Clinical Otolaryngology最新文献

{"title":"Optimising Early Intervention: A Retrospective Study on the Role of Hyperbaric Oxygen Therapy in Enhancing Hearing Recovery for Sudden Sensorineural Hearing Loss.","authors":"Bang-Yan Zhang, Tzong-Yun Tsai, Kai-Chieh Chan","doi":"10.1111/coa.70004","DOIUrl":"https://doi.org/10.1111/coa.70004","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy of hyperbaric oxygen therapy (HBOT) as an adjunct to corticosteroids in the treatment of sudden sensorineural hearing loss (SSNHL) and to determine the optimal timing for HBOT initiation, considering the severity of initial hearing loss.</p><p><strong>Methods: </strong>A retrospective review was conducted on 128 patients diagnosed with unilateral SSNHL who received corticosteroids and HBOT. The inclusion criteria were the initiation of steroid treatment within 14 days and HBOT within 30 days of SSNHL onset, with at least five HBOT sessions completed. Audiometric evaluations were performed pre- and post-treatment to assess hearing gains. Statistical analyses, including logistic regression and ROC curves, were utilised to identify factors influencing hearing recovery.</p><p><strong>Results: </strong>The results showed that 72.7% of patients experienced significant hearing improvement. Early initiation of HBOT within 12.5 days of onset was associated with better hearing outcomes. Multivariate analysis and sensitivity testing further confirmed that HBOT timing was the most robust predictor of hearing gain, independent of baseline hearing severity.</p><p><strong>Conclusion: </strong>Early HBOT initiation, particularly within 12.5 days, enhances hearing recovery in SSNHL patients. These findings support the use of HBOT as a valuable adjunctive treatment and underscore the need for standardised protocols in future studies.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Microvascular Free Flap Reconstruction With One Versus Two Primary Surgeons.","authors":"Jamison Macke, Tuleen Sawaf, Natalie Schelbar, Bryan Renslo, Heather Schopper, Kevin J Sykes, Andres Bur, Justin Bond, Yelizaveta Shnayder, Terance T Tsue, Douglas Girod, Kiran Kakarala","doi":"10.1111/coa.70006","DOIUrl":"https://doi.org/10.1111/coa.70006","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate operative efficiency and quality in head and neck free flap reconstruction with one versus two primary surgeons by comparing procedure duration, hospital length of stay, complications and readmission rates.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Single-institution tertiary care centre.</p><p><strong>Methods: </strong>A total of 583 patients who received head and neck surgery with free flap reconstruction at the University of Kansas Medical Center between November 2010 and January 2021 were stratified into two cohorts: one-surgeon cohort and two-surgeon cohort. In the two-surgeon cohort, one surgeon performed tissue resection and the second performed reconstruction (n = 329), whereas one primary surgeon performed both resection and reconstruction in the one-surgeon cohort (n = 254). Patient age, sex, American Society of Anaesthesia (ASA) status and Charlson comorbidity index (CCI) at time of surgery were collected.</p><p><strong>Results: </strong>No significant difference in baseline clinicodemographic characteristics was found between groups. A reduced mean procedure duration was found in the one-surgeon cohort (424.9 min, SD 127.6) compared to the two-surgeon cohort (552.4 min, SD 119.2) (mean difference 127.5 min, Cohen d = 1.04). A slightly greater proportion of osteocutaneous free flaps was performed in the two-surgeon cohort compared to the one-surgeon cohort (one-surgeon: 53.5%; two-surgeon 62.3%). All other secondary quality measures showed nonsignificant differences with the exception of the proportion requiring intraoperative pressors (86.2% in one-surgeon cohort vs. 74.5% in two-surgeon cohort, mean difference 11.7%, Cohen d = 0.29).</p><p><strong>Conclusions: </strong>This study demonstrates at least noninferior efficiency and quality outcomes in free flap cases led by single primary surgeons at our institution. The optimal approach to maximise operative efficiency and quality likely differs across surgeons and centres.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in the Study of Electrode Migration Following Cochlear Implantation: Insights and Recommendations.","authors":"Tuochen Lv, Jie Wang","doi":"10.1111/coa.70007","DOIUrl":"https://doi.org/10.1111/coa.70007","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Utility of the Preoperative Systemic Immune-Inflammatory Index in Chronic Rhinosinusitis.","authors":"Abdullah A Memon, David M Poetker, Jazzmyne Adams, David R Friedland, Lauren M North","doi":"10.1111/coa.70001","DOIUrl":"https://doi.org/10.1111/coa.70001","url":null,"abstract":"<p><strong>Background: </strong>CRS is a multifactorial pathology associated with inflammatory comorbidities including asthma, allergic rhinitis (AR) and nasal polyposis (NP). The systemic immune-inflammatory index (SII) has been shown to have prognostic efficacy in gauging systemic inflammation.</p><p><strong>Objective: </strong>To evaluate the potential utility of the SII in assessing the extent of surgery and CRS-mediated comorbidities in patients undergoing ESS.</p><p><strong>Methods: </strong>13-year retrospective study of 147 adults undergoing ESS with preoperative platelet, neutrophil and lymphocyte counts for SII calculation ((platelets × neutrophils)/lymphocytes). Lund-Mackay scores, surgery extent and comorbidities were collected. For analyses, numeric versus categorical utilised a two-tailed t-test, categorical versus categorical utilised a Chi-square test of independence. Significance set at p < 0.05.</p><p><strong>Results: </strong>147 patients met criteria, 75 had CRS and 72 had other sinonasal conditions (exploratory control). Average SII for all patients was 1080.6 ± 1134.6 (range 0-8119, median 735). Significant differences in average SII existed between CRS and other sinonasal disorders (1479 ± 1186 vs. 1007 ± 1082, p = 0.013). No significant differences were found in Lund-McKay scores between CRS patients with SII above or below previously reported critical thresholds (i.e., SII > 330 or > 895.6). Significant inverse association was observed between comorbidities and SII in CRS patients; those with SII < 895.6 had statistically significant higher prevalence of asthma (p = 0.001) and AR (p = 0.0143). No association was found between SII and nasal polyps, or with number of sinuses opened during surgery.</p><p><strong>Conclusion: </strong>CRS patients requiring ESS had higher SII values than those with other indications. Contrary to previous reports, our study found that SII in CRS patients was inversely associated with asthma and AR, and was not associated with surgical extent.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Second PET-CT 1 Year After Treatment of Oropharyngeal Cancer Predicts Low Mortality and Recurrence.","authors":"Nir Livneh, Chen Weinstein Wexler, Gilad Feinmesser, Iris Granot, Eran Alon","doi":"10.1111/coa.70003","DOIUrl":"https://doi.org/10.1111/coa.70003","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prediction value of a second PET-CT imaging study performed 1 year after treatment for patients with oropharyngeal carcinoma.</p><p><strong>Methods: </strong>A Retrospective single-institution tertiary care centre study. Included are all patients diagnosed with oropharyngeal cancer between 2010 and 2020 at a tertiary medical centre. All 77 suitable patients completed at least two ET-CT scans during the post-treatment period, the first at 3 months and the second at 1 year. The follow-up extended to 5 years after treatment. The main outcome measures were overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>In total, 55 (65%) patients had no evidence of disease (NED) on the 1-year PET-CT. The negative predictive value of 1-year PET-CT was 91% for 4-year DFS and 100% for 4-year OS. Regression analysis of NED on the 1-year PET-CT correlated with 5-year DFS (odds ratio [OR] 55, 95% confidence interval [CI] 5.2-500, p = 0.001) and low probability of 5-year recurrence rates (OR 11.23, 1.23-100, p = 0.03).</p><p><strong>Conclusions: </strong>The findings of this study demonstrate that NED on PET-CT performed 1 year after the completion of treatment for oropharyngeal cancer is indicative of very low recurrence rates and almost non-existent mortality. We suggest performing a second PET-CT study at 1 year post-treatment on all patients with negative results on the first one performed at 3 months post-treatment. Negative findings on the second study may allow for a more lenient clinical follow-up protocol.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Development Testing of the Symptom Group Assessment Scale for Patients With Sudden Deafness: A Comprehensive Study.","authors":"Jin Lei, Muhammad Asad Iqbal, Li Zhengjing, Amjad Ali, Nida Fatima Moazzam, Zhuang Ruo","doi":"10.1111/coa.14318","DOIUrl":"https://doi.org/10.1111/coa.14318","url":null,"abstract":"<p><strong>Background: </strong>The objective is to create a symptom assessment scale specifically designed for people experiencing sudden deafness and thereafter evaluate its reliability and validity.</p><p><strong>Methods: </strong>A literature review and semi-structured interviews were used to create a symptom experience model-based scale item pool. After two rounds of expert deliberation, the first scale was finalised. An initial 30-item survey provided descriptive definitions and reference standards for symptom severity. One hundred sixty patients completed the questionnaire, but 7 patients who did not meet the requirements were excluded, and 153 patients who met the criteria in the otolaryngology department admitted to a tertiary hospital in Zhenjiang City between March 2022 and September 2023 were surveyed to assess the scale's validity and reliability.</p><p><strong>Results: </strong>The Symptom Group Assessment Scale for Sudden Deafness Patients comprises three dimensions and a total of 13 items. These dimensions include the Ear Symptom Group, consisting of five items, the systemic symptom group, consisting of five items, and the psychosomatic symptom group, consisting of three items. By conducting exploratory factor analysis, we were able to identify three shared components, which accounted for a total of 57.780% of the variance. The confirmatory factor analysis demonstrated that the model exhibited excellent flexibility. The Cronbach's alpha coefficient for the scale is 0.942, indicating a high level of internal consistency.</p><p><strong>Conclusion: </strong>The validated scale provides clinicians and nurses with a reliable tool to systematically assess symptom burden in sudden deafness patients. Its integration into clinical practice can inform tailored nursing interventions, such as symptom monitoring and psychosocial support, while aiding in the development of individualised management plans. This enhances patient-centred care and contributes to improved clinical outcomes in this population.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoring System for Predicting the Cure Rate of Unilateral Idiopathic Sudden Sensorineural Hearing Loss","authors":"Tongxiang Diao,&nbsp;Yixu Wang,&nbsp;Junbo Zhang,&nbsp;Shiming Yang,&nbsp;Xin Ma,&nbsp;Lisheng Yu","doi":"10.1111/coa.14340","DOIUrl":"10.1111/coa.14340","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Due to the clinical heterogeneity of unilateral idiopathic sudden sensorineural hearing loss, its prognosis is difficult to predict. This study aims to establish a system that could incorporate multiple factors for better prediction of the prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven hundred eighty-four adult patients with unilateral idiopathic sudden sensorineural hearing loss who were hospitalised for treatment between Jan 2016 and Dec 2020 were included. Pure tone audiometry hearing threshold calculated by the average value of hearing thresholds at 250, 500, 1000, 2000, 4000 and 8000 Hz was used for evaluating treatment efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The final cure rate was 31.0% (232/748). Age, onset-therapy time, initial hearing level, audiogram shape, and vertigo were found to be independently predictive for the prognosis. A scoring system that could incorporate all these five factors based on their prediction weights was then successfully created. The equation of total score was as follows: Total score = 1.2 × Age (score) + 1.6 × Onset-therapy time (score) + 1.3 × Initial hearing level (score) + 2.3 × Audiogram shape (score) + 2.8 × Vertigo (score). The cure rate of patients with scores of &lt; 5 could reach as high as 81.4%, whereas it was only 10.1% in patients with scores of ≥ 12.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study created a scoring system for predicting the prognosis of unilateral idiopathic sudden sensorineural hearing loss. The cure rates decreased with the increase of score. Patients could be given more individualised treatment according to the preliminary prediction of our system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"905-912"},"PeriodicalIF":1.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Vestibular Function Assessment Methods for Patients With Peripheral Vertigo Disease: A 5-Year Retrospective Study","authors":"Lin Zhang,&nbsp;Yongkang Ou,&nbsp;Yan Liu,&nbsp;Shunlin Ouyang,&nbsp;Ling Chen,&nbsp;Yongmei Xiao,&nbsp;Xiaowu Tang","doi":"10.1111/coa.14338","DOIUrl":"10.1111/coa.14338","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the relationship and differences between caloric test (CT) and video head impulse test (vHIT) in assessing vestibular function in patients with unilateral peripheral vertigo, and to comprehensively understand the functional status of horizontal and vertical (posterior and anterior) semicircular canals (SCCs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study retrospectively collected data from 240 patients with unilateral peripheral vertigo. Analyse the correlation and risk association between the severity of unilateral weakness (UW) and vestibulo-ocular reflex (VOR) outcomes of lateral, posterior and anterior SCCs in vHIT. Compare the correlation between the result parameters obtained from these two tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant correlation (<i>p</i> &lt; 0.05) was found between moderate and severe caloric UW groups and predictable abnormal VOR results in the ipsilateral lateral, posterior and anterior SCCs of vHIT, with incidence rates significantly higher than in the normal caloric group (lateral OR 6–8, posterior OR ≈ 5, anterior OR ≈ 11). A positive correlation existed between the sum of slow phase velocities of the affected side and gain in the lateral, posterior and anterior SCCs. UW negatively correlated with gain in the lateral and anterior SCCs but positively correlated with gain asymmetry between the left lateral-right lateral and right anterior-left posterior SCCs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The abnormal rate of vHIT lateral, posterior and anterior SCCs increased with higher UW values. It seems that the concurrent involvement of high-frequency vestibular responses, as assessed by vHIT, is more probable in moderate or greater caloric unilateral weakness, with a higher abnormal risk in the anterior semicircular canal compared to others. Evaluating vertical semicircular canal function deserves attention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"897-904"},"PeriodicalIF":1.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of Topical Haemocoagulase Solution Application in Tonsillectomy: A Double-Blinded Study","authors":"Raadhika Shree,&nbsp;Meenakshi Srinivasan","doi":"10.1111/coa.14330","DOIUrl":"10.1111/coa.14330","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to evaluate the benefit of topical haemocoagulase application during tonsillectomy in diminishing the operation time and intraoperative blood loss, as well as postoperative healing effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomised controlled trial was conducted including 60 patients undergoing tonsillectomy with or without adenoidectomy. The patients were randomly assigned into two groups of 30 each: the topical haemocoagulase applied in the tonsillectomy procedure as Group A (<i>n</i> = 30) (interventional group) and patients undergoing tonsillectomy using a conventional saline pressure pack as Group B (<i>n</i> = 30) (control group). After obtaining informed and written consent from the study population, patients were categorised into Group A and Group B through randomisation. Outcome measures evaluated included operation time, intraoperative blood loss, slough formation and clearance rate, postoperative pain and feeding habits. Data analysis was performed using SPSS version 19, employing descriptive statistics, Shapiro–Wilk tests for normality, independent <i>t</i>-tests for normally distributed data and chi-square tests for categorical variables, with statistical significance set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results revealed that Group A had significantly reduced operation times (<i>p</i> &lt; 0.001), less intraoperative blood loss, faster slough clearance, and improved postoperative feeding habits compared to Group B.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Topical haemocoagulase is a safe, effective and cost-efficient adjunct in tonsillectomy, offering significant advantages in surgical efficiency and postoperative recovery. Its ease of application and affordability make it a practical addition to routine surgical practice, benefiting both patients and healthcare providers. This study underscores the potential of haemocoagulase to enhance surgical outcomes and improve the overall quality of care in tonsillectomy procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"890-896"},"PeriodicalIF":1.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review","authors":"M. Achanta,&nbsp;P. Kasetti,&nbsp;M. Fortune-Ely,&nbsp;T. Ross,&nbsp;T. Magos,&nbsp;J. G. Manjaly","doi":"10.1111/coa.14339","DOIUrl":"10.1111/coa.14339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and is treated with steroid therapy. Despite adverse events (AEs) associated with long-term steroid use being well evidenced, there is sparsity of literature regarding the AEs of short-course prescriptions in the SSNHL cohort, which limits the quality of patient counselling and informed consent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A literature search was performed on the Medline and Embase databases for studies assessing AEs in adults with SSNHL managed with oral (OST), intratympanic (ITS) and intravenous steroid therapy (IVS). Two authors screened titles, abstracts and full-text articles, with conflicts resolved by a third reviewer. Forty-three papers were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In systemic steroid therapies, hyperglycaemia and hypertension are reported in up to 29.8% and 37.9% of patients respectively. Patients with medication-dependent diabetes and hypertension are at higher risk. Gastric and mood disturbances affected up to 27.9% and 44.6% of patients respectively. ITS carried risks of otalgia (up to 54.3%), dizziness (up to 27.1%), perforations (up to 11.5%) and otitis media (up to 4.7%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Comprehensive counselling is key in obtaining informed consent, especially in cohorts with diabetes mellitus (DM) and hypertension where monitoring of glucose and blood pressure is recommended. Gastroprotection should be considered. Future focus is required to study short-term steroid AEs and raise awareness among prescribing clinicians and patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"821-830"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}