Clinical Otolaryngology最新文献

{"title":"Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial.","authors":"Constanze Scholman, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat","doi":"10.1111/coa.14293","DOIUrl":"https://doi.org/10.1111/coa.14293","url":null,"abstract":"<p><strong>Objectives: </strong>Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).</p><p><strong>Design: </strong>Prospective randomised controlled trial.</p><p><strong>Setting: </strong>Tertiary head and neck oncologic center.</p><p><strong>Participants: </strong>257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.</p><p><strong>Main outcome measures: </strong>Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.</p><p><strong>Results: </strong>Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).</p><p><strong>Conclusions: </strong>Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.</p><p><strong>Trial registration: </strong>This randomised clinical trial was registered at the research register UMCG with the number 201500918.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Photobiomodulation Treatment With the TINI Laser Device for Managing Chronic High-Frequency Tinnitus: A Randomised Controlled Trial.","authors":"Ji Eun Choi, Min Young Lee, Jae Yun Jung","doi":"10.1111/coa.14291","DOIUrl":"https://doi.org/10.1111/coa.14291","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the efficacy of the TINI laser device, a photobiomodulation (PBM) therapy, for managing chronic high-frequency tinnitus in patients with unilateral or bilateral tinnitus.</p><p><strong>Methods: </strong>A randomised, single-blind, placebo-controlled clinical trial was conducted with 38 participants. Subjects were divided into three groups: The TINI 1 group received eight active laser treatments over 4 weeks, the TINI 2 group received four active treatments followed by four sham treatments, and the control group received only sham treatments. The Tinnitus Handicap Inventory (THI), Tinnitus Functional Index (TFI) and Tinnitus Magnitude Index (TMI) were used to assess tinnitus-related outcomes. Psychological assessments were also conducted to measure levels of depression, stress and anxiety.</p><p><strong>Results: </strong>Significant improvements were observed in the emotional subscale of the THI, and in the loudness and perception scores of the TMI in the TINI 1 group. The TINI 2 group showed significant reductions in TFI and TMI scores following active treatments, although these effects diminished after sham treatments. No placebo effects were observed except for TFI scores in the control group.</p><p><strong>Conclusion: </strong>The study indicates that intermittent PBM therapy using the TINI laser may be effective in managing chronic tinnitus. Further research is necessary to explore long-term efficacy and safety.</p><p><strong>Trial registration: </strong>cris.nih.go.kr identifier: PRE20240926-004.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Surgical Treatment for Tracheocutaneous Fistula in Paediatric Population: A Meta-Analysis.","authors":"Jeyasakthy Saniasiaya, Graeme van der Meer, Ed Toll, Craig McCaffer, Colin Barber, Michel Neeff, Md Asiful Islam","doi":"10.1111/coa.14292","DOIUrl":"https://doi.org/10.1111/coa.14292","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of persistent tracheocutaneous fistula (TCF) in children has dramatically increased with the increasing number of tracheostomies performed earlier in the paediatric population. Despite the various emerging techniques, two fundamental surgical approaches are primary closure and healing by secondary intention. We aim to compare the surgical outcomes between the two procedures.</p><p><strong>Data source: </strong>PubMed, EMBASE and Scopus databases were searched from inception to 31 December 2023 with no restrictions on the setting or design of studies.</p><p><strong>Review methods: </strong>Data were pooled using a random effects model to assess the success and complication rates between the two surgical techniques.</p><p><strong>Results: </strong>A total of 26 studies were identified with a total of 1263 children. Persistent TCF was surgically treated with primary closure in 24 studies (n = 898), whereas healing by secondary intention was reported in 12 studies (n = 366). The success rate following primary closure and healing by secondary intention is 97.3% (95% CI: 95.7%-99.0%) and 94.0% (95% CI: 91.2%-96.7%), respectively. The pooled rate of complications following primary closure was 14.1% (95% CI: 8.9%-19.4%) and 8.4% (95% CI: 3.4%-13.3%) following healing by secondary intention.</p><p><strong>Conclusion: </strong>Based on the pooled results, healing by secondary intention is a safer surgical option in children with persistent TCF.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Association Found Between Uric Acid Levels and Peripheral Vertigo Disorders: Results From a Two-Sample Mendelian Randomization Study.","authors":"Shihan Liu, Yiyi Lin, Lingli Zhang, Wenlong Luo","doi":"10.1111/coa.14288","DOIUrl":"https://doi.org/10.1111/coa.14288","url":null,"abstract":"<p><strong>Background: </strong>The association between serum uric acid levels and peripheral vertigo diseases, namely Benign Paroxysmal Positional Vertigo (BPPV), Meniere's Disease (MD), and Vestibular Neuritis (VN), remains a subject of controversy. This study utilises the Mendelian Randomization (MR) approach to investigate the potential link between uric acid levels and these peripheral vertigo diseases, with the goal of informing preventative measures and early intervention strategies.</p><p><strong>Methods: </strong>Datasets pertaining to uric acid levels (sample size = 343 836) and BPPV (ncase = 3834, ncontrol = 209 582), MD (ncase = 1511, ncontrol = 209 582), and VN (ncase = 1224, ncontrol = 209 582) were selected from Genome-Wide Association Studies (GWAS). Two-sample MR was employed to analyse the correlation between the exposure (uric acid levels) and outcomes (BPPV, MD, VN). The MR analysis methods encompassed Inverse Variance Weighting (IVW), MR-Egger, Simple Mode, Weighted Mode, and Weighted Median methods. The results derived from the IVW analysis were considered as the primary analytical outcomes.</p><p><strong>Result: </strong>The findings indicated no significant correlation between uric acid levels and BPPV (IVW: OR = 1.152, 95% CI: 0.971-1.367, p = 0.103), MD (IVW: OR = 1.010, 95% CI: 0.757-1.348, p = 0.943), and VN (IVW: OR = 1.005, 95% CI: 0.744-1.358, p = 0.969).</p><p><strong>Conclusion: </strong>This study employed a two-sample Mendelian randomization approach to conduct an in-depth analysis of the relationship between serum uric acid levels and peripheral vestibular diseases (BPPV, MD, and VN). Our findings indicate that no significant association was found between serum uric acid levels and these diseases. The results of the study do not support the hypothesis that uric acid is an independent risk factor for these conditions.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilising Free Middle Turbinate Mucosal Grafts to Reconstruct the Septal Donor Site Following Nasoseptal Flap Harvesting in Endoscopic Endonasal Approach for Sellar and Parasellar Lesions.","authors":"Chin-Hsuan Liu, Tsai Shan Lin, Yu-Wen Huang, Chien-Fu Yeh, Li-Ting Hung, Ming-Ying Lan, Wei-Hsin Wang","doi":"10.1111/coa.14287","DOIUrl":"https://doi.org/10.1111/coa.14287","url":null,"abstract":"<p><strong>Introduction: </strong>The nasoseptal flap (NSF) has become a widely favoured choice for reconstructing skull base defects following the endoscopic endonasal approach (EEA). However, the exposed septal cartilage and bone at the donor site often require an extended duration for secondary healing. This study investigated whether the free middle turbinate (MT) mucosa grafting at the septal donor site could mitigate post-operative nasal morbidity.</p><p><strong>Methods: </strong>We retrospectively reviewed patients with sellar and parasellar lesions who underwent NSF harvesting in EEA between 2015 and 2023. In most cases, the MT mucosa was harvested as a free mucosal graft and placed on the exposed nasal septal donor site. The degree of septal mucosalisation and the presence of nasal crusting were assessed during follow-up appointments.</p><p><strong>Results: </strong>A total of 104 patients were included in this study, comprising 41 males and 63 females. All patients underwent NSF harvesting for skull base defect reconstruction and 99 patients received MT mucosa grafting at the septal donor site. The average duration for complete mucosalisation of the exposed septal cartilage with the MT graft was 38.7 days, significantly different from 59.6 days for patients without the MT graft (p < 0.0001). At the 3-month post-operative follow-up, 34% of the patients with MT graft displayed no crusting compared to 20% of patients without MT graft.</p><p><strong>Conclusions: </strong>The use of free MT mucosal grafting represents a promising technique for improving mucosalization and minimising crusting at the nasal septal donor site following the harvest of the NSF in EEA for sellar and parasellar lesions.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Final Bow? Increased Mortality in Elderly Patients With Acute Bacterial Parotitis: A Retrospective Observational Study.","authors":"Sara Lim, Niall Woodley, Raees Vanker, Richard Townsley","doi":"10.1111/coa.14289","DOIUrl":"https://doi.org/10.1111/coa.14289","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Induced Sleep Endoscopy-Directed Tongue Surgery to Treat Persistent Pediatric Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.","authors":"R Kenneth Sims, Alexander Leeds, Grace Johnson, Anna Davide, Macario Camacho","doi":"10.1111/coa.14283","DOIUrl":"https://doi.org/10.1111/coa.14283","url":null,"abstract":"<p><strong>Objective: </strong>To systematically review the literature for articles evaluating outcomes of drug-induced sleep endoscopy (DISE) directed tongue surgery in children with prior adenotonsillectomy and persistent or recurrent obstructive sleep apnea (OSA), and to perform a meta-analysis on the polysomnographic (PSG) data.</p><p><strong>Design: </strong>Systematic review and metanalysis in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement guidelines.</p><p><strong>Outcome measures: </strong>Primary, post-operative apnea-hypopnea index (AHI) and lowest oxygen saturation (LSAT); Secondary, surgical response rate.</p><p><strong>Results: </strong>Seven studies (283 patients) met criteria and reported PSG outcome data for the systematic review. The mean ± standard deviation surgical response rate was 70.0% ± 17.0% [95% CI 67.6, 71.6]. Six of the seven studies (270 patients) reported specific pre- and post-operative PSG data included in our meta-analysis. The pre- and post-operative AHI decreased from 9.5 ± 12.1 to 4.2 ± 6.9 events/h (p < 0.04) with a mean difference (MD) of -5.13 [95% CI -7.13, -3.13], Z-score 5.02 (p < 0.00001). LSAT improved from 87.8 ± 5.7 to 90.1% ± 5.1% (p < 0.02) with a MD of 2.71 [95% CI 1.53, 3.89], Z-score 4.51 (p < 0.0001).</p><p><strong>Conclusion: </strong>Existing literature demonstrates DISE-directed tongue surgery in children with persistent OSA can reduce AHI by approximately 50%, improve LSAT by nearly 3%, and have an overall positive response to surgery rate of 70%. There is collective evidence that DISE-directed tongue surgery is effective; limitations include heterogeneity in reported outcomes influenced by confounding factors.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropharyngeal Squamous Cell Carcinoma in the West of Scotland: A Retrospective Analysis of 1001 Patients From 2012 to 2020.","authors":"Matthew Donachie, Jan Horackiewicz, Nichola Philp, Mohd Afiq Mohd Slim, Rhona Hurley, Catriona Douglas","doi":"10.1111/coa.14282","DOIUrl":"https://doi.org/10.1111/coa.14282","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay of Weight Status and Sleep Autonomic Function in Mediating and Moderating the Link Between Disease Severity and Blood Pressure in Paediatric Obstructive Sleep Apnoea.","authors":"Yuan Chao, Hai-Hua Chuang, Wan-Ni Lin, Li-Jen Hsin, Tuan-Jen Fang, Hsueh-Yu Li, Chung-Guei Huang, Li-Ang Lee","doi":"10.1111/coa.14286","DOIUrl":"https://doi.org/10.1111/coa.14286","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnoea (OSA) in children is associated with numerous adverse outcomes, including elevated blood pressure. While the associations between OSA, obesity, and autonomic dysfunction are recognised, the precise mechanisms linking these factors and their relationship with elevated blood pressure in children remain unclear.</p><p><strong>Methods: </strong>This retrospective case series included 76 children with OSA. The relationships between night-time systolic and diastolic blood pressures, body mass index, and clinical, polysomnographic, and sleep heart rate variability variables were investigated. Mediation and moderation analyses were performed.</p><p><strong>Results: </strong>Correlation analyses revealed significant associations between both systolic and diastolic blood pressures with body mass index, age, sex, adenoidal-nasopharyngeal ratio, apnoea-hypopnoea index, and sleep low frequency/high frequency (LF/HF) ratio. In multivariable linear regression models, body mass index, adenoidal-nasopharyngeal ratio, and LF/HF ratio were independently associated with systolic blood pressure, while body mass index and adenoidal-nasopharyngeal ratio were independently associated with diastolic blood pressure. Mediation and moderation analyses identified a conceptual mediation with a moderated direct path model in which body mass index mediated, and the LF/HF ratio moderated, the relationship between apnoea-hypopnoea index and systolic blood pressure. Additionally, children with concomitant OSA and attention deficit hyperactivity disorder had a significantly higher LF/HF ratio than those with OSA alone.</p><p><strong>Conclusion: </strong>In children with OSA, the relationship between apnoea-hypopnoea index and systolic blood pressure was mediated by weight status and modulated by sleep sympathovagal balance. Children with OSA and attention deficit hyperactivity disorder exhibited greater disturbances in sympathovagal balance. Further research is warranted to explore these associations.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Retraction in Otolaryngology Journals: A Thirty Year Analysis.","authors":"Albina S Islam, Elizabeth M Mastoloni, John E Fenton, Daniel H Coelho","doi":"10.1111/coa.14285","DOIUrl":"https://doi.org/10.1111/coa.14285","url":null,"abstract":"<p><strong>Objectives: </strong>To gain insight into the integrity of research in Otolaryngology-Head & Neck Surgery (OHNS) literature through characterising retracted articles, analysing the reason for their retraction, and the trends in the collected data.</p><p><strong>Methods: </strong>Pubmed, Embase, and Retraction Watch Database were queried for retracted articles published between the dates of 1/31/92 and 9/30/22. Articles with titles relating to OHNS subjects and published in OHNS journals, as determined by Scimago Journal and Country Ranking, were selected for further analysis. Variables recorded included journal name, journal impact factor, article type, article subspecialty subject, reason for retraction, whether re-published, number of authors, time to retraction, and article citations.</p><p><strong>Results: </strong>Based on title and article content, 245 articles related to the field of OHNS were identified, of which 68 were published in OHNS journals and analysed for reason of retraction. Of those, 16 (23.5%) were replaced due to erratum concerns (spelling, formatting, etc.) rather than content or data-related issues and were excluded. Among the 52 (76.5%) permanent retractions the most common reasons for retraction include article duplication (n = 26), concerns/issues/errors with data (n = 7), and plagiarism (n = 5). The median time between publication and retraction was 2 years (range, 0-19). The median impact factor was 1.64 (range, 0.08-4.68). The median number of citations per article was 7 (range, 0-86).</p><p><strong>Conclusion: </strong>Retractions continue to occur in the field of OHNS despite increasing education in ethical publication standards and safeguards. There are, however, improved time intervals to retraction indicating improved surveillance of published articles.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}