Sam P J van Dijk, Carolien C H M Maas, Ali Alshangi, M H Elise van Driel, Eline A Feitsma, Caroline M J van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P Peeters, Tessa M van Ginhoven
{"title":"完全或完全甲状腺切除术后持续性甲状旁腺功能减退的预后模型的建立和验证。","authors":"Sam P J van Dijk, Carolien C H M Maas, Ali Alshangi, M H Elise van Driel, Eline A Feitsma, Caroline M J van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P Peeters, Tessa M van Ginhoven","doi":"10.1111/coa.70039","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.</p><p><strong>Methods: </strong>This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.</p><p><strong>Results: </strong>Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84-0.92) with moderately calibrated predictions.</p><p><strong>Conclusions: </strong>The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.\",\"authors\":\"Sam P J van Dijk, Carolien C H M Maas, Ali Alshangi, M H Elise van Driel, Eline A Feitsma, Caroline M J van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P Peeters, Tessa M van Ginhoven\",\"doi\":\"10.1111/coa.70039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.</p><p><strong>Methods: </strong>This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.</p><p><strong>Results: </strong>Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84-0.92) with moderately calibrated predictions.</p><p><strong>Conclusions: </strong>The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.</p>\",\"PeriodicalId\":10431,\"journal\":{\"name\":\"Clinical Otolaryngology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Otolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/coa.70039\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/coa.70039","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.
Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.
Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.
Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84-0.92) with moderately calibrated predictions.
Conclusions: The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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