Clinical Obesity最新文献

Exploring the Efficacy and Safety of Tirzepatide in Obesity Management and Cardiometabolic Risk Factors: A Comprehensive Systematic Review and Meta-Analysis. 探索替西帕肽在肥胖管理和心脏代谢危险因素中的有效性和安全性：一项全面的系统评价和荟萃分析。

IF 2.2

Clinical Obesity Pub Date : 2025-07-21 DOI: 10.1111/cob.70036

Jian-Ying Wang, Jyun-Wei Kang, Tzu-Rong Peng, Hsin-Yen Chen, Shih-Ming Chen, Ming-Chia Lee

{"title":"Exploring the Efficacy and Safety of Tirzepatide in Obesity Management and Cardiometabolic Risk Factors: A Comprehensive Systematic Review and Meta-Analysis.","authors":"Jian-Ying Wang, Jyun-Wei Kang, Tzu-Rong Peng, Hsin-Yen Chen, Shih-Ming Chen, Ming-Chia Lee","doi":"10.1111/cob.70036","DOIUrl":"https://doi.org/10.1111/cob.70036","url":null,"abstract":"The global prevalence of obesity and its related complications continue to rise, emphasising the need for effective treatment strategies. Tirzepatide, a novel glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual agonist, has emerged as a promising pharmacological option in obesity management due to its potential in weight reduction and cardiometabolic improvement. We conducted a systematic review and meta-analysis following PRISMA guidelines, including randomised controlled trials (RCTs) comparing the efficacy and safety of Tirzepatide with placebo in adults with obesity, with or without type 2 diabetes. We searched PubMed, Cochrane Library, and EMBASE databases up to December 15, 2024. Ten RCTs were included, comprising 6257 participants. Tirzepatide significantly reduced body weight compared to placebo, with a total pooled mean difference of -11.62 kg (95% confidence interval: -14.24 to -9.01, p < 0.001). In the highest dosage group of 15 mg, 88.1%, 63.3%, and 51.8% of participants achieved weight reductions exceeding 5%, 10%, and 15% respectively. Significant improvements were also noted in cardiometabolic risk factors, including haemoglobin A1C, waist circumference, body mass index, and lipid profiles. Tirzepatide showed a favourable safety profile, without increasing the risk of serious adverse events or impacting mortality rates. Tirzepatide has demonstrated effectiveness in achieving significant weight loss and enhancing cardiometabolic health in adults with obesity. While it maintains a favourable safety profile, further studies are essential to investigate its long-term safety and determine the optimal duration of treatment.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70036"},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Supervised Exercised Training Before Bariatric Surgery on Body Composition. 减肥手术前监督运动训练对身体成分的影响。

IF 2.2

Clinical Obesity Pub Date : 2025-07-09 DOI: 10.1111/cob.70033

Erika Cornu, Camille Gaulier, Elise Le Roy Feret, Muriel Guilmain, Christine Faure, Mickaël Galeas, Jérémy Hermann, Sara Kidri, Elodie Le Gregam, Tiphanie Satizelle, Marie Bois, Helena Mosbah, Estelle Caron, Séverine Magne, Laetitia Paradisi-Prieur, Anne-Laure Proust, Anne-Cécile Paepegaey

{"title":"Impact of Supervised Exercised Training Before Bariatric Surgery on Body Composition.","authors":"Erika Cornu, Camille Gaulier, Elise Le Roy Feret, Muriel Guilmain, Christine Faure, Mickaël Galeas, Jérémy Hermann, Sara Kidri, Elodie Le Gregam, Tiphanie Satizelle, Marie Bois, Helena Mosbah, Estelle Caron, Séverine Magne, Laetitia Paradisi-Prieur, Anne-Laure Proust, Anne-Cécile Paepegaey","doi":"10.1111/cob.70033","DOIUrl":"https://doi.org/10.1111/cob.70033","url":null,"abstract":"The aim of this study was to determine if a program including exercise training before surgery is effective in maintaining muscle mass 1 year after bariatric surgery. This is a nonrandomised, retrospective, single-centre study. Patients were operated on between January 2021 and December 2023. During the preparatory course, patients are offered to join the metabolic rehabilitation protocol. This consists of 3 h of day hospital three times a week during eight consecutive weeks, before surgery. A total of 178 patients were included in the study: 63 (35.4%) in the exercise group and 115 (64.6%) in the control group. A total of 150 (84.3%) were female, with a mean age was 42.0 years and a mean body mass index (BMI) was 41.8 ± 6.0 kg/m2. Patients in the exercise group were older than patients in the control group, 45.6 ± 11.8 versus 40.1 ± 10.7 years old (p = 0.002), they had higher LDLc 1.34 ± 0.41 versus 1.21 ± 0.33 g/L (p = 0.05), and more of them were diabetics (p = 0.01). There were no significant differences between the two groups, but the increase in muscle mass seemed higher in exercise group versus control group: 6.3% ± 5.2% versus 5.2% ± 4.4% (p = 0.14). HDLc and delta LDLc seemed higher in the exercise group versus control group: 0.57 ± 0.13 versus 0.55 ± 0.12 g/L and - 0.29 ± 0.27 versus - 0.22 ± 0.26 g/L, and CRP tends to be lower in the exercise group 1.1 ± 1.2 versus 1.8 ± 3.4 mg/L, but these results were not significant. The implementation of a rehabilitation protocol before surgery is difficult in patients with obesity. Nevertheless, it probably allows the patients to establish regular and lasting physical activity.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70033"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Metabolic Obesity Phenotypes and Atherosclerotic Cardiovascular Disease Risk in Arab Adults. 探讨阿拉伯成人代谢性肥胖表型和动脉粥样硬化性心血管疾病风险

IF 2.2

Clinical Obesity Pub Date : 2025-06-27 DOI: 10.1111/cob.70032

Kaiser Wani, Balvir Kumar, Nasser M Al-Daghri, Shaun Sabico

{"title":"Exploring Metabolic Obesity Phenotypes and Atherosclerotic Cardiovascular Disease Risk in Arab Adults.","authors":"Kaiser Wani, Balvir Kumar, Nasser M Al-Daghri, Shaun Sabico","doi":"10.1111/cob.70032","DOIUrl":"https://doi.org/10.1111/cob.70032","url":null,"abstract":"This study investigates the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in different metabolic obesity phenotypes in Saudi adults. A cohort of 5460 adults (aged 40-79) was categorised based on metabolic status, body mass index (BMI), and visceral adiposity index (VAI). Using the ASCVD Risk Estimator Plus, the 10-year risk scores were calculated and explored in different metabolic phenotypes. Females showed higher obesity prevalence, while males had a higher metabolically unhealthy phenotype prevalence. Despite being considered healthy by traditional metrics, individuals with Metabolically Healthy Obesity (MHO) exhibited significantly higher ASCVD risk scores compared to Metabolically Healthy Normal Weight (MHNW) counterparts (2.44 vs. 1.34 in females, p < 0.001; 9.60 vs. 6.72 in males, p = 0.008). When obesity was defined by BMI, in men, MHO showed a substantially higher age-adjusted odds ratio (OR) for greater ASCVD risk than MHNW (OR = 2.04, 95% CI 1.3-3.3, p = 0.003). However, when obesity was characterised by VAI rather than BMI, ASCVD risk in metabolically healthy with high VAI (MHHV), equivalent to MHO, was similar to its normal VAI counterpart, independent of gender (OR = 0.92, 95% CI 0.7-1.2, p = 0.55 for females; OR = 1.23, 95% CI 0.9-1.7, p = 0.25 for men). The study provides insights into ASCVD risk in multiple metabolic and obesity phenotypes among Saudi individuals, indicating that VAI outperforms BMI in identifying the metabolically healthy obese phenotype.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70032"},"PeriodicalIF":2.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Dietitian in Weight Management of Adults With Obesity Without Diabetes Using Glucagon Like Peptide-1 Agonist Receptors: A Systematic Review and Meta-Analysis of Randomised Controlled Clinical Trials. 营养学家在使用胰高血糖素样肽-1激动剂受体的成人肥胖无糖尿病患者体重管理中的作用：随机对照临床试验的系统评价和荟萃分析

IF 2.2

Clinical Obesity Pub Date : 2025-06-18 DOI: 10.1111/cob.70030

Israa Moetaz, Suhad Abumweis, Sarah Alqadi, Mahmoud AbuGhoush

{"title":"The Role of the Dietitian in Weight Management of Adults With Obesity Without Diabetes Using Glucagon Like Peptide-1 Agonist Receptors: A Systematic Review and Meta-Analysis of Randomised Controlled Clinical Trials.","authors":"Israa Moetaz, Suhad Abumweis, Sarah Alqadi, Mahmoud AbuGhoush","doi":"10.1111/cob.70030","DOIUrl":"https://doi.org/10.1111/cob.70030","url":null,"abstract":"The aims are (1) to identify and interpret the role of registered dietitian in clinical trials on the efficacy of glucagon like peptide-1 (GLP-1) agonists in adult individuals with obesity but without diabetes, and (2) to quantify the effect of GLP-1 agonists on body weight loss in adult individuals with obesity but without diabetes. An electronic search using PubMed and Scopus was implemented to locate eligible randomised clinical trials. Data extraction and quality assessment were conducted for 13 studies that met the inclusion criteria. Medical nutrition therapy (MNT) steps were evaluated based on the registered dietitian (RD) interventions and procedures that are included in six studies. Data analysis was carried out using specialised software. The meta-analysis results showed pooled mean differences in weight change of -5.4 kg (95% CI: -5.8, -5.0), in waist circumference change of -5.5 cm (95% CI: -7.7, -3.25), and in weight loss as a percentage from baseline of -7.75% (95% CI: -11.1, -4.3). Quality assessment and bias of each study have been reported. Nutrition practice guidelines and MNT are also listed to include screening, assessment, intervention, and monitoring. Based on current available evidence, using GLP-1 agonists for weight loss shows their effectiveness to reduce weight and waist circumference. However, further incorporation of RD in trials will help in understanding the sole effect of MNT in treating obesity using GLP-1 agonists.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70030"},"PeriodicalIF":2.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.2

Clinical Obesity Pub Date : 2025-06-18 DOI: 10.1111/cob.70031

Vignesh Balasubaramaniam, Geoffrey Yuet Mun Wong, Alessandro Martinino, Manel Riera, Mohamed Abouelazayem, Juan Pablo Scarano Pereira, Amira Said, Yitka Graham, Rajesh Kumar Jain, Helen Imseeh, Osama Aljaiuossi, Mustafa Ahmad Abu Jayyab, Said N A Alyacoubi, Kamal Mahawar, Rishi Singhal

{"title":"Mortality Related to Bariatric Surgery (MORSE Study): A Retrospective, International Collaborative Audit.","authors":"Vignesh Balasubaramaniam, Geoffrey Yuet Mun Wong, Alessandro Martinino, Manel Riera, Mohamed Abouelazayem, Juan Pablo Scarano Pereira, Amira Said, Yitka Graham, Rajesh Kumar Jain, Helen Imseeh, Osama Aljaiuossi, Mustafa Ahmad Abu Jayyab, Said N A Alyacoubi, Kamal Mahawar, Rishi Singhal","doi":"10.1111/cob.70031","DOIUrl":"https://doi.org/10.1111/cob.70031","url":null,"abstract":"Bariatric surgery is associated with low but definite early and late mortality. This study aims to further understand early (≤ 90 days) and delayed (> 90 days) mortality related to bariatric surgery. This is a retrospective collaborative audit of patients who had undergone bariatric surgery and developed complications that ultimately led to death. Individuals who were 18 years or older and had undergone bariatric surgery (primary, revisional, and endoscopic procedures) and subsequently died within 90 days or after 90 days following the surgery between 1 January 2022, and 31 December 2022. A descriptive analysis was conducted. About 30 centres from 21 countries submitted data on 82 patients where patient death was deemed to be related to bariatric surgery. Mortality within 90 days post-surgery was observed in 58 individuals (70.7%), while 24 patients (29.3%) died after this period. Causes of mortality after SG include GI leak, PE, respiratory infection, and malnutrition. Causes of mortality after RYGB include GI leak, coronary heart disease, and bleeding. Reported common causes of early mortality in this study were gastrointestinal leaks, bleeding, coronary heart disease, and pulmonary embolism. Reported common causes of delayed mortality were gastrointestinal leaks and malnutrition. This study characterises patients where death was attributed to a bariatric procedure and identifies common causes of death in these patients. This could aid development of strategies for preventing and managing these complications in the future.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70031"},"PeriodicalIF":2.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional analysis of emotional and binge eating in UK adults enrolled on the NHS low-calorie diet pilot for type 2 diabetes. 英国国民保健服务低热量饮食试验2型糖尿病患者的情绪化和暴饮暴食横断面分析。

IF 2.2

Clinical Obesity Pub Date : 2025-06-18 DOI: 10.1111/cob.70025

Jordan Marwood, Duncan Radley, Tamla Evans, Jamie Matu, Kenneth Clare, Chirag Bakhai, Louisa J Ells

{"title":"A cross-sectional analysis of emotional and binge eating in UK adults enrolled on the NHS low-calorie diet pilot for type 2 diabetes.","authors":"Jordan Marwood, Duncan Radley, Tamla Evans, Jamie Matu, Kenneth Clare, Chirag Bakhai, Louisa J Ells","doi":"10.1111/cob.70025","DOIUrl":"https://doi.org/10.1111/cob.70025","url":null,"abstract":"This study presents data gathered as part of the Re:Mission evaluation of the NHS low-calorie diet programme pilot for type 2 diabetes, to address two research questions: (1) What is the presence and severity of emotional and binge eating within this population? (2) Are demographic and health factors associated with the presence of binge eating or the severity of emotional eating? An online survey gathered data from n = 580 individuals who were enrolled on the programme but had not yet begun total diet replacement. The survey assessed emotional eating (TFEQ-R21), potential binge eating disorder diagnosis (BEDS-7), wellbeing (Short Warwick-Edinburgh Mental Wellbeing Scale), quality of life (EQ-5D-5L), frequency of weight cycling and demographic factors (collected via NHS England programme monitoring). Descriptive statistics and regression analyses were used to address the research questions. The mean emotional eating score from the TFEQ-R21 was 2.58 (0.96), and the presence of a potential binge eating disorder diagnosis was demonstrated in 26.0% of the sample. Regression analyses suggested that being female and engaging in more frequent weight cycling were associated with higher emotional eating and a greater likelihood of binge eating. Lower wellbeing and lower quality of life were associated with emotional and binge eating, respectively. Rates of emotional and binge eating in the NHS low-calorie diet pilot sample are higher than in the general public and in other similar samples. Consideration should be given to screening for emotional and disordered eating and for additional tailored support and monitoring for such individuals.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70025"},"PeriodicalIF":2.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of body size, prior care quality, and weight gain on health care utilization during the COVID-19 pandemic. COVID-19大流行期间体重、先前护理质量和体重增加对医疗保健利用的影响

IF 2.2

Clinical Obesity Pub Date : 2025-06-08 DOI: 10.1111/cob.70019

Sean M Phelan, Samantha R Philip, Amelia K Barwise, Jay-Sharee P Akambase, Matthew G Johnson, Lily Huang, Megan A Allyse

{"title":"The impact of body size, prior care quality, and weight gain on health care utilization during the COVID-19 pandemic.","authors":"Sean M Phelan, Samantha R Philip, Amelia K Barwise, Jay-Sharee P Akambase, Matthew G Johnson, Lily Huang, Megan A Allyse","doi":"10.1111/cob.70019","DOIUrl":"https://doi.org/10.1111/cob.70019","url":null,"abstract":"The goal of this study was to ascertain the effect of patient body size on clinic- or patient-delayed health care during the COVID-19 pandemic and factors predicting delay. Primary survey data were collected in August 2021 from 3593 individuals living within the communities near Mayo Clinic facilities in Minnesota, Wisconsin, Arizona, and Florida. More people who identified with the higher-weight BMI categories reported having their care appointments cancelled (62.3%) compared to those who identified with normative weight (38.0%) or underweight (47.7%; p < .001) and reported more frequently delaying their own care (67.9%) relative to those who identified with normative weight (47.0%) or underweight (62.3%; p < .001). Higher-weight people were more likely than others to report delay was due to not knowing where to get care (UW: 5.6%, NW: 3.5%, HW: 7.0%, pchi-square < .001), worrying about weight-based judgement (UW: 2.1%, NW: 2.1%, HW: 4.5%, pchi-square < .001), and fearing discrimination (UW: 2.9%, NW: 2.4%, HW: 5.5%, pchi-square < .001). There was no difference across groups in delay due to fear of COVID-19 exposure. Weight gain was associated with care delay in higher-weight and normative weight groups. Having experienced more patient-centred care pre-COVID was associated with less care delay in the normative weight group, but more care delay in other groups. Higher-weight people were more likely to have their care delayed by health care providers and to delay care themselves. Patient weight gain and concerns about discrimination and judgement about weight gain may have driven the delay of needed care during COVID-19.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70019"},"PeriodicalIF":2.2,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in child and adolescent health across the Arab Gulf countries-Focus on metabolic health. 阿拉伯海湾国家儿童和青少年健康面临的挑战——关注代谢健康。

IF 2.2

Clinical Obesity Pub Date : 2025-06-04 DOI: 10.1111/cob.70027

Basma Haris, Madeeha Kamal, Sadriya Alkohji, Shahrad Taheri, Khalid Hussain

{"title":"Challenges in child and adolescent health across the Arab Gulf countries-Focus on metabolic health.","authors":"Basma Haris, Madeeha Kamal, Sadriya Alkohji, Shahrad Taheri, Khalid Hussain","doi":"10.1111/cob.70027","DOIUrl":"https://doi.org/10.1111/cob.70027","url":null,"abstract":"The Gulf Cooperation Council (GCC) consists of six member states (Bahrain, Kuwait, Oman, Qatar Saudi Arabia and the United Arab Emirates). The combination of an increasing youth population combined with rapid modernisation, increasing per capita income and the paradigm shift towards unhealthy and affluent lifestyles has created a significant burden of non-communicable diseases (NCDs), especially obesity and diabetes. The aim of this review is to discuss the prevalence of childhood/adolescent obesity and diabetes in the GCC region, which are some of the highest in the world. The review also focuses on the major challenges the GCC region faced in dealing with these lifestyle-related NCDs. Children and adolescents lack access to specialised professionals for disease management across all healthcare services in the region, with a lack of multidisciplinary teams and support groups. The development of culturally acceptable and community-based strategies to promote healthy lifestyles at home and in schools will be essential to achieve sustainable change in these countries to reduce the health and economic burden of metabolic health diseases in children and adolescents in the region.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70027"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating the association and timing of occurrence between obesity and related comorbidity outcomes in a real-world setting: A cohort study in the United States. 在现实世界中估计肥胖和相关合并症结果之间的关联和发生时间：美国的一项队列研究

IF 2.2

Clinical Obesity Pub Date : 2025-06-04 DOI: 10.1111/cob.70026

Firas Dabbous, Jigish Bhavsar, Jayashri Desai, Anthony Fabricatore, Bríain Ó Hartaigh, Wojciech Michalak, Sariya Udayachalerm, Cynthia Saiontz-Martinez, Zhenxiang Zhao, Fatima Cody Stanford

{"title":"Estimating the association and timing of occurrence between obesity and related comorbidity outcomes in a real-world setting: A cohort study in the United States.","authors":"Firas Dabbous, Jigish Bhavsar, Jayashri Desai, Anthony Fabricatore, Bríain Ó Hartaigh, Wojciech Michalak, Sariya Udayachalerm, Cynthia Saiontz-Martinez, Zhenxiang Zhao, Fatima Cody Stanford","doi":"10.1111/cob.70026","DOIUrl":"https://doi.org/10.1111/cob.70026","url":null,"abstract":"To understand the prevalence, incidence and sequence of obesity-related comorbidities (ORCs) among people with obesity compared with those with a normal body mass index (BMI). People with obesity (BMI ≥30 kg/m2) and normal BMI (BMI 18.5 to <25 kg/m2) were matched 1:1 using a large United States claims-linked electronic health record database. The index date was the date of the first qualifying BMI. Prevalence was assessed at baseline (12 months pre-index date); incidence and sequence of new ORCs were assessed during follow-up. Each cohort included 57 978 people. At least 1 ORC was present at baseline in 61.1% and 49.6% of the obesity and normal BMI cohorts, respectively. During follow-up (median 61 months) event rates per 1000 person-years of new ORCs were higher in the obesity cohort than the normal BMI cohort (572 vs. 378, respectively). In both cohorts, musculoskeletal pain was the most frequent new ORC, followed by dyslipidemia and hypertension. Median times to the first, second and third new ORC were shorter in the obesity cohort compared with the normal BMI cohort by 0.67, 0.81 and 0.66 years, respectively. People with obesity had a higher prevalence and incidence, and accelerated onset of ORCs compared with those with normal BMI.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70026"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of weight on daily activities questionnaire in patients with overweight or obesity: Psychometric evaluation using data from the OASIS 1 trial. 体重对超重或肥胖患者日常活动问卷的影响：使用OASIS 1试验数据的心理测量学评估

IF 2.2

Clinical Obesity Pub Date : 2025-06-01 DOI: 10.1111/cob.70015

Lisa von Huth Smith, Diane Whalley, Stuart Yarr, Jonathan Comins, Sheri E Fehnel

{"title":"Impact of weight on daily activities questionnaire in patients with overweight or obesity: Psychometric evaluation using data from the OASIS 1 trial.","authors":"Lisa von Huth Smith, Diane Whalley, Stuart Yarr, Jonathan Comins, Sheri E Fehnel","doi":"10.1111/cob.70015","DOIUrl":"https://doi.org/10.1111/cob.70015","url":null,"abstract":"The Impact of Weight on Daily Activities Questionnaire (IWDAQ) is a patient-reported outcome measure that uses a novel, adaptive design to assess the limitations in daily activities that are most important to individuals attempting to lose weight. During the first round of completing the IWDAQ, respondents are presented with 18 everyday activities that can be limited by excess weight and asked to choose the three activities they would most like to see improve with weight loss. They are then asked to rate the degree of limitation they experience with these three activities at baseline and at follow-up assessments. Using data from a weight-management clinical trial (OASIS 1, NCT05035095), we evaluated the IWDAQ's measurement properties, determined optimal scoring, and estimated thresholds of meaningful within-patient change. Our analyses demonstrated that the IWDAQ Composite Score offers a reliable and valid personalized measure of limitations in daily activities due to excess weight. The adaptive design of the IWDAQ ensures the patient-centricity of the measure, thereby complementing existing measures of functioning in the context of weight-management clinical trials. Evaluations using data from additional studies would be valuable in extending the psychometric evidence for the IWDAQ.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":" ","pages":"e70015"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0