Clinical Otolaryngology最新文献_第2页

SCORE 2 and SCORE 2-OP Risk Scales as Prognostic Factors After Sudden Idiopathic Hearing Loss. SCORE 2和SCORE 2- op风险量表作为突发性特发性听力损失的预后因素

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-11 DOI: 10.1111/coa.70034

Mehmet Ali Say, Fahri Çakan, Volkan Bilge Yiğit

{"title":"SCORE 2 and SCORE 2-OP Risk Scales as Prognostic Factors After Sudden Idiopathic Hearing Loss.","authors":"Mehmet Ali Say, Fahri Çakan, Volkan Bilge Yiğit","doi":"10.1111/coa.70034","DOIUrl":"https://doi.org/10.1111/coa.70034","url":null,"abstract":"Objectives: This study aimed to investigate whether the Systematic Coronary Risk Estimation 2 and Systematic Coronary Risk Estimation 2-Older Persons (SCORE 2 and SCORE 2-OP) cardiovascular disease (CVD) risk scales can be used as prognostic factor for sudden sensorineural hearing loss (SSHL).Design: Prospective observational study.Setting: Single-center study.Methods: The study included 62 patients diagnosed with SSHL. SCORE 2 and SCORE 2-OP risks were calculated using the data collected from each participant. Patients were categorised into Green (low-moderate) and Non-Green (Yellow and Red, containing high and very high) risk groups. Recovery was categorised based on changes in pure-tone average (PTA). Statistical analyses included Pearson's correlation, univariate and multivariate logistic regression and ROC curve analysis.Results: A significantly higher proportion of patients in the Complete Recovery group had a Green SCORE risk classification (63.6%) than in the non-complete recovery group (32.5%, p = 0.018). The Green SCORE classification and lower pre-treatment PTA levels were significantly associated with better recovery outcomes. In multivariate analysis, Green SCORE remained an independent predictor of complete recovery (OR = 4.052, 95% CI: 1.218-13.487, p = 0.023). ROC analysis revealed moderate discriminative ability (AUC = 0.656, p = 0.044; sensitivity, 63.6%; specificity, 67.5%), with a negative predictive value of 77.1%.Conclusion: The SCORE2 and SCORE2-OP cardiovascular risk scores, particularly the Green risk category, are valuable predictors of hearing recovery in SSHL. This finding has the potential to serve as a guide for clinicians, informing the adaptation of treatment intensity or the investigation of adjunctive therapies within populations characterised by elevated risk.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Radiomics to Predict Disease Recurrence in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. 放射组学预测鼻窦鳞状细胞癌复发的作用：一项系统综述和荟萃分析。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-05 DOI: 10.1111/coa.70031

Caitlin Waters, Tamzin Hall, Hugo C Temperley, Holly Jones, Niall J O'Sullivan, Alison McHugh, Fariba Tohidinezhad, Thavakumar Subramaniam

{"title":"Role of Radiomics to Predict Disease Recurrence in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Caitlin Waters, Tamzin Hall, Hugo C Temperley, Holly Jones, Niall J O'Sullivan, Alison McHugh, Fariba Tohidinezhad, Thavakumar Subramaniam","doi":"10.1111/coa.70031","DOIUrl":"https://doi.org/10.1111/coa.70031","url":null,"abstract":"Introduction: Radiomics offers the potential to predict oncological outcomes from pre-operative imaging, aiding in the identification of 'high risk' patients with sinonasal cancer who are at an increased risk of recurrence. This study aims to comprehensively review the current literature on the role of radiomics as a predictor of disease recurrence in sinonasal squamous cell carcinoma.Methods: A systematic search was conducted in Medline, EMBASE and Web of Science databases. Retrospective and prospective studies examining the use of radiomics to predict post-operative recurrence in sinonasal cancer that met the inclusion criteria were included. Study quality was assessed using the QUADAS-2 and Radiomics Quality Score (RQS) tools.Results: Five studies met the inclusion criteria, encompassing 638 participants. All studies were single-centre and utilised MRI-based radiomics in the construction of their models. Radiomic models demonstrated excellent predictive performance. The median AUC, sensitivity and specificity were 0.947, 0.86 and 0.923 in the training set, and 0.914, 0.833 and 0.878 in the validation set. A pooled meta-analysis estimated the combined AUC across training sets as 0.931 (95% CI, 0.898-0.963) and 0.922 (95% CI, 0.880-0.964) for validation sets.Conclusion: Our systematic review provides evidence supporting the role of radiomics in predicting post-operative disease recurrence in sinonasal cancer. Radiomics shows promise in enhancing personalised treatment strategies by improving prognostic accuracy. However, further research is needed to standardise methodologies and validate these findings in larger, multicentre cohorts.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal Bitter Taste Testing for Chronic Rhinosinusitis: A Pilot Proof-of-Concept Study. 慢性鼻窦炎的鼻苦味测试：一项试点概念验证研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-03 DOI: 10.1111/coa.70026

Shankar Ramasundram, Ramiza Ramza Ramli, Norasnieda Md Shukri, Sakinah Mohamad, Sivakumar Kumarasamy

{"title":"Nasal Bitter Taste Testing for Chronic Rhinosinusitis: A Pilot Proof-of-Concept Study.","authors":"Shankar Ramasundram, Ramiza Ramza Ramli, Norasnieda Md Shukri, Sakinah Mohamad, Sivakumar Kumarasamy","doi":"10.1111/coa.70026","DOIUrl":"10.1111/coa.70026","url":null,"abstract":"Objectives: The expression and functionality of bitter taste receptors (T2Rs) in the sinonasal mucosa have been linked to variations in chronic rhinosinusitis (CRS) severity and susceptibility, suggesting a potential therapeutic target for managing this chronic condition. This study is an initial proof-of-concept study to explore the potential of nasal bitter taste testing as a screening tool for CRS, aiming at developing a screening method to detect the bitter taste receptor in the nose and its sensitivity between healthy individuals and those with CRS using available bitter ligands; therefore, coming up with a suitable titration of this ligand for future use.Methods: A cross-sectional study of 84 adults (42 with CRS and 42 healthy controls) evaluated nasal glucose levels and phenylthiocarbamide (PTC) taste sensitivity. Colorimetric and statistical tests were used to analyse PTC threshold values and nasal glucose levels.Results: Based on 0.13% as the most suitable dilution for intranasal testing of PTC, there is an association between nasal bitter taste testing among CRS and control groups with a p value of < 0.001.Conclusions: The bitter taste testing on the nose seems to be a simple and inexpensive way for screening patients with CRS. The titration and intranasal sites suggested in this study can be used as a basis for further prospective studies to view the outcome of patients with CRS. Targeting these receptors in diagnostics could open a new window of opportunity in the management of patients with CRS.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative Albumin-To-Globulin Ratio, Not Neutrophil-To-Lymphocyte Ratio, Predicts Overall Survival After Total Laryngectomy. 术前白蛋白与球蛋白比值，而非中性粒细胞与淋巴细胞比值，预测全喉切除术后的总生存率。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-09-01 DOI: 10.1111/coa.70030

Noa Talmor, Tzahi Yamin, Tomer Kerman, Yarden Tenenbaum Weiss, Keren Oren, Oren Ziv, Oded Cohen

{"title":"Preoperative Albumin-To-Globulin Ratio, Not Neutrophil-To-Lymphocyte Ratio, Predicts Overall Survival After Total Laryngectomy.","authors":"Noa Talmor, Tzahi Yamin, Tomer Kerman, Yarden Tenenbaum Weiss, Keren Oren, Oren Ziv, Oded Cohen","doi":"10.1111/coa.70030","DOIUrl":"https://doi.org/10.1111/coa.70030","url":null,"abstract":"Objective: To evaluate the prognostic significance of preoperative inflammatory markers including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and albumin-to-globulin ratio (AGR) in patients with laryngeal squamous cell carcinoma (LSCC) undergoing total laryngectomy (TL).Methods: Patients were stratified by preoperative inflammatory markers: NLR > 3, PLR > 109.54, and AGR < 1.29; values were obtained from blood tests within 6 months prior to surgery. The primary outcome was overall survival (OS). Secondary outcomes included postoperative complications, emergency department (ED) visits, and length of hospitalisation. Multivariable analyses adjusted for age, sex, comorbidity burden, socioeconomic status, and prior radiation exposure.Results: A total of 616 patients included (mean age 67 years; 85% male). Low AGR was significantly associated with longer hospital stays, higher ED visit rates at 3, 6, and 12 months (p < 0.001), and reduced 1, 2, and 5-year survival (p = 0.01, 0.02, 0.003). NLR > 3 predicted longer hospitalisation (p = 0.019) and more frequent ED visits (p < 0.01), and PLR > 109.54 was associated with increased ED visits and lower 5-year survival. In multivariable models, only AGR < 1.29 remained a strong independent predictor of ED visits and mortality. Stratified analysis showed that this association persisted in patients without prior radiation (HR: 3.32; p = 0.002), but not in those who underwent salvage TL.Conclusion: Low preoperative albumin-to-globulin ratio (AGR) is an independent predictor of reduced OS in patients undergoing TL for LSCC. Incorporating AGR into preoperative risk assessment may help identify high-risk patients and inform clinical decision-making.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Patient Frailty on Morbidity, Mortality and Overall Survival Following Laryngectomy Procedures. 患者虚弱对喉切除术后发病率、死亡率和总生存率的影响。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-28 DOI: 10.1111/coa.70029

Eoin F Cleere, Justin M Hintze, David Brinkman, James P O'Neill, Conrad V I Timon, John Kinsella, Paul Lennon, Conall W R Fitzgerald

{"title":"The Effect of Patient Frailty on Morbidity, Mortality and Overall Survival Following Laryngectomy Procedures.","authors":"Eoin F Cleere, Justin M Hintze, David Brinkman, James P O'Neill, Conrad V I Timon, John Kinsella, Paul Lennon, Conall W R Fitzgerald","doi":"10.1111/coa.70029","DOIUrl":"https://doi.org/10.1111/coa.70029","url":null,"abstract":"Background: The present study evaluated the impact of frailty on patient morbidity and survival following laryngectomy surgery.Methods: A retrospective cohort study of patients undergoing laryngectomy over a 10-year period. Frailty was measured using the 5-item modified Frailty Index (5mFI).Results: A total of 233 patients (mean [SD] age, 63.7 [±10.0] years) were included. Eighty-two (35.2%) patients were frail and frail patients had a greater mean age (66.3 vs. 62.2 years, p = 0.006). On multivariable regression, frail patients were more likely to: develop pharyngocutaneous fistula (OR 2.62, 95% CI 1.33-5.18, p = 0.006), have a longer hospital stay (β 25.53 days, 95% CI 14.64-36.41, p < 0.001) and be discharged to a non-home setting (OR 5.31, 95% CI 2.49-11.35, p < 0.001). In case-matched patients, 3-year overall survival (OS) was similar in frail and not frail patients (p = 0.715).Conclusions: Use of the 5mFI pre-laryngectomy may identify patients requiring increased support to optimise their peri-operative risk.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cone-Beam Computed Tomography for Identifying Levels of Obstruction in Obstructive Sleep Apnea: Prospective Cohort Study. 锥束计算机断层扫描识别阻塞性睡眠呼吸暂停的阻塞程度：前瞻性队列研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-27 DOI: 10.1111/coa.70025

Roee Noy, Roni Barzilai, Yona Vaisbuch, Jacob T Cohen, Marc Boukhris

引用次数: 0

Comparison of Sensory Organisation Test Results in Patients With Ménière's Disease and Vestibular Migraine: A Retrospective, Cross-Sectional Study in a Chinese Cohort. 一项中国队列回顾性横断面研究：msamni<e:1>病和前庭偏头痛患者感觉组织测试结果的比较

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-27 DOI: 10.1111/coa.70027

Yangming Leng, Yingzhao Liu, Renhong Zhou, Bo Liu

{"title":"Comparison of Sensory Organisation Test Results in Patients With Ménière's Disease and Vestibular Migraine: A Retrospective, Cross-Sectional Study in a Chinese Cohort.","authors":"Yangming Leng, Yingzhao Liu, Renhong Zhou, Bo Liu","doi":"10.1111/coa.70027","DOIUrl":"https://doi.org/10.1111/coa.70027","url":null,"abstract":"Objectives: We aimed to characterise the sensory organisation test (SOT) performance and compare the posturographic difference between patients with Ménière's disease (MD) and those with vestibular migraine (VM) in the Chinese population.Design: This cross-sectional comparative study was conducted in accordance with the STROBE guidelines.Setting: Tertiary medical centre.Participants: Seventy-one patients with unilateral definite MD, 57 patients with definite VM, and 58 controls.Main outcome measure: Audiometry, caloric test and SOT were conducted. The balance-related variables included: equilibrium score (ES) in each SOT condition, composite ES and sensory ratios (SOM, VIS, VEST and PREF).Results: Composite ES and ESs in SOT 5 and 6 were dramatically lower in MD patients than in VM counterparts. For the sensory ratio, the abnormal rate was highest for VIS ratio (31.6%), followed by VEST (19.3%) and PREF ratio (1.8%) in VM patients. In MD patients, the abnormal rate was highest for VEST ratio (42.3%), followed by VIS (32.4%) and PREF ratio (12.7%). Ménière's stage was negatively correlated with ES in SOT 5, composite ES and VEST ratio. In the VM group, ESs (composite and in SOT 1-6) and sensory ratios were not correlated with gender, age or caloric results. Compared with VM patients, MD patients were more likely to have lower or abnormal VEST ratio.Conclusion: Despite similar clinical manifestations, MD and VM display distinct patterns of balance impairment demonstrated by SOT, which may be associated with different underlying pathophysiological mechanisms. Future study with disease subtyping and phase stratification using comprehensive vestibular tests is warranted.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Ipsilateral Nasoseptal Flap in Spontaneous Lateral Recess of Sphenoid Meningoencephalocele Repair by Transpterygoid Approach: A Retrospective Cohort Study. 同侧鼻中隔皮瓣在经蝶窦入路修复蝶骨脑膜膨出自发性外侧隐窝中的作用：一项回顾性队列研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-23 DOI: 10.1111/coa.70023

Ashwin Gajendran Vedhapoodi, Saravana Selvan Velmurugan, Marimangalam Premchandrababu Chandramouli, Sengottuvelu Palanisamy, Saujanya Saravanakumar

引用次数: 0

A Prospective Pilot Study of the Efficacy of Oral Propranolol in Reduction of the Frequency and Severity of Epistaxis in Hereditary Haemorrhagic Telangiectasia. 口服心得安降低遗传性出血性毛细血管扩张患者出血频率和严重程度的前瞻性先导研究。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-23 DOI: 10.1111/coa.70017

C Grigg, A Walker, A Cervin, K Girling, Z Liu, J Earnshaw

引用次数: 0

Examining the Impact of Race, Ethnicity, and Language on Pursuit of Cochlear Implantation. 考察种族、民族和语言对人工耳蜗植入的影响。

IF 1.5 4区医学

Clinical Otolaryngology Pub Date : 2025-08-20 DOI: 10.1111/coa.70020

Aneesh A Patel, Jessica R Levi, Peter C Weber

{"title":"Examining the Impact of Race, Ethnicity, and Language on Pursuit of Cochlear Implantation.","authors":"Aneesh A Patel, Jessica R Levi, Peter C Weber","doi":"10.1111/coa.70020","DOIUrl":"10.1111/coa.70020","url":null,"abstract":"Introduction: It is unclear whether primary language impacts decision to pursue cochlear implantation (CI) and which factors seen in White patients may account for higher odds of implantation. The aim of this study was to further define factors that contribute to decision to pursue or decline cochlear implantation.Methods: Retrospective chart review of patients older than 18 years who underwent cochlear implant evaluation (CPT 92626/92627), from January 1, 2017 to October 31, 2023 and were determined to be cochlear implantation candidates was completed. Those who pursued CI were compared to those who did not, in addition to White and non-White patients. T-testing, Chi-square analysis, and multivariate analysis were used to compare the groups.Results: From January 1, 2017 to October 31, 2023, a total of 93 patients met inclusion criteria, of which 46 (49.5%) underwent CI. White candidates had 4.33 the odds of pursuing cochlear implantation compared to those who were not White (95% CI: 1.15, 1.86; p = 0.04). White candidates and those who did not need interpreters were noted to have significantly higher preoperative scores for bilateral (p < 0.0001) and unilateral AZBio in quiet (p < 0.0001), unilateral Consonant-Nucleus-Consonant (CNC) words, and unilateral CNC phonemes (p < 0.0001) compared to non-White candidates.Conclusion: White patients had significantly higher odds of pursuing cochlear implantation compared to non-White patients. White patients were noted to have significantly higher preoperative AzBio in quiet and CNC word/phoneme scores compared to non-White patients.","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0