Clinical Obesity最新文献

{"title":"Medical weight loss in older persons with obesity","authors":"Alessandro Gavras,&nbsp;John A. Batsis","doi":"10.1111/cob.12684","DOIUrl":"10.1111/cob.12684","url":null,"abstract":"<div>\u0000 \u0000 <p>The prevalence of individuals with obesity or overweight has steadily increased over the past decades both worldwide, and in the United States. This trend is also evident in the older adult population, which has experienced a continuous rise in the number of individuals with overweight or obesity. This is relevant due to the impact of obesity in older adults' quality of life, physical function, morbidity, and healthcare costs. This review aims to provide practical guidance and currently available approaches for healthcare professionals in managing this population. Both non-pharmacological methods such as intensive behavioural therapy, nutritional interventions, and physical activity, as well as anti-obesity medications, are discussed, with a focus on their potential positive and negative effects in older adults. Additionally, bariatric therapy is evaluated, including current procedures available and the associated results and risks in the older population.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of healthy lean body mass and function during weight loss","authors":"T. J. Wilkinson,&nbsp;D. Papamargaritis,&nbsp;J. A. King,&nbsp;J. A. Sargeant,&nbsp;C. Sutcliffe,&nbsp;L. A. Baker,&nbsp;S. Taheri,&nbsp;T. Yates,&nbsp;M. J. Davies","doi":"10.1111/cob.12683","DOIUrl":"10.1111/cob.12683","url":null,"abstract":"","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like-peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association","authors":"Anthony Nguyen,&nbsp;Emily Smith,&nbsp;Habiba Hashemy,&nbsp;Sri Mahavir Agarwal,&nbsp;Margaret K. Hahn,&nbsp;Andrew D. Paterson,&nbsp;Satya Dash","doi":"10.1111/cob.12676","DOIUrl":"10.1111/cob.12676","url":null,"abstract":"<p>Glucagon-like-peptide 1 receptor agonists (GLP-1RA) have transformed type 2 diabetes (T2D) and obesity management. Multiple regulatory agencies are investigating reported associations between GLP1-RA and increased suicide attempts (SA), but observational data may be prone to confounding. Randomised control trials (RCT) of GLP-1RA were largely undertaken in people at lower risk of SA. Real-world data suggest semaglutide use associates with reduced suicidal ideation and depression but was under-powered to statistically assess risk of SA. Mendelian randomisation (MR) leverages genetic instrument(s) to infer potential causal association between an exposure and an outcome. We undertook MR using missense variants in the gene encoding <i>GLP1R</i> that improve glycemia, lower T2D risk and/or lower BMI, to investigate potential causal association between GLP-1RA and SA. In people of European ancestry, MR did not find evidence genetically proxied GLP1RA increased SA in a general population cohort: (rs10305492, exposure: HbA1c, odds ratio [OR] and 95% confidence interval [CI]: 1.38, 0.41–4.62, <i>p</i> = .60), (rs10305492, exposure: FG, OR 1.27, 0.52–3.13, <i>p</i> = .60) and (rs1042044, exposure BMI, OR 0.30, 0.06–1.48) with concordant results in a multi-ancestry SA case–control cohort. In conclusion, we did not find MR evidence that increased GLP-1RA impacts SA. This awaits confirmation with RCT and real-world data.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal important difference in weight loss following bariatric surgery: Enhancing BODY-Q interpretability","authors":"Farima Dalaei,&nbsp;Phillip J. Dijkhorst,&nbsp;Sören Möller,&nbsp;Claire E. E. de Vries,&nbsp;Lotte Poulsen,&nbsp;Sophocles H. Voineskos,&nbsp;Manraj N. Kaur,&nbsp;Jørn Bo Thomsen,&nbsp;Ruben N. van Veen,&nbsp;Claus B. Juhl,&nbsp;Alin Andries,&nbsp;René K. Støving,&nbsp;Stefan J. Cano,&nbsp;Anne F. Klassen,&nbsp;Andrea L. Pusic,&nbsp;Jens A. Sørensen","doi":"10.1111/cob.12675","DOIUrl":"10.1111/cob.12675","url":null,"abstract":"<p>BODY-Q is a patient-reported outcome measure for comprehensive assessment of outcomes specific to patients undergoing bariatric surgery. The clinical utility of BODY-Q is hampered by the lack of guidance on score interpretation. This study aimed to determine minimal important difference (MID) for assessment of BODY-Q. Prospective BODY-Q data from Denmark and the Netherlands pre- and post-bariatric surgery were collected. Two distribution-based methods were used to estimate MID by 0.2 standard deviations of baseline scores and the mean standardized response change of scores from baseline to 3-years postoperatively. In total, 5476 assessments from 2253 participants were included of which 1628 (72.3%) underwent Roux-en-Y gastric bypass, 586 (26.0%) sleeve gastrectomy, 33 (1.5%) gastric banding, and 6 (0.03%) other surgeries. The mean age was 45.1 ± 10.9 with a mean BMI of 46.6 ± 9.6. Baseline MID ranged from 1 to 4 in health-related quality of life (HRQL) and from 2 to 8 in appearance scales. The mean change of scores ranged from 4 to 5 in HRQL and from 4 to 7 in the appearance scales. The estimated MID for the change in BODY-Q HRQL and appearance scales ranged from 3 to 8 and is recommended for use to interpret BODY-Q scores and assess treatment effects in bariatric surgery.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations on self-management interventions for adults living with obesity: COMPAR-EU project","authors":"Melixa Medina-Aedo,&nbsp;Jessica Beltran,&nbsp;Claudia Valli,&nbsp;Carlos Canelo-Aybar,&nbsp;Yang Song,&nbsp;Marta Ballester,&nbsp;Jacqueline Bowman-Busato,&nbsp;Christos Christogiannis,&nbsp;Maria G. Grammatikopoulou,&nbsp;Oliver Groene,&nbsp;Monique Heijmans,&nbsp;Martine Hoogendorn,&nbsp;Sarah Louise Killeen,&nbsp;Katerina-Maria Kontouli,&nbsp;Dimitris Mavridis,&nbsp;Inka Miñambres,&nbsp;Beate Sigrid Mueller,&nbsp;Ena Niño de Guzman,&nbsp;Janneke Noordman,&nbsp;Carola Orrego,&nbsp;Lilisbeth Perestelo-Perez,&nbsp;Zuleika Saz-Parkinson,&nbsp;Georgios Seitidis,&nbsp;Rosa Suñol,&nbsp;Sofia Tsokani,&nbsp;Pablo Alonso-Coello","doi":"10.1111/cob.12667","DOIUrl":"10.1111/cob.12667","url":null,"abstract":"<div>\u0000 \u0000 <p>Self-management interventions (SMIs) may improve disease management in adults living with obesity. We formulated evidence-based recommendations for SMIs within the context of the COMPAR-EU project. The multidisciplinary panel selected critical outcomes based on the COMPAR-EU core outcome set and established decision thresholds for each outcome. Recommendations were informed by systematic reviews of effects, cost-effectiveness, and a contextual assessment. To assess the certainty of the evidence and formulate the recommendations, we used the GRADE approach guidance. Overall, SMIs were deemed to have a small impact, but the absence of harmful effects and potential cumulative benefits indicated a favourable balance of effects, despite low certainty. SMIs showed variations in structure, intensity, and resource utilisation, but overall are likely to be cost-effective. Adapting SMIs to local contexts would enhance equity, acceptability, and feasibility, considering patients' values, and availability of resources and teamwork. Consequently, the panel made conditional recommendations favouring SMIs over usual care. The rigorous and explicit recommendations demonstrated the effectiveness of SMIs for adults living with obesity. However, the gaps in the literature influenced the panel to make only conditional recommendations in favour of SMIs. Further research is needed to strengthen the evidence base and improve recommendations' certainty and applicability.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in weight-loss outcomes among race-gender subgroups by behavioural intervention delivery mode: An analysis of the POWER trial","authors":"Kristal L. Brown,&nbsp;Nae-Yuh Wang,&nbsp;Wendy L. Bennett,&nbsp;Kimberly A. Gudzune,&nbsp;Gail Daumit,&nbsp;Arlene Dalcin,&nbsp;Gerald J. Jerome,&nbsp;Janelle W. Coughlin,&nbsp;Lawrence J. Appel,&nbsp;Jeanne M. Clark","doi":"10.1111/cob.12670","DOIUrl":"10.1111/cob.12670","url":null,"abstract":"<p>Prior in-person behavioural intervention studies have documented differential weight loss between men and women and by race, with Black women receiving the least benefit. Remotely delivered interventions are now commonplace, but few studies have compared outcomes by race-gender groups and delivery modality. We conducted a secondary analysis of POWER, a randomized trial (NCT00783315) designed to determine the effectiveness of 2 active, lifestyle-based, weight loss interventions (remote vs. in-person) compared to a control group. Participants with obesity and at least one cardiovascular disease risk factor (<i>N</i> = 415) were recruited in the Baltimore, MD area. Data from 233 white and 170 Black individuals were used for this analysis. Following an intention-to-treat approach, we compared the mean percent weight loss at 24 months by race-gender subgroups using repeated-measures, mixed-effects models. Everyone lost weight in the active interventions however, weight loss differed by race and gender. white and Black men had similar results for both interventions (white: in-person (−7.6%) remote (−7.4%); Black: in-person (−4.7%) remote (−4.4%)). In contrast, white women lost more weight with the in-person intervention (in-person (−7.2%) compared to the remote (−4.4%)), whereas Black women lost less weight in the in-person group compared to the remote intervention at 24 months (−2.0% vs. −3.0%, respectively; <i>p</i> for interaction &lt;.001). We found differences between the effectiveness of the 2 weight loss interventions—in-person or remote—in white and Black women at 24 months. Future studies should consider intervention modality when designing weight loss interventions for women.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACTION Teens Saudi Arabia: Perceptions, attitudes, motivators, and barriers among adolescents living with obesity, caregivers, and healthcare professionals in Saudi Arabia","authors":"Bassam Bin-Abbas,&nbsp;Afaf Al Sagheir,&nbsp;Lama Taher,&nbsp;Hussein Elbadawi,&nbsp;Abdulah Al Fares,&nbsp;Mohammed Al Harbi,&nbsp;Mohamed Refaat,&nbsp;Ahmed Ashmawy","doi":"10.1111/cob.12674","DOIUrl":"10.1111/cob.12674","url":null,"abstract":"<p>Obesity is predicted to affect approximately one-quarter of children/adolescents in Saudi Arabia by 2030, but there is limited evidence regarding the perceptions, attitudes, behaviours, and barriers to effective obesity care for adolescents living with obesity (ALwO), caregivers of ALwO, and healthcare professionals (HCPs). We report data from 500 ALwO (aged 12–&lt;18 years), 500 caregivers, and 200 HCPs surveyed in Saudi Arabia as part of the global, cross-sectional ACTION Teens study (NCT05013359). Nearly all respondents recognized that obesity has a strong impact on overall health (ALwO 88%; caregivers 85%; HCPs 90%). Most ALwO and caregivers were aware of the ALwO's obesity status (95% and 99%, respectively) and worried about weight impacting the ALwO's future health (both ≥99%), and social media was their most commonly used source of weight-management information (60% and 53%, respectively). Among ALwO and caregivers who had discussed weight with an HCP in the past year, most experienced ≥1 negative feeling following their most recent discussion (61% and 59%, respectively). Although 81% of HCPs felt motivated to help their ALwO patients lose weight, 57% believed weight loss was completely the ALwO's responsibility (compared with only 37% of ALwO and 35% of caregivers). This may reflect the finding that only 24% of HCPs had received advanced training in obesity/weight management after medical school. Overall, while respondents had similar perceptions of the impact of obesity, we found HCPs' attitudes towards weight loss were not aligned with those of ALwO and caregivers, suggesting a need for improved communication and obesity education.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' perspective on their drug therapy after bariatric surgery: A quantitative, cross-sectional interview study","authors":"Susanne Schiek,&nbsp;Melissa Drotleff,&nbsp;Dorit Schueler,&nbsp;Katrin Heinitz,&nbsp;Annett Frisch,&nbsp;Lars Selig,&nbsp;Yvonne Remane,&nbsp;Arne Dietrich,&nbsp;Matthias Blüher,&nbsp;Thilo Bertsche","doi":"10.1111/cob.12672","DOIUrl":"10.1111/cob.12672","url":null,"abstract":"<p>Drug therapy in patients who have undergone bariatric surgery is challenging. We aimed to investigate the patients' perspective on their drug therapy. This should allow deriving tailored measures to better support patients and their healthcare professionals with drug therapy after bariatric surgery. We conducted a quantitative telephone-based interview study with patients who have undergone bariatric surgery. The interview consisted of assessments in three parts: (i) current drug therapy: prescription, administration and adherence, (ii) changes after bariatric surgery and (iii) adverse events. (i) The 105 enrolled patients were taking a median of 10 (range: 3–30) drugs. In 1017 of 1080 drugs (94%), expectations in drug effectiveness were (rather) met. Of the 105 patients, 27% reported difficulties in drug administration, 44% forgot to take their drugs at least one time and 20% reported deviations from the prescription. (ii) Sixteen percent of the patients observed changes in drug effectiveness or tolerability—additionally to therapy adjustment by physicians. (iii) Seventy-four percent recognised at least one adverse event right before and/or after bariatric surgery, most frequently in gastrointestinal disorders. Patients who have undergone bariatric surgery have to deal with many difficulties in drug handling and adverse events. Our study emphasises the need for better and more individual support for patients with their drug therapy after bariatric surgery and, therefore, suggests a multidisciplinary approach that includes pharmacists. The stronger involvement of the patients' perspective seems to be a valuable source in research and practice.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of obesity and the clinical course of hospitalised COVID-19 survivors","authors":"Ali Emamjomeh,&nbsp;Noushin Mohammadifard,&nbsp;Mehdi Abbasi,&nbsp;Mozhde Askari,&nbsp;Marzieh Taheri,&nbsp;Sahel Javanbakht,&nbsp;Mahshid Ahmadian,&nbsp;Maedeh Sayyah,&nbsp;Shirin Mahmoudi,&nbsp;Kamal Heidari,&nbsp;Nizal Sarrafzadegan","doi":"10.1111/cob.12663","DOIUrl":"10.1111/cob.12663","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity is a risk factor for chronic inflammation and severe pulmonary infections. This study aimed to assess the association between obesity and the clinical courses of hospitalised COVID-19 survivors. This cross-sectional study used the Isfahan COVID Cohort (ICC) baseline data. The ICC is an ongoing, 5-year prospective, longitudinal cohort study conducted on hospitalised COVID-19 survivors in affiliated hospitals of the Medical University of Isfahan (MUI), Iran. Patients aged 19 and over throughout Isfahan County were recruited using a consecutive sampling method 1 month after discharge. Demographic and basic characteristics, symptoms and clinical features of these patients were collected and analysed. A total of 3843 hospitalised patients with COVID-19 were included in this study. Regarding the body mass index classification in the general obesity group, the patients with overweight and obesity had more extended hospitalisation and a higher frequency of low O₂ saturation compared to the normal weight patients, and the highest frequency of low O₂ saturation and more extended hospitalisation was observed in patients with obesity (5.9 ± 3.8 vs. 6.8 ± 5.4 vs. 7.1 ± 5.3, respectively; <i>p</i> = .001 and 59% vs. 64.5% vs. 65.5%; <i>p</i> &lt; .001). Furthermore, individuals with abdominal obesity had a significantly longer duration of hospitalisation compared to the non-abdominal obesity group (6.3 ± 4.6 vs. 7.0 ± 5.3; <i>p</i> &lt; .001). In the fully adjusted model, a significant association was observed between abdominal obesity and an increased occurrence of low oxygen saturation compared to general obesity (odds ratio: 1.25, 95% confidence interval: 1.03–1.44). Obesity was associated with more extended hospitalisation and hypoxia in patients with COVID-19. However, no significant relationship was found between obesity and other clinical courses.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features and behaviours for weight loss in the Chilean cohort with obesity from the ACTION study","authors":"Ada Cuevas,&nbsp;Fabián Pardo,&nbsp;Rodrigo Alonso,&nbsp;Eric Barros,&nbsp;Adriana Rendón","doi":"10.1111/cob.12673","DOIUrl":"10.1111/cob.12673","url":null,"abstract":"<p>In Latin America, obesity rates are among the highest in the world. Currently, people with obesity (PWO) receive suboptimal care due to several challenges and barriers. The international ACTION-IO study aimed to identify perceptions, attitudes and behaviours of PWO and healthcare providers (HCP), and to assess potential barriers to effective obesity care. The aim of this subanalysis of the Chilean cohort was to compare their characteristics, perceptions, attitudes and behaviours according to the percentage of weight loss (lower weight loss [LWL; ≤10%] or higher weight loss [HWL; &gt;10%] of basal weight). The ACTION-IO survey was completed by 1000 Chilean PWO and 200 HCPs. Mean age of PWO was 38 years (range 18–75); 62% were female. The majority had class I obesity. HWL subgroup represented 17.2% of all Chilean subset. Specific characteristics of patients with HWL were identified (higher educational level, lower proportion of class III obesity, preference for consulting obesity specialists, considering conversations with HCP as very helpful). HWL patients reported higher rates of favourable outcomes following HCP advice and a higher probability of attending scheduled follow-up visits. Certain demographic and behavioural variables (educational level, consultation to obesity specialists, adherence to HCP advice, follow-up scheduled visits and becoming aware of the obesity state) may identify PWO with a higher probability of a greater weight loss.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12673","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}