The Effect of Patient Frailty on Morbidity, Mortality and Overall Survival Following Laryngectomy Procedures.

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-08-28 DOI:10.1111/coa.70029

Eoin F Cleere, Justin M Hintze, David Brinkman, James P O'Neill, Conrad V I Timon, John Kinsella, Paul Lennon, Conall W R Fitzgerald

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引用次数: 0

Abstract

Background: The present study evaluated the impact of frailty on patient morbidity and survival following laryngectomy surgery.

Methods: A retrospective cohort study of patients undergoing laryngectomy over a 10-year period. Frailty was measured using the 5-item modified Frailty Index (5mFI).

Results: A total of 233 patients (mean [SD] age, 63.7 [±10.0] years) were included. Eighty-two (35.2%) patients were frail and frail patients had a greater mean age (66.3 vs. 62.2 years, p = 0.006). On multivariable regression, frail patients were more likely to: develop pharyngocutaneous fistula (OR 2.62, 95% CI 1.33-5.18, p = 0.006), have a longer hospital stay (β 25.53 days, 95% CI 14.64-36.41, p < 0.001) and be discharged to a non-home setting (OR 5.31, 95% CI 2.49-11.35, p < 0.001). In case-matched patients, 3-year overall survival (OS) was similar in frail and not frail patients (p = 0.715).

Conclusions: Use of the 5mFI pre-laryngectomy may identify patients requiring increased support to optimise their peri-operative risk.

查看原文本刊更多论文

患者虚弱对喉切除术后发病率、死亡率和总生存率的影响。

背景：本研究评估了虚弱对喉切除术后患者发病率和生存率的影响。方法：回顾性队列研究的患者接受喉切除术超过10年的时间。虚弱度采用5项修正的虚弱指数（5mFI）进行测量。结果：共纳入233例患者（平均[SD]年龄63.7[±10.0]岁）。82例（35.2%）患者体弱，体弱患者的平均年龄较大（66.3 vs 62.2岁，p = 0.006）。在多变量回归中，体弱患者更容易发生咽皮瘘（OR 2.62, 95% CI 1.33-5.18, p = 0.006），住院时间更长（β 25.53天，95% CI 14.64-36.41, p）。结论：使用5mFI喉切除术前可以识别需要增加支持的患者，以优化其围手术期风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.