Clinical Obesity最新文献_第2页

Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial 有氧运动加低热量饮食对原发性高血压和超重/肥胖成人血清瘦素浓度的影响：来自Exercise - hta试验的结果。

IF 2.4

Clinical Obesity Pub Date : 2026-08-12 DOI: 10.1111/cob.70094

Maajid Mohi Ud Din Malik

引用次数: 0

Burden and Risk of Depression in Patients Receiving Semaglutide: A Systematic Review and Meta-Analysis 接受西马鲁肽患者的抑郁负担和风险：一项系统回顾和荟萃分析。

IF 2.4

Clinical Obesity Pub Date : 2026-08-12 DOI: 10.1111/cob.70105

Gaurab Bhaduri, Shilanjan Roy, Anchin Kalia, Rutul Gokalani, Banshi Saboo

{"title":"Burden and Risk of Depression in Patients Receiving Semaglutide: A Systematic Review and Meta-Analysis","authors":"Gaurab Bhaduri, Shilanjan Roy, Anchin Kalia, Rutul Gokalani, Banshi Saboo","doi":"10.1111/cob.70105","DOIUrl":"10.1111/cob.70105","url":null,"abstract":"<div>\u0000 \u0000 <p>Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide, are widely used for Type 2 diabetes mellitus (T2DM), obesity and related metabolic conditions. Evidence on potential neuropsychiatric effects remains inconsistent. This systematic review and meta-analysis evaluated depression risk among patients receiving semaglutide. Following PRISMA 2020 guidelines, major biomedical databases, trial registries, pharmacovigilance databases, conference abstracts and grey literature were searched from inception to January 2026. Eligible studies included randomised controlled trials, observational studies, large database analyses and pharmacovigilance disproportionality studies involving patients receiving semaglutide. Risk of bias was assessed using ROBINS-I and the Newcastle–Ottawa Scale. The pooled risk ratio for depression was 1.25 (95% CI: 0.95–1.65; <i>I</i><sup>2</sup> = 98%). For anxiety and suicidal ideation/attempt, pooled risk ratios were 1.22 (95% CI: 0.93–1.60; <i>I</i><sup>2</sup> = 99%) and 1.20 (95% CI: 0.90–1.62; <i>I</i><sup>2</sup> = 92%), respectively. No statistically significant differences were observed between semaglutide and comparator/placebo groups for outcomes. Pooled estimates did not show a statistically significant increase in depression, anxiety or suicidal ideation/attempt among patients receiving semaglutide compared with comparator groups. However, the certainty of evidence was limited by substantial heterogeneity, risk of bias and reliance on heterogeneous data sources, including spontaneous-reporting studies. These findings are reassuring but should be interpreted as the absence of a detected increased risk in the available evidence, rather than definitive proof of no psychiatric risk.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correspondence Concerning ‘Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial’ 关于“有氧运动加低热量饮食对原发性高血压和超重/肥胖成人血清瘦素浓度的影响：来自Exercise - hta试验的结果”的对应。

IF 2.4

Clinical Obesity Pub Date : 2026-08-12 DOI: 10.1111/cob.70103

Sara Maldonado-Martín, Pablo Corres, Ilargi Gorostegi-Anduaga, Virginia A. Aparicio

引用次数: 0

The Association Between Obesity Class and Cause-Specific Mortality by Age and Sex in US Adults 美国成年人按年龄和性别划分的肥胖类别和病因特异性死亡率之间的关系。

IF 2.4

Clinical Obesity Pub Date : 2026-08-12 DOI: 10.1111/cob.70104

Amir Yazdanparast, Hala Tamim, Alison K. Macpherson, Jennifer L. Kuk

{"title":"The Association Between Obesity Class and Cause-Specific Mortality by Age and Sex in US Adults","authors":"Amir Yazdanparast, Hala Tamim, Alison K. Macpherson, Jennifer L. Kuk","doi":"10.1111/cob.70104","DOIUrl":"10.1111/cob.70104","url":null,"abstract":"<p>To investigate differences in cause-specific mortality risks between obesity classes stratified by age and sex, using a nationally representative sample of the US population. Differences in mortality risk by standard body mass index (BMI) categories with examination of Obesity Classes I–III, stratified by age (less or more than 65 years) and sex were examined using Cox proportional hazard ratios with data from NHANES Continuous (1999–2018) with mortality follow-up through 31 December 2019. Among younger adults (< 65 years), Obesity Class III was associated with higher all-cause, cardiovascular, non-cardiovascular/non-cancer and diabetes-related mortality compared to Class I. Among older adults (≥ 65 years), there were fewer significant associations with only cardiovascular and diabetes-related mortality risks being elevated in men with Obesity Class III and none in women. There were no differences in mortality risks between Obesity Classes I and II, except for diabetes-related mortality in younger adults and older men. Obesity Class III is strongly associated with higher mortality risk in younger adults (< 65 years) and to a lesser degree in older adults (≥ 65 years). Mortality risks were generally similar between obesity Classes I and II. Therefore, younger adults under 65 years of age with severe obesity may benefit more from aggressive obesity management.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proportion of Gestational Diabetes Mellitus Attributable to Overweight/Obesity Among South Asian Women: A Retrospective Cohort Study in Delhi, India 南亚妇女妊娠期糖尿病归因于超重/肥胖的比例：印度德里的一项回顾性队列研究

IF 2.4

Clinical Obesity Pub Date : 2026-08-11 DOI: 10.1111/cob.70106

John Punnose, Rajeev Kumar Malhotra, Rashika M. Rijhwani, Naimaa Choudhary

{"title":"Proportion of Gestational Diabetes Mellitus Attributable to Overweight/Obesity Among South Asian Women: A Retrospective Cohort Study in Delhi, India","authors":"John Punnose, Rajeev Kumar Malhotra, Rashika M. Rijhwani, Naimaa Choudhary","doi":"10.1111/cob.70106","DOIUrl":"10.1111/cob.70106","url":null,"abstract":"<div>\u0000 \u0000 <p>To assess the variability in the population attributable fraction (PAF) of GDM to overweight/obesity and the relationship of BMI and GDM across three diagnostic criteria: IADPSG, NICE and Diabetes in Pregnancy Study Group India (DIPSI). The PAF of GDM to overweight/obesity and the relationship of GDM and BMI were estimated using Poisson regression models in a retrospective cohort of 4317 women who underwent GDM screening during the 2013–2017 period. Multiple linear regression models were applied to associate BMI with fasting, 1-h and 2-h plasma glucose values. The PAF of GDM to overweight/obesity for IADPSG, NICE and DIPSI criteria was 34.84%, 28.17% and 18.44%, respectively. There was a quadratic relationship between BMI and GDM for all criteria, and the peak BMI values for IADPSG, NICE and DIPSI criteria were 34.26, 33.28 and 32.01 kg/m<sup>2</sup>, respectively. The relationship between BMI and PG values was also quadratic, with peaks in FPG, 1-h and 2-h PG at BMI values of 40.91, 35.50 and 33.04 kg/m<sup>2</sup>, respectively. PAF of GDM to overweight/obesity among South Asian women varies by the GDM diagnostic criteria. The quadratic relationship between BMI and GDM probability and between BMI and plasma glucose values is a novel observation.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight Loss Outcomes of Routine Dietetic Treatment in Primary Care 初级保健中常规饮食治疗的减肥效果。

IF 2.4

Clinical Obesity Pub Date : 2026-08-11 DOI: 10.1111/cob.70101

Annemieke van de Riet, Carliene van Dronkelaar, Barbara S. van der Meij, Willemijn M. Meijer, Marian A. E. de van der Schueren, Jacqueline A. E. Langius

{"title":"Weight Loss Outcomes of Routine Dietetic Treatment in Primary Care","authors":"Annemieke van de Riet, Carliene van Dronkelaar, Barbara S. van der Meij, Willemijn M. Meijer, Marian A. E. de van der Schueren, Jacqueline A. E. Langius","doi":"10.1111/cob.70101","DOIUrl":"10.1111/cob.70101","url":null,"abstract":"<p>Clinically relevant weight loss (≥ 5%) is a key treatment goal in dietetic care for patients with overweight or obesity. While clinical trials often demonstrate successful weight loss, less is known about success rates in routine dietetic practice, timing of weight loss and maintenance. This study examined when patients achieve and maintain ≥ 5% weight loss during 12 months of dietetic treatment in Dutch primary care, and how this relates to treatment intensity and patient characteristics. In this retrospective cohort study, routinely collected data from dietetic electronic health records (EHRs) was used. Follow-up duration was 12 months. Weight change was analysed at 3, 6, 9 and 12 months. The study included 4503 adults (≥ 18 years) with overweight or obesity (BMI ≥ 25 kg/m<sup>2</sup>) receiving dietetic treatment between 2016 and 2020 in over 70 primary care dietetic practices in the Netherlands. The primary outcome was achieving and maintaining ≥ 5% weight loss from baseline at 3, 6, 9 and 12 months. Multivariable logistic regression assessed associations of ≥ 5% weight loss with visit frequency, visit time, sex, age, BMI and comorbidity. Overall, 33% of patients achieved ≥ 5% weight loss. Of these, 60% did so within 3 months. Each additional visit in the first 3 months was associated with threefold higher odds of success (OR = 3.0). In months 3–6, each additional visit was associated with 61% higher odds of success. Early dietetic treatment intensity is strongly associated with weight loss success. Structuring care around the early treatment phase warrants prospective evaluation in routine dietetic practice.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neurological Impact of Metabolic and Bariatric Surgery: A Systematic Review of Post-Operative Neuropathic and Non-Neuropathic Complications 代谢和减肥手术对神经系统的影响：对术后神经性和非神经性并发症的系统回顾。

IF 2.4

Clinical Obesity Pub Date : 2026-08-05 DOI: 10.1111/cob.70102

Srishruthi Thirumalai, G. Balamurugan, Saurabh Jagdale, Khadeija Hussain, Layla Sayyadi, Sreekrishna Kumar Ambalaparambil Vasu, Chloe Turner, Mahmoud Abuawwad

{"title":"The Neurological Impact of Metabolic and Bariatric Surgery: A Systematic Review of Post-Operative Neuropathic and Non-Neuropathic Complications","authors":"Srishruthi Thirumalai, G. Balamurugan, Saurabh Jagdale, Khadeija Hussain, Layla Sayyadi, Sreekrishna Kumar Ambalaparambil Vasu, Chloe Turner, Mahmoud Abuawwad","doi":"10.1111/cob.70102","DOIUrl":"10.1111/cob.70102","url":null,"abstract":"<div>\u0000 \u0000 <p>Metabolic and bariatric surgery achieves durable weight loss and meaningful improvement in obesity-related comorbidities yet carries a risk of neurological complications that remains under-recognised in routine clinical practice. This systematic review, registered with PROSPERO (CRD42024591611) and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, searched MEDLINE, Embase, Emcare, CINAHL and Cochrane databases through September 2023 to evaluate the incidence, spectrum, timing, pathophysiology and management of post-operative neurological complications. Twelve studies comprising over 5000 patients were included. Reported incidence ranged from 1.4% to 16%, with peripheral neuropathy the most frequent manifestation. Mononeuropathies, particularly carpal tunnel syndrome, were prominent in several cohorts, while central complications including Wernicke encephalopathy occurred less commonly but with considerably greater severity. Thiamine deficiency was the predominant aetiological factor. Onset varied from days to several years postoperatively, with early presentations typically compression-related and later ones nutritionally mediated. Outcomes were generally favourable with early intervention, though severe or delayed cases were associated with persistent neurological deficits and occasional mortality. Neurological complications after bariatric surgery are heterogeneous and largely preventable, and structured post-operative follow-up with consistent adherence to nutritional supplementation remains central to reducing long-term harm.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002–2022) 肥胖症指数对20年2型糖尿病累积发病率的综合评价：ATTICA队列研究（2002-2022）。

IF 2.4

Clinical Obesity Pub Date : 2026-07-24 DOI: 10.1111/cob.70100

Ioanna Kechagia, Sofia-Panagiota Giannakopoulou, Fotios Barkas, Mary Yannakoulia, Evangelos Liberopoulos, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos

{"title":"A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002–2022)","authors":"Ioanna Kechagia, Sofia-Panagiota Giannakopoulou, Fotios Barkas, Mary Yannakoulia, Evangelos Liberopoulos, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos","doi":"10.1111/cob.70100","DOIUrl":"10.1111/cob.70100","url":null,"abstract":"<p>The aim of this study was to evaluate the association between indices of adiposity and 20-year cumulative incidence of type 2 diabetes (T2D) among apparently healthy adults participating in the ATTICA cohort study (2002–2022). The present analysis included data from 2000 individuals free of atherosclerotic cardiovascular disease (ASCVD) and T2D at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations. Obesity-related anthropometric indices, in terms of total and central adiposity, along with dysfunctional adipose tissue-related indices, were measured. The 20-year cumulative incidence of T2D was 26.3% (95% CI [24.4%, 28.3%]). All indices were independently associated with the 20-year incidence of T2D, with an overall predictive accuracy of approximately 75%. With the exception of LAP (lipid accumulation product), all indices reflecting adipose tissue dysfunction demonstrated moderate discriminative accuracy for incident T2D (<i>C</i>-statistic varied between 0.70 and 0.80) over the 20-year follow-up period, in line with obesity-related anthropometric indices assessing total and central adiposity (<i>C</i>-statistic 0.70–0.80). Obesity-related anthropometric indices as well as dysfunctional adipose tissue-related indices were moderately predictive of long-term T2D onset, highlighting the complex role of increased body weight on glucose metabolism.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Data-Driven Insights in Obesity: A Comparative Cross-Sectional Analysis of General Practice and a Specialized Obesity Clinic in Belgium—An IMI2 SOPHIA Study 真实世界数据驱动的肥胖洞察：比利时一般实践和专业肥胖诊所的比较横断面分析-一项IMI2 SOPHIA研究。

IF 2.4

Clinical Obesity Pub Date : 2026-07-22 DOI: 10.1111/cob.70098

Amar Daniël Emanuel van Laar, Sofia Pazmino, Pavlos Mamouris, Nele Steenackers, Roman Vangoitsenhoven, Ann Mertens, Ellen Deleus, Matthias Lannoo, Margo Hulsmans, Caroline Simoens, Bert Vaes, Bart Van der Schueren

{"title":"Real-World Data-Driven Insights in Obesity: A Comparative Cross-Sectional Analysis of General Practice and a Specialized Obesity Clinic in Belgium—An IMI2 SOPHIA Study","authors":"Amar Daniël Emanuel van Laar, Sofia Pazmino, Pavlos Mamouris, Nele Steenackers, Roman Vangoitsenhoven, Ann Mertens, Ellen Deleus, Matthias Lannoo, Margo Hulsmans, Caroline Simoens, Bert Vaes, Bart Van der Schueren","doi":"10.1111/cob.70098","DOIUrl":"10.1111/cob.70098","url":null,"abstract":"<div>\u0000 \u0000 <p>There is a lack of knowledge on the registration of body mass index (BMI) and prevalence of obesity-related complications in the Belgian healthcare system. We therefore evaluated these in Belgians living with overweight or obesity. BMI registration and obesity-related complication prevalences were determined using cross-sectional data from a Belgian general practitioners' morbidity registry (Intego) with 208 891 personal records and from 3605 visitors to an obesity clinic. Two Intego data subsets were used: 53 555 individuals with and 84 017 individuals without registered BMI. Groups were compared using chi-square tests (<i>p</i>-value of < 0.05). For Intego data, BMI was registered in 25.6% of cases. Individuals with registered BMI (mean BMI 27.1 ± 5.5 kg/m<sup>2</sup>) had a higher prevalence of hypertension (30.1% vs. 17.0%), dyslipidemia (26.9% vs. 14.7%), prediabetes (17.0% vs. 7.9%), type 2 diabetes (12.7% vs. 4.4%) and sleep apnea (3.8% vs. 1.5%) compared to people without registered BMI. People assessed at the obesity clinic (mean BMI 39.0 ± 6.5 kg/m<sup>2</sup>) had higher prevalences of hypertension (43.1% vs. 37.5%), dyslipidemia (44.4% vs. 32.9%) and sleep apnea (37.9% vs. 5.5%) compared to Intego individuals with BMI ≥ 25 kg/m<sup>2</sup>(mean BMI 30.3 ± 4.3 kg/m<sup>2</sup>). BMI is registered only in 25% of patient files in general practice, and people with a registered BMI in general practice have a substantially higher prevalence of the five obesity-related complications than people without registered BMI. When registered, mean BMI is substantially lower than in the obesity clinic, but the prevalence of complications is already substantial, though lower than in the obesity clinic.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Naltrexone HCl and Bupropion HCl (Contrave) Extended-Release Tablet (NB-ER) for Weight Maintenance in Adult Patients After a 6-Month Intensive Behaviour Modification Program Combined With Meal Replacements 盐酸纳曲酮和盐酸安非他酮缓释片（NB-ER）对6个月强化行为矫正联合代餐后成人患者体重维持的影响

IF 2.4

Clinical Obesity Pub Date : 2026-07-21 DOI: 10.1111/cob.70099

V. Tony Chetty, Liviu Denescu, Boris Zevin, Suzana Damjanovic, Iris M. Balodis, Adell Elsharif, Gary Foster

{"title":"Effect of Naltrexone HCl and Bupropion HCl (Contrave) Extended-Release Tablet (NB-ER) for Weight Maintenance in Adult Patients After a 6-Month Intensive Behaviour Modification Program Combined With Meal Replacements","authors":"V. Tony Chetty, Liviu Denescu, Boris Zevin, Suzana Damjanovic, Iris M. Balodis, Adell Elsharif, Gary Foster","doi":"10.1111/cob.70099","DOIUrl":"10.1111/cob.70099","url":null,"abstract":"<div>\u0000 \u0000 <p>The prevalence of obesity is increasing worldwide, with approximately nine million people affected in Canada. Obesity is associated with high rates of morbidity and mortality as well as significant healthcare costs and economic burden. The primary therapeutic options for weight maintenance and treatment of weight regain include behaviour modification, lifestyle intervention and pharmacotherapy. This randomised, double-blind, placebo-controlled, crossover trial aimed to determine the effect of a fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER) (commonly known as Contrave) on weight maintenance and further weight loss following the intensive portion of a behaviour modification program. The results from this study demonstrate that after an intensive lifestyle intervention program, treatment with NB-ER for six months prevented weight regain compared to placebo. Additionally, a greater proportion of subjects experienced weight maintenance and less absolute weight regain on NB-ER compared to placebo, supporting the use of NB-ER as an effective option for weight maintenance in patients with significant prior weight loss.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0