Clinical Obesity最新文献

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Treatment of childhood obesity based on the reduction of ultra-processed foods plus energy restriction: A randomised controlled trial based on the Brazilian guidelines 通过减少超加工食品和限制能量来治疗儿童肥胖症:基于巴西指南的随机对照试验。
IF 3.3
Clinical Obesity Pub Date : 2024-02-24 DOI: 10.1111/cob.12648
Joana Maia Brandão, Rosely Sichieri, Vitor Barreto Paravidino, Simone Augusta Ribas, Diana Barbosa Cunha
{"title":"Treatment of childhood obesity based on the reduction of ultra-processed foods plus energy restriction: A randomised controlled trial based on the Brazilian guidelines","authors":"Joana Maia Brandão,&nbsp;Rosely Sichieri,&nbsp;Vitor Barreto Paravidino,&nbsp;Simone Augusta Ribas,&nbsp;Diana Barbosa Cunha","doi":"10.1111/cob.12648","DOIUrl":"10.1111/cob.12648","url":null,"abstract":"<div>\u0000 \u0000 <p>Reducing ultra-processed foods (UPF) improves diet quality and may curb energy consumption. This study aimed to compare an intervention based on the reduction of UPF, according to the Dietary Guideline for the Brazilian Population (DGBP), with and without advice on energy intake. A parallel and randomised controlled trial was carried out with children with obesity from 7 to 12 years old. Both control (CG) and intervention groups (IG) participated monthly in 6 standardised educational activities based on the 10 steps of the DGBP. An individualised food plan was also provided to the IG. The rate of change for body mass index (BMI), waist circumference, body weight, and UPF consumption were investigated based on mixed-effect models. At the end of the study, the BMI declined in the IG (Δ = −0.27 kg/m<sup>2</sup>) compared to the CG (Δ = + 0.53 kg/m<sup>2</sup>) (<i>p</i> = .0002). Both groups showed a decline in grams of UPF until the fourth month and a gradual increase in the following months. Combining the qualitative approach of the DGBP with counselling on energy restriction through the diet plan proved to be effective in reducing childhood obesity. <b>Clinical Trial Registration</b>: This trial is registered at the Brazilian Registry of Clinical Trials (REBEC), under the RBR-3st5sn registry, available at http://www.ensaiosclinicos.gov.br/rg/RBR-3st5sn/. The datasets generated by the current study are not publicly available but are available from the corresponding author on reasonable request.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139939799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between neck circumference and hepatic steatosis determined by controlled attenuation parameter 通过受控衰减参数确定的颈围与肝脏脂肪变性之间的相关性。
IF 3.3
Clinical Obesity Pub Date : 2024-02-16 DOI: 10.1111/cob.12647
Sakkarin Chirapongsathorn, Pakapop Jinatongthai, Sudatip Sirichana, Apussanee Boonyavarakul, Sombat Treeprasertsuk, Nakarin Sansanayudh
{"title":"Correlation between neck circumference and hepatic steatosis determined by controlled attenuation parameter","authors":"Sakkarin Chirapongsathorn,&nbsp;Pakapop Jinatongthai,&nbsp;Sudatip Sirichana,&nbsp;Apussanee Boonyavarakul,&nbsp;Sombat Treeprasertsuk,&nbsp;Nakarin Sansanayudh","doi":"10.1111/cob.12647","DOIUrl":"10.1111/cob.12647","url":null,"abstract":"<div>\u0000 \u0000 <p>Neck circumference is an attractive method for determining metabolic profiles and has many advantages over waist circumference. However, the correlation between neck circumference and hepatic fibrosis has not been evaluated. The aim of this study was to evaluate the correlation between neck circumference and hepatic fibrosis and define the optimal cut-off point for neck circumference to determine hepatic fibrosis. A cross-sectional study (<i>n</i> = 333) was conducted among Thai healthcare workers at Phramongkutklao Hospital who received an annual health maintenance program. Neck circumference was measured at the lower margin of the laryngeal prominence. Fibroscan® with a controlled attenuation parameter was used to measure the degree of hepatic fibrosis and steatosis by an experienced, well-trained operator. In the cross-sectional analysis, it was found that the large circumference of the neck was associated with hepatic fibrosis (<i>r</i> = 0.19, <i>p</i> = .001) and hepatic steatosis (<i>r</i> = 0.58, <i>p</i> &lt; .001). Hepatic fibrosis (<i>r</i> = 0.15, <i>p</i> = .004) and steatosis (<i>r</i> = 0.53, <i>p</i> &lt; .001) were also associated with waist circumference. The neck circumferences of 40 and 34 cm were the best cut-offs for male and female participants, respectively.Neck circumference is closely related to hepatic fibrosis and steatosis, which should be promoted and has a better advantage than waist circumference in the screening of hepatic steatosis.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of COVID-19 pandemic on sleep parameters and characteristics in individuals living with overweight and obesity COVID-19 大流行对超重和肥胖症患者睡眠参数和特征的影响。
IF 3.3
Clinical Obesity Pub Date : 2024-02-13 DOI: 10.1111/cob.12646
Stephen A. Glazer, Michael Vallis
{"title":"Impact of COVID-19 pandemic on sleep parameters and characteristics in individuals living with overweight and obesity","authors":"Stephen A. Glazer,&nbsp;Michael Vallis","doi":"10.1111/cob.12646","DOIUrl":"10.1111/cob.12646","url":null,"abstract":"<div>\u0000 \u0000 <p>Coronavirus disease 2019 (COVID-19) has been very challenging for those living with overweight and obesity. The magnitude of this impact on sleep requires further attention to optimise patient care and outcomes. This study assessed the impact of the COVID-19 lockdown on sleep duration and quality as well as identify predictors of poor sleep quality in individuals with reported diagnoses of obstructive sleep apnoea and those without sleep apnoea. An online survey (June–October 2020) was conducted with two samples; one representative of Canadians living with overweight and obesity (<i>n</i> = 1089) and a second of individuals recruited through obesity clinical services or patient organisations (<i>n</i> = 980). While overall sleep duration did not decline much, there were identifiable groups with reduced or increased sleep. Those with changed sleep habits, especially reduced sleep, had much poorer sleep quality, were younger, gained more weight and were more likely to be female. Poor sleep quality was associated with medical, social and eating concerns as well as mood disturbance. Those with sleep apnoea had poorer quality sleep although this was offset to some degree by use of CPAP. Sleep quality and quantity has been significantly impacted during the early part of the COVID-19 pandemic in those living with overweight and obesity. Predictors of poor sleep and the impact of sleep apnoea with and without CPAP therapy on sleep parameters has been evaluated. Identifying those at increased risk of sleep alterations and its impact requires further clinical consideration.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The double burden: Navigating type 1 diabetes and obesity 双重负担:驾驭 1 型糖尿病和肥胖症。
IF 3.3
Clinical Obesity Pub Date : 2024-02-09 DOI: 10.1111/cob.12645
Nele Steenackers, Alix Nessa Feldman, Chantal Mathieu, Jonathan Rosen, Jeannette Soderberg, Ebaa Al-Ozairi, Carel W. le Roux, Bart Van der Schueren
{"title":"The double burden: Navigating type 1 diabetes and obesity","authors":"Nele Steenackers,&nbsp;Alix Nessa Feldman,&nbsp;Chantal Mathieu,&nbsp;Jonathan Rosen,&nbsp;Jeannette Soderberg,&nbsp;Ebaa Al-Ozairi,&nbsp;Carel W. le Roux,&nbsp;Bart Van der Schueren","doi":"10.1111/cob.12645","DOIUrl":"10.1111/cob.12645","url":null,"abstract":"","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACTION APAC: Understanding perceptions, attitudes and behaviours in obesity and its management across south and Southeast Asia 亚太行动:了解南亚和东南亚地区对肥胖症及其管理的看法、态度和行为。
IF 3.3
Clinical Obesity Pub Date : 2024-02-08 DOI: 10.1111/cob.12644
Kwang Wei Tham, Asma Ahmed, Apussanee Boonyavarakul, Mariana Mercado Garcia, Miroslava Guajardo, Zubaidah Nor Hanipah, Tran Quang Nam, Nemencio A. Nicodemus Jr., Faruque Pathan, Jack Garcia Uranga Romano, Sidartawan Soegonda, Edgardo L. Tolentino Jr., Ambika Gopalakrishnan (A. G). Unnikrishnan, Brian J. Oldfield
{"title":"ACTION APAC: Understanding perceptions, attitudes and behaviours in obesity and its management across south and Southeast Asia","authors":"Kwang Wei Tham,&nbsp;Asma Ahmed,&nbsp;Apussanee Boonyavarakul,&nbsp;Mariana Mercado Garcia,&nbsp;Miroslava Guajardo,&nbsp;Zubaidah Nor Hanipah,&nbsp;Tran Quang Nam,&nbsp;Nemencio A. Nicodemus Jr.,&nbsp;Faruque Pathan,&nbsp;Jack Garcia Uranga Romano,&nbsp;Sidartawan Soegonda,&nbsp;Edgardo L. Tolentino Jr.,&nbsp;Ambika Gopalakrishnan (A. G). Unnikrishnan,&nbsp;Brian J. Oldfield","doi":"10.1111/cob.12644","DOIUrl":"10.1111/cob.12644","url":null,"abstract":"<p>To identify perceptions and attitudes among people with obesity (PwO) and healthcare professionals (HCPs) toward obesity and its management in nine Asia-Pacific (APAC) countries, a cross-sectional online survey was conducted among adult PwO with self-reported body mass index of ≥25 kg/m<sup>2</sup> (≥27 kg/m<sup>2</sup>, Singapore), and HCPs involved in direct patient care. In total, 10 429 PwO and 1901 HCPs completed the survey. Most PwO (68%) and HCPs (84%) agreed that obesity is a disease; however, a significant proportion of PwO (63%) and HCPs (41%) believed weight loss was the complete responsibility of PwO and only 43% of PwO discussed weight with an HCP in the prior 5 years. Most respondents acknowledged that weight loss would be extremely beneficial to PwO's overall health (PwO 76%, HCPs 85%), although nearly half (45%) of PwO misperceived themselves as overweight or of normal weight. Obesity was perceived by PwO (58%) and HCPs (53%) to negatively impact PwO forming romantic relationships. HCPs cited PwOs' lack of interest (41%) and poor motivation (37%) to lose weight as top reasons for not discussing weight. Most PwO (65%) preferred lifestyle changes over medications to lose weight. PwO and HCPs agreed that lack of exercise and unhealthy eating habits were the major barriers to weight loss. Our data highlights a discordance between the understanding of obesity as a disease and the actual behaviour and preferred approaches to manage it among PwO and HCPs. The study addresses a need to align these gaps to deliver optimal care for PwO.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining success in adult obesity management: A systematic review and framework synthesis of clinical practice guidelines 成人肥胖症管理成功的定义:临床实践指南的系统回顾和框架综述。
IF 3.3
Clinical Obesity Pub Date : 2024-02-06 DOI: 10.1111/cob.12631
Nicole Juul-Hindsgaul, Zahra Alalwani, Anne-Marie Boylan, Jamie Hartmann-Boyce, David Nunan
{"title":"Defining success in adult obesity management: A systematic review and framework synthesis of clinical practice guidelines","authors":"Nicole Juul-Hindsgaul,&nbsp;Zahra Alalwani,&nbsp;Anne-Marie Boylan,&nbsp;Jamie Hartmann-Boyce,&nbsp;David Nunan","doi":"10.1111/cob.12631","DOIUrl":"10.1111/cob.12631","url":null,"abstract":"<p>Obesity is a chronic and complex disease affecting millions of people worldwide. Currently, there is no standard definition of success for the management of obesity. We set out to complete a synthesis of clinical practice guidelines for obesity management for adult populations, aiming to provide both a quantitative descriptive and qualitative analysis of definitions of success in clinical practice guidelines. An electronic search retrieved 4477 references. Sixteen clinical practice guidelines were included after screening and full-text review. We coded definitions of success 147 times across the included guidelines. No standard or explicit definition of success was identified in the guidelines but rather success was implicitly defined. We developed three themes describing how success was defined in the clinical practice guidelines: <i>Knowledge-based decision making</i>; <i>management of expectations; and the perception of control</i>. The review reinforced that success is an inherently subjective and complex concept. Defining success is limited by existing studies that focus on weight loss and would benefit from additional research on different outcomes. Equally, the relationship between people living with obesity and their clinicians should be further explored to understand how defining success is controlled, discussed and framed in a clinical setting.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘Surgery is my only hope’: A qualitative study exploring perceptions of living with obesity and the prospect of having bariatric surgery 手术是我唯一的希望":一项定性研究,探讨肥胖症患者的生活观念和接受减肥手术的前景。
IF 3.3
Clinical Obesity Pub Date : 2024-02-01 DOI: 10.1111/cob.12643
Rebecca Keyte, Michail Mantzios, Misba Hussain, Abd A. Tahrani, Sally Abbott, Rachel Strachan, Rishi Singhal, Helen Egan
{"title":"‘Surgery is my only hope’: A qualitative study exploring perceptions of living with obesity and the prospect of having bariatric surgery","authors":"Rebecca Keyte,&nbsp;Michail Mantzios,&nbsp;Misba Hussain,&nbsp;Abd A. Tahrani,&nbsp;Sally Abbott,&nbsp;Rachel Strachan,&nbsp;Rishi Singhal,&nbsp;Helen Egan","doi":"10.1111/cob.12643","DOIUrl":"10.1111/cob.12643","url":null,"abstract":"<p>The health benefits of bariatric surgery are well documented; however, the occurrence of weight-regain after surgery, along with the development of mental health difficulties poses a question of how contemporary psychology could assist to prepare people living with obesity prior to undergoing bariatric surgery. This research explored individuals' (in the immediate pre-operative and post-operative population) attitudes, beliefs and experiences towards obesity and their journey to bariatric surgery. Seventeen adult participants (males <i>n</i> = 4; age range: 26–64 years) were recruited and participated in a semi-structured interview. Twelve individuals participated prior to undergoing bariatric surgery. Five individuals participated in the early post-operative period (&lt;3 months post-surgery). People living with obesity displayed high optimism for positive outcomes, with participants hoping that bariatric surgery would be different to previous attempts at weight regulation, with there being a clear shift in the locus of control for weight management from self to healthcare professionals. Whilst this is adaptive, there was the presence of seemingly unrealistic optimism, with many pre-surgery participants not relaying the realistic possibility of post-surgery weight-regain. Despite the optimism individuals feel about bariatric surgery, participants felt that the psychological factors influencing eating behaviours are not being addressed by healthcare. These findings suggest that mindfulness, mindful eating, and self-compassion approaches should be incorporated into clinical practice to support weight regulation and adaption to physiological changes after bariatric surgery.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring potential reach and representativeness of a self-weighing weight gain prevention intervention in adults with overweight and obesity 探索针对超重和肥胖成年人的自我称重体重增加预防干预措施的潜在覆盖范围和代表性。
IF 3.3
Clinical Obesity Pub Date : 2024-02-01 DOI: 10.1111/cob.12641
Kellie B. Scotti, Melinda Rajoria, Montserrat Carrera Seoane, Kathryn M. Ross, Sofia Muenyi, Megan A. McVay
{"title":"Exploring potential reach and representativeness of a self-weighing weight gain prevention intervention in adults with overweight and obesity","authors":"Kellie B. Scotti,&nbsp;Melinda Rajoria,&nbsp;Montserrat Carrera Seoane,&nbsp;Kathryn M. Ross,&nbsp;Sofia Muenyi,&nbsp;Megan A. McVay","doi":"10.1111/cob.12641","DOIUrl":"10.1111/cob.12641","url":null,"abstract":"<div>\u0000 \u0000 <p>Most adults with obesity do not enrol in comprehensive weight loss interventions when offered. For these individuals, lower burden self-weighing interventions may offer an acceptable alternative, though data is lacking on the potential for reach and representativeness of such interventions. Health system patients with BMI ≥30 kg/m<sup>2</sup> (or 25–30 kg/m<sup>2</sup> with an obesity comorbidity) completed a general health survey. During the survey, patients were given information about comprehensive weight loss interventions. If they denied interest or did not enrol in a comprehensive intervention, they were offered enrolment in a low-burden weight gain prevention intervention focused on daily self-weighing using a cellular network-connected in-home scale without any dietary or physical activity prescriptions. Enrolment in this program was documented. Among patients offered the self-weighing intervention (<i>n</i> = 85; 55.3% men; 58.8% White; BMI = 34.2 kg/m<sup>2</sup>), 44.2% enrolled. Compared to those who did not enrol, enrollers had higher educational attainment (57.1% vs. 42.9% with bachelor's degree <i>p</i> = .02), social anxiety (5.8 vs. 2.8, <i>p</i> &lt; .001), and perceptions of the effectiveness of the self-weighing intervention (25.8 vs. 20.9 on 35, <i>p</i> = .007). The most highly endorsed reason for not enrolling in the self-weighing intervention was that it would make individuals overly focused on weight. A low-intensity weight gain prevention intervention may serve as a viable alternative to comprehensive weight loss interventions for the substantial portion of patients who are at risk for continued weight gain but would otherwise not enrol in a comprehensive intervention. Differential enrolment by education, however, suggests potential for inequitable uptake.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of glucagon-like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity—A systematic review 胰高血糖素样肽 1 受体激动剂在控制后天性下丘脑肥胖症患者体重方面的作用--系统综述。
IF 3.3
Clinical Obesity Pub Date : 2024-01-25 DOI: 10.1111/cob.12642
Victoria Wen Wei Ng, Gheslynn Gerard, Jonathan Jin Kai Koh, Kah Yin Loke, Yung Seng Lee, Nicholas Beng Hui Ng
{"title":"The role of glucagon-like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity—A systematic review","authors":"Victoria Wen Wei Ng,&nbsp;Gheslynn Gerard,&nbsp;Jonathan Jin Kai Koh,&nbsp;Kah Yin Loke,&nbsp;Yung Seng Lee,&nbsp;Nicholas Beng Hui Ng","doi":"10.1111/cob.12642","DOIUrl":"10.1111/cob.12642","url":null,"abstract":"<div>\u0000 \u0000 <p>Hypothalamic obesity does not respond well to conventional interventions for obesity. GLP-1 receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. This systematic review summarizes the efficacy and safety of GLP-1 receptor agonists use in hypothalamic obesity. A PRISMA-compliant systematic review was performed. Data was extracted from included studies and analysed based on change in weight, body mass index, glycaemic control, satiety, and safety profile with GLP-1 receptor agonist use. Ten studies comprising 5 case reports, 4 case series and 1 randomized-controlled trial included 54 patients (24 males, 30 females) with mean age of 25.2 (range 13–71) years with hypothalamic obesity who had received GLP-1 receptor agonists (exenatide = 48, liraglutide = 5 and dulaglutide = 1) over a mean duration of treatment of 12 (range 3–51) months. Mean weight reduction of 7.4 (SD 7.92) kg was observed in patients in whom weight was reported, with 85.7% of patients experiencing weight loss. All patients on liraglutide had weight reduction post-therapy. The sole trial had reported a non-significant reduction in BMI post-exenatide. Glycaemic control had either improved/maintained in all patients in whom this was measured. The main side effects of GLP-1 receptor agonist in individuals with hypothalamic obesity were nausea and vomiting; there were no major safety concerns. Based on limited published experience, GLP-1RA may be effective and safe for weight control in hypothalamic obesity, with the added benefit of improved glycaemic control in those with concurrent diabetes mellitus.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term changes in lung function after Roux-en-Y gastric bypass in patients with severe obesity 重度肥胖症患者进行 Roux-en-Y 胃旁路术后肺功能的长期变化。
IF 3.3
Clinical Obesity Pub Date : 2024-01-18 DOI: 10.1111/cob.12640
Kjetil Roth, Maria Støle, Ingvild Vadseth, Eivind Ottersen Samstad, Jorunn Sandvik, Dag Arne Lihaug Hoff
{"title":"Long-term changes in lung function after Roux-en-Y gastric bypass in patients with severe obesity","authors":"Kjetil Roth,&nbsp;Maria Støle,&nbsp;Ingvild Vadseth,&nbsp;Eivind Ottersen Samstad,&nbsp;Jorunn Sandvik,&nbsp;Dag Arne Lihaug Hoff","doi":"10.1111/cob.12640","DOIUrl":"10.1111/cob.12640","url":null,"abstract":"<p>Obesity can decrease the lung function. The proposed mechanisms of reduced lung function in persons with obesity have been altered mechanical properties in the lung and chest wall, airway narrowing and increased respiratory resistance. The aim of this current study was to analyse the long-term results after gastric bypass surgery in patients with reduced lung function. The bariatric surgery observation study invited patients to a follow up 10 years after gastric bypass surgery. We compared the spirometry results before surgery to the spirometry 10 years after surgery. Thirty percent of 198 participants had reduced lung function before surgery. There was no significant relation between body mass index before surgery and lung function. Seventy-three percent of the participants with reduced lung function had normal lung function 10 years after surgery. There was no significant relation between the degree of weight loss and the improvement in lung function. Most participants with reduced lung function had normal lung function 10 years after gastric bypass surgery. There was no significant correlation between weight loss and improvement in lung function.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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