Clinical Obesity最新文献_第10页

Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene? 在胰岛素受体基因突变的情况下，肥胖是否会加重高胰岛素血症?

IF 3.3

Clinical Obesity Pub Date : 2023-09-17 DOI: 10.1111/cob.12619

Valeria Calcaterra, Gianvincenzo Zuccotti, Alessandra Mari, Fernanda Iafusco, Giovanna Maione, Dario Iafusco, Nadia Tinto

{"title":"Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene?","authors":"Valeria Calcaterra, Gianvincenzo Zuccotti, Alessandra Mari, Fernanda Iafusco, Giovanna Maione, Dario Iafusco, Nadia Tinto","doi":"10.1111/cob.12619","DOIUrl":"10.1111/cob.12619","url":null,"abstract":"<div>\u0000 \u0000 Insulin receptor gene (INSR) mutations are a relatively rare and diverse cause of insulin resistance (IR), typically associated with a lean phenotype. However, we present a unique case of severe obesity and Type A severe IR syndrome in a patient with a heterozygous mutation of the INSR gene. Next Generation Sequencing (NGS) analysis was conducted to identify the genetic variant. A 16-year-old girl with severe obesity (BMI-SDS +2.79) exhibited markedly elevated basal insulin levels (>800 mcU/L). Despite obesity being a known cause of hyperinsulinism, further investigation was pursued due to the severity of hyperinsulinaemia. A heterozygous nucleotide variant at the donor splicing site of intron 13 (c.2682 + 1G > A) of the INSR gene was identified. This mutation was also present in the proband's normal-weight mother and her two younger brothers with obesity. Metformin treatment provided limited benefits, but subsequent liraglutide therapy resulted in weight loss and decreased IR 3 months after initiation. Our findings suggest that obesity can exacerbate hyperinsulinaemia in individuals with an INSR gene mutation. Although INSR signalling defects play a minor role in the aetiology of IR, they should still be considered in the diagnostic pathway, particularly in severe phenotypes. Clinicians should not overlook the possibility of genetic causes in patients with obesity and IR, as they may require personalized management approaches.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nature of expectations of bariatric surgery in patients during the pre- and post-operative period: A unicentric, qualitative study of patient perspectives 术前和术后患者对减肥手术期望的本质:一项单中心的定性研究

IF 3.3

Clinical Obesity Pub Date : 2023-09-11 DOI: 10.1111/cob.12621

Li Anne Mercier, Annabelle Fortin, Essé Julien Atto, Kim L. Lavoie

{"title":"The nature of expectations of bariatric surgery in patients during the pre- and post-operative period: A unicentric, qualitative study of patient perspectives","authors":"Li Anne Mercier, Annabelle Fortin, Essé Julien Atto, Kim L. Lavoie","doi":"10.1111/cob.12621","DOIUrl":"10.1111/cob.12621","url":null,"abstract":"Many patients (20%–30%) experience suboptimal weight loss (WL) after bariatric surgery (BS), and unrealistic preoperative WL expectations may be a contributing factor. This study aimed to describe the nature of patients' general expectations of BS during the pre-surgical period, and how patients determined whether their expectations and WL goals (WLGs) were realistic. The extent to which patients' expectations and WLGs were met and/or changed during the post-surgical period was also assessed. Semi-structured interviews were conducted with 15 preoperative patients recruited approximately 6-months before surgery. Focus groups were also conducted with 14 post-operative patients recruited approximately 6-months after surgery. Interviews and focus groups were audio-recorded, transcribed verbatim and analysed using qualitative content analysis. Preoperative patients reported expectations that BS would positively impact physical and psychological health, social relationships, as well as quality of care. Preoperative patients perceived that they and their health care professionals had unrealistically high expectations of WL. Post-operative patients reported being generally satisfied with the outcomes of surgery, even though many did not reach their expected WL. Finally, most post-operative patients reported changing their expectations from pre- to post-surgery. This study provides data that may help inform the development of preoperative interventions focusing on helping patients set realistic expectations for WL and related outcomes, which could better prepare patients for the challenges they will face after surgery.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental trajectory of appetitive traits and their bidirectional relations with body mass index from infancy to early childhood 从婴儿期到幼儿期食欲特征的发展轨迹及其与体重指数的双向关系

IF 3.3

Clinical Obesity Pub Date : 2023-09-05 DOI: 10.1111/cob.12620

Jenna R. Cummings, Leah M. Lipsky, Myles S. Faith, Tonja R. Nansel

{"title":"Developmental trajectory of appetitive traits and their bidirectional relations with body mass index from infancy to early childhood","authors":"Jenna R. Cummings, Leah M. Lipsky, Myles S. Faith, Tonja R. Nansel","doi":"10.1111/cob.12620","DOIUrl":"10.1111/cob.12620","url":null,"abstract":"<div>\u0000 \u0000 Appetitive traits, including food responsiveness, enjoyment of food, satiety responsiveness and slowness in eating, are associated with childhood body mass index. Change in appetitive traits from infancy to childhood and the direction of causality between appetitive traits and body mass index are unclear. The present study examined the developmental trajectory of appetitive traits and their bidirectional relations with body mass index, from infancy to early childhood. Mothers in the Pregnancy Eating Attributes Study and follow-up (n = 162) reported child appetitive traits using the Baby and Child Eating Behaviour Questionnaires at ages 6 months and 3.5 years, respectively. Standardized body mass index (zBMI) was calculated from child anthropometrics. Cross-lagged panel models estimated bidirectional relations between appetitive traits and zBMI. Food responsiveness, satiety responsiveness and slowness in eating increased from infancy to early childhood. In cross-lagged panel models, lower infant satiety responsiveness (B ± SE = −0.45 ± 0.19, p = .02) predicted greater child zBMI. Infant zBMI did not predict child appetitive traits (p-values >.36). From infancy to early childhood, appetitive traits may amplify. Appetitive traits, particularly satiety responsiveness, appear to influence body mass index during this period, suggesting early intervention targeting these traits may reduce childhood obesity.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the role of psychology in bariatric surgery? A survey of the differing views of psychologists, the multidisciplinary team, and patients in the UK 心理学在减肥手术中的作用是什么?对英国心理学家、多学科团队和患者不同观点的调查

IF 3.3

Clinical Obesity Pub Date : 2023-08-29 DOI: 10.1111/cob.12612

Denise Ratcliffe, Esme Banting

{"title":"What is the role of psychology in bariatric surgery? A survey of the differing views of psychologists, the multidisciplinary team, and patients in the UK","authors":"Denise Ratcliffe, Esme Banting","doi":"10.1111/cob.12612","DOIUrl":"10.1111/cob.12612","url":null,"abstract":"Although psychologists are a key member of the bariatric multidisciplinary team (MDT), there is a lack of clarity about the specific remit of their role. This exploratory study was conducted to identify differences, priorities and clarify how the role of psychology is perceived in the United Kingdom. We conducted surveys of three major stakeholder groups (psychologists, patients, and the bariatric multidisciplinary team) which focused on their perception of psychology in bariatric surgery. The results showed that in UK bariatric services, psychologists are spending the majority of their clinical time providing pre-operative assessments. Differences emerged between psychologists and MDT in how they viewed the purpose of these assessments, with the MDT viewing them as identifying contraindications to surgery whereas psychologists viewed them as identifying readiness for surgery. A total of 51% of patients reported they had not been able to access psychology services when needed and viewed provision of post-operative psychological support to be a key priority. Key themes and tensions emerged around (a) high demand for services yet limited psychology resource, (b) the purpose of the pre-operative assessment and (c) the provision of pre-operative versus post-operative support. These themes combine and interact in a way that currently makes it extremely challenging to provide coherent psychology services. There is clearly a need for education, consensus and adequate resourcing of the psychology role within bariatric surgery services in the United Kingdom.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10467227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term weight outcomes in patients treated with liraglutide 3.0 mg in real-world clinical practice 在实际临床实践中，利拉鲁肽 3.0 毫克对患者体重的长期影响

IF 3.3

Clinical Obesity Pub Date : 2023-08-24 DOI: 10.1111/cob.12622

Andrew Grannell, Werd Al-Najim, Carel le Roux

{"title":"Long-term weight outcomes in patients treated with liraglutide 3.0 mg in real-world clinical practice","authors":"Andrew Grannell, Werd Al-Najim, Carel le Roux","doi":"10.1111/cob.12622","DOIUrl":"10.1111/cob.12622","url":null,"abstract":"<div>\u0000 \u0000 Long-term weight outcomes reflect the success of obesity treatment. Weight regain during treatment for obesity is a biologically maladaptive response that can be considered a central feature of the disease. This phenomenon has been well documented in patients treated with lifestyle changes and bariatric surgery. In patients treated with liraglutide 3.0 mg this has been documented in randomized control trials, but real-world analysis is lacking. The aim of this retrospective observational study was to explore the long-term weight outcomes in patients treated with liraglutide 3.0 mg in a real-world clinical practice. The association between body composition changes and weight outcomes was also explored. The study included 25 patients treated with multi-modal care that included liraglutide 3.0 mg over a period of 78 weeks. Body composition was examined via dual x-ray absorptiometry at 16 and 32 weeks, with body weight captured up until 78 weeks for all patients. Weight loss (R2 = 0.39, p < .001), fat mass loss (R2 = 0.32, p = .003) and fat-free mass loss (R2 = 0.19, p = .03) were all associated with weight change from artificial nadir, which was, on average, 3.8 kg. For body composition, after adjustment, only fat mass loss was associated weight regain (R2 = 0.32, p = .01). In conclusion, in patients with clinical obesity treated with liraglutide 3.0 mg in a real-world clinical setting, fat mass loss was associated with weight regain. Whilst weight regain occurred on average, the magnitude was less than that observed in patients treated with lifestyle alone and weight loss remained clinically significant for most patients.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy 胃灌胃术对减酸药物使用、胃食管反流二次手术及袖胃切除术后主观反流症状的长期影响

IF 3.3

Clinical Obesity Pub Date : 2023-08-15 DOI: 10.1111/cob.12618

Tone Nygaard Flølo, Alexander Fosså, Jonas Ingolf Petersson Nedkvitne, Jo Erling Riise Waage, Magne Rekdal, Simon Nitter Dankel, Johan Fernø, Gunnar Mellgren, Bjørn Gunnar Nedrebø

{"title":"Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy","authors":"Tone Nygaard Flølo, Alexander Fosså, Jonas Ingolf Petersson Nedkvitne, Jo Erling Riise Waage, Magne Rekdal, Simon Nitter Dankel, Johan Fernø, Gunnar Mellgren, Bjørn Gunnar Nedrebø","doi":"10.1111/cob.12618","DOIUrl":"10.1111/cob.12618","url":null,"abstract":"We investigated whether adding gastropexy to sleeve gastrectomy (SG) reduced gastroesophageal reflux disease (GERD) in patients operated for severe obesity, assessed mainly by use of anti-reflux medication (ARM) and second operations due to GERD worsening. In a prospective non-randomized study, patients undergoing SG at two Norwegian hospitals were included from 2011 to 2015 and followed for 7 years. GERD was defined by regular use of ARM, and epigastric pain and heartburn were measured by the Rome II questionnaire. Gastropexy was done by suturing the gastrocolic ligament to the staple line. Patients undergoing SG only, mainly before gastropexia was introduced in 2013, were compared to those with additional gastropexy from 2013 onwards. Of 376 included patients (75% females, mean age 42.6 years and BMI 42.9 kg/m2), 350 (93%) and 232 (62%) were available for evaluation after 1 and 7 years, respectively. Baseline characteristics in the no-gastropexy (n = 235) and gastropexy groups (n = 141) were similar. In patients without ARM use before surgery, the use increased and in those that used ARM at baseline, the proportion decreased, with no difference in the no-gastropexy and gastropexy groups. With a combined endpoint of ARM use and/or second operation for GERD, there was no difference during follow-up between the two groups. With time, adding gastropexy did not reduce symptoms of GERD significantly. In this population, adding gastropexy to SG did not reduce use of ARM and/or second operation for uncontrolled GERD, epigastric pain or heartburn during the first 7 postoperative years.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of non-invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta-analysis 使用非侵入性脑刺激技术减少体重和对食物的渴望:一项系统回顾和荟萃分析

IF 3.3

Clinical Obesity Pub Date : 2023-08-14 DOI: 10.1111/cob.12611

Yousef Abdullah Alhindi, Najat Khalifa, Waleed Al-Khyatt, Iskandar Idris

{"title":"The use of non-invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta-analysis","authors":"Yousef Abdullah Alhindi, Najat Khalifa, Waleed Al-Khyatt, Iskandar Idris","doi":"10.1111/cob.12611","DOIUrl":"10.1111/cob.12611","url":null,"abstract":"Several studies demonstrated non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are safe and simple techniques that can reduce body weight, food cravings, and food consumption in patients with obesity. However, a systematic to evaluate the efficacy of active NIBS versus sham stimulation in reducing body weight and food cravings in patients with obesity is not available. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) using PubMed, Embase, MEDLINE, and Cochrane Central Register of Control Trial between January 1990 and February 2022. Mean differences (MDs) for continuous outcome variables with 95% confidence intervals (95% CIs) were used to examine the effects of NIBS on body weight and body mass index (BMI), whereas the hedges's g test was used to measure the effects on food craving. Nineteen RCTs involving 571 participants were included in this study. Active neurostimulation (TMS and tDCS) was significantly more likely than sham stimulation to reduce body weight (TMS: −3.29 kg, 95% CI [−5.32, −1.26]; I2 = 48%; p < .001; tDCS: −0.82 kg, 95% CI [−1.01, −0.62]; I2 = 0.0%; p = .00) and BMI (TMS: −0.74, 95% CI [−1.17, −0.31]; I2 = 0% p = .00; tDCS: MD = −0.55, 95% CI [−2.32, 1.21]; I2 = 0% p = .54) as well as food cravings (TMS: g = −0.91, 95% CI [−1.68, −0.14]; I2 = 88 p = .00; tDCS: g = −0.32, 95% CI [−0.62, −0.02]; p = .04). Compared with sham stimulation, our findings indicate that active NIBS can significantly help to reduce body weight and food cravings. Hence, these novel techniques may be used as primary or adjunct tools in treating patients with obesity.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9981545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical students' perceived comfort and competence performing physical examinations on patients with obesity: A mixed-methods needs assessment 医科学生对肥胖症患者进行体格检查的舒适度和能力感知：混合方法需求评估

IF 3.3

Clinical Obesity Pub Date : 2023-08-09 DOI: 10.1111/cob.12617

Christine B. Tenedero, Kathleen T. O'Brien, Barkha P. Patel, Michele Strom, Arin C. Deveci, Lisa Chu, Sanasi Jayawardena, Rebecca Noseworthy, Amy C. McPherson, Catharine M. Walsh, Jill K. Hamilton

{"title":"Medical students' perceived comfort and competence performing physical examinations on patients with obesity: A mixed-methods needs assessment","authors":"Christine B. Tenedero, Kathleen T. O'Brien, Barkha P. Patel, Michele Strom, Arin C. Deveci, Lisa Chu, Sanasi Jayawardena, Rebecca Noseworthy, Amy C. McPherson, Catharine M. Walsh, Jill K. Hamilton","doi":"10.1111/cob.12617","DOIUrl":"10.1111/cob.12617","url":null,"abstract":"<div>\u0000 \u0000 Physicians are unsatisfied with their training in the care of patients with obesity. Physical examination is a key component of care, and modifications to techniques are often necessary for patients with obesity. To determine learning needs, we examined medical students' perceived comfort and competency in conducting physical examinations on patients with obesity. This mixed-methods study of Canadian medical students used a questionnaire and semi-structured focus groups to assess medical students' perceived comfort and competence in examining patients with obesity. Participants included 175 Canadian medical students. A minority of medical students felt comfortable (42%) or competent (14%) examining patients with obesity. Physical exam challenges included modifying exam manoeuvres, interpreting findings and communicating sensitively around weight. Lack of early exposure to patients with obesity, minimal instruction by preceptors and a lack of curricular focus on obesity were felt to be barriers to improving these skills. Students perceived their lack of confidence as negatively impacting their ability to manage patients with obesity and more training in this area was desired to prevent disparities in care. Medical students feel that adequate training on how to perform an obesity-specific physical examination is lacking. Developing curricula and including formal teaching around these key competencies within medical education is essential.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10338683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking family-based obesity treatment 重新思考以家庭为基础的肥胖治疗

IF 3.3

Clinical Obesity Pub Date : 2023-08-02 DOI: 10.1111/cob.12614

Joseph A. Skelton, Mara Vitolins, Keeley J. Pratt, Leila Hamzi DeWitt, Sally G. Eagleton, Callie Brown

{"title":"Rethinking family-based obesity treatment","authors":"Joseph A. Skelton, Mara Vitolins, Keeley J. Pratt, Leila Hamzi DeWitt, Sally G. Eagleton, Callie Brown","doi":"10.1111/cob.12614","DOIUrl":"10.1111/cob.12614","url":null,"abstract":"Emerging research in paediatric obesity has demonstrated that parental involvement in the weight management process can improve weight outcomes in children. Recent guidelines by the American Academy of Pediatrics note the importance of parent and family involvement in treatment. However, it is currently unknown if including the entire family in obesity treatment can supersede outcomes associated with participation of only one parent. Family Systems Theory (FST) provides the theoretical foundation for examining one's healthy behaviours as they exist within the context of their family, defined by family dynamics. This narrative review aims to reconsider prior definitions of paediatric family-based management using the FST framework to be inclusive of family and household diversity and in doing so, inform research not only within weight management but also other domains of clinical care requiring family support or change. Applying FST to paediatric weight management highlights the link between family dynamics and paediatric obesity, demonstrating the association of dysfunctional family dynamics with more severe obesity. While family-based weight management remains the gold standard for treatment of paediatric obesity, more investigation is needed in expanding family-based interventions to impact entire families and potentially improve outcomes more broadly for overall family health and wellbeing.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"13 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shedding light on eye disease in obesity: A review 揭示肥胖症引发的眼疾：综述

IF 3.3

Clinical Obesity Pub Date : 2023-08-02 DOI: 10.1111/cob.12616

Shravika Lam, Jennifer Lindsey, Barbara Gisella Carranza Leon, Sahar Takkouche

{"title":"Shedding light on eye disease in obesity: A review","authors":"Shravika Lam, Jennifer Lindsey, Barbara Gisella Carranza Leon, Sahar Takkouche","doi":"10.1111/cob.12616","DOIUrl":"10.1111/cob.12616","url":null,"abstract":"<div>\u0000 \u0000 Obesity is known to be associated with numerous ocular manifestations, including but not limited to, diabetic retinopathy (DR), age-related macular degeneration (AMD), cataracts, glaucoma, and dry eye disease. This review aims to provide an overview of the ophthalmological findings in obesity. A literature search was conducted using PubMed and Cochrane databases for studies describing randomized clinical trials, meta-analyses, systematic reviews, and observational studies published from 1 January 2017 to 1 April 2023. The search terms used included relevant keywords such as ‘obesity’, ‘body mass index’, ‘waist-to-hip ratio’, ‘bariatric’, ‘ophthalmology’, ‘eye disease’, ‘myopia’, ‘retinopathy’, ‘glaucoma’, and ‘cataract’. This literature search was performed on 1 April 2023. Obesity is associated with increased risk of developing DR, a sight-threatening complication of diabetes mellitus. Similarly, obesity has been shown to increase risk of AMD, cataracts, glaucoma, and ocular surface disease. Multiple mechanisms linking obesity to ophthalmic disease have been proposed. Adipose tissue produces various inflammatory cytokines that can affect ocular tissues, leading to disease progression. Additionally, obesity is associated with systemic metabolic changes that can influence ocular health. Bariatric surgery has been shown to be protective against development of ophthalmic disease. Obesity is a significant risk factor for several ophthalmological diseases. Healthcare providers should encourage weight loss in patients with overweight or obesity to prevent or delay the onset of ocular complications. Further research is needed to better understand the underlying mechanisms of this association, and to identify effective strategies for preventing or managing ophthalmic disease in patients with obesity.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0