Clinical Obesity最新文献

The association of motivational factors with weight loss and treatment time in a publicly funded weight management clinic. 动机因素与减肥和治疗时间在公共资助的体重管理诊所的关系。

IF 2.2

Clinical Obesity Pub Date : 2025-04-08 DOI: 10.1111/cob.70014

Amir Yazdanparast, Sean Wharton, Hala Tamim, Alison K Macpherson, Jennifer L Kuk

{"title":"The association of motivational factors with weight loss and treatment time in a publicly funded weight management clinic.","authors":"Amir Yazdanparast, Sean Wharton, Hala Tamim, Alison K Macpherson, Jennifer L Kuk","doi":"10.1111/cob.70014","DOIUrl":"https://doi.org/10.1111/cob.70014","url":null,"abstract":"The objective of the study is to explore differences in weight loss (WL) and treatment time with having health, mobility, and/or aesthetics motivations for attempting WL. Data from 7540 adults with overweight or obesity who participated in a publicly funded weight management programme at the Wharton Medical Clinic were analysed. Patients' WL motivations were categorised into six groups: Health only; Health and Aesthetics; Health and Mobility; Health, Mobility and Aesthetics; No Health; and None. Women with Health, Mobility and Aesthetics or No Health motivations had marginally higher WL goals compared to other groups, with no differences in men. Men with Health and Aesthetics or Health and Mobility motivations showed marginally higher 6-month attendance rates. Men who discontinued after one visit were 40% less likely to have a Health and Aesthetics motivation as opposed to Health only, compared to those who continued. No differences were observed in WL between motivation groups in either sex. No correlation was found between WL goals and WL attained. Only weak correlations between treatment time and WL were observed across most motivation groups. Despite small differences in treatment time and WL goals, motivations for attempting WL were not significantly associated with differences in the WL achieved.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70014"},"PeriodicalIF":2.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early obesity risk prediction via non-dietary lifestyle factors using machine learning approaches. 利用机器学习方法通过非饮食生活方式因素进行早期肥胖风险预测。

IF 2.2

Clinical Obesity Pub Date : 2025-04-03 DOI: 10.1111/cob.70011

Ker Ming Seaw, Melvin Khee Shing Leow, Xinyan Bi

{"title":"Early obesity risk prediction via non-dietary lifestyle factors using machine learning approaches.","authors":"Ker Ming Seaw, Melvin Khee Shing Leow, Xinyan Bi","doi":"10.1111/cob.70011","DOIUrl":"https://doi.org/10.1111/cob.70011","url":null,"abstract":"Obesity poses a significant health threat, contributing to the development of noncommunicable diseases (NCDs). Early identification of individuals at higher risk for obesity is crucial for implementing effective prevention strategies. This study explores the viability of non-dietary factors such as lifestyle, family history, and demographics as predictors of obesity risk. The dataset comprised 1068 males and 1043 females, aged between 14 and 61 years. Only non-dietary factors were used to build the machine learning models, including decision tree, random forest, support vector classification (SVC), k-nearest neighbour (KNN), and Gaussian Naïve Bayes (GNB). Random forest emerged as the optimal model, demonstrating 66.9% test accuracy, 66.4% precision, 66.9% recall, 66.4% F1-score, 94.5% specificity and 92.3% area under the receiver operating characteristic curve (AUC-ROC). Variability of the models' performance was also evaluated through bootstrapping. Lifestyle factors, while less impactful than family history and demographics, also contributed to predictive power. This indicates the potential for predicting obesity while relying less on dietary data, paving the way for future studies to refine predictive models. This could play a crucial role in identifying lifestyle factors as predictors of obesity, thereby preventing and intervening early to address obesity-related complications.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70011"},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations in the treatment of individuals with obesity and periodontitis. 肥胖和牙周炎患者治疗的注意事项。

IF 2.2

Clinical Obesity Pub Date : 2025-03-26 DOI: 10.1111/cob.70002

Abigail S Q Cheong, Jean E Suvan

{"title":"Considerations in the treatment of individuals with obesity and periodontitis.","authors":"Abigail S Q Cheong, Jean E Suvan","doi":"10.1111/cob.70002","DOIUrl":"https://doi.org/10.1111/cob.70002","url":null,"abstract":"Two common non-communicable diseases, obesity and periodontitis, are responsible for and affected by systemic inflammation, sharing common risk factors and mechanistic pathways. Periodontitis is an irreversible immune-mediated inflammatory disease of hard and soft tissue supporting teeth. If left untreated, periodontitis can lead to tooth loss, affecting food choices and healthy eating, therefore affecting overall health. Obesity is an independent predictive factor for worsened periodontal inflammation, increased onset, progression, severity, and recurrence of infection, as well as delayed wound healing. Thus, managing obesity and associated metabolic dysfunctions may improve periodontal therapy outcomes. The chronic inflammatory state of obesity impairs immune regulation exacerbating the inflammatory gingival tissue destruction of periodontitis, which can also systemically contribute to inflammatory mediators. Furthermore, bariatric surgeons and dietitians should educate patients with obesity regarding the risk of elevated caries, xerostomia, and periodontitis risk from acid reflux and frequent food intake. Non-dental healthcare professionals should recognise periodontal disease signs to prompt dental referral when warranted. Asking patients about recent dental visits promotes patient involvement in cross-discipline dialogue to enhance patient care coordination between medicine and dentistry. This article discusses the association between these two diseases, the challenges of achieving optimal periodontal treatment outcomes, and the clinical strategies to enhance holistic care. It also explores oral health considerations in dietary and surgical interventions in the treatment of obesity.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70002"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of health literacy and general self-efficacy on surgical outcomes 2 years after bariatric surgery. 健康素养和一般自我效能感对减肥手术后2年手术结果的影响

IF 2.2

Clinical Obesity Pub Date : 2025-03-10 DOI: 10.1111/cob.70009

Maria Jaensson, Karuna Dahlberg, Yang Cao, Anders Thorell, Johanna Österberg, Ulrica Nilsson, Erik Stenberg

{"title":"Impact of health literacy and general self-efficacy on surgical outcomes 2 years after bariatric surgery.","authors":"Maria Jaensson, Karuna Dahlberg, Yang Cao, Anders Thorell, Johanna Österberg, Ulrica Nilsson, Erik Stenberg","doi":"10.1111/cob.70009","DOIUrl":"https://doi.org/10.1111/cob.70009","url":null,"abstract":"After bariatric surgery, adherence to lifestyle recommendations is crucial. Health literacy and self-efficacy may impact recovery after surgery. In this multicentre study performed in three hospitals in Sweden, we evaluated any relation between preoperative health literacy and general self-efficacy on the one side and weight loss, health-related quality of life, length of stay, and complications up to 2 years after bariatric surgery on the other. Of 686 included patients, 56% (n = 382) had limited functional health literacy, 42% (n = 278) had limited communicative and critical health literacy, and 40% (n = 266) reported low general self-efficacy. Preoperative functional, communicative and critical health literacy, and general self-efficacy were not associated with the degree of weight loss at 1 or 2 years after surgery. However, limited health literacy and low general self-efficacy scores were associated with both reduced quality of life and obesity-related problems postoperatively. Further, a higher proportion of those with inadequate health literacy had a prolonged length of stay. Although patients with limited health literacy and self-efficacy may experience similar maximum weight loss after bariatric surgery as other patients, they still might have reduced health-related quality of life in terms of obesity-related problems. Increased awareness of this association as well as patient-centered support before and after bariatric surgery may be of benefit.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70009"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic outcomes of bariatric surgery versus lifestyle intervention in adolescents with severe obesity: A systematic review and meta-analysis. 重度肥胖青少年减肥手术与生活方式干预的代谢结果：一项系统回顾和荟萃分析

IF 2.2

Clinical Obesity Pub Date : 2025-03-06 DOI: 10.1111/cob.70008

A B M Kamrul-Hasan, Joseph M Pappachan, Lakshmi Nagendra, Hamid Ashraf, Deep Dutta, Saptarshi Bhattacharya, Nitin Kapoor

{"title":"Metabolic outcomes of bariatric surgery versus lifestyle intervention in adolescents with severe obesity: A systematic review and meta-analysis.","authors":"A B M Kamrul-Hasan, Joseph M Pappachan, Lakshmi Nagendra, Hamid Ashraf, Deep Dutta, Saptarshi Bhattacharya, Nitin Kapoor","doi":"10.1111/cob.70008","DOIUrl":"https://doi.org/10.1111/cob.70008","url":null,"abstract":"Data from clinical trials evaluating the effectiveness and safety of metabolic and bariatric surgery (MBS) compared to lifestyle modifications (LSM) in children and adolescents with obesity are scarce. This systematic review and meta-analysis (SRM) sought to fill this knowledge gap. Randomised or non-randomised trials spanning at least one-year involving children and adolescents with severe obesity receiving any form of MBS in the intervention group and LSM for weight loss in the control group were systematically searched through electronic databases. This SRM adhered to the guidelines outlined in the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA checklists. The primary outcome of interest was the change in body weight from the baseline. Five trials (three randomised, open-label and two non-randomised) with 1-2 years follow-up durations were analysed, including 367 participants aged 10-19 years. MBS resulted in greater reductions in body weight (mean difference [MD] -25.83 kg, 95% confidence interval [CI] [-36.91, -14.75], p < .00001) and per cent body weight (MD -24.54%, 95% CI [-33.19, -15.89], p < .00001) compared to LSM. Furthermore, MBS outperformed LSM in reducing body mass index (BMI), BMI z-score, waist circumference, glycated haemoglobin, fasting plasma glucose, insulin resistance, triglycerides, alanine aminotransferase, high sensitivity C-reactive protein and an overall improvement of physical functioning and quality of life. The safety profile was comparable between the two groups; however, data was scarce. Larger, longer-term trials that include multinational and multiethnic representation are essential for making solid clinical practice recommendations regarding MBS for children with obesity.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70008"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An exploration of self-perception of weight status, weight-related variables, and preferences for weight management strategies among South Asians in the US. 美国南亚人对体重状况、体重相关变量和体重管理策略偏好的自我认知的探索。

IF 2.2

Clinical Obesity Pub Date : 2025-03-03 DOI: 10.1111/cob.70007

Maya E Joseph, Nisha Mathews, Lydia H Albuquerque, Peter Chen

{"title":"An exploration of self-perception of weight status, weight-related variables, and preferences for weight management strategies among South Asians in the US.","authors":"Maya E Joseph, Nisha Mathews, Lydia H Albuquerque, Peter Chen","doi":"10.1111/cob.70007","DOIUrl":"https://doi.org/10.1111/cob.70007","url":null,"abstract":"Objective: This study aimed to explore the relationships between self-perception of weight status, weight-related variables, and weight management preferences of South Asians (SA) to assist in building culturally tailored interventions for obesity management.Methods: This was a cross-sectional, descriptive, and correlational study. The sample consisted of 272 South Asians over 18 years of age. Data analyses included descriptive and inferential statistics.Results: Based on ethnic-specific BMI criteria, 88.6% of participants were overweight/obese, and 53.5% had abdominal obesity. Among participants, 37% misperceived their weight status. Older individuals had lower chances of accepting weight loss medications (OR = 0.96, 95%CI: 0.94-0.99), while overweight/obese participants had lower odds of accepting weight management surgery (OR = 0.34, 95%CI: 0.13-0.85). The odds of accepting medication therapy were higher if the healthcare provider discussed weight status with them (OR = 1.84, 95% CI:1.06-3.21). Finally, compared to their counterparts, men, those with overweight/obesity, and those with abdominal obesity had 66%, 65%, and 49% lower odds of accurately perceiving their weight status, respectively.Conclusion: This study highlights the high prevalence of overweight and obesity, the misperceptions of weight status, the need for provider involvement in care, and the specific subgroups of SAs with more misperceptions of weight status.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70007"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterising first, recent and worst experiences of weight stigma in a clinical sample of adults with high body weight and high internalised stigma. 首先，在高体重和高内化病耻感的成人临床样本中，描述最近和最糟糕的体重病耻感经历。

IF 2.2

Clinical Obesity Pub Date : 2025-03-03 DOI: 10.1111/cob.70005

Rebecca L Pearl, Laurie C Groshon, Marian Hernandez, Caroline Bach, Erica M LaFata, Hannah F Fitterman-Harris, Dakota L Leget, Miriam Sheynblyum, Thomas A Wadden

{"title":"Characterising first, recent and worst experiences of weight stigma in a clinical sample of adults with high body weight and high internalised stigma.","authors":"Rebecca L Pearl, Laurie C Groshon, Marian Hernandez, Caroline Bach, Erica M LaFata, Hannah F Fitterman-Harris, Dakota L Leget, Miriam Sheynblyum, Thomas A Wadden","doi":"10.1111/cob.70005","DOIUrl":"https://doi.org/10.1111/cob.70005","url":null,"abstract":"This research aimed to systematically characterise experiences of weight stigma and their impacts among weight-loss treatment-seeking adults with high body weight and high levels of internalised weight stigma. Participants recruited for two clinical trials completed a semi-structured interview about weight stigma (Study 1 n = 84, Mage = 47.8 ± 11.2 years, 83.3% women, 67.9% Black; Study 2 n = 129, Mage = 50.0 ± 12.2 years, 88.4% women, 65.1% White). Study 1 focused on first and most recent experiences of weight-based teasing, bullying, discrimination and unfair treatment, and Study 2 focused on the worst examples of these experiences; participants in both studies also identified their overall worst experiences. Participants reported the age at which the experiences occurred and rated (1-5) how upsetting they were. Interview responses were coded for interpersonal sources of weight stigma and impacts of these experiences. Across studies, weight teasing was the most commonly reported experience of weight stigma and the most frequently identified worst experience. Family members were the most commonly identified interpersonal source of weight stigma. Weight stigma experiences were reported across the lifespan and were predominantly described as having negative emotional impacts. Findings provide insights into the types and characteristics of weight stigma experiences that may contribute to the internalisation of this stigma and other adverse consequences.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70005"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient and professional perceptions for long-term success: Developing a framework for bariatric surgery care in Portugal. 患者和专业人士对长期成功的看法：在葡萄牙制定减肥手术护理框架。

IF 2.2

Clinical Obesity Pub Date : 2025-02-27 DOI: 10.1111/cob.70004

Cláudia Mendes, Manuel Carvalho, João Gregório

{"title":"Patient and professional perceptions for long-term success: Developing a framework for bariatric surgery care in Portugal.","authors":"Cláudia Mendes, Manuel Carvalho, João Gregório","doi":"10.1111/cob.70004","DOIUrl":"https://doi.org/10.1111/cob.70004","url":null,"abstract":"A multidisciplinary health team for perioperative care of the bariatric patient, sustained in a viable framework, may provide a comprehensive bariatric surgery process analysis. This study aimed to analyse patients' and professionals' experiences with the perioperative care process and identify their perceptions of the bariatric surgery process to support the long-term management of obesity surgical treatment. This study also wants to develop a framework to sustain a long-term follow-up. This qualitative study was conducted in July 2022 at a bariatric surgery centre in southern Portugal, comprising four focus group sessions. Participants included seven health professionals in one focus group and 16 patients divided across three focus groups. Patients were selected based on specific criteria, including those awaiting bariatric surgery and those who had undergone surgery within the past 1 to 5 years. The patient focus group script consisted of 11 open-ended main questions with follow-up prompts to explore motivations, experiences with the presurgery and postsurgery processes and perceptions of lifestyle changes. Sessions lasted between 40 and 70 min. Participants reported the need for a reference professional in the hospital to contact, the importance of psychological support to help patients deal with the 'ups and downs' of postsurgery life and the financial support for physical activity programmes. This research helped identify a need for a framework for long-term follow-up and showed priorities to tailor health services for managing bariatric surgery patients. This team should be led by a dedicated case manager and include physical activity specialists.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70004"},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is personality associated with the lived experience of the NHS England low calorie diet programme: A pilot study. 性格与英国国民保健服务低卡路里饮食计划的生活经历有关：一项试点研究。

IF 2.2

Clinical Obesity Pub Date : 2025-02-25 DOI: 10.1111/cob.70003

Stuart W Flint, Ezra Goldberg, Mohammad Kaykanloo, Stuart Sherman, Duncan Radley, Sarah R Kingsbury, Louisa Ells

{"title":"Is personality associated with the lived experience of the NHS England low calorie diet programme: A pilot study.","authors":"Stuart W Flint, Ezra Goldberg, Mohammad Kaykanloo, Stuart Sherman, Duncan Radley, Sarah R Kingsbury, Louisa Ells","doi":"10.1111/cob.70003","DOIUrl":"https://doi.org/10.1111/cob.70003","url":null,"abstract":"This pilot study explored the use of a novel behavioural artificial intelligence (AI) tool to examine whether personality is associated with the lived experience of the NHS England launched a low calorie diet (LCD). A cross-sectional survey was disseminated to service users to gather data on emotional wellbeing, physical activity, pain, motivation to manage diabetes, motivation to lose weight, rating of total diet replacement (TDR) products and frequency of using fibre supplements. The scaled insights behavioural AI tool was used to infer personality traits from service users' language construction, and in doing so, examine associations with the outcomes indicated above. Findings show that service users can be profiled by personality, and this can provide a method of understanding programme outcomes. Three clusters of personality traits were identified. Despite this, there was no association between personality features and emotional wellbeing, physical activity, pain, motivation to manage diabetes, motivation to lose weight, rating of TDR products and frequency of using fibre supplements. As the self-selected sample size was limited, future research should examine the use of behavioural AI tools and personality using larger and longitudinal samples.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70003"},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisional endoscopic sleeve gastroplasty versus semaglutide and tirzepatide for weight recidivism after sleeve gastrectomy. 内镜下套筒胃成形术与西马鲁肽和替西帕肽治疗套筒胃切除术后体重再犯的比较。

IF 2.2

Clinical Obesity Pub Date : 2025-02-05 DOI: 10.1111/cob.70001

Firas Bahdi, Sagar Shah, Fadi Dahoud, Maryam Farooq, Philip Kozan, Stephen Kim, Alireza Sedarat, Na Shen, Adarsh Thaker, Jennifer M Kolb, Erik Dutson, V Raman Muthusamy, Danny Issa

{"title":"Revisional endoscopic sleeve gastroplasty versus semaglutide and tirzepatide for weight recidivism after sleeve gastrectomy.","authors":"Firas Bahdi, Sagar Shah, Fadi Dahoud, Maryam Farooq, Philip Kozan, Stephen Kim, Alireza Sedarat, Na Shen, Adarsh Thaker, Jennifer M Kolb, Erik Dutson, V Raman Muthusamy, Danny Issa","doi":"10.1111/cob.70001","DOIUrl":"https://doi.org/10.1111/cob.70001","url":null,"abstract":"Background and aims: Weight recidivism following sleeve gastrectomy (SG) is common. Adjuvant treatments include new glucagon-like peptide 1 and glucose-dependent insulinotropic peptide receptor agonists (GLP1/GIP-RA) or revisional endoscopic sleeve gastroplasty (R-ESG). We here compare the outcomes of these treatments.Methods: A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre. Primary outcomes were total body weight loss (TBWL) and adverse events (AEs). Secondary outcomes were changes in metabolic parameters. Tertiary outcome was to compare GLP1/GIP-RA outcomes in SG patients to matched patients with intact stomach.Results: Our study included 68 (prior SG + GLP1/GIP-RA) and 22 (prior SG + R-ESG). R-ESG offered higher TBWL% than GLP1/GIP-RA at 3 (11.2% vs. 4.3%, p < .001), 6 (13.5% vs. 6.8%, p < .001) and 12 months (13.4% vs. 9.2%, p = .07) with no significant difference in AEs or change in metabolic parameters. On subgroup analysis, tirzepatide achieved similar 12-months TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04). Compared to patients with intact stomach (n = 87), GLP1/GIP-RA achieved significantly lower TBWL% in patients with prior SG at 3 (4.3% vs. 5.7%, p = .02), 6 (6.8% vs. 9.2%, p = .02) and 12 months (9.2% vs. 12.7%, p = .03). Medication refills were difficult in 41.3% of patients.Conclusions: In a single-centre real-world experience study, R-ESG and tirzepatide appear to offer more weight loss than semaglutide in SG patients with weight recidivism although GLP1/GIP-RA were underdosed. GLP1/GIP-RA achieved higher weight loss in patients with intact stomach than those with prior SG.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70001"},"PeriodicalIF":2.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0