Nasal Bitter Taste Testing for Chronic Rhinosinusitis: A Pilot Proof-of-Concept Study.

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-09-03 DOI:10.1111/coa.70026

Shankar Ramasundram, Ramiza Ramza Ramli, Norasnieda Md Shukri, Sakinah Mohamad, Sivakumar Kumarasamy

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引用次数: 0

Abstract

Objectives: The expression and functionality of bitter taste receptors (T2Rs) in the sinonasal mucosa have been linked to variations in chronic rhinosinusitis (CRS) severity and susceptibility, suggesting a potential therapeutic target for managing this chronic condition. This study is an initial proof-of-concept study to explore the potential of nasal bitter taste testing as a screening tool for CRS, aiming at developing a screening method to detect the bitter taste receptor in the nose and its sensitivity between healthy individuals and those with CRS using available bitter ligands; therefore, coming up with a suitable titration of this ligand for future use.

Methods: A cross-sectional study of 84 adults (42 with CRS and 42 healthy controls) evaluated nasal glucose levels and phenylthiocarbamide (PTC) taste sensitivity. Colorimetric and statistical tests were used to analyse PTC threshold values and nasal glucose levels.

Results: Based on 0.13% as the most suitable dilution for intranasal testing of PTC, there is an association between nasal bitter taste testing among CRS and control groups with a p value of < 0.001.

Conclusions: The bitter taste testing on the nose seems to be a simple and inexpensive way for screening patients with CRS. The titration and intranasal sites suggested in this study can be used as a basis for further prospective studies to view the outcome of patients with CRS. Targeting these receptors in diagnostics could open a new window of opportunity in the management of patients with CRS.

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慢性鼻窦炎的鼻苦味测试：一项试点概念验证研究。

目的：鼻腔黏膜中苦味受体（T2Rs）的表达和功能与慢性鼻窦炎（CRS）严重程度和易感性的变化有关，提示治疗这种慢性疾病的潜在治疗靶点。本研究是一项初步的概念验证性研究，旨在探索鼻腔苦味测试作为CRS筛查工具的潜力，旨在开发一种利用可用的苦味配体检测健康个体和CRS患者鼻腔苦味受体及其敏感性的筛查方法；因此，提出了一种合适的配体滴定方法以供将来使用。方法：对84名成年人（42名CRS患者和42名健康对照者）进行横断面研究，评估鼻腔葡萄糖水平和苯硫代氨基脲（PTC）味觉敏感性。采用比色法和统计学方法分析PTC阈值和鼻腔葡萄糖水平。结果：以0.13%为鼻内检测PTC的最适稀释度，CRS患者鼻苦味检测与对照组存在相关性，p值为。结论：鼻苦味检测是一种简单、廉价的筛查CRS患者的方法。本研究建议的滴注和鼻内部位可作为进一步前瞻性研究的基础，以观察CRS患者的预后。在诊断中针对这些受体可以为CRS患者的管理打开一个新的机会之窗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.