{"title":"SCORE 2 and SCORE 2-OP Risk Scales as Prognostic Factors After Sudden Idiopathic Hearing Loss.","authors":"Mehmet Ali Say, Fahri Çakan, Volkan Bilge Yiğit","doi":"10.1111/coa.70034","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate whether the Systematic Coronary Risk Estimation 2 and Systematic Coronary Risk Estimation 2-Older Persons (SCORE 2 and SCORE 2-OP) cardiovascular disease (CVD) risk scales can be used as prognostic factor for sudden sensorineural hearing loss (SSHL).</p><p><strong>Design: </strong>Prospective observational study.</p><p><strong>Setting: </strong>Single-center study.</p><p><strong>Methods: </strong>The study included 62 patients diagnosed with SSHL. SCORE 2 and SCORE 2-OP risks were calculated using the data collected from each participant. Patients were categorised into Green (low-moderate) and Non-Green (Yellow and Red, containing high and very high) risk groups. Recovery was categorised based on changes in pure-tone average (PTA). Statistical analyses included Pearson's correlation, univariate and multivariate logistic regression and ROC curve analysis.</p><p><strong>Results: </strong>A significantly higher proportion of patients in the Complete Recovery group had a Green SCORE risk classification (63.6%) than in the non-complete recovery group (32.5%, p = 0.018). The Green SCORE classification and lower pre-treatment PTA levels were significantly associated with better recovery outcomes. In multivariate analysis, Green SCORE remained an independent predictor of complete recovery (OR = 4.052, 95% CI: 1.218-13.487, p = 0.023). ROC analysis revealed moderate discriminative ability (AUC = 0.656, p = 0.044; sensitivity, 63.6%; specificity, 67.5%), with a negative predictive value of 77.1%.</p><p><strong>Conclusion: </strong>The SCORE2 and SCORE2-OP cardiovascular risk scores, particularly the Green risk category, are valuable predictors of hearing recovery in SSHL. This finding has the potential to serve as a guide for clinicians, informing the adaptation of treatment intensity or the investigation of adjunctive therapies within populations characterised by elevated risk.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/coa.70034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
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Abstract
Objectives: This study aimed to investigate whether the Systematic Coronary Risk Estimation 2 and Systematic Coronary Risk Estimation 2-Older Persons (SCORE 2 and SCORE 2-OP) cardiovascular disease (CVD) risk scales can be used as prognostic factor for sudden sensorineural hearing loss (SSHL).
Design: Prospective observational study.
Setting: Single-center study.
Methods: The study included 62 patients diagnosed with SSHL. SCORE 2 and SCORE 2-OP risks were calculated using the data collected from each participant. Patients were categorised into Green (low-moderate) and Non-Green (Yellow and Red, containing high and very high) risk groups. Recovery was categorised based on changes in pure-tone average (PTA). Statistical analyses included Pearson's correlation, univariate and multivariate logistic regression and ROC curve analysis.
Results: A significantly higher proportion of patients in the Complete Recovery group had a Green SCORE risk classification (63.6%) than in the non-complete recovery group (32.5%, p = 0.018). The Green SCORE classification and lower pre-treatment PTA levels were significantly associated with better recovery outcomes. In multivariate analysis, Green SCORE remained an independent predictor of complete recovery (OR = 4.052, 95% CI: 1.218-13.487, p = 0.023). ROC analysis revealed moderate discriminative ability (AUC = 0.656, p = 0.044; sensitivity, 63.6%; specificity, 67.5%), with a negative predictive value of 77.1%.
Conclusion: The SCORE2 and SCORE2-OP cardiovascular risk scores, particularly the Green risk category, are valuable predictors of hearing recovery in SSHL. This finding has the potential to serve as a guide for clinicians, informing the adaptation of treatment intensity or the investigation of adjunctive therapies within populations characterised by elevated risk.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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