Clinical Obesity最新文献_第3页

Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories 肥胖症的分类和严重程度评估在多病轨迹的临床风险预测中的作用。

IF 2.4

Clinical Obesity Pub Date : 2026-07-15 DOI: 10.1111/cob.70097

Afua Ampadu-Yeboah, Alistair Carr, Frederick Ho, Jason Gill, Naveed Sattar, Bhautesh Dinesh Jani

{"title":"Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories","authors":"Afua Ampadu-Yeboah, Alistair Carr, Frederick Ho, Jason Gill, Naveed Sattar, Bhautesh Dinesh Jani","doi":"10.1111/cob.70097","DOIUrl":"10.1111/cob.70097","url":null,"abstract":"Obesity is a key risk factor for chronic disease and multimorbidity, yet variation in how obesity is defined may influence risk estimation in clinical practise. Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) are better at capturing fat distribution than body mass index (BMI) and may have a role in obesity related multimorbidity prediction. To examine multimorbidity risk across obesity groups classified using BMI in combination with WHR/WHtR. A UK Biobank cohort free of comorbidity at baseline (n = 179 876) was followed for incident first long-term condition and multimorbidity (≥ 2 of 38 conditions) over a mean of 9.9 years. Six adiposity categories combining BMI with WHR/WHtR were analysed using Cox proportional hazards models. Subgroup analyses evaluated whether high central obesity (WHtR ≥ 0.6) provided additional risk stratification within BMI groups. Combined general with central obesity showed highest risk for the first condition (HR 1.11; 95% CI 1.087–1.138) and multimorbidity (HR 1.13; 95% CI 1.093–1.172). However, BMI-stratified subgroup analyses, central obesity provided additional risk discrimination only among individuals in the overweight category (BMI 25–29.9 kg/m2), but not among those with BMI ≥ 30 kg/m2. Waist-based measures improved risk identification in adults with overweight BMI, supporting the potential role of combined BMI-waist approaches for earlier multimorbidity prevention.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight Gains Across Adulthood—The ELSA-Brasil Study 成年期体重增加——elsa -巴西研究。

IF 2.4

Clinical Obesity Pub Date : 2026-07-07 DOI: 10.1111/cob.70095

Scheine L. Canhada, Paula A. Bracco, Maria de Jesus Fonseca, Maria Del Carmen Bisi Molina, Maria Inês Schmidt, Bruce B. Duncan

{"title":"Weight Gains Across Adulthood—The ELSA-Brasil Study","authors":"Scheine L. Canhada, Paula A. Bracco, Maria de Jesus Fonseca, Maria Del Carmen Bisi Molina, Maria Inês Schmidt, Bruce B. Duncan","doi":"10.1111/cob.70095","DOIUrl":"10.1111/cob.70095","url":null,"abstract":"Our objective was to describe weight, fat mass, skeletal mass and waist gains across the adult lifespan. We analysed data from 11 611 participants in the Brazilian Longitudinal Study of Adult Health, aged 35–74 years at baseline and followed from 2008 to 2024. Anthropometric measurements were performed at all visits, and bioimpedance at follow-up visits. Weight at age 20 was self-reported. Age-related changes in weight, fat and muscle mass and waist circumference were estimated using generalised estimating equations with restricted cubic splines. Participants' weight increased a mean of 15 kg from age 20–60, when weight peaked. Most of this increase (50%) occurred before age 35. While obesity manifested mainly in later life, maximum annual weight gains were seen up to age 40–45. Gains then tapered, and weight stabilised across ages 55–65, and then decreased at older ages. While fat and muscle mass followed trajectories similar to that of weight, waist circumference increased steadily up to age 75. Approximately half of the difference in adult weight occurred before age 35. Population-based and clinical interventions to limit weight gain in young adulthood, if effective, could have a major impact on the incidence and long-term burden of obesity","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Service Evaluation of a Specialist Multi-Disciplinary Weight Management Service Based in Primary Care Including Long-Term Follow-Up Data 基于初级保健的多学科体重管理专家服务评价，包括长期随访数据。

IF 2.4

Clinical Obesity Pub Date : 2026-07-02 DOI: 10.1111/cob.70096

Helen M. Parretti, Carly A. Hughes, Sally Erskine, Nicholas Steel, Amy Jennings

{"title":"A Service Evaluation of a Specialist Multi-Disciplinary Weight Management Service Based in Primary Care Including Long-Term Follow-Up Data","authors":"Helen M. Parretti, Carly A. Hughes, Sally Erskine, Nicholas Steel, Amy Jennings","doi":"10.1111/cob.70096","DOIUrl":"10.1111/cob.70096","url":null,"abstract":"This service evaluation of a primary care-based specialist weight management service reports data from 1094 patients over 5 years (2014–2019), including weight data at 1-year post-discharge. The results show clinically and statistically significant improvements in weight, diet, physical activity, quality of life, blood pressure and blood glucose control (in people living with type 2 diabetes). Change in weight was statistically significant for all timepoints in all subgroups. At 1-year completers (n = 560) had lost a mean of 8.3 kg (SD 0.3) and 133 patients (23.8%) had lost ≥ 10% of their starting weight. Using baseline observation carried forward analysis on the whole cohort (n = 1094) the mean weight loss at the end of the 1-year programme was 4.5 kg (SD 0.2) and 144 (13.2%) had lost ≥ 10% of their starting weight. A year after discharge completers demonstrated a mean weight loss of 8.3% (SD 10.3 n = 303) and 35.6% (n = 108) of completers had maintained ≥ 10% change in body weight. Analysis showed a mean weight loss of 2.5% (SD 6.8 n = 1094) in the whole cohort using baseline observation carried forward, demonstrating maintenance of weight loss and suggesting that specialist weight management services in primary care may be effective in the longer-term.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Scale: Patient Perceptions and Experiences of Bariatric Surgery Support—A Qualitative Analysis of the BELONG II Study 量表之外：患者对减肥手术支持的感知和体验——归属II研究的定性分析。

IF 2.4

Clinical Obesity Pub Date : 2026-06-23 DOI: 10.1111/cob.70093

Cecelia L. Crawford, Laurel D. Hansell, Clarissa W. Hsu, Jessica Mogk, Silvia R. Paz, Darren D. Moore, Mayra Macias, Bhumi B. Bhakta, Debi Ellis, Cecilia Lopez, Tonce Jackson, Angela Borruso, Reggie Graves, Vincent Corralejo, Marlaine Figueroa Gray, Deborah R. Young, Adam Drewnowski, Kristina H. Lewis, Karen J. Coleman

{"title":"Beyond the Scale: Patient Perceptions and Experiences of Bariatric Surgery Support—A Qualitative Analysis of the BELONG II Study","authors":"Cecelia L. Crawford, Laurel D. Hansell, Clarissa W. Hsu, Jessica Mogk, Silvia R. Paz, Darren D. Moore, Mayra Macias, Bhumi B. Bhakta, Debi Ellis, Cecilia Lopez, Tonce Jackson, Angela Borruso, Reggie Graves, Vincent Corralejo, Marlaine Figueroa Gray, Deborah R. Young, Adam Drewnowski, Kristina H. Lewis, Karen J. Coleman","doi":"10.1111/cob.70093","DOIUrl":"10.1111/cob.70093","url":null,"abstract":"<div>\u0000 \u0000 To examine surgical experiences of diverse participants with obesity who underwent bariatric surgery and interacted with nurses and physicians in the prior 2–5 years. Qualitative analysis of a prospective longitudinal cohort study to understand adult experiences of people with obesity before and after bariatric surgery. Semi-structured interview data (n = 68) were analysed to identify patterns in supportive practices and unmet needs of participants with obesity. Two theme categories emerged describing supportive care and care gaps. Supportive themes were Appreciation, Support, Listening, and Understanding, Impact of Classes, and Importance of Information. Care gap themes included Stigma, Bias, and Judgement Lack of Decision Support, More Than Losing Weight, Weight Bias, Lack of Support/Communication, Lack of Follow-Up, Few Mental Health Supports, and Not Being Seen and Heard. Participants with obesity described experiences of bias, stigma, and concerns about knowledge and communication. Our study found stigma, bias, and judgement experienced by patients with obesity are barriers to bariatric care and successful outcomes. Gaps in communication, follow-up, and mental health contributed to feelings the participants expressed of “not being seen and heard.” Active listening, transparent communication, and coordinated care were perceived by participants with obesity as essential for trust, respect, and belonging.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemia in the Context of Post-Bariatric Clinical Follow-Up: Is There a Blind Spot in Research and Care? 减肥后临床随访背景下的低血糖：研究和护理是否存在盲点？

IF 2.4

Clinical Obesity Pub Date : 2026-06-17 DOI: 10.1111/cob.70090

Daniel Sant’Anna da Silva, Karynne Grutter Lopes, Luiz Guilherme Kraemer-Aguiar

{"title":"Hypoglycemia in the Context of Post-Bariatric Clinical Follow-Up: Is There a Blind Spot in Research and Care?","authors":"Daniel Sant’Anna da Silva, Karynne Grutter Lopes, Luiz Guilherme Kraemer-Aguiar","doi":"10.1111/cob.70090","DOIUrl":"10.1111/cob.70090","url":null,"abstract":"<div>\u0000 \u0000 Post-bariatric hypoglycemia (PBH) is classically defined as venous glucose levels < 54 mg/dL accompanied by sympathetic or neuroglycopenic symptoms, with resolution after glucose correction (Whipple's triad), occurring in a typical post-surgical context (1–3 years after surgery, 2–4 h postprandially), after exclusion of other causes. Since 2015, studies using continuous glucose monitoring (CGM) have revealed a more complex glycemic profile following metabolic bariatric surgery (MBS) characterised by CGM-detected asymptomatic and nocturnal low interstitial glucose values, frequently occurring during prolonged intermeal periods, along with increased 24-h glycemic variability. Provocative tests are limited by non-physiological stimuli or poor standardisation. Meanwhile, although diagnostic workups for alternative etiologies not related to diabetes are recommended, these conditions are exceedingly rare compared with real-world CGM-detected events. Evidence from cohorts of individuals with diabetes links CGM metrics, such as nocturnal and prolonged intermeal low glucose exposure and glycemic variability, to adverse outcomes, including cardiovascular mortality, stroke, arrhythmias, next-day cognitive slowing, retinopathy, microalbuminuria, and arterial stiffness. These findings may support the potential prognostic relevance of similar phenotypes following MBS. We argue for: (1) a critical revision of diagnostic criteria, including standardised interstitial thresholds, event definitions, and the role of symptoms; and (2) prospective CGM cohorts of post-MBS patients without diabetes adequately sized to assess clinically meaningful endpoints, such as cardiovascular, microvascular, and cognitive outcomes. CGM has uncovered a likely blind spot in PBH, particularly asymptomatic and nocturnal hypoglycemia. Recognising this spectrum and aligning definitions, diagnostics, and care may improve outcomes.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight-Lowering Drugs and Natural Female Fertility—A Systematic Review and Meta-Analysis 减肥药与女性自然生育能力——系统综述与meta分析。

IF 2.4

Clinical Obesity Pub Date : 2026-06-17 DOI: 10.1111/cob.70092

Shaikha Jabor Alnaimi, Dana Muwafag Alsugeir, Li Wei, Kirsten Harvey, Ruth Brauer

{"title":"Weight-Lowering Drugs and Natural Female Fertility—A Systematic Review and Meta-Analysis","authors":"Shaikha Jabor Alnaimi, Dana Muwafag Alsugeir, Li Wei, Kirsten Harvey, Ruth Brauer","doi":"10.1111/cob.70092","DOIUrl":"10.1111/cob.70092","url":null,"abstract":"Overweight and obesity are global health concerns linked to impaired female fertility. Weight-lowering drugs are an alternative for achieving weight loss; however, their effect on natural female fertility is unclear. A systematic review and meta-analysis were conducted to summarise the literature on the effects of weight-lowering drugs on ovulation, conception, pregnancy and live birth rates. Inclusion criteria comprised interventional and observational studies involving women with overweight or obesity receiving weight-lowering drugs, compared with non-users, lifestyle modifications or other medications. MEDLINE, Embase, CINAHL, CENTRAL and ClinicalTrials.gov were searched, yielding 2731 records. After screening, seven clinical trials were included (n = 575), six of which were randomised. Sample sizes ranged from 40 to 120 women aged 25.9–29.7 years. Six trials evaluated orlistat, while one assessed semaglutide. In four trials, orlistat was associated with a higher ovulation rate than lifestyle modifications. A meta-analysis of ovulation rates comparing orlistat and metformin showed no significant difference (RR = 0.78, 95% CI: 0.41–1.49; p = 0.45). Two studies reported pregnancy rates: one found a higher rate with orlistat compared to lifestyle modifications (23.3% vs. 6.7%, p = 0.044), and another showed that adding semaglutide to metformin increased the pregnancy rate compared to metformin alone (35% vs. 15%, p < 0.05). Future studies should address current limitations and evaluate the effects of newer weight-lowering drugs on natural pregnancy and live birth rates in adequately powered studies.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-Onset Obesity and Heart Failure Burden Independent of Cardiometabolic Risk Factors 早发性肥胖和心力衰竭负担独立于心脏代谢危险因素。

IF 2.1

Clinical Obesity Pub Date : 2026-06-12 DOI: 10.1111/cob.70091

Shiza Sarfraz, Ameer Haider Cheema, Ali Zayam Tayyab, Hassam Ali, Harigopal Sandhyavenu

{"title":"Early-Onset Obesity and Heart Failure Burden Independent of Cardiometabolic Risk Factors","authors":"Shiza Sarfraz, Ameer Haider Cheema, Ali Zayam Tayyab, Hassam Ali, Harigopal Sandhyavenu","doi":"10.1111/cob.70091","DOIUrl":"10.1111/cob.70091","url":null,"abstract":"<div>\u0000 \u0000 The timing of obesity onset may influence long-term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and cardiovascular outcomes remains uncertain. We analysed adults with obesity (BMI ≥ 30 kg/m2) from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Participants were classified as having early-onset obesity (with obesity at approximately age 25) or adult-onset obesity (with obesity at study enrolment but not at age 25). Primary outcomes included measured hypertension and a composite of cardiovascular disease (CVD) (congestive heart failure [CHF], coronary heart disease, angina, myocardial infarction or stroke). The weighted population represented 19.4 million U.S. adults with obesity, including 2.56 million with early-onset obesity. Adjusted cardiometabolic measures did not differ. CHF was more common with early-onset obesity (13.5% vs. 6.6%), and adult-onset obesity was associated with lower odds of CHF (adjusted OR: 0.43, 95% CI: 0.23–0.82). No differences were observed for coronary heart disease, angina, myocardial infarction, stroke or hard CVD. Among U.S. adults with obesity, early-onset obesity is associated with a higher burden of CHF, suggesting a potential role of cumulative obesity exposure in heart failure development.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Epicardial and Visceral Fat in Severe Respiratory Infections: Associations With Adverse Outcomes 心外膜和内脏脂肪在严重呼吸道感染中的作用：与不良结局的关联

IF 2.1

Clinical Obesity Pub Date : 2026-06-10 DOI: 10.1111/cob.70089

Rebecca Baumgartner, Jéssica A. de Paula, Cleverson A. Leitão, Gabriela Lazzaron-Slob, Estela I. Rabito, Emilton L. Junior

{"title":"The Role of Epicardial and Visceral Fat in Severe Respiratory Infections: Associations With Adverse Outcomes","authors":"Rebecca Baumgartner, Jéssica A. de Paula, Cleverson A. Leitão, Gabriela Lazzaron-Slob, Estela I. Rabito, Emilton L. Junior","doi":"10.1111/cob.70089","DOIUrl":"10.1111/cob.70089","url":null,"abstract":"Excess adipose tissue has been extensively studied due to its role in the development of chronic diseases and inflammatory conditions. Obesity and visceral adipose tissue (VAT, fat stored within the abdominal cavity and around organs) are associated with increased susceptibility to respiratory infections and chronic low-grade systemic inflammation. This study investigates the relationship among VAT, epicardial adipose tissue (EAT, fat surrounding the heart), and mortality in critically ill patients diagnosed with COVID-19, aiming to identify which measure is more strongly associated with adverse outcomes. A retrospective observational cohort study was conducted with patients admitted to the Intensive Care Unit (ICU) who underwent chest computed tomography (CT). Measurements of VAT and EAT were obtained from contrast-free CT images. Statistical analysis included the Mann–Whitney U test and logistic regression. Individuals who died had a larger EAT area. In patients with BMI < 30 Kg/m2, an increase in EAT was associated with a higher risk of mortality (OR = 1.06, 95% CI 1.015–1.107, p < 0.01). EAT area measurement was associated with mortality risk in critically ill individuals without obesity (BMI < 30 kg/m2) diagnosed with COVID-19 and may serve as a prognostic marker for risk stratification in this population.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Edmonton Obesity Staging System Clinical Support Tool: A Structured EOSS-Domain-Based Tool for Primary Care 埃德蒙顿肥胖分期系统临床支持工具：一个结构化的基于eoss域的初级保健工具。

IF 2.1

Clinical Obesity Pub Date : 2026-06-03 DOI: 10.1111/cob.70088

Annalena Philipp, Christel Moll, Arya M. Sharma, Christine Joisten

{"title":"The Edmonton Obesity Staging System Clinical Support Tool: A Structured EOSS-Domain-Based Tool for Primary Care","authors":"Annalena Philipp, Christel Moll, Arya M. Sharma, Christine Joisten","doi":"10.1111/cob.70088","DOIUrl":"10.1111/cob.70088","url":null,"abstract":"Although body mass index (BMI) is widely used to diagnose obesity, it is an imprecise measure of health. The Edmonton Obesity Staging System (EOSS) assesses the health impacts of elevated BMI based on medical, mental and functional complications and has been shown to predict mortality more accurately than BMI alone. This study aimed to develop a simple clinical support tool for structured assessment of the EOSS domains in routine clinical practice. An EOSS-based clinical support tool was developed through an iterative Delphi process with obesity-care experts, including pilot testing with patients and general practitioners, a test–retest reliability assessment and a final consensus meeting. The final instrument consists of 48 items across six domains: personal information, medical history, lifestyle, weight-reduction measures, psychosocial burden and functional limitations. Pilot testing indicated good feasibility and clarity, and the test–retest reliability assessment indicated good temporal stability; low-reliability items were revised. This clinical support tool, based on the EOSS domains, is designed to support the structured collection of information on obesity-related medical, functional and psychosocial aspects. Further research is needed to evaluate its validity, feasibility in routine practice and implementation across diverse primary care settings.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of the IWQOL-Lite-CT in Observational Research: Comparison of Baseline Scores With a Clinical Trial Population and Psychometric Evaluation IWQOL-Lite-CT在观察性研究中的实施：基线评分与临床试验人群和心理测量评估的比较。

IF 2.1

Clinical Obesity Pub Date : 2026-06-03 DOI: 10.1111/cob.70087

Lisa von Huth Smith, Shanshan Qin, Sidsel Marie Bernt Jørgensen, Dane Korver, Stuart Yarr, Sheri E. Fehnel, Ronette L. Kolotkin

{"title":"Implementation of the IWQOL-Lite-CT in Observational Research: Comparison of Baseline Scores With a Clinical Trial Population and Psychometric Evaluation","authors":"Lisa von Huth Smith, Shanshan Qin, Sidsel Marie Bernt Jørgensen, Dane Korver, Stuart Yarr, Sheri E. Fehnel, Ronette L. Kolotkin","doi":"10.1111/cob.70087","DOIUrl":"10.1111/cob.70087","url":null,"abstract":"The aims of this study were to compare baseline Impact of Weight on Quality of Life–Lite Clinical Trials Version (IWQOL-Lite-CT) scores between adults with obesity participating in either observational or clinical studies and to conduct a psychometric evaluation of the IWQOL-Lite-CT in the context of observational research. Analyses of covariance were used to compare baseline IWQOL-Lite-CT Total, Physical, Physical Function, and Psychosocial composite scores between participants with a body mass index (BMI) ≥ 30 in a US longitudinal survey (an observational study) and a multinational phase 3a study of subcutaneous semaglutide 2.4 mg for weight management (STEP 1). Data from the longitudinal survey were also used to evaluate the psychometric properties of the IWQOL-Lite-CT composite scores. Adjusting for BMI, age, and sex, on average, participants in the longitudinal survey scored lower than STEP 1 participants at baseline by 23.4 points on the IWQOL-Lite-CT Total, 20.7 on the Physical composite, 20.3 on the Physical Function composite, and 24.8 on the Psychosocial composite. While the internal consistency, test–retest reliability, and construct validity of the IWQOL-Lite-CT composite scores were confirmed in the longitudinal survey, responsiveness analyses were limited by small changes in weight. The weight-related functioning of US individuals with obesity who participated in a longitudinal survey was more limited than that of participants in the STEP 1 clinical trial. Psychometric results support use of the IWQOL-Lite-CT in observational research in addition to the clinical trial setting.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0