Clinical Otolaryngology最新文献

The Role of Nasal Cytology in the Phenotyping and Monitoring of Chronic Rhinitis in Children. 鼻细胞学在儿童慢性鼻炎表型和监测中的作用。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-10-07 DOI: 10.1111/coa.70040

Damla Baysal Bakır, Özge Atay, Halime Yağmur, Gizem Kabadayı, Dilek Tezcan, Suna Asilsoy, Nevin Uzuner

{"title":"The Role of Nasal Cytology in the Phenotyping and Monitoring of Chronic Rhinitis in Children.","authors":"Damla Baysal Bakır, Özge Atay, Halime Yağmur, Gizem Kabadayı, Dilek Tezcan, Suna Asilsoy, Nevin Uzuner","doi":"10.1111/coa.70040","DOIUrl":"https://doi.org/10.1111/coa.70040","url":null,"abstract":"Background: Local allergic rhinitis (LAR) is a rhinitis subtype characterised by an IgE-mediated response in the nasal mucosa. Although the nasal provocation test (NPT) is the diagnostic gold standard, it is impractical in many centres. Consequently, patients are often misclassified as having non-allergic rhinitis, delaying appropriate treatment. This study evaluated the role of nasal cytology in the classifying and monitoring paediatric allergic rhinitis (AR), distinguishing probable LAR (pLAR), and guiding treatment.Methods: This retrospective study analysed data from 255 patients diagnosed with chronic rhinitis between March and June 2024. After applying exclusion criteria (recent allergy treatment, nasal deformities, incomplete records), 48 patients were included and grouped as pLAR (n = 11) or AR (n = 37). Nasal eosinophilia and atopy markers were assessed with clinical symptoms, before and after treatment.Results: The mean age was 10.5 years (range: 3-17), with 64.6% male. AR was diagnosed in 77% and pLAR in 23%. Asthma was the most common comorbidity (37.5%). Persistent, moderate-severe symptoms were seen in 68.8%, with pollen sensitivity present in 76.3%. After treatment, both VAS scores and nasal eosinophil rates (NEOS%) significantly decreased in both groups (p < 0.05). NEOS% was higher in patients with atopic dermatitis and lower in those with adenoidal hypertrophy. AEC and NEOS% were positively correlated (p < 0.001), suggesting a link between systemic and local eosinophilia.Conclusions: Patients with pLAR showed clinical and laboratory improvement similar to AR following treatment. Nasal cytology may be a useful diagnostic and monitoring tool in children with chronic rhinitis.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sinonasal Inverted Papilloma-Relevance of Radiological Anatomy in Disease Recurrence. 鼻窦内翻性乳头状瘤：与疾病复发的放射解剖学相关性。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-10-06 DOI: 10.1111/coa.70046

Rakesh R Bright, Madhavi Kandagaddala, Lisa Mary Cherian, Regi Kurien, Vedantam Rupa, Belavendra Antonisamy, Aparna Irodi, Lalee Varghese

{"title":"Sinonasal Inverted Papilloma-Relevance of Radiological Anatomy in Disease Recurrence.","authors":"Rakesh R Bright, Madhavi Kandagaddala, Lisa Mary Cherian, Regi Kurien, Vedantam Rupa, Belavendra Antonisamy, Aparna Irodi, Lalee Varghese","doi":"10.1111/coa.70046","DOIUrl":"https://doi.org/10.1111/coa.70046","url":null,"abstract":"Objective: To describe the radiological anatomy of patients with inverted papilloma (IP) and to evaluate the association between radiological findings and disease recurrence.Methods: Retrospective observational study of patients with inverted papilloma who underwent surgery between January 2010 and December 2019. Patients were grouped as primary and recurrent cases, and later at follow-up, depending on disease status, they were subcategorized into 'primary with no recurrence' (PnR), 'primary with recurrence' (PwR), 'recurrent with no further recurrence' (RnR) and 'recurrent with further recurrence' (RwR) groups. Radiological and surgical data were collected and analysed.Results: Among the 117 patients, zygomatic recess was anatomically the most prevalent maxillary recess. Palatonasal was the most commonly affected recess in both primary and recurrent groups. Within the maxillary sinus, the most common sites of recurrence were the lateral wall and floor. Anterior ethmoid (p = 0.047), frontal recess (p = 0.017) and frontal sinus (p = 0.026) showed significantly higher radiological involvement in recurrent cases compared to primary cases. Among the recurrent cases, involvement of posterior ethmoid (p = 0.030), frontal recess (p = 0.017), intraorbital extraconal compartment (p = 0.036) and Krouse stage T4 (p = 0.002) were significantly higher in those with repeated disease recurrence (RwR).Conclusion: In recurrent IP, predictors of repeated recurrence include the site of initial recurrence being the frontal recess/sinus region, involvement of the posterior ethmoid, frontal recess and intraorbital extraconal compartment, and Krouse stage T4 at the time of diagnosis.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Eustachian Tube Plugging Method for Patulous Eustachian Tube Disorder. 扩张性耳咽管疾病的最佳耳咽管堵塞方法。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-10-04 DOI: 10.1111/coa.70043

Seong Hoon Bae, Taeuk Cheon, Soo-Keun Kong, In Seok Moon

{"title":"Optimal Eustachian Tube Plugging Method for Patulous Eustachian Tube Disorder.","authors":"Seong Hoon Bae, Taeuk Cheon, Soo-Keun Kong, In Seok Moon","doi":"10.1111/coa.70043","DOIUrl":"https://doi.org/10.1111/coa.70043","url":null,"abstract":"Introduction: Patulous Eustachian tube disorder (PET) causes disabling symptoms due to abnormal tubal patency. Eustachian tube plugging is a surgical option, but the optimal surgical position and plug material remain undetermined. To evaluate the success rate and complications of Eustachian tube plugging according to surgical position (sitting vs. supine) and plug material (silicone vs. angiocatheter).Methods: This retrospective study included 50 ears from 42 patients who underwent Eustachian tube plugging between May 2019 and May 2025. Surgical outcomes and complications were assessed up to 3 months postoperatively.Results: The overall complete remission (CR) rate was 70.0%, and 88.0% of patients experienced clinical improvement. Obstructive Eustachian tube dysfunction occurred in 14.6% of ears, exclusively in CR cases. No tympanic membrane perforation was observed. The sitting position showed a higher CR rate (80.0%) compared to supine (60.0%) in short-term outcome.Conclusion: Sitting-position surgery may improve CR outcomes due to real-time symptom feedback. Angiocatheters are effective but prone to extrusion. Plugging is a promising procedure for PET with a favourable safety profile.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy. 完全或完全甲状腺切除术后持续性甲状旁腺功能减退的预后模型的建立和验证。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-10-02 DOI: 10.1111/coa.70039

Sam P J van Dijk, Carolien C H M Maas, Ali Alshangi, M H Elise van Driel, Eline A Feitsma, Caroline M J van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P Peeters, Tessa M van Ginhoven

{"title":"Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.","authors":"Sam P J van Dijk, Carolien C H M Maas, Ali Alshangi, M H Elise van Driel, Eline A Feitsma, Caroline M J van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P Peeters, Tessa M van Ginhoven","doi":"10.1111/coa.70039","DOIUrl":"https://doi.org/10.1111/coa.70039","url":null,"abstract":"Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84-0.92) with moderately calibrated predictions.Conclusions: The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphenopalatine Artery Ligation for Refractory Epistaxis in Children With Coagulopathies: A Retrospective Case Series. 蝶腭动脉结扎治疗凝血障碍患儿难治性鼻出血：回顾性病例系列。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-30 DOI: 10.1111/coa.70037

Sophie Wilkinson, Haytham Kubba

引用次数: 0

Prevalence and Associated Factors of Olfactory and Gustatory Loss in Patients With Nasal Septal Deviation. 鼻中隔偏曲患者嗅觉和味觉丧失的患病率及相关因素。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-30 DOI: 10.1111/coa.70042

Ja-Yoon Kim, Hyung-Ju Cho, Chang-Hoon Kim, Min-Seok Rha

{"title":"Prevalence and Associated Factors of Olfactory and Gustatory Loss in Patients With Nasal Septal Deviation.","authors":"Ja-Yoon Kim, Hyung-Ju Cho, Chang-Hoon Kim, Min-Seok Rha","doi":"10.1111/coa.70042","DOIUrl":"https://doi.org/10.1111/coa.70042","url":null,"abstract":"Objectives: This study aimed to evaluate the olfactory and gustatory functions of patients with nasal septal deviation (NSD) and identify the factors associated with olfactory loss (OL) and gustatory loss (GL).Design and setting: Retrospective data analysis of cohort group.Participants: Two-hundred fourteen adult patients with NSD at a tertiary hospital.Main outcome measures: Olfactory and gustatory functions were assessed using the psychophysical olfactory and gustatory function tests. The association of various demographic and clinical factors, including age, sex, NSD type, allergic sensitization status, presence of concha bullosa (CB), total serum immunoglobulin E (IgE) level, blood eosinophil count, and acoustic rhinometry parameters, with OL and GL was analysed.Results: Among the patients, 20.6% (44/214) and 16.4% (35/213) had OL and GL, respectively. Patients with CB showed a significantly lower threshold, discrimination, and identification (TDI) score than those without CB (p = 0.012). Conversely, the TDI score did not differ according to age group, sex, NSD type, or allergic sensitization status. Blood eosinophil count was inversely correlated with the TDI score (p = 0.003), whereas nasal cavity volume, minimal cross-sectional area, and serum IgE level were not correlated with the TDI score. In the multivariable analysis, the presence of CB (p = 0.029, odds ratio [OR] = 2.281) and a blood eosinophil count ≥ 190 (p = 0.030, OR = 2.155) were identified as significant factors associated with OL. No factors were significantly associated with GL.Conclusion: The presence of CB and a high blood eosinophil count are significant predictors of OL in patients with NSD.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of Plasma Biomarkers of Neurodegeneration in Obstructive Sleep Apnea-Related Mild Cognitive Impairment. 阻塞性睡眠呼吸暂停相关轻度认知障碍患者神经变性血浆生物标志物的研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-21 DOI: 10.1111/coa.70035

Lina Ma, Na Liu, Yani Feng, Simin Zhu, Yanuo Zhou, Xiaoxin Niu, Xi Chen, Yuqi Yuan, Yonglong Su, Yushan Xie, Yewen Shi, Xiaoyong Ren, Haiqin Liu

{"title":"Exploration of Plasma Biomarkers of Neurodegeneration in Obstructive Sleep Apnea-Related Mild Cognitive Impairment.","authors":"Lina Ma, Na Liu, Yani Feng, Simin Zhu, Yanuo Zhou, Xiaoxin Niu, Xi Chen, Yuqi Yuan, Yonglong Su, Yushan Xie, Yewen Shi, Xiaoyong Ren, Haiqin Liu","doi":"10.1111/coa.70035","DOIUrl":"https://doi.org/10.1111/coa.70035","url":null,"abstract":"Objectives: Obstructive sleep apnea (OSA) is currently viewed as a chronic, multisystem condition associated with an increased risk of cognitive impairment, especially mild cognitive impairment (MCI). As biomarkers of neurodegeneration, we evaluated whether neurofilament light (NfL), amyloid-β 42(Aβ-42) and amyloid-β 40 (Aβ-40) can be used to indicate MCI in OSA.Design: A cross-sectional study.Setting: Single-centre trial at tertiary medical institutions.Participants: A total of 153 newly diagnosed subjects with OSA.Main outcomes measures: All participants completed polysomnography, neuropsychological assessments, and plasma biomarkers of neurodegeneration detection, including NfL, Aβ-42 and Aβ-40.Results: Compared to the cognitively normal group, only the levels of plasma NfL were increased in the MCI group. The plasma NfL levels were associated with an increased risk of cognitive impairment in OSA patients after adjusting for age, gender, body mass index, and education year. Plasma NfL outperformed other biomarkers in differentiating MCI from normal cognition (area under the ROC curve [AUC] = 0.829). Plasma NfL, in combination with conventional factors (age, body mass index, smoking, alcohol consumption, diabetes mellitus, hypertension, history of snoring, history of apneic episodes and time ratio of SaO2 < 90%) yielded an AUC of 0.907 for differentiating between MCI and normal cognition.Conclusions: These findings indicate that the plasma NfL was increased in OSA patients with cognitive impairment. Furthermore, plasma NfL appears to be superior to plasma Aβ for identifying MCI in OSA and holds potential as an objective biomarker associated with MCI in these patients.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Safety and Efficacy of Pre-Incisional Peritonsillar Lornoxicam in Paediatric Post-Tonsillectomy Pain: A Prospective Double-Blind, Placebo-Controlled, Split-Body Clinical Study. 一项前瞻性双盲、安慰剂对照、分裂体临床研究：切前扁桃体周围氯诺昔康治疗小儿扁桃体切除术后疼痛的安全性和有效性。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-21 DOI: 10.1111/coa.70028

{"title":"RETRACTION: Safety and Efficacy of Pre-Incisional Peritonsillar Lornoxicam in Paediatric Post-Tonsillectomy Pain: A Prospective Double-Blind, Placebo-Controlled, Split-Body Clinical Study.","authors":"","doi":"10.1111/coa.70028","DOIUrl":"https://doi.org/10.1111/coa.70028","url":null,"abstract":"Retraction: H. S. Abdel-Ghaffar, H. G. Abdel-Azeem, and M. M. Roushdy, \"Safety and Efficacy of Pre-Incisional Peritonsillar Lornoxicam in Paediatric Post-Tonsillectomy Pain: A Prospective Double-Blind, Placebo-Controlled, Split-Body Clinical Study,\" Clinical Otolaryngology 40, no. 3 (2015): 219-226. https://doi.org/10.1111/coa.12351. The above article, published online on 17 November 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, James Tysome; and John Wiley & Sons Ltd. A third party reported that the graph in Figure 2 included erroneous error bars as well as an implausible range of pain scores. An analysis by the publisher confirmed that the error bars in Figure 2 appear to be manually inserted and that there are missing error bars for the VRS24 time-point. The authors responded to a request for the original data by the publisher, but they were unable to provide the original data within an acceptable time-frame. The authors further stated that the graphical inconsistencies in Figure 2 reflect formatting limitations at the time of figure preparation. A review by the editors found that the fundamental conclusions of the paper rely on the postoperative pain score data presented in Figure 2. Because the figure shows missing data and manually edited elements, the conclusions are considered unreliable. Therefore, the parties agree that the article must be retracted. The authors disagree with the retraction.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voice and Swallowing Outcomes After Early Laryngeal Cancer: A UK Based Multi-Centre Study. 早期喉癌后的声音和吞咽结果：基于英国的多中心研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-15 DOI: 10.1111/coa.70033

M Bhabra, D Sellstrom, C Robertson, S Rothrie, E Fahy, S H Woodman, D W Hamilton, J M Patterson

{"title":"Voice and Swallowing Outcomes After Early Laryngeal Cancer: A UK Based Multi-Centre Study.","authors":"M Bhabra, D Sellstrom, C Robertson, S Rothrie, E Fahy, S H Woodman, D W Hamilton, J M Patterson","doi":"10.1111/coa.70033","DOIUrl":"https://doi.org/10.1111/coa.70033","url":null,"abstract":"Background: Early laryngeal cancer is effectively treated with transoral laser microsurgery (TLM) or radiotherapy, both offering comparable oncological outcomes. The impact on voice and swallowing remains unclear.Objectives: To evaluate voice and swallowing outcomes following treatment with TLM or radiotherapy for early laryngeal cancer in a UK multi-centre prospective study.Methods: A total of 137 patients with T1 or T2 laryngeal cancer were recruited from five UK head and neck cancer centres. Patients received either TLM or radiotherapy (up to 55 Gy). Voice and swallowing function were assessed at baseline, 3 months and 6 months post-treatment using a multidimensional protocol: Voice Handicap Index (VHI-10), maximum phonation time (MPT), GRBAS perceptual voice scale, 100 mL timed water swallow test and Normalcy of Diet (NoD).Results: VHI scores improved significantly following radiotherapy at 3 months (MD 8.66, SD 11.46, 95% CI 5.5, 11.8, p < 0.001). MPT was also significantly longer in the radiotherapy group (MD 2.47, SD 6.2, 95% CI 0.7-4.2, p = 0.007). Perceptual voice ratings showed reduced hoarseness post-radiotherapy at 3 months (MD 0.71, SD 1.11, 95% CI 0.43, 0.98, p < 0.001). No significant differences were found between treatments for swallowing function or NoD, which remains stable up to 6 months.Conclusion: Radiotherapy is associated with better short-term voice outcomes compared to TLM. Swallowing function remains largely unaffected by treatment type. This study highlights the need to include functional outcomes in treatment decisions and is the first UK multicentre prospective study to use standardised, multidimensional assessments of early recovery following treatment for early laryngeal cancer.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study. 我们是否有任何环境或围产期因素可能导致儿童呼吸道疾病？意大利人口前瞻性研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-14 DOI: 10.1111/coa.70032

Cecilia Rosso, Federica Turati, Alberto Maria Saibene, Elvira Verduci, Giuseppe Banderali, Monica Ferraroni, Giovanni Felisati, Carlotta Pipolo

{"title":"Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study.","authors":"Cecilia Rosso, Federica Turati, Alberto Maria Saibene, Elvira Verduci, Giuseppe Banderali, Monica Ferraroni, Giovanni Felisati, Carlotta Pipolo","doi":"10.1111/coa.70032","DOIUrl":"https://doi.org/10.1111/coa.70032","url":null,"abstract":"Background: Paediatric airway diseases such as asthma, allergies, rhinitis, upper respiratory tract infections and acute otitis media are major health challenges for children globally. The prevalence of these conditions has been increasing, impacting children's quality of life, educational attainment and imposing a substantial economic burden.Objectives: This longitudinal prospective study investigated the prevalence rates and environmental links associated with paediatric airway diseases in the first 3 years of life in 241 newborns, with the goal of contributing to early detection, prevention and management strategies.Methods: Structured questionnaires were administered to parents at birth, 1 year and 3 years of age. Data on socioeconomic factors, pregnancy and delivery characteristics, parental smoking, breastfeeding, childcare attendance and children's health history were collected. Skin prick tests were conducted in year 3 to assess allergic sensitisation.Results: Two hundred seven patients completed three-year follow-up. Factors such as having siblings, exclusive breastfeeding and attending kindergarten were associated with increased risks of certain diseases at 1 and 3 years. Smoking exposure appeared protective against wheezing in the first year. Breastfeeding showed mixed results, with protective effects against URTIs at 1 year but a potential risk factor for asthma at 1 year. Kindergarten attendance was associated with increased risks of URTIs and AOM at 3 years but appeared protective against inhalant allergies.Conclusion: The study highlighted the complex interplay of various factors in the development of paediatric airway diseases. Further research is needed to refine our understanding of these factors and their impact on paediatric diseases.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0