Clinical Obesity最新文献_第7页

Changes in Eating Behaviour During Treatment With Obesity Medications 减肥药治疗期间饮食行为的改变

IF 2.1

Clinical Obesity Pub Date : 2025-12-19 DOI: 10.1111/cob.70065

Ming Chuen Chong, Tak Ying Louise Ko, Philippus L. le Roux, Carel W. le Roux

{"title":"Changes in Eating Behaviour During Treatment With Obesity Medications","authors":"Ming Chuen Chong, Tak Ying Louise Ko, Philippus L. le Roux, Carel W. le Roux","doi":"10.1111/cob.70065","DOIUrl":"10.1111/cob.70065","url":null,"abstract":"<p>Obesity is a chronic, relapsing disease influenced by biological, environmental and behavioural factors. Pharmacological therapies have demonstrated substantial effects in weight loss, appetite suppression and modulation of food-related thoughts; however, the long-term effects of medications and eating behaviours across treatment phases throughout time remain poorly understood. This qualitative study involves 31 semi-structured interviews exploring patients in the dynamic and stable phase of weight loss. The interviews were conducted, transcribed, then analysed thematically. The five main themes that emerged were hunger, fullness, thoughts of food, portion size and palatability. The dynamic phase reported profound appetite suppression, early fullness, reduced ‘food noise’ with diminished cravings and smaller portion size. Portion control remained a persistent behavioural change across both phases. Long-term goals shifted from weight loss in the dynamic phase to weight maintenance in the stable phase. This transition is best described as a spectrum of change rather than a strict dichotomy. With a perceived loss of efficacy, some also report consideration of switching medications, especially in the stable phase. Overall, this cross sectional, patient-centred qualitative study may change practice of prescribers, policymakers, and the focus of future research.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Perspectives on the Course of Alcohol Use After Metabolic and Bariatric Surgery: Implications for Prevention, Intervention, and Future Research 代谢和减肥手术后患者对酒精使用过程的看法：预防、干预和未来研究的意义

IF 2.1

Clinical Obesity Pub Date : 2025-12-18 DOI: 10.1111/cob.70061

Erin N. Haley, Alyssa M. Vanderziel, Jordan M. Braciszewski, Heidi Westerman, Roland S. Moore, Kristina M. Jackson, Aaron Hamann, Arthur M. Carlin, Lisa R. Miller-Matero

{"title":"Patient Perspectives on the Course of Alcohol Use After Metabolic and Bariatric Surgery: Implications for Prevention, Intervention, and Future Research","authors":"Erin N. Haley, Alyssa M. Vanderziel, Jordan M. Braciszewski, Heidi Westerman, Roland S. Moore, Kristina M. Jackson, Aaron Hamann, Arthur M. Carlin, Lisa R. Miller-Matero","doi":"10.1111/cob.70061","DOIUrl":"10.1111/cob.70061","url":null,"abstract":"<p>Despite substantial benefits of metabolic and bariatric surgery (MBS), up to 1 in 5 patients develop an alcohol use disorder (AUD) within 5 years post-operatively. Cognitive-behavioural processes that are relevant to the reinitiation and escalation of alcohol use post-MBS are not well understood. Through content analysis of 20 patient interviews, we explored the course of alcohol use among individuals 6 months to 5 years post-MBS and examined potential differences by level of use. Over half (55%) of the participants reported high alcohol use, most described a gradual reintroduction to alcohol post-MBS, and escalation to misuse was thought to occur at an accelerated pace (i.e., potentially within months). Pre-operative intentions, attitudes/beliefs about post-MBS alcohol use, social factors, mood, visual cues, and post-MBS biological changes were reported to influence the course of post-MBS alcohol use. Although most features did not differ widely between those with higher versus lower alcohol consumption, reinitiating alcohol less than 12 months post-operatively and certain attitudinal factors (i.e., minimising the risks) may relate to greater alcohol use post-MBS. Findings illustrate the importance of early and long-term monitoring of post-MBS alcohol use. Several implications for early intervention and future research are discussed.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation Between Adiposity Measures and the Risk of a Composite of Cardiovascular Events, Diabetes, and Cancer in Patients With Cardiovascular Disease 心血管疾病患者肥胖措施与心血管事件、糖尿病和癌症复合风险之间的关系

IF 2.1

Clinical Obesity Pub Date : 2025-12-17 DOI: 10.1111/cob.70064

Ritobrata Bhattacharya, Frank L. J. Visseren, Manon G. van der Meer, Martin Teraa, Jannick A. N. Dorresteijn, Ynte M. Ruigrok, Thomas T. van Sloten, the UCC-Smart Study Group

{"title":"Relation Between Adiposity Measures and the Risk of a Composite of Cardiovascular Events, Diabetes, and Cancer in Patients With Cardiovascular Disease","authors":"Ritobrata Bhattacharya, Frank L. J. Visseren, Manon G. van der Meer, Martin Teraa, Jannick A. N. Dorresteijn, Ynte M. Ruigrok, Thomas T. van Sloten, the UCC-Smart Study Group","doi":"10.1111/cob.70064","DOIUrl":"10.1111/cob.70064","url":null,"abstract":"<p>Adiposity contributes to multiple non-communicable diseases. To guide prevention of morbidity, this study aimed to quantify the relation between waist circumference (WC), body mass index (BMI), waist to height ratio (WtHR), abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) and the risk of a composite outcome including recurrent cardiovascular events, incident type 2 diabetes and incident cancer, as well as each individual disease and all-cause mortality. Data were used from the UCC-SMART cohort study from 6138 patients with cardiovascular disease. Cox proportional hazard models estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) for adiposity measures, modelled as quartiles and per 1 SD increase, in relation to disease outcomes. All adiposity measures, except SAT, were related to higher risk of the composite outcome. WC and VAT showed the strongest relation (HR 1.62, 95% CI: 1.43, 1.83 and 1.62, 95% CI: 1.44, 1.83, respectively). Only WC and VAT were related to all-cause mortality (HRs 1.17, 95% CI: 1.01, 1.37 and 1.26, 95% CI: 1.08, 1.46, respectively). In patients with cardiovascular disease, WC and VAT are most strongly related to the risk of the composite outcome and to all-cause mortality. Monitoring adiposity with WC and VAT may help identify high-risk patients and could guide earlier interventions.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Skinfolds Based Predictive Equations for Estimating Body Fat Percentage in Older Adults: A Comparison Using Digital Adipometer (Lipowise) and Dual-Energy X-Ray Absorptiometry (DXA) 基于皮肤褶皱的老年人体脂率预测方程评估：数字脂肪计（Lipowise）和双能x射线吸收仪（DXA）的比较

IF 2.1

Clinical Obesity Pub Date : 2025-12-10 DOI: 10.1111/cob.70063

Gabriela Benatti de Oliveira, Lara Vilar Fernandes, Teresa F. Amaral, Ana Carolina Junqueira Vasques, Ligiana Pires Corona

{"title":"Evaluation of Skinfolds Based Predictive Equations for Estimating Body Fat Percentage in Older Adults: A Comparison Using Digital Adipometer (Lipowise) and Dual-Energy X-Ray Absorptiometry (DXA)","authors":"Gabriela Benatti de Oliveira, Lara Vilar Fernandes, Teresa F. Amaral, Ana Carolina Junqueira Vasques, Ligiana Pires Corona","doi":"10.1111/cob.70063","DOIUrl":"https://doi.org/10.1111/cob.70063","url":null,"abstract":"<p>Accurate assessment of body fat percentage (%BF) is essential for predicting health risks in older adults, as age-related changes affect fat distribution and measurement accuracy. While dual-energy x-ray absorptiometry (DXA) is a standard reference, it is costly and less accessible. This pilot study evaluated the validity of four skinfold equations using a digital calliper, with DXA as the reference to estimate %BF in older adults. A cross-sectional study included 149 participants (28 men and 121 women) aged 60 to 86 years. The Lean, Durnin-Womersley, and Visser equations (using 2 and 4 skinfolds) were analysed to estimate %BF. Statistical analyses were performed using SPSS (v.29), including Student's t-test, Mann–Whitney, Cohen's Kappa, and Bland–Altman. Skinfold equations differed significantly from DXA-derived %BF. In women, DXA values were lower than Lean but higher than Durnin-Womersley; in men, DXA showed lower %BF than Lean and higher than others. Agreement with DXA was moderate (Kappa 0.54–0.59). Durnin-Womersley underestimated %BF, especially in men (11.5%); Lean slightly overestimated (1.3%). Visser showed minimal bias—slight overestimation in women (0.3%, 0.4%) and underestimation in men (3.7%, 4.3%). Age-related physiological factors may impact equation accuracy. Discrepancies between DXA and skinfold equations highlight the need for age-specific prediction models for older adults.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Weight Loss Composition Following Metabolic-Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All-Cause Mortality 代谢减肥手术后的减重组成与主要不良心血管事件和全因死亡率的关系。

IF 2.1

Clinical Obesity Pub Date : 2025-11-18 DOI: 10.1111/cob.70054

Malou A. H. Nuijten, Bente M. de Roos, Jan H. M. Karregat, Eric J. Hazebroek, Valerie M. Monpellier, Ignace M. C. Janssen, Maria T. E. Hopman, Esmée A. Bakker, Thijs M. H. Eijsvogels

{"title":"Association of Weight Loss Composition Following Metabolic-Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All-Cause Mortality","authors":"Malou A. H. Nuijten, Bente M. de Roos, Jan H. M. Karregat, Eric J. Hazebroek, Valerie M. Monpellier, Ignace M. C. Janssen, Maria T. E. Hopman, Esmée A. Bakker, Thijs M. H. Eijsvogels","doi":"10.1111/cob.70054","DOIUrl":"10.1111/cob.70054","url":null,"abstract":"<p>Severe obesity is associated with an increased cardiovascular risk. Metabolic-bariatric surgery (MBS) can reduce the risk of cardiovascular events and mortality, potentially depending on weight loss composition. This study assessed the association between post-MBS weight loss composition and major adverse cardiovascular events (MACE) and all-cause mortality. This retrospective, single-center study included patients who underwent MBS between 2012 and 2020. Twelve-month total weight loss (TWL), fat mass loss (FML), fat-free mass loss (FFML), and proportion of FFML within weight loss (FFML/WL) were assessed. The primary endpoint was a composite of MACE and all-cause mortality. The event rate was compared across weight composition tertiles, while adjusting for cardiometabolic medication, age, sex, preoperative weight and surgery type. In total, 5889 patients (21% men; 44.3 ± 11.1 years) were included. During a follow-up of 4.9 ± 2.2 years, a total of 106 patients (1.8%) reached the primary endpoint. TWL, FFML, FML and FFML/WL were not associated with the composite endpoint after adjustment for confounders. Nevertheless, stratified analysis revealed that older patients (≥ 45 years) with a high TWL (HR = 1.68 [95% CI, 1.03–2.75]) and high FFML/WL (HR = 1.78 [95% CI, 1.12–2.85]) had a higher risk of MACE and all-cause mortality. Weight loss composition was not related to MACE and mortality in the total population, but higher TWL and FFML/WL ≥ 30% at 12 months post-MBS were associated with a worse prognosis among patients aged ≥ 45 years. The harm associated with excessive TWL and FFML post-MBS, along with potential countermeasures, should be further investigated to optimise clinical outcomes.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Sleep Duration and Overweight/Obesity: A Comprehensive Overview of Meta-Analyses 睡眠时间与超重/肥胖的关系：meta分析的综合综述。

IF 2.1

Clinical Obesity Pub Date : 2025-11-14 DOI: 10.1111/cob.70051

Mateus Assis Benfica, Tamiles Costa Ribeiro, Kallyane Santos Oliveira Silva, Marcelle Reis Nascimento Oliveira, Ericka Luanny Machado Maia, Eduardo Koji Tamura, David Ohara, Eduardo da Silva Alves

{"title":"Relationship Between Sleep Duration and Overweight/Obesity: A Comprehensive Overview of Meta-Analyses","authors":"Mateus Assis Benfica, Tamiles Costa Ribeiro, Kallyane Santos Oliveira Silva, Marcelle Reis Nascimento Oliveira, Ericka Luanny Machado Maia, Eduardo Koji Tamura, David Ohara, Eduardo da Silva Alves","doi":"10.1111/cob.70051","DOIUrl":"10.1111/cob.70051","url":null,"abstract":"<div>\u0000 \u0000 <p>Overweight and obesity are increasing globally and have an important impact on individuals' health and healthcare costs. Several factors contribute to this growth, and changes in normal sleep duration (SD) have been recognised. This relationship has given rise to numerous systematic reviews with meta-analyses (SRMAs) over the last years. Thus, synthesising these studies could help researchers and clinicians offering the highest level of evidence synthesis. Therefore, we aimed to provide a comprehensive overview of SRMAs that explored the relationship between SD and overweight/obesity. Searches were conducted in PubMed, Web of Science, Embase and Scopus. The quality of the reviews was evaluated using the Risk Of Bias In Systematic reviews (ROBIS) tool. The inverse variance heterogeneity model (IVhet) was adopted to assess the pooled relative risks (RR) and 95% confidence intervals (CIs) of SRMAs. After the selection process, 18 SRMAs were included in the synthesis. Short SD increased the risk of being overweight/obese in younger children (RR = 1.39; 95% CI: 1.27–153), older children (RR = 2.21; 95% CI: 1.59–3.07), adolescents (RR = 1.36; 95% CI: 1.22–1.51) and adults (RR = 1.30; 95% CI: 1.17–1.44). Long SD increases the risk in adults (RR = 1.05; 95% CI: 1.02–1.08), but has a protective effect in children (RR = 0.86; 95% CI: 0.78–0.95). These findings reinforce the role of SD as a significant and modifiable risk factor for overweight and obesity.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Endoscopic Sleeve Gastroplasty (ESG) at a Single Institution: The First Report on Weight Loss and Complication Rates in Japan 内镜下套管胃成形术（ESG）在单一机构的结果：日本体重减轻和并发症发生率的第一份报告。

IF 2.1

Clinical Obesity Pub Date : 2025-11-08 DOI: 10.1111/cob.70053

Kodai Takahashi

{"title":"Outcomes of Endoscopic Sleeve Gastroplasty (ESG) at a Single Institution: The First Report on Weight Loss and Complication Rates in Japan","authors":"Kodai Takahashi","doi":"10.1111/cob.70053","DOIUrl":"10.1111/cob.70053","url":null,"abstract":"<div>\u0000 \u0000 <p>Endoscopic sleeve gastroplasty (ESG) has gained recognition as a minimally invasive endoscopic treatment for obesity; however, clinical data in Japan is lacking. A retrospective review was conducted of 91 individuals with obesity who underwent ESG between January 2023 and November 2024. Eligibility included BMI ≥ 27.5 with at least one obesity-related comorbidity and preference for non-surgical therapy. Primary outcomes were the percentage of total weight loss (%TWL) at 1 month, 6 months and 1 year, and the rate of complications. The mean %TWL was 10.1% at 1 month, 15.2% at 6 months and 19.8% at 1 year. The follow-up completion rates were 100% at 1 month, 96.7% at 6 months and 87.9% at 12 months. Improvement in obesity-related comorbidities was observed in 57.1% of individuals with hypertension, 94.7% with dyslipidemia, 91.7% with diabetes, 96.9% with fatty liver disease and 75.0% with obstructive sleep apnea. One adverse event (1.1%) occurred, a pyriform sinus injury that resolved with conservative management; no severe complications were observed. ESG demonstrated favourable short-term weight loss and safety outcomes in Japan. These findings suggest ESG as a viable treatment option for Japanese individuals with obesity.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the 2025 Lancet Diagnostic Criteria on Obesity Treatment in the United States 2025年柳叶刀诊断标准对美国肥胖治疗的影响。

IF 2.1

Clinical Obesity Pub Date : 2025-11-05 DOI: 10.1111/cob.70050

Maryna Chumakova, Francis M. Finucane, Yi-Jun Chen, Yen-Yi Juo

{"title":"Impact of the 2025 Lancet Diagnostic Criteria on Obesity Treatment in the United States","authors":"Maryna Chumakova, Francis M. Finucane, Yi-Jun Chen, Yen-Yi Juo","doi":"10.1111/cob.70050","DOIUrl":"10.1111/cob.70050","url":null,"abstract":"<div>\u0000 \u0000 <p>For decades, clinicians have diagnosed obesity using body mass index (BMI). In January 2025, the updated Lancet guideline recommended the use of anthropometric index in addition to BMI. It also recommended routine treatment for clinical obesity, that is those with organ dysfunction or activity limitations, but for preclinical obesity, only treatment based on individual risk–benefit assessment. The objective of this study is to evaluate how the guideline could change obesity management on a national level. In this cross-sectional study, we projected the 2025 Lancet guideline onto the 2021–2023 National Health and Nutrition Examination Survey (NHANES), a nationally representative population survey. We characterised the change in treatment recommendation that would occur if the Lancet guideline replaced current treatment guidelines. According to the Lancet guideline, the national prevalence of obesity was about 39.6 (1.8) %. The addition of the anthropometric index did not alter obesity diagnosis in most participants, as 96.8 (0.5) % of participants with a BMI > 30 kg/m<sup>2</sup> also had elevated waist circumference. Approximately 80.3 (1.2) % of participants with obesity were classified as having clinical obesity. There is a large discrepancy between current medical guidelines and the Lancet guideline. Approximately 41.3% ± 1.2% of people who fit the indication for pharmaceutical treatment do not have clinical obesity, according to the Lancet guideline. Although the Lancet guideline would not alter obesity diagnosis for most people, it would encourage providers to take a more individual-based and multi-organ approach to managing obesity.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145450972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Relationship Between Obesity, Weight Loss and Health-Related Quality of Life: An Updated Systematic Review of Reviews 探讨肥胖、体重减轻和健康相关生活质量之间的关系：一项最新的系统综述。

IF 2.1

Clinical Obesity Pub Date : 2025-11-03 DOI: 10.1111/cob.70049

Tone Nygaard Flølo, Hui-Hsuan Liu, John Roger Andersen, Ronette L. Kolotkin

{"title":"Exploring the Relationship Between Obesity, Weight Loss and Health-Related Quality of Life: An Updated Systematic Review of Reviews","authors":"Tone Nygaard Flølo, Hui-Hsuan Liu, John Roger Andersen, Ronette L. Kolotkin","doi":"10.1111/cob.70049","DOIUrl":"10.1111/cob.70049","url":null,"abstract":"<p>The aim of this systematic literature review (SLR) of reviews was to update the evidence, established in a 2017 SLR, on the impact of obesity and weight loss by various interventions on health-related quality of life (HRQoL). In total, eight SLRs and/or meta-analyses published since 2017 were identified. The results consistently demonstrated a negative association between obesity and HRQoL, with some evidence suggesting poorer HRQoL in people with adverse metabolic profiles. In addition to substantial weight or body mass index reduction, metabolic and bariatric surgery (MBS) or endoscopic bariatric therapies resulted in significant and clinically relevant HRQoL improvements, with pronounced and persistent effects on the physical components in particular. HRQoL typically improved within 1–2 years after MBS and stabilised or deteriorated while remaining above baseline in subsequent years, likely due to weight regain. Evidence for the benefits of exercise interventions on HRQoL was inconclusive. Notably, no SLRs on anti-obesity medications were identified, limiting conclusions on this emerging treatment area. This updated SLR expands on previous findings from the 2017 SLR, providing additional insights into underexplored areas, including the role of metabolic profiles in HRQoL and trends of HRQoL after MBS. Evidence synthesis remains challenging due to heterogeneity in HRQoL measurements used in this field.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Effect of a Hospital-Based Intervention Program on BMI Trajectories in Danish Children and Adolescents With Overweight and Obesity: A 6-Year Follow-Up 基于医院的干预方案对丹麦超重和肥胖儿童和青少年BMI轨迹的长期影响：6年随访

IF 2.1

Clinical Obesity Pub Date : 2025-11-02 DOI: 10.1111/cob.70052

Mette Fogh, Jane Nautrup Østergaard, Rasmus Møller Jørgensen, Eeva-Liisa Røssell, Marianne Eg, Helle Terkildsen Maindal, Gunnar Toft, Henrik Støvring, Jens Meldgaard Bruun

{"title":"Long-Term Effect of a Hospital-Based Intervention Program on BMI Trajectories in Danish Children and Adolescents With Overweight and Obesity: A 6-Year Follow-Up","authors":"Mette Fogh, Jane Nautrup Østergaard, Rasmus Møller Jørgensen, Eeva-Liisa Røssell, Marianne Eg, Helle Terkildsen Maindal, Gunnar Toft, Henrik Støvring, Jens Meldgaard Bruun","doi":"10.1111/cob.70052","DOIUrl":"10.1111/cob.70052","url":null,"abstract":"<div>\u0000 \u0000 <p>Childhood obesity is associated with adverse health and psychosocial outcomes, often persisting into adulthood. Hospital-based lifestyle interventions may provide intensive support, but evidence on long-term effectiveness is limited. To evaluate changes in Body Mass Index z-score (BMIz) among children and adolescents with overweight and obesity participating in a hospital-based intervention compared to matched controls. This matched prospective cohort study includes children and adolescents aged 5–15 years. The intervention consisted of a family-centered hospital-based lifestyle program focusing on diet, physical activity, sleep and screen time management. Controls were matched on age, sex, weight category, and calendar year. BMI trajectories were analyzed using mixed effects models with linear splines, adjusting for socioeconomic factors from national registries. A total sample size of 1897 children and adolescents was included (325 intervention, 1572 controls). The intervention group achieved a higher reduction in BMIz during the first 6 months (−0.74 SD/years, 95% CI: −0.89; −0.60) and up to 12 months (−0.31 SD/years, −0.45; −0.16), compared to controls. From 12 to 36 months, a rebound in BMIz occurred (0.14, SD/years, 0.10; 0.17), and continued to rise through 72 months. The intervention was associated with improvements in BMIz up to 12 months after the intervention. However, the effects were not sustained at 6 years of follow-up.</p>\u0000 <p><b>Trial Registration:</b> Clinicaltrials.Gov identifier: NCT05790174</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0