Clinical Obesity最新文献

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Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials 在SURMOUNT-1和SURMOUNT-4临床试验中,替西肽治疗对平台加重的时间。
IF 2.2
Clinical Obesity Pub Date : 2025-01-12 DOI: 10.1111/cob.12734
Deborah B. Horn, Scott Kahan, Rachel L. Batterham, Dachuang Cao, Clare J. Lee, Madhumita Murphy, Sylvia Gonsahn-Bollie, Farai Chigutsa, Adam Stefanski, Julia P. Dunn
{"title":"Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials","authors":"Deborah B. Horn,&nbsp;Scott Kahan,&nbsp;Rachel L. Batterham,&nbsp;Dachuang Cao,&nbsp;Clare J. Lee,&nbsp;Madhumita Murphy,&nbsp;Sylvia Gonsahn-Bollie,&nbsp;Farai Chigutsa,&nbsp;Adam Stefanski,&nbsp;Julia P. Dunn","doi":"10.1111/cob.12734","DOIUrl":"10.1111/cob.12734","url":null,"abstract":"<p>The rate of weight reduction during obesity treatment declines over time and eventually reaches a weight plateau. We investigated factors associated with time to weight plateau (TTWP) in tirzepatide-treated participants with obesity or overweight in a post-hoc analysis of SURMOUNT-1 and SURMOUNT-4 trials. Participants adherent to tirzepatide treatment and achieving ≥5% weight loss by primary endpoint (week 72 SURMOUNT-1; week 88 SURMOUNT-4) were included. Weight plateau was defined as a weight change &lt;5% over a 12-week interval and all subsequent 12-week intervals. TTWP was time from randomization to the start of the first 12-week interval. Association between baseline characteristics and TTWP was assessed. Overall, 1438 participants in SURMOUNT-1 and 259 in SURMOUNT-4 were included. Across BMI categories (overweight, class I, II, and III), median TTWP in SURMOUNT-1 was 24.3, 26.0, 36.1, and 36.1 weeks, respectively (<i>p</i> &lt;.05, class II and III vs. overweight). By week 72, 90.2%, 88.9%, 87.6%, and 87.8% of participants in SURMOUNT-1 had reached a weight plateau across respective BMI categories [Correction added on 22 January 2025, after first online publication: The “72%” has been changed to “72” in this version.]. Higher doses of tirzepatide (10/15 mg), younger age, and female sex were more likely to reach a weight plateau later. Results in SURMOUNT-4 were similar. In this post-hoc analysis, most participants reached a weight plateau by week 72. Higher doses of tirzepatide, younger age, and female sex were associated with a longer TTWP. Further research into modifiers of weight reduction phases with tirzepatide may inform treatment decisions for its use in chronic weight management. <i>Clinical Trial Registration</i>: ClinicalTrials.gov, identifiers NCT04184622 (SURMOUNT-1) and NCT04660643 (SURMOUNT-4), available at http://www.clinicaltrials.gov/</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in gastrointestinal motility and gut hormone secretion after Roux-en-Y gastric bypass and sleeve gastrectomy for individuals with severe obesity 重度肥胖患者Roux-en-Y胃旁路和袖式胃切除术后胃肠运动和肠道激素分泌的变化
IF 2.2
Clinical Obesity Pub Date : 2024-12-27 DOI: 10.1111/cob.12721
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee
{"title":"Changes in gastrointestinal motility and gut hormone secretion after Roux-en-Y gastric bypass and sleeve gastrectomy for individuals with severe obesity","authors":"Jennifer A. Wilbrink,&nbsp;Mark van Avesaat,&nbsp;Simon W. Nienhuijs,&nbsp;Arnold Stronkhorst,&nbsp;Ad A. M. Masclee","doi":"10.1111/cob.12721","DOIUrl":"10.1111/cob.12721","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bariatric surgery is very effective in long-term weight management. The present study was undertaken to investigate the short-term effects of sleeve gastrectomy (SG) and of Roux-en-Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro-cecal transit time and (b) secretion of regulatory gut peptides and (c) their interrelationship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective single-centre study in which we assessed gastric emptying, oro-cecal transit time and gut peptide release in 28 severely obese individuals before and 2, respectively, 12 months after bariatric surgery (either SG or RYGB). Plasma PYY, GLP-1, ghrelin, insulin and glucose levels were measured fasting and after intake of a solid standard 459 kcal meal at each occasion. Gastric emptying was measured by 13 C octanoic acid breath testing, and oro-cecal transit time was measured by lactulose H<sub>2</sub> breath testing. Satiation was measured using VAS scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After both RYGB and SG gastric emptying become significantly accelerated, and postprandial release of the distal gut peptides GLP-1 and PYY becomes significantly increased, pointing to ileal brake activation. Oro-cecal transit time becomes significantly accelerated after SG but not after RYGB. No significant correlations were observed between changes in distal gut peptide release, changes in GI motility and clinical parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both SG and RYGB resulted in significant weight loss and significantly affected GI motility and PYY and GLP-1 secretion. Subtle differences between both procedures were found in effect on oro-cecal transit time and patterns of peptide secretion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of interventions with exercise according to the adherence of adults with obesity: A systematic review 根据成人肥胖患者依从性的运动干预特征:一项系统综述。
IF 2.2
Clinical Obesity Pub Date : 2024-12-27 DOI: 10.1111/cob.12733
Anne Ribeiro Streb, Willen Remon Tozetto, Caroline Soares da Silva, Cecília Bertuol, Giseli Minatto, Giovani Firpo Del Duca
{"title":"Characteristics of interventions with exercise according to the adherence of adults with obesity: A systematic review","authors":"Anne Ribeiro Streb,&nbsp;Willen Remon Tozetto,&nbsp;Caroline Soares da Silva,&nbsp;Cecília Bertuol,&nbsp;Giseli Minatto,&nbsp;Giovani Firpo Del Duca","doi":"10.1111/cob.12733","DOIUrl":"10.1111/cob.12733","url":null,"abstract":"<div>\u0000 \u0000 <p>The aim was to summarize the characteristics of exercise interventions based on the adherence of adults with obesity. Studies were identified through a systematic review of the literature conducted in databases in June 2022. The articles selected were from clinical trials involving adults with obesity. The total number of prescribed sessions and the mean or percentage of sessions attended by participants who completed the intervention were identified, along with details of the exercise prescription, including duration, attendance, and intensity control. A total of 21 studies were included in the synthesis. The adherence percentage ranged from 18% to 99% of the prescribed exercise sessions. Interventions that provided only guidance meetings for physical activities without supervising the training—allowing participants to choose the modality and loads—resulted in adherence to less than half of the prescribed sessions. The session duration and weekly attendance varied between 30–60 min and 2–3 times per week across the studies synthesized. These variables did not appear to significantly affect adherence percentages in this population. It was possible to conclude that supervised interventions, with combined training, which include moderate to high-intensity physical exercises and/or interval training and with some social support, resulted in greater adherence to sessions in adults with obesity.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of Roux-en-Y gastric bypass and sleeve gastrectomy in achieving diabetes remission in patients with diabetes-related vascular diseases: A multicentred study Roux-en-Y胃旁路术与袖式胃切除术在糖尿病相关血管疾病患者中实现糖尿病缓解的比较效果:一项多中心研究
IF 2.2
Clinical Obesity Pub Date : 2024-12-21 DOI: 10.1111/cob.12732
Wissam Ghusn, Pearl Ma, Kayla Ikemiya, Marita Salame, Karl Hage, Kamal Abi Mosleh, Andrew C. Storm, Michael Kendrick, Barham K. Abu Dayyeh, Kelvin Higa, Omar M. Ghanem
{"title":"Comparative effectiveness of Roux-en-Y gastric bypass and sleeve gastrectomy in achieving diabetes remission in patients with diabetes-related vascular diseases: A multicentred study","authors":"Wissam Ghusn,&nbsp;Pearl Ma,&nbsp;Kayla Ikemiya,&nbsp;Marita Salame,&nbsp;Karl Hage,&nbsp;Kamal Abi Mosleh,&nbsp;Andrew C. Storm,&nbsp;Michael Kendrick,&nbsp;Barham K. Abu Dayyeh,&nbsp;Kelvin Higa,&nbsp;Omar M. Ghanem","doi":"10.1111/cob.12732","DOIUrl":"10.1111/cob.12732","url":null,"abstract":"<div>\u0000 \u0000 <p>Metabolic and bariatric surgeries (MBS), including Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG), have proven effective in promoting long-term diabetes remission among patients with type-2 diabetes (T2D). In this multicentre retrospective cohort study, we investigated the effectiveness of RYGB and SG in achieving diabetes remission, specifically among patients with T2D and vascular complications, while accounting for similar baseline diabetes severity. Although various scores predict diabetes remission after bariatric surgery, they do not consider diabetes-related vascular complications, which can influence outcomes even in patients with similar baseline T2D severity. We collected preoperative data on microvascular (retinopathy, nephropathy, neuropathy) and macrovascular comorbidities (coronary artery disease, cerebrovascular accidents, peripheral artery disease) to compare the efficacy of RYGB and SG. Among 961 patients analysed, those with vascular complications showed higher remission rates with RYGB (OR: 1.97) compared to SG, despite similar baseline diabetes severity. Notably, RYGB patients with microvascular complications had a significant advantage in achieving T2D remission (OR: 2.95). However, no significant differences in remission were observed in patients with macrovascular complications. These findings suggest that RYGB may be more effective than SG in specific patient populations, particularly those with microvascular complications, emphasizing the need for personalized treatment strategies.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing lymphoscintigraphic specificity of lymphoedema diagnosis in patients with lipoedema 提高脂肪性水肿患者淋巴管造影诊断的特异性。
IF 2.2
Clinical Obesity Pub Date : 2024-12-20 DOI: 10.1111/cob.12730
Hadrien Amiel, Julien Coulie, Raphaël Georis, Raquel van la Parra, Genevieve Pirson, Christine Deconinck
{"title":"Enhancing lymphoscintigraphic specificity of lymphoedema diagnosis in patients with lipoedema","authors":"Hadrien Amiel,&nbsp;Julien Coulie,&nbsp;Raphaël Georis,&nbsp;Raquel van la Parra,&nbsp;Genevieve Pirson,&nbsp;Christine Deconinck","doi":"10.1111/cob.12730","DOIUrl":"10.1111/cob.12730","url":null,"abstract":"<div>\u0000 \u0000 <p>This study addresses the diagnostic challenges of identifying lymphoedema in patients with lipoedema using lymphoscintigraphy. Overdiagnosis of lymphoedema in this patient population is frequent and may result in reduced proposed surgical interventions. We retrospectively analyzed clinical data from patients followed for lipoedema, lymphoedema or lipolymphoedema and who underwent lymphoscintigraphy. All patients were assigned a clinical or lymphoscintigraphic diagnosis of lymphoedema and concordance between clinical and lymphoscintigraphic diagnosis was assessed. A modification of lymphoscintigraphic criteria interpretation was proposed to enhance the diagnosis specificity. We included 94 female patients (188 lower limbs). One hundred and thirty-seven limbs presented with signs of lipoedema (137/188; 72.9%) and 42 with clinical signs of lymphoedema (42/188; 22.3%). Overall, 125 limbs presented with a diagnosis of lymphoedema on lymphoscintigraphy (125/188; 66.5%). Using lymphoscintigraphy to diagnose lymphoedema in patients with lipoedema resulted in low specificity (38.3%). By adjusting the interpretation criteria of the lymphoscintigraphic anomalies, we could achieve a specificity of 80.85%, reducing the risk of overdiagnosing lymphoedema in patients with lipoedema. This study contributes to the ongoing efforts to optimize the assessment and management of patients with lipoedema and potential lymphatic involvement, by modifying the interpretation of lymphoscintigraphic criteria.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internal hernia in patients after duodenal switch: A multi-centred comparative analysis 十二指肠转换后患者的内疝:一项多中心比较分析。
IF 2.2
Clinical Obesity Pub Date : 2024-12-18 DOI: 10.1111/cob.12729
Romulo P. Lind, Estela Abich, Graziella Galvao Goncalves, Amanda Belluzzi, Karl Hage, Juliana Antunes, Muhammad Ghanem, Muhammad A. Jawad, Michael Kendrick, Omar M. Ghanem, Andre F. Teixeira
{"title":"Internal hernia in patients after duodenal switch: A multi-centred comparative analysis","authors":"Romulo P. Lind,&nbsp;Estela Abich,&nbsp;Graziella Galvao Goncalves,&nbsp;Amanda Belluzzi,&nbsp;Karl Hage,&nbsp;Juliana Antunes,&nbsp;Muhammad Ghanem,&nbsp;Muhammad A. Jawad,&nbsp;Michael Kendrick,&nbsp;Omar M. Ghanem,&nbsp;Andre F. Teixeira","doi":"10.1111/cob.12729","DOIUrl":"10.1111/cob.12729","url":null,"abstract":"<div>\u0000 \u0000 <p>Biliopancreatic diversion with duodenal switch (BPD-DS) and single anastomosis duodeno-ileostomy with sleeve (SADI-S) are associated with superior and sustained weight loss outcomes. Despite their growing popularity, long-term safety profiles, particularly the risk of internal hernia (IH), remain underexplored. This study aimed to evaluate the incidence and characteristics of IH following BPD-DS and SADI-S procedures, comparing their clinical presentation, diagnostic methods, and outcomes. A retrospective chart review was performed for patients who underwent BPD-DS or SADI-S between 2008 and 2023 in two high-volume tertiary referral centres for bariatric surgery in the United States. Demographic data, comorbidities, operative details, and follow-up outcomes were collected. A subgroup analysis of IH cases was conducted to compare the incidence, location of hernias, and diagnostic modalities between procedures. Out of 1160 patients (85.1% BPD-DS; 14.9% SADI-S), the overall incidence of IH was 1.12%, with a higher rate in BPD-DS (0.8%) than in SADI-S (0.57%). Most IHs occurred within the first 24 months postoperatively. The majority of IHs in BPD-DS patients were in the pseudo-Petersen's space. The single IH case in the SADI-S group occurred in the same space. Most patients presented with abdominal pain and were diagnosed by CT imaging. SADI-S showed a lower IH rate compared to BPD-DS, but further studies are needed to confirm these findings. The variability in clinical presentation complicates the diagnosis of IH, emphasizing the need for increased clinical vigilance.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fewer patients with insufficient weight loss after one anastomosis gastric bypass compared to Roux-en-Y gastric bypass after 5 years of follow-up 随访5年后,与Roux-en-Y胃旁路相比,一次吻合胃旁路术后体重减轻不足的患者较少。
IF 2.2
Clinical Obesity Pub Date : 2024-12-18 DOI: 10.1111/cob.12728
Lindsy van der Laan, Dionne Sizoo, Loek J. M. de Heide, André P. van Beek, Marloes Emous
{"title":"Fewer patients with insufficient weight loss after one anastomosis gastric bypass compared to Roux-en-Y gastric bypass after 5 years of follow-up","authors":"Lindsy van der Laan,&nbsp;Dionne Sizoo,&nbsp;Loek J. M. de Heide,&nbsp;André P. van Beek,&nbsp;Marloes Emous","doi":"10.1111/cob.12728","DOIUrl":"10.1111/cob.12728","url":null,"abstract":"<p>This study aims to give a comprehensive overview of the one anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) during 5 years of follow-up in terms of weight loss, the remission of obesity-associated diseases and complications. We performed a retrospective cohort study, with a 1:1 propensity-score matched (PSM) comparison between all adult patients who underwent a primary OAGB or RYGB in 2016. Patients with a body mass index (BMI) ≥50 kg/m<sup>2</sup> were excluded. In total, 372 patients underwent OAGB and 113 patients RYGB. After performing a 1:1 PSM, we obtained two nearly identical cohorts of 113 patients. After OAGB, the percentage of total weight loss (%TWL) was significantly higher during 5 years of follow-up. Also, more patients after OAGB had a successful weight loss (TWL &gt; 20%) after 5 years (86% vs. 72%; <i>p</i> = .019). The remission of obesity-associated diseases and short-term complications did not differ between both procedures. Persistent reflux was the reason for conversion to RYGB in 11.3% of the patients after OAGB. More internal herniations were seen after RYGB (10.4% vs. 1.9%; <i>p</i> = .010). Overall, the proportion of patients with major mid-term complications did not differ between both procedures. In conclusion, OAGB resulted in more weight reduction and especially fewer patients with insufficient weight loss during 5 years of follow-up, while remission of obesity-associated diseases remained the same.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet 减肥手术或低热量饮食后8周和52周胰岛素敏感性和肠道肽的变化。
IF 2.2
Clinical Obesity Pub Date : 2024-12-17 DOI: 10.1111/cob.12726
Adam C. Lowe, Dorien Reijnders, Charmaine S. Tam, Leanne M. Redman, Robbie Beyl, Karl A. LeBlanc, Mark G. Hausmann, Vance L. Albaugh, Frank L. Greenway, Eric Ravussin
{"title":"Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet","authors":"Adam C. Lowe,&nbsp;Dorien Reijnders,&nbsp;Charmaine S. Tam,&nbsp;Leanne M. Redman,&nbsp;Robbie Beyl,&nbsp;Karl A. LeBlanc,&nbsp;Mark G. Hausmann,&nbsp;Vance L. Albaugh,&nbsp;Frank L. Greenway,&nbsp;Eric Ravussin","doi":"10.1111/cob.12726","DOIUrl":"10.1111/cob.12726","url":null,"abstract":"<div>\u0000 \u0000 <p>The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [<i>n</i> = 5] or sleeve gastrectomy [<i>n</i> = 7]) or LCD (<i>n</i> = 7) in this parallel-arm, prospective observational study. We assessed insulin sensitivity via a two-step hyperinsulinemic–euglycemic clamp (20 and 80 mU/min/m<sup>2</sup> insulin). Plasma glucose, insulin, and gut peptides were measured around a mixed meal tolerance test (400 kcal). Visual analogue scales (VAS) were used to rate subjective appetite sensations. All assessments were conducted at baseline and after 8 weeks and 1 year of intervention. Whole-body insulin sensitivity was unchanged 8 weeks after the intervention. One year after surgery, insulin sensitivity at both 20 and 80 mU/m<sup>2</sup>/min insulin infusion doses increased with BS weight loss (−33.8% ± 1.4% body weight) but was unchanged in LCD with small weight loss (−3.7% ± 2.0% body weight). Postprandial total PYY increased more following BS while total and acylated ghrelin decreased more following BS compared to LCD. Hunger decreased and fullness increased with BS compared to LCD (<i>p</i> = .037; <i>p</i> = .010, respectively). Insulin sensitivity was improved only 1 year after BS, despite significant weight loss after 8 weeks. Changes in gut peptides after BS paralleled reduced hunger and increased fullness. Most improvements in cardiometabolic health were related to weight loss.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the physical: The interplay of experienced weight stigma, internalised weight bias and depression in lipoedema 超越物理:经验体重耻辱,内化体重偏见和抑郁在脂肪水肿的相互作用。
IF 2.2
Clinical Obesity Pub Date : 2024-12-14 DOI: 10.1111/cob.12727
Chantelle Clarke, James N. Kirby, Talitha Best
{"title":"Beyond the physical: The interplay of experienced weight stigma, internalised weight bias and depression in lipoedema","authors":"Chantelle Clarke,&nbsp;James N. Kirby,&nbsp;Talitha Best","doi":"10.1111/cob.12727","DOIUrl":"10.1111/cob.12727","url":null,"abstract":"<p>This study explored experienced weight stigma, internalised weight bias and depressive symptom severity in lipoedema, a chronic health condition that primarily affects women and involves painful and disproportionate adipose tissue. This study utilised an international cross-sectional online survey involving <i>N</i> = 1070 women over 18 years old (<i>M</i><sub>age</sub> = 48.9 years old) with self-reported diagnosed or suspected lipoedema. Participants completed measures of demographic and health characteristics, experienced weight stigma, internalised weight bias and depressive symptoms (PHQ-9). Chi-square analysis showed experienced weight stigma differed between those with stage 1 (<i>n</i> = 57), stage 2 (<i>n</i> = 311), Stage 3 (<i>n</i> = 664) and stage unknown (<i>n</i> = 38) lipoedema. Hierarchical linear regression determined the effects of weight stigma on depression and the mediating role of internalised weight bias. Experienced weight stigma (<i>p</i> &lt; .001) and internalised weight bias (<i>p</i> &lt; .001) were related to depressive symptoms beyond age and symptoms of lipoedema (BMI, lipoedema symptom severity and mobility). Internalised weight bias partially mediated the effect of experienced weight stigma on depression. Psychological attributes of experienced weight stigma and internalised weight bias uniquely contribute to depressive symptoms in lipoedema. Increased awareness of the psychological effects of weight stigma and the role of internalised weight bias in women's experience of lipoedema on depression is needed.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An international Delphi consensus on patient preparation for metabolic and bariatric surgery 关于代谢和减肥手术患者准备工作的国际德尔菲共识。
IF 2.2
Clinical Obesity Pub Date : 2024-12-14 DOI: 10.1111/cob.12722
Danielle R. Clyde, Reza Adib, Sarfaraz Baig, Aparna G. Bhasker, James Byrne, David Cameron, Copaescu Catalain, Ken Clare, Andrew de Beaux, Gillian Drummond, Hayssam Fawal, Martin Fried, Omar Ghanem, Yitka Graham, Ramen Goel, George Hopkins, Farah Husain, Brian Joyce, Mohammad Kermansaravi, Shanu Kothari, Lilian Kow, Silvia Leite, Brij Madhok, David Mahon, Karl Miller, Alex Miras, Osama Moussa, Manoel G. Neto, Abdelrahman Nimeri, Mary O'Kane, Chetan Parmar, Ralph Peterli, Luis Poggi, Paulina Saliminen, Rupa Sarkar, Jon Shenfine, Stephanie Sogg, Erik Stenberg, Michel Suter, Safwan Taha, Abd Tahrani, Ramon Vilallonga, Kelvin Voon, Richard Welbourn, Carlos Zerrweck, Peter Lamb, Kamal K. Mahawar, Wah Yang, Andrew G. N. Robertson
{"title":"An international Delphi consensus on patient preparation for metabolic and bariatric surgery","authors":"Danielle R. Clyde,&nbsp;Reza Adib,&nbsp;Sarfaraz Baig,&nbsp;Aparna G. Bhasker,&nbsp;James Byrne,&nbsp;David Cameron,&nbsp;Copaescu Catalain,&nbsp;Ken Clare,&nbsp;Andrew de Beaux,&nbsp;Gillian Drummond,&nbsp;Hayssam Fawal,&nbsp;Martin Fried,&nbsp;Omar Ghanem,&nbsp;Yitka Graham,&nbsp;Ramen Goel,&nbsp;George Hopkins,&nbsp;Farah Husain,&nbsp;Brian Joyce,&nbsp;Mohammad Kermansaravi,&nbsp;Shanu Kothari,&nbsp;Lilian Kow,&nbsp;Silvia Leite,&nbsp;Brij Madhok,&nbsp;David Mahon,&nbsp;Karl Miller,&nbsp;Alex Miras,&nbsp;Osama Moussa,&nbsp;Manoel G. Neto,&nbsp;Abdelrahman Nimeri,&nbsp;Mary O'Kane,&nbsp;Chetan Parmar,&nbsp;Ralph Peterli,&nbsp;Luis Poggi,&nbsp;Paulina Saliminen,&nbsp;Rupa Sarkar,&nbsp;Jon Shenfine,&nbsp;Stephanie Sogg,&nbsp;Erik Stenberg,&nbsp;Michel Suter,&nbsp;Safwan Taha,&nbsp;Abd Tahrani,&nbsp;Ramon Vilallonga,&nbsp;Kelvin Voon,&nbsp;Richard Welbourn,&nbsp;Carlos Zerrweck,&nbsp;Peter Lamb,&nbsp;Kamal K. Mahawar,&nbsp;Wah Yang,&nbsp;Andrew G. N. Robertson","doi":"10.1111/cob.12722","DOIUrl":"10.1111/cob.12722","url":null,"abstract":"<div>\u0000 \u0000 <p>Global obesity rates have risen dramatically, now exceeding deaths from starvation. Metabolic and bariatric surgery (MBS), initially for severe obesity (BMI ≥35 kg/m<sup>2</sup>), is performed globally over 500 000 times annually, offering significant metabolic benefits beyond weight loss. However, varying eligibility criteria globally impact patient care and healthcare resources. Updated in 2022, ASMBS and IFSO guidelines aim to standardise MBS indications, reflecting current understanding and emphasising comprehensive preoperative assessments. Yet, clinical variability persists, necessitating consensus-based recommendations. This modified Delphi study engaged 45 global experts to establish consensus on perioperative management in MBS. Experts selected from bariatric societies possessed expertise in MBS and participated in a two-round Delphi protocol. Consensus was achieved on 90 of 169 statements (53.3%), encompassing multidisciplinary team composition, patient selection criteria, preoperative testing, and referral pathways. The agreement highlighted the critical role of comprehensive preoperative assessments and the integration of healthcare professionals in MBS. These findings offer essential insights to standardise perioperative practices and advocate for evidence-based guidelines in MBS globally. The study underscores the need for unified protocols to optimise outcomes and guide future research in MBS.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"15 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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