong>Conclusion: </strong>M3 agenesis was highly prevalent in both Indian and Malaysian dental students, with no significant difference in overall prevalence between the two groups. Although quadrant-specific variations were observed, most comparisons did not demonstrate statistically significant intergroup differences.</p>","PeriodicalId":10445,"journal":{"name":"Clinical, Cosmetic and Investigational Dentistry","volume":"18 ","pages":"579884"},"PeriodicalIF":1.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}